The many faces of macrophage activation

NITRIC OXIDE AND MACROPHAGE FUNCTION

MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,245

M-1/M-2 Macrophages and the Th1/Th2 Paradigm

Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287

Interleukin 4 potently enhances murine macrophage mannose receptor activity: A marker of alternative immunologic macrophage activation

Stein, M., Keshav, S., Harris, N., & Gordon, S. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.1.287 · Cited by 1,960

Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation.

Huynh, M.-L. N., Fadok, V., & Henson, P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci11638 · Cited by 1,333

Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation

Huynh, M.-L. N., Fadok, V. A., & Henson, P. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0211638 · Cited by 957

Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of l -Arginine Metabolism

Hesse, M., Modolell, M., Flamme, A. C. L., Schito, M. L., Fuentes, J. M., Cheever, A. W., Pearce, E. J., & Wynn, T. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6533 · Cited by 723

Other Functions, Other Genes

Goerdt, S., & Orfanos, C. E. (1999) · Immunity · doi:10.1016/s1074-7613(00)80014-x · Cited by 678

Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow‐derived macrophages by TH 1 and TH 2 cytokines

Modolell, M., Corraliza, I. M., Link, F., Soler, G., & Eichmann, K. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250436 · Cited by 554

Reprogramming of the Macrophage Transcriptome in Response to Interferon-γ and Mycobacterium tuberculosis

Ehrt, S., Schnappinger, D., Bekiranov, S., Drenkow, J., Shi, S., Gingeras, T., Gaasterland, T., Schoolnik, G. K., & Nathan, C. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.8.1123 · Cited by 467

Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts

Song, E., Ouyang, N., Hörbelt, M., Antus, B., Wang, M., & Exton, M. S. (2000) · Cellular Immunology · doi:10.1006/cimm.2000.1687 · Cited by 447

Macrophages escape Klotho gene silencing in the mdx mouse model of Duchenne muscular dystrophy and promote muscle growth and increase satellite cell numbers through a Klotho-mediated pathway

Wehling‐Henricks, M., Welc, S. S., Samengo, G., Rinaldi, C., Lindsey, C., Wang, Y., Lee, J., Kuro‐o, M., & Tidball, J. G. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx380 · Cited by 59

Shaping the immune landscape: Multidimensional environmental stimuli refine macrophage polarization and foster revolutionary approaches in tissue regeneration

Xue, J., Gao, J., Tang, A.-F., & Feng, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e37192 · Cited by 66

Regulatory role of periodontal ligament fibroblasts for innate immune cell function and differentiation

Konermann, A., Stabenow, D., Knolle, P. A., Held, S. A. E., Deschner, J., & Jäger, A. (2012) · Innate Immunity · doi:10.1177/1753425912440598 · Cited by 60

Temporal changes in monocyte and macrophage subsets and microglial macrophages following spinal cord injury in the lys-egfp-ki mouse model

Thawer, S. G., Mawhinney, L., Chadwick, K., de Chickera, S. N., Weaver, L. C., Brown, A. M., & Dekaban, G. A. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.04.008 · Cited by 62

Soluble Immune Complexes Shift the TLR-Induced Cytokine Production of Distinct Polarized Human Macrophage Subsets towards IL-10

Ambarus, C. A., Santegoets, K. C. M., van Bon, L. G., Wenink, M. H., Tak, P. P., Radstake, T. R. D. J., & Baeten, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035994 · Cited by 59

Differentiation and Glucocorticoid Regulated Apopto-Phagocytic Gene Expression Patterns in Human Macrophages. Role of Mertk in Enhanced Phagocytosis

Zahuczky, G., Kristóf, E., Majai, G. E., & Fésüs, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021349 · Cited by 57

Regulatory macrophages as therapeutic targets and therapeutic agents in solid organ transplantation

Broichhausen, C., Riquelme, P., Geissler, E. K., & Hutchinson, J. A. (2012) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e328355a979 · Cited by 59

