The DOI matches its Crossref record; 217 of the 218 references it cites were found in a registry or an index.
Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores.
Open accessAbstract
Fatty acids (FAs) are essential components of all lipid classes and pivotal substrates for energy production in all vertebrates. Additionally, they act directly or indirectly as signaling molecules and, when bonded to amino acid side chains of peptides, anchor proteins in biological membranes. In vertebrates, FAs are predominantly stored in the form of triacylglycerol (TG) within lipid droplets of white adipose tissue. Lipid droplet-associated TGs are also found in most nonadipose tissues, including liver, cardiac muscle, and skeletal muscle. The mobilization of FAs from all fat depots depends on the activity of TG hydrolases. Currently, three enzymes are known to hydrolyze TG, the well-studied hormone-sensitive lipase (HSL) and monoglyceride lipase (MGL), discovered more than 40 years ago, as well as the relatively recently identified adipose triglyceride lipase (ATGL). The phenotype of HSL- and ATGL-deficient mice, as well as the disease pattern of patients with defective ATGL activity (due to mutation in ATGL or in the enzyme's activator, CGI-58), suggest that the consecutive action of ATGL, HSL, and MGL is responsible for the complete hydrolysis of a TG molecule. The complex regulation of these enzymes by numerous, partially uncharacterized effectors creates the "lipolysome," a complex metabolic network that contributes to the control of lipid and energy homeostasis. This review focuses on the structure, function, and regulation of lipolytic enzymes with a special emphasis on ATGL.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Insulin suppresses lipolysis by increasing the activity of phosphodiesterase 3B (PDE3B), leading to decreased cAMP-mediated activation of protein kinase A (PKA), and, consequently, reduced phosphorylation of hormone-sensitive lipase (HSL) and perilipin (PLIN).”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Zechner et al., 2009
Citations
Cites
1 retracted
Watt, M. J., van Denderen, B. J. W., Castelli, L. A., Bruce, C. R., Hoy, A. J., Kraegen, E. W., Macaulay, L. S., & Kemp, B. E. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0485 · Cited by 37
RetractedInflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Critical nodes in signalling pathways: insights into insulin action
Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760
Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529
2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain
Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., Itoh, K., Yamashita, A., & Waku, K. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2437 · Cited by 2,196
Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
Zimmermann, R., Bogner‐Strauß, J. G., Haemmerle, G., Schoiswohl, G., Birner‐Gruenberger, R., Riederer, M., Lass, A., Neuberger, G., Eisenhaber, F., Hermetter, A., et al. (2004) · Science · doi:10.1126/science.1100747 · Cited by 2,121
Self-citationDefective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
Haemmerle, G., Lass, A., Zimmermann, R., Gorkiewicz, G., Meyer, C., Rozman, J., Heldmaier, G., Maier, R., Theussl, C., Eder, S., et al. (2006) · Science · doi:10.1126/science.1123965 · Cited by 1,375
Self-citationBrain monoglyceride lipase participating in endocannabinoid inactivation
Dinh, T. P., Carpenter, D., Leslie, F. M., Freund, T. F., Katona, I., Sensi, S. L., Kathuria, S., & Piomelli, D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152334899 · Cited by 1,373
Cravatt, B. F., Demarest, K., Patricelli, M. P., Bracey, M. H., Giang, D. K., Martin, B. R., & Lichtman, A. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161191698 · Cited by 1,310
Research works printed but not linked: 1
- Quagliarello, 1932, The existence of a lipase in adipose tissue., Arch. Sci. Biol., 17, 513
Cited by
Sorted by citations
Insect Fat Body: Energy, Metabolism, and Regulation
Arrese, E. L., & Soulages, J. L. (2009) · Annual Review of Entomology · doi:10.1146/annurev-ento-112408-085356 · Cited by 2,604
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
Ravikumar, B., Sarkar, S., Davies, J. E., Futter, M., García-Arencibia, M., Green-Thompson, Z. W., Jiménez-Sánchez, M., Korolchuk, V. I., Lichtenberg, M., Luo, S., et al. (2010) · Physiological Reviews · doi:10.1152/physrev.00030.2009 · Cited by 1,789
Li‐Beisson, Y., Shorrosh, B. S., Beisson, F., Andersson, M. X., Arondel, V., Bates, P. D., Baud, S., Bird, D. A., DeBono, A., Durrett, T. P., et al. (2013) · The Arabidopsis Book · doi:10.1199/tab.0161 · Cited by 1,575
Lipid Droplets Finally Get a Little R-E-S-P-E-C-T
Farese, R. V., & Walther, T. C. (2009) · Cell · doi:10.1016/j.cell.2009.11.005 · Cited by 1,047
The biophysics and cell biology of lipid droplets
Thiam, A. R., Farese Jr, R. V., & Walther, T. C. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3699 · Cited by 986
Zou, Y., Palte, M. J., Deik, A. A., Li, H., Eaton, J. K., Wang, W., Tseng, Y.-Y., Deasy, R., Kost-Alimova, M., Dančík, V., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09277-9 · Cited by 887
Lipolysis and lipid mobilization in human adipose tissue
Lafontan, M., & Langin, D. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.05.001 · Cited by 884
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
Haemmerle, G., Moustafa, T., Wölkart, G., Büttner, S., Schmidt, A. G., van de Weijer, T., Hesselink, M. K. C., Jaeger, D., Kienesberger, P. C., Zierler, K. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2439 · Cited by 767
Self-citationWeight loss and lipolysis promote a dynamic immune response in murine adipose tissue
Kosteli, A., Sugaru, E., Haemmerle, G., Martin, J. F., Lei, J., Zechner, R., & Ferrante, A. W. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42845 · Cited by 726
Self-citationAdipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia
Das, S. K., Eder, S., Schauer, S., Diwoky, C., Temmel, H., Guertl, B., Gorkiