The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression
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An intact SREBP2 pathway is functionally required to drive the SREBP1-controlled genetic program.
“the functional requirement of an intact SREBP2 pathway to drive the SREBP1-controlled genetic program53,56”
From Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism (2020) · cites this paper as [53]
In “SREBP-2 influences limb development and SREBP-1 regulation” (p. 417), the paper says SREBP-2 is required for basal Srebf1c expression and for sterol regulation of many SREBP target genes. It does not establish a requirement for the entire SREBP-1-controlled program: Srebf1a is explicitly an exception. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe embryonic lethality associated with Spring ablation is similar to that observed in mouse models of Srebf1 and Srebf2 deletion, although in those models embryonic lethality is not absolute.
“The embryonic lethality associated with Spring ablation is similar to that observed in mouse models of Srebf1 and Srebf2 deletion53,54, albeit in these models embryonic lethality is not absolute.”
From Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism (2020) · cites this paper as [53]
Global deletion of Srebf2 is not tolerated.
“while that of Srebf2 (encoding SREBP2) is not tolerated30”
From Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans (2023) · cites this paper as [30]
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Citations
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MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis
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Cited by
Sorted by citations
Mechanisms and regulation of cholesterol homeostasis
Luo, J., Yang, H., & Song, B.-L. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0190-7 · Cited by 1,980
Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP
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Loregger, A., Raaben, M., Nieuwenhuis, J., Tan, J. M. E., Jae, L. T., van den Hengel, L. G., Hendrix, S., van den Berg, M., Scheij, S., Song, J.-Y., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14811-1 · Cited by 51
Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans
Hendrix, S., Kingma, J., Ottenhoff, R., Valiloo, M., Svecla, M., Zijlstra, L. F., Sachdev, V., Kovac, K., Levels, J. H. M., Jongejan, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40943-1 · Cited by 34
Metadata
- Authors
- Vergnes, L., Chin, R. G., de Aguiar Vallim, T., Fong, L. G., Osborne, T. F., Young, S. G., & Reue, K.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 57
- Issue
- 3
- Pages
- 410-421
- ISSN
- 0022-2275
- Cited by
- 72
- References
- 5
- Language
- en
- Licence
- Funders
- National Institutes of Health (P01 090553, U01 HL066621)
- American Heart Association (14SDG18440015)
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