Lack of Smad3 signaling leads to impaired skeletal muscle regeneration

Ge, X., Vajjala, A., McFarlane, C., Wahli, W., Sharma, M., & Kambadur, R. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00113.2012 · Cited by 57

Novel Molecular Insights into Classical and Alternative Activation States of Microglia as Revealed by Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-based Proteomics*

Bell‐Temin, H., Culver‐Cochran, A. E., Chaput, D., Carlson, C., Kuehl, M. N., Burkhardt, B. R., Bickford, P. C., Liu, B., & Stevens, S. M. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.053926 · Cited by 62

Reduced inflammatory response by incorporating magnesium into porous TiO2 coating on titanium substrate

Li, X., Huang, Q., Liu, L., Zhu, W., Elkhooly, T. A., Liu, Y., Feng, Q., Li, Q., Zhou, S., Liu, Y., et al. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.07.032 · Cited by 58

Evaluation of epigallocatechin-3-gallate (EGCG)-modified scaffold determines macrophage recruitment

Chu, C., Liu, L., Wang, Y., Yang, R., Hu, C., Rung, S., Man, Y., & Qu, Y. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.03.007 · Cited by 59

Toxin gamma from Tityus serrulatus scorpion venom plays an essential role in immunomodulation of macrophages

Petricevich, V. L., Cruz, A. H., Coronas, F. I. V., & Possani, L. D. (2007) · Toxicon · doi:10.1016/j.toxicon.2007.06.001 · Cited by 57

Stimulation of Innate Immune Function by Panax ginseng after Heat Processing

Shin, M., Song, J. H., Choi, P., Lee, J. H., Kim, S., Shin, K., Ham, J., & Kang, K. S. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b00152 · Cited by 58

The Expression of Heparin-Binding Epidermal Growth Factor-Like Growth Factor by Regulatory Macrophages

Edwards, J. P., Zhang, X., & Mosser, D. M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802703 · Cited by 55

Microarray analysis of activated mixed glial (microglia) and monocyte-derived macrophage gene expression

Albright, A. V., & González‐Scarano, F. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.09.007 · Cited by 57

Immunomodulatory mechanism of a purified polysaccharide isolated from Isaria cicadae Miquel on RAW264.7 cells via activating TLR4-MAPK-NF-κB signaling pathway

Xu, Z., Lin, R., Hou, X., Wu, J., Zhao, W., Ma, H., Fan, Z., Li, S., Zhu, Y. S., & Zhang, D. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.09.035 · Cited by 56

Dysregulation of Leukocyte Trafficking in Type 2 Diabetes: Mechanisms and Potential Therapeutic Avenues

Pezhman, L., Tahrani, A. A., & Chimen, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.624184 · Cited by 61

STAT1 deficiency redirects IFN signalling toward suppression of TLR response through a feedback activation of STAT3

Kim, H. S., Kim, D. C., Kim, H.-M., Kwon, H., Kwon, S. J., Kang, S., Kim, S. C., & Choi, G.-E. (2015) · Scientific Reports · doi:10.1038/srep13414 · Cited by 60

Minireview: Emerging Concepts in Islet Macrophage Biology in Type 2 Diabetes

Morris, D. L. (2015) · Molecular Endocrinology · doi:10.1210/me.2014-1393 · Cited by 57

Oxidative Stress, Inflammatory Biomarkers, and Toxicity in Mouse Lung and Liver after Inhalation Exposure to 100% Biodiesel or Petroleum Diesel Emissions

Shvedova, A. A., Yanamala, N. V. K., Murray, A. R., Kisin, E. R., Оскарович, Х. Т., Hatfield, M. K., Tkach, A. V., Krantz, Q. T., Nash, D. G., King, C. J., et al. (2013) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2013.825217 · Cited by 56

Macrophage diversity in cardiac inflammation: A review

Barin, J. G., Rose, N. R., & Čiháková, D. (2012) · Immunobiology · doi:10.1016/j.imbio.2011.06.009 · Cited by 56

Mutations in the Aeromonas salmonicida subsp. salmonicida type III secretion system affect Atlantic salmon leucocyte activation and downstream immune responses

