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The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Dose-dependent effects of siRNA-mediated inhibition of SCAP on PCSK9, LDLR, and plasma lipids in mouse and rhesus monkey

Jensen, Kristian K., Tadin-Strapps, Marija, Wang, Sheng-ping, Hubert, James, Kan, Yanqing, Ma, Yong, McLaren, David G., Previs, Stephen F., Herath, Kithsiri B., Mahsut, Ablatt, Liaw, Andy, Wang, Shubing, Stout, Steven J., Keohan, CarolAnn, Forrest, Gail, Coelho, David, Yendluri, Satya, Williams, Stephanie, Koser, Martin, Bartz, Steven, Akinsanya, Karen O., Pinto, Shirly·2016·Journal of Lipid Research
DOI 10.1194/jlr.m071498PMC PMC5321219
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Crossref · 10.1194/jlr.m071498

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  • Pharmacological or antisense-mediated inhibition of hepatic SCAP function in rodents and non-human primates is emerging as a potential lipid-lowering and hepato/cardio-protective strategy.

    “pharmacological or antisense-mediated inhibition of hepatic SCAP function in rodents and non-human primates is emerging as a potential lipid-lowering and hepato/cardio-protective strategy32,42,43”

    From Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans (2023) · cites this paper as [42]

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Research works printed but not linked: 32

  1. Brown, 2009, Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL, J. Lipid Res., 50(Suppl), S15, 10.1194/jlr.R800054-JLR200 · DOI · Paper page
  2. Horton, 2002, SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver, J. Clin. Invest., 109, 1125, 10.1172/JCI0215593 · DOI · Paper page
  3. Hua, 1996, Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein, Cell., 87, 415, 10.1016/S0092-8674(00)81362-8 · DOI · Paper page
  4. Horton, 2003, Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes, Proc. Natl. Acad. Sci. USA., 100, 12027, 10.1073/pnas.1534923100 · DOI · Paper page
  5. Engelking, 2004, Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis, J. Clin. Invest., 113, 1168, 10.1172/JCI20978 · DOI · Paper page
  6. Matsuda, 2001, SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation, Genes Dev., 15, 1206, 10.1101/gad.891301 · DOI · Paper page
  7. Moon, 2012, The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals, Cell Metab., 15, 240, 10.1016/j.cmet.2011.12.017 · DOI · Paper page
  8. Shimano, 1996, Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a, J. Clin. Invest., 98, 1575, 10.1172/JCI118951 · DOI
  9. Horton, 1998, Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2, J. Clin. Invest., 101, 2331, 10.1172/JCI2961 · DOI
  10. Shimomura, 1999, Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus, J. Biol. Chem., 274, 30028, 10.1074/jbc.274.42.30028 · DOI
  11. Zhang, 2012, An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes, Int. J. Biol. Sci., 8, 310, 10.7150/ijbs.3524 · DOI
  12. Roddy, 2014, Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques, Eur. J. Pharmacol., 740, 410, 10.1016/j.ejphar.2014.04.015 · DOI
  13. Yin, 2012, Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia, J. Lipid Res., 53, 51, 10.1194/jlr.M019927 · DOI
  14. Tadin-Strapps, 2011, siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids, J. Lipid Res., 52, 1084, 10.1194/jlr.M012872 · DOI
  15. Frank-Kamenetsky, 2008, Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates, Proc. Natl. Acad. Sci. USA., 105, 11915, 10.1073/pnas.0805434105 · DOI
  16. Tadin-Strapps, 2015, Development of lipoprotein(a) siRNAs for mechanism of action studies in non-human primate models of atherosclerosis, J. Cardiovasc. Transl. Res., 8, 44, 10.1007/s12265-014-9605-1 · DOI
  17. Chen, 2015, Proof-of-concept studies for siRNA-mediated gene silencing for coagulation factors in rat and rabbit, Mol. Ther. Nucleic Acids., 4, e224, 10.1038/mtna.2014.75 · DOI
  18. McLaren, 2013, The use of [13C18] oleic acid and mass Isotopomer distribution analysis to study synthesis of plasma triglycerides in vivo: analytical and experimental Considerations, Anal. Chem., 85, 6287, 10.1021/ac400363k · DOI
  19. Lemieux, 1999, A stable isotope method using a [2H5] glycerol bolus to measure very low density lipoprotein triglyceride kinetics in humans, J. Lipid Res., 40, 2111, 10.1016/S0022-2275(20)32434-2 · DOI
  20. Jiang, 1992, Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences, J. Clin. Invest., 90, 1290, 10.1172/JCI115993 · DOI
  21. Han, 2012, Comparison of lipoprotein separation and lipid analysis methodologies for human and cynomolgus monkey plasma samples, J. Cardiovasc. Transl. Res., 5, 75, 10.1007/s12265-011-9340-9 · DOI
  22. Shah, 2010, Headspace analyses of acetone: A rapid method for measuring the 2 H-labeling of water, Anal. Biochem., 404, 235, 10.1016/j.ab.2010.05.010 · DOI
  23. Jensen, 2012, Demonstration of diet-induced decoupling of fatty acid and cholesterol synthesis by combining gene expression array and 2H2O quantification, Am. J. Physiol. Endocrinol. Metab., 302, E209, 10.1152/ajpendo.00436.2011 · DOI
  24. Previs, 2011, Quantifying cholesterol synthesis in vivo using 2H2O: enabling back-to-back studies in the same subject, J. Lipid Res., 52, 1420, 10.1194/jlr.D014993 · DOI
  25. McLaren, 2013, Tracking fatty acid kinetics in distinct lipoprotein fractions in vivo: a novel high-throughput approach for studying dyslipidemia in rodent models, J. Lipid Res., 54, 276, 10.1194/jlr.D030791 · DOI
  26. Goldstein, 2009, The LDL receptor, Arterioscler. Thromb. Vasc. Biol., 29, 431, 10.1161/ATVBAHA.108.179564 · DOI · Paper page
  27. Dietschy, 1993, Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans, J. Lipid Res., 34, 1637, 10.1016/S0022-2275(20)35728-X · DOI · Paper page
  28. Zhang, 2007, Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation, J. Biol. Chem., 282, 18602, 10.1074/jbc.M702027200 · DOI · Paper page
  29. Ason, 2011, Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9, J. Lipid Res., 52, 679, 10.1194/jlr.M013664 · DOI
  30. Rakhshandehroo, 2010, Peroxisome proliferator-activated receptor alpha target genes, PPAR Res., 2010, 612089, 10.1155/2010/612089 · DOI · Paper page
  31. Verheijen, 2009, SCAP is required for timely and proper myelin membrane synthesis, Proc. Natl. Acad. Sci. USA., 106, 21383, 10.1073/pnas.0905633106 · DOI · Paper page
  32. McFarlane, 2015, Scap is required for sterol synthesis and crypt growth in intestinal mucosa, J. Lipid Res., 56, 1560, 10.1194/jlr.M059709 · DOI · Paper page

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Metadata

Authors
Jensen, K. K., Tadin-Strapps, M., Wang, S.-P., Hubert, J., Kan, Y., Ma, Y., McLaren, D. G., Previs, S. F., Herath, K. B., Mahsut, A., Liaw, A., Wang, S., Stout, S. J., Keohan, C., Forrest, G., Coelho, D., Yendluri, S., Williams, S., Koser, M., Bartz, S., Akinsanya, K. O., & Pinto, S.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2016-12
Volume
57
Issue
12
Pages
2150-2162
ISSN
0022-2275
DOI
10.1194/jlr.m071498
PMC
PMC5321219
Cited by
27
References
2
Language
en
Licence

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