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Clinical staging in psychiatry: a cross-cutting model of diagnosis with heuristic and practical value
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Staging models are used routinely in general medicine for potentially serious or chronic physical disorders such as diabetes, arthritis and cancers, describing the links between biomarkers, clinical phenotypes and disease extension, and promoting a personalised or stratified medicine approach to treatment planning. Clinical staging involves a detailed description of where an individual exists on a continuum of disorder progression from stage 0 (an at-risk or latency stage) through to stage IV (late or end-stage disease). The approach is popular owing to its clinical utility and is increasingly being applied in psychiatry. The concept offers an informed approach to research and the active promotion of indicated prevention and early intervention strategies. We suggest that for young persons with emerging bipolar disorder, such transdiagnostic staging models could provide a framework that better reflects the developmental psychopathology and matches the complex longitudinal inter-relationships between subsyndromal and syndromal mood, psychotic and other disorders.
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“Transdiagnostic approaches have subsequently been endorsed by paradigms that propose dimensional approaches that cut across diagnostic criteria such as the Research Domain Criteria (RDoC) and the clinical staging model of psychiatry (Scott et al., 2013; Cuthbert, 2014).”
From An Emotion Regulation and Impulse Control (ERIC) Intervention for Vulnerable Young People: A Multi-Sectoral Pilot Study (2021) · cites this paper as Scott et al., 2013
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“These ideas have also gained acceptance in the field of mental health care (15), especially in the field of early intervention for psychosis [e.”
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Clinical staging models: From general medicine to mental disorders
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M c L ean O n T rack: a transdiagnostic program for early intervention in first‐episode psychosis
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Prodrome or risk syndrome: what’s in a name?
Geoffroy, P. A., & Scott, J. L. (2017) · International Journal of Bipolar Disorders · doi:10.1186/s40345-017-0077-5 · Cited by 33
Self-citationFornaro, M., Berardis, D. D., Anastasia, A., Novello, S., Fusco, A., Cattaneo, C. I., Solmi, M., Monaco, F., Veronese, N., Kim, Y., et al. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.08.034 · Cited by 33
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Challenges and developments in research of the early stages of bipolar disorder
Brietzke, E. M., Rosa, A. R., Pedrini, M., Noto, M. N., Kapczinski, F. P., & Scott, J. L. (2016) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2016-1975 · Cited by 31
Self-citationUsing Staged Care to Provide “Right Care First Time” to People With Common Affective Disorders
Sawrikar, V., Stewart, E. M., LaMonica, H. M., Iorfino, F., Davenport, T. A., Cross, S. P. M., Scott, E. M., Naismith, S. L., Mowszowski, L., Guastella, A. J., et al. (2021) · Psychiatric Services · doi:10.1176/appi.ps.202000145 · Cited by 31
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Neuroticism and facial emotion recognition in healthy adults
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Clinical characteristics and influence of childhood trauma on the prodrome of bipolar disorder
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Self-citationBetween wellness, relapse, and remission: Stages of illness in anorexia nervosa
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Illness, at-risk and resilience neural markers of early-stage bipolar disorder
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Strategies and foundations for scientific discovery in longitudinal studies of bipolar disorder
McInnis, M. G., Andreassen, O. A., Andreazza, A. C., Alon, U., Berk, M., Brister, T. S., Burdick, K. E., Cui, D., Frye, M. A., Leboyer, M., et al. (2022) · Bipolar Disorders · doi:10.1111/bdi.13198 · Cited by 27
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Self-citationSleep–wake cycle phenotypes in young people with familial and non‐familial mood disorders
Scott, J. L., Naismith, S. L., Grierson, A. B., Carpenter, J. S., Hermens, D. F., Scott, E. M., & Hickie, I. B. (2016) · Bipolar Disorders · doi:10.1111/bdi.12450 · Cited by 27
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Metadata
- Authors
- Scott, J., Leboyer, M., Hickie, I., Berk, M., Kapczinski, F., Frank, E., Kupfer, D., & McGorry, P.
- Affiliations
- Inserm (FR)
- The University of Sydney (AU)
- Barwon Health (AU)
- University of Pittsburgh (US)
- The University of Melbourne (AU)
- Corresponding author
- Scott, Jan
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2013-04
- Volume
- 202
- Issue
- 4
- Pages
- 243-245
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2122348552
- Cited by
- 260
- References
- 11
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 17 · 2023: 12 · 2022: 18 · 2021: 21 · 2020: 23 · 2019: 27 · 2018: 21 · 2017: 22 · 2016: 21 · 2015: 21 · 2014: 25 · 2013: 8
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Deakin Research Online (Deakin University) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Fondation FondaMental
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- clinical staging, developmental psychopathology, psychosis, early intervention, prevention, stratified medicine
- MeSH terms
- Bipolar Disorder, Humans, Disease Progression
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