Fast, M. D., Tse, B., Boyd, J. M., & Johnson, S. C. (2009) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2009.09.009 · Cited by 56

Hard to heal pressure ulcers (stage III–IV): Efficacy of injected activated macrophage suspension (AMS) as compared with standard of care (SOC) treatment controlled trial

Zuloff‐Shani, A., Adunsky, A., Even-Zahav, A., Semo, H., Orenstein, A., Tamir, J., Regev, E., Shinar, E., & Danon, D. (2010) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2009.11.015 · Cited by 55

Eyeballing cholesterol efflux and macrophage function in disease pathogenesis

Sène, A., & Apte, R. S. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.10.007 · Cited by 56

The clinical and immunologic features of pulmonary fibrosis in sarcoidosis

Patterson, K. C., Hogarth, K. D., Husain, A. N., Sperling, A. I., & Niewold, T. B. (2012) · Translational research · doi:10.1016/j.trsl.2012.03.005 · Cited by 57

Immune-Stimulatory and Therapeutic Activity of Tinospora cordifolia : Double-Edged Sword against Salmonellosis

Alsuhaibani, S. A., & Khan, M. A. (2017) · Journal of Immunology Research · doi:10.1155/2017/1787803 · Cited by 56

Pulmonary and systemic toxicity in rats following inhalation exposure of 3-D printer emissions from acrylonitrile butadiene styrene (ABS) filament

Farcas, M. T., McKinney, W., Qi, C., Mandler, K., Battelli, L. A., Friend, S. A., Stefaniak, A. B., Jackson, M., Orandle, M. S., WINN, A. C., et al. (2020) · Inhalation Toxicology · doi:10.1080/08958378.2020.1834034 · Cited by 56

Diversity in Phenotype and Steroid Hormone Dependence in Dendritic Cells and Macrophages in the Mouse Uterus1

Keenihan, S., & Robertson, S. A. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.024794 · Cited by 56

VISTA Re-programs Macrophage Biology Through the Combined Regulation of Tolerance and Anti-inflammatory Pathways

ElTanbouly, M. A., Schaafsma, E., Smits, N. C., Shah, P. S., Cheng, C., Burns, C. M., Blazar, B. R., Noelle, R. J., & Mabaera, R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.580187 · Cited by 55

Biomarker Analysis Revealed Distinct Profiles of Innate and Adaptive Immunity in Infants with Ocular Lesions of Congenital Toxoplasmosis

Machado, A. S., Carneiro, A. C. A. V., Béla, S. R., de Andrade, G. M. Q., Vasconcelos-Santos, D. V., Januário, J. N., Coelho-dos-Reis, J. G. A., Ferro, E. A. V., Teixeira‐Carvalho, A., Vítor, R. W. A., et al. (2014) · Mediators of Inflammation · doi:10.1155/2014/910621 · Cited by 55

Macrophage Heterogeneity: Relevance and Functional Implications in Atherosclerosis

Stöger, J. L., Goossens, P., & de Winther, M. P. J. (2010) · Current Vascular Pharmacology · doi:10.2174/157016110790886983 · Cited by 54

M2b Monocytes Predominated in Peripheral Blood of Severely Burned Patients

Kobayashi, M., Jeschke, M. G., Shigematsu, K., Asai, A., Yoshida, S., Herndon, D. N., & Suzuki, F. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903935 · Cited by 55

The effect of inflammation on the generation of plasma DNA from dead and dying cells in the peritoneum

Jiang, N., & Pisetsky, D. S. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0704411 · Cited by 55

Dissociation of Endotoxin Tolerance and Differentiation of Alternatively Activated Macrophages

Rajaiah, R., Perkins, D. J., Polumuri, S. K., Zhao, A., Keegan, A. D., & Vogel, S. N. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202407 · Cited by 60

Peroxisome Proliferator-Activated Receptor-γ Regulates the Expression of Alveolar Macrophage Macrophage Colony-Stimulating Factor

