Cited by 175Hallucinations in medical conditionsSchizophrenia research and treatmentFunctional Brain Connectivity Studies

Misattribution of speech and impaired connectivity in patients with auditory verbal hallucinations

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Mechelli, Andrea, Allen, Paul, Amaro, Edson, Fu, Cynthia H.Y., Williams, Steven C.R., Brammer, Michael J., Johns, Louise C., McGuire, Philip K.·2007·Human Brain Mapping

Abstract

Several studies report that patients with schizophrenia who experience auditory verbal hallucinations (AVH) tend to misidentify their own speech as that of somebody else. We tested the hypothesis that this tendency is associated with poor functional integration within the network of regions that mediate the evaluation of speech. Using functional magnetic resonance imaging, we measured brain responses from 11 schizophrenics with AVH, 10 schizophrenics without AVH, and 10 healthy controls. Stimuli comprised prerecorded words, which varied for their source (self, alien) and acoustic quality (undistorted, distorted). Participants had to indicate whether each word was spoken in their own or another person's voice via a button press. Using dynamic causal modeling, we estimated the impact of one region over another ("effective connectivity") and how this was modulated by source and distortion. In controls and in patients without AVH, the connectivity between left superior temporal and anterior cingulate cortex was significantly greater for alien- than for self-generated speech; in contrast, the reverse trend was found in schizophrenic patients with AVH. In conclusion, when patients with AVH appraise their own speech we find impaired functional integration between left superior temporal and anterior cingulate cortex. Although this finding is based on external rather than internal speech, the same mechanism may contribute to the faulty appraisal of inner speech that putatively underlies AVH.

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  1. Gold JM, Weinberger DR (1991): Frontal lobe structure, function and connectivity in schizophrenia. In: Kerwin R, Dawbarn D, McCulloch J, Tamminga C, editors. Cambridge Medical Reviews: Neurobiology and Psychiatry. Cambridge: Cambridge University Press. pp 39-59.

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Authors
Mechelli, A., Allen, P., Amaro, E., Fu, C. H. Y., Williams, S. C. R., Brammer, M. J., Johns, L. C., & McGuire, P. K.
Affiliations
King's College London (GB)
Venue
Human Brain Mapping
Publisher
Wiley
Published
2007-01-31
Volume
28
Issue
11
Pages
1213-1222
ISSN
  • 1065-9471 (ISSN-L)
  • 1097-0193
OpenAlex
W2087708838
Cited by
175
References
52
Citations by year
2026: 2 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 10 · 2021: 7 · 2020: 9 · 2019: 6 · 2018: 9 · 2017: 10 · 2016: 9 · 2015: 11 · 2014: 10 · 2013: 19 · 2012: 13
FWCI
6.33
Type
journal article
Language
en
Open access
Locations
  • Human Brain Mapping (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
auditory verbal hallucinations, schizophrenia, effective connectivity, superior temporal cortex, anterior cingulate cortex, dynamic causal modeling, inner speech, speech perception
MeSH terms
Adult, Auditory Cortex, Brain, Brain Mapping, Delusions, Gyrus Cinguli, Hallucinations, Humans, Image Processing, Computer-Assisted, Language Tests, Functional Laterality, Magnetic Resonance Imaging, Male, Nerve Net, Schizophrenia, Schizophrenic Psychology, Speech Perception, Verbal Behavior

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