Iron and peripheral arterial disease: revisiting the iron hypothesis in a different light

Ramakrishna, Gautam; Rooke, Thom W; Cooper, Leslie T

doi:10.1191/1358863x03vm493ra

Cited by 54Iron Metabolism and DisordersPeripheral Artery Disease ManagementAtherosclerosis and Cardiovascular Diseases

Iron and peripheral arterial disease: revisiting the iron hypothesis in a different light

Ramakrishna, Gautam, Rooke, Thom W, Cooper, Leslie T·2003·Vascular Medicine

DOI 10.1191/1358863x03vm493ra

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Abstract

The relationship between iron status and atherosclerosis has long been a topic of debate in the literature. Despite more than 25 years of research, there is no consensus regarding a causal relationship. To date, the vast majority of studies have focused on iron burden with respect to a hypothesized role in the onset and progression of coronary artery disease. However, the effect of iron in the coronary arterial system may differ mechanistically and therefore clinically from its effect in the peripheral arterial system. This review will summarize the biochemical, pathologic, animal, and clinical research data with respect to iron and atherosclerosis. This background will be expanded upon to provide insights into ongoing studies and paths for future investigations into the role of iron and peripheral arterial disease.

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Iron and oxidised lipids are both found in atherosclerotic lesions.
“Iron and oxidised lipids are both found in atherosclerotic lesions [141,765-777]”
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Authors: Ramakrishna, G., Rooke, T. W., & Cooper, L. T.
Affiliations: Mayo Clinic (US)
Corresponding author: Cooper, Leslie T
ORCID: Rooke, Thom W
Cooper, Leslie T
Venue: Vascular Medicine
Publisher: SAGE Publications
Published: 2003-08
Volume: 8
Issue: 3
Pages: 203-210
ISSN: 1358-863X (ISSN-L)
1477-0377
DOI: 10.1191/1358863x03vm493ra
OpenAlex: W2138860809
Cited by: 54
References: 100
Citations by year: 2025: 2 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 1
FWCI: 0.33
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Vascular Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Surgery › Peripheral Artery Disease Management
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords: iron status, peripheral arterial disease, atherosclerosis, iron hypothesis, iron overload, coronary artery disease, iron metabolism
MeSH terms: Animals, Arteriosclerosis, Disease Models, Animal, Humans, Iron, Oxidative Stress, Iron Overload

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Iron and peripheral arterial disease: revisiting the iron hypothesis in a different light

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