Bonfield, T. L., Thomassen, M. J., Farver, C. F., Abraham, S., Koloze, M., Zhang, X., Mosser, D. M., & Culver, D. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.235 · Cited by 55

Glycyrrhizic Acid Promotes M1 Macrophage Polarization in Murine Bone Marrow‐Derived Macrophages Associated with the Activation of JNK and NF‐ κ B

Mao, Y., Wang, B., Xu, X., Du, W., Li, W., & Wang, Y. (2015) · Mediators of Inflammation · doi:10.1155/2015/372931 · Cited by 55

Steroidal alkaloid solanine A from Solanum nigrum Linn. exhibits anti-inflammatory activity in lipopolysaccharide/interferon γ-activated murine macrophages and animal models of inflammation

Zhao, L., Wang, L., Di, S.-N., Xu, Q., Ren, Q.-C., Chen, S.-Z., Huang, N., Jia, D., & Shen, X. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.019 · Cited by 56

The Staphylococcal Biofilm: Adhesins, Regulation, and Host Response

Paharik, A. E., & Horswill, A. R. (2016) · ASM Press eBooks · doi:10.1128/9781555819286.ch19 · Cited by 61

Role of M-CSF-dependent macrophages in colitis is driven by the nature of the inflammatory stimulus

Ghia, J., Galeazzi, F., Ford, D. C., Hogaboam, C. M., Vallance, B. A., & Collins, S. M. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00453.2007 · Cited by 53

TLR7 and TLR9 ligands regulate antigen presentation by macrophages

Celhar, T., Pereira-Lopes, S., Thornhill, S. I., Lee, H. Y., Dhillon, M. K., Poidinger, M., Connolly, J. E., Lim, L. H. K., Biswas, S. K., & Fairhurst, A.-M. (2016) · International Immunology · doi:10.1093/intimm/dxv066 · Cited by 52

Heterogeneity of atherosclerotic plaque macrophage origin, phenotype and functions: Implications for treatment

Nagenborg, J., Goossens, P., Biessen, E. A. L., & Donners, M. M. P. C. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.10.005 · Cited by 50

The Development of Classically and Alternatively Activated Macrophages Has Different Effects on The Varied Stages of Radiation-induced Pulmonary Injury in Mice

Zhang, H., Han, G., Liu, H., Ji, C. H. E. N., Ji, X., Zhou, F., Zhou, Y., & Xie, C. (2011) · Journal of Radiation Research · doi:10.1269/jrr.11054 · Cited by 58

A modified murine model of systemic sclerosis: bleomycin given by pump infusion induced skin and pulmonary inflammation and fibrosis

Liang, M., Lv, J., Zou, L., Yang, W., Xiong, Y., Chen, X., Guan, M., He, R., & Zou, H. (2014) · Laboratory Investigation · doi:10.1038/labinvest.2014.145 · Cited by 56

Serum levels of soluble CD163 in patients with systemic sclerosis

Nakayama, W., Jinnin, M., Makino, K., Kajihara, I., Makino, T., Fukushima, S., Inoue, Y., & Ihn, H. (2010) · Rheumatology International · doi:10.1007/s00296-010-1691-z · Cited by 54

CCL1 released from M2b macrophages is essentially required for the maintenance of their properties

Asai, A., Nakamura, K., Kobayashi, M., Herndon, D. N., & Suzuki, F. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0212107 · Cited by 54

The influence of macrophage depletion on ligament healing

Chamberlain, C. S., Leiferman, E. M., Frisch, K. E., Wang, S., Yang, X., van Rooijen, N., Baer, G. S., Brickson, S. L., & Vanderby, R. (2010) · Connective Tissue Research · doi:10.3109/03008207.2010.511355 · Cited by 54

Isolation of Adipose-Derived Stromal Vascular Fraction Cells Using a Novel Point-of-Care Device: Cell Characterization and Review of the Literature

Brown, J. C., Shang, H., Li, Y., Yang, N., Patel, N., & Katz, A. J. (2017) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2016.0377 · Cited by 56

Activation of Macrophages in Response to Biomaterials

Rayahin, J., & Gemeinhart, R. A. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-54090-0_13 · Cited by 58

Targeting dendritic cells for priming cellular immune responses

Gogolák, P., Réthi, B., Hajas, G., & Rajnavölgyi, É. (2003) · Journal of Molecular Recognition · doi:10.1002/jmr.650 · Cited by 54

Cell Biology of T Cell Activation and Differentiation

Santana, M. A., & Esquivel-Guadarrama, F. R. (2006) · International review of cytology · doi:10.1016/s0074-7696(06)50006-3 · Cited by 61

Microarray analysis reveals that Type I interferon strongly increases the expression of immune-response related genes in Ubp43 (Usp18) deficient macrophages

Zou, W., Kim, J. H., Handidu, A., Li, X., Kim, K. I., Yan, M., Li, J., & Zhang, D. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.02.101 · Cited by 51

Potential mechanisms regulating pulmonary pathology in inflammatory bowel disease

Mateer, S. W., Maltby, S., Marks, E., Foster, P. S., Horvat, J. C., Hansbro, P. M., & Keely, S. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ru1114-563r · Cited by 56

Effects of a blend of essential oils and an enzyme combination on nutrient digestibility, ileum histology and expression of inflammatory mediators in weaned piglets

Jiang, X., Awati, A., Agazzi, A., Vitari, F., Ferrari, A., Bento, H., Crestani, M., Domeneghini, C., & Bontempo, V. (2014) · animal · doi:10.1017/s1751731114002444 · Cited by 53

CXCL16 signaling mediated macrophage effects on tumor invasion of papillary thyroid carcinoma

Cho, S. W., Kim, Y. A., Sun, H. J., Kim, Y. A., Oh, B., Yi, K. H., Park, D. J., & Park, Y. J. (2015) · Endocrine Related Cancer · doi:10.1530/erc-15-0196 · Cited by 53

Infection, modulation and responses of antigen-presenting cells to African swine fever viruses

Franzoni, G., Giudici, S. D., & Oggiano, A. (2018) · Virus Research · doi:10.1016/j.virusres.2018.10.007 · Cited by 54

New therapeutic strategies for IPF: Based on the “phagocytosis-secretion-immunization” network regulation mechanism of pulmonary macrophages

Liu, G., Zhai, H., Zhang, T., Li, S., Li, N., Chen, J., Gu, M., Qin, Z., & Liu, X. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109230 · Cited by 55

Type 2 Diabetes Impairs Insulin Receptor Substrate-2-Mediated Phosphatidylinositol 3-Kinase Activity in Primary Macrophages to Induce a State of Cytokine Resistance to IL-4 in Association with Overexpression of Suppressor of Cytokine Signaling-3

O’Connor, J. C., Sherry, C. L., Guest, C. B., & Freund, G. G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6886 · Cited by 55

Receptor tyrosine kinases and the regulation of macrophage activation

Correll, P. H., Morrison, A. C., & Lutz, M. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0703347 · Cited by 53

Phenotypic changes in bone marrow-derived murine macrophages cultured on PEG-based hydrogels activated or not by lipopolysaccharide

Lynn, A. D., & Bryant, S. J. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.07.033 · Cited by 52

A distinct subset of podoplanin (gp38) expressing F4/80+ macrophages mediate phagocytosis and are induced following zymosan peritonitis

Hou, T. Z., Byström, J., Sherlock, J. P., Qureshi, O. S., Parnell, S. M., Anderson, G., Gilroy, D. W., & Buckley, C. D. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.07.053 · Cited by 52

Macrophages are essential contributors to kidney injury in murine cryoglobulinemic membranoproliferative glomerulonephritis

Guo, S., Wietecha, T., Hudkins, K. L., Kida, Y., Spencer, M. W., Pichaiwong, W., Kojima, I., Duffield, J. S., & Alpers, C. E. (2011) · Kidney International · doi:10.1038/ki.2011.249 · Cited by 52

Statin Attenuates Experimental Anti-Glomerular Basement Membrane Glomerulonephritis Together with the Augmentation of Alternatively Activated Macrophages

Fujita, E., Shimizu, A., Masuda, Y., Kuwahara, N., Arai, T., Nagasaka, S., Aki, K., Mii, A., Natori, Y., Iino, Y., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090608 · Cited by 52

Novel Highly Sensitive IL-10–β-Lactamase Reporter Mouse Reveals Cells of the Innate Immune System as a Substantial Source of IL-10 In Vivo

Bouabe, H., Liu, Y., Moser, M., Bösl, M. R., & Heesemann, J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101477 · Cited by 54

The Effect of Tacrolimus and Mycophenolic Acid on CD14+ Monocyte Activation and Function

Kannegieter, N. M., Hesselink, D. A., Dieterich, M., Kraaijeveld, R., Rowshani, A. T., Leenen, P. J. M., & Baan, C. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170806 · Cited by 53

Regulation of gene expression in RAW 264.7 macrophage cell line by interferon-γ

Kota, R. S., Rutledge, J. C., Gohil, K., Kumar, A., Enelow, R. I., & Ramana, C. V. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.02.087 · Cited by 54

Opposing roles for heat and heat shock proteins in macrophage functions during inflammation: a function of cell activation state?

Lee, C.-T., & Repasky, E. A. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00140 · Cited by 51

Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators

Raza, S., Barnett, M. W., Barnett‐Itzhaki, Z., Amit, I., Hume, D. A., & Freeman, T. C. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.6hi0313-169r · Cited by 49

Effect of Senescence on Macrophage Polarization and Angiogenesis

Dace, D. S., & Apte, R. S. (2008) · Rejuvenation Research · doi:10.1089/rej.2007.0614 · Cited by 51

IFN-γ-Dependent Regulatory Circuits in Immune Inflammation Highlighted in Diabetes

Calderón, B., Suri, A., Pan, X., Mills, J. C., & Unanue, E. R. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.6964 · Cited by 52

Tyrosine Phosphorylation of CD13 Regulates Inflammatory Cell–Cell Adhesion and Monocyte Trafficking

Subramani, J., Ghosh, M., Rahman, M., Caromile, L. A., Gerber, C., Rezaul, K., Han, D. K. M., & Shapiro, L. H. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301348 · Cited by 50

Water-soluble polysaccharide obtained from Acorus calamus L. classically activates macrophages and stimulates Th1 response

Belska, N. V., Guriev, А. M., Данилец, М. Г., Трофимова, Е. С., Учасова, Е. Г., Ligacheva, A. A., Белоусов, М. В., Агафонов, В. И., Golovchenko, V. G., Yusubov, M. S., et al. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.05.005 · Cited by 50

Eosinophils and mast cells in leishmaniasis

Rodríguez, N. E., & Wilson, M. E. (2014) · Immunologic Research · doi:10.1007/s12026-014-8536-x · Cited by 50

IKKβ/NF-κB and the miscreant macrophage

Timmer, A. M., & Nizet, V. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081056 · Cited by 48

M1 and M2 macrophage proteolytic and angiogenic profile analysis in atherosclerotic patients reveals a distinctive profile in type 2 diabetes

Roma-Lavisse, C., Tagzirt, M., Zawadzki, C., Lorenzi, R., Vincentelli, A., Haulon, S., Juthier, F., Rauch, A., Corseaux, D., Staels, B., et al. (2015) · Diabetes and Vascular Disease Research · doi:10.1177/1479164115582351 · Cited by 50

IL-4 Induces Metallothionein 3- and SLC30A4-Dependent Increase in Intracellular Zn2+ that Promotes Pathogen Persistence in Macrophages

Vignesh, K. S., Figueroa, J. A. L., Porollo, A., Divanovic, S., Caruso, J. A., & Deepe, G. S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.057 · Cited by 50

Negative Immune Regulator TIPE2 Promotes M2 Macrophage Differentiation through the Activation of PI3K-AKT Signaling Pathway

Liu, R., Fan, T., Geng, W., Chen, Y. H., Ruan, Q., & Zhang, C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170666 · Cited by 51

Intracellular codelivery of anti-inflammatory drug and anti-miR 155 to treat inflammatory disease

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In Vitro and In Vivo Induction of Heme Oxygenase 1 in Mouse Macrophages following Melanocortin Receptor Activation

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Biological Implications of Heme Metabolism

Sassa, S. (2006) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.38.138 · Cited by 50

Role of trehalose in resistance to macrophage killing: study with a tps1/tps1 trehalose-deficient mutant of Candida albicans

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Transplanted Mesoangioblasts Require Macrophage IL-10 for Survival in a Mouse Model of Muscle Injury

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Effector Function of Diabetogenic CD4 Th1 T Cell Clones: A Central Role for TNF-α

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Integrin Signals, Transcription Factors, and Monocyte Differentiation

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Macrophage and T-Cell Gene Expression in a Model of Early Infection with the Protozoan Leishmania chagasi

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Colonic epithelial response to injury requires Myd88 signaling in myeloid cells

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Immunomodulatory activities on macrophage of a polysaccharide from Sipunculus nudus L.

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Alternatively activated RAW264.7 macrophages enhance tumor lymphangiogenesis in mouse lung adenocarcinoma

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Increase in a distinct pulmonary macrophage subset possessing an antigen-presenting cell phenotype and in vitro APC activity following silica exposure

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Altered Polarization, Morphology, and Impaired Innate Immunity Germane to Resident Peritoneal Macrophages in Mice with Long-Term Type 2 Diabetes

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EPA protects against muscle damage in the mdx mouse model of Duchenne muscular dystrophy by promoting a shift from the M1 to M2 macrophage phenotype

de Carvalho, S. C., Apolinário, L. M., Matheus, S. M. M., Neto, H. S., & Marques, M. J. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.09.007 · Cited by 50

Mycobacterium tuberculosis Cell Wall released Fragments by the Action of the Human Lung Mucosa modulate Macrophages to Control Infection in a IL-10 Dependent Manner

Arcos, J., Sasindran, S., Moliva, J. I., Scordo, J. M., Sidiki, S., Guo, H., Venigalla, P., Kelley, H. V., Lin, G., Diangelo, L., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.115 · Cited by 49

Abdominal surgery induced gastric ileus and activation of M1-like macrophages in the gastric myenteric plexus: prevention by central vagal activation in rats

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Macrophage reprogramming: Influence of latex beads with various functional groups on macrophage phenotype and phagocytic uptakein vitro

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Distinct Subpopulations of Epithelial Ovarian Cancer Cells Can Differentially Induce Macrophages and T Regulatory Cells Toward a Pro‐Tumor Phenotype

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Involvement of Notch signaling pathway in regulating IL-12 expression via c-Rel in activated macrophages

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Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-31RA Expression

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Optic nerve and vitreal inflammation are both RGC neuroprotective but only the latter is RGC axogenic

Ahmed, Z., Aslam, M., Lorber, B., Suggate, E. L., Berry, M., & Logan, A. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.10.024 · Cited by 47

Tunable hydrogel-microsphere composites that modulate local inflammation and collagen bulking

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Differentiation of human induced pluripotent stem cells to authentic macrophages using a defined, serum-free, open-source medium

Vaughan-Jackson, A., Stodolak, S., Ebrahimi, K. H., Browne, C., Reardon, P. K., Pires, E., Gilbert‐Jaramillo, J., Cowley, S. A., & James, W. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.05.018 · Cited by 41

Role of prostaglandin E2 in macrophage polarization: Insights into atherosclerosis

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Alternative activation of macrophages: immune function and cellular biology

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Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease

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Receptor Is Associated with Alternative Macrophage Activation

Hamann, J. (2015)

Alternative activation of macrophages

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The Alternatively Activated Human—Redux

Scott, A. L. (2009) · The Journal of Infectious Diseases · doi:10.1086/599091 · Cited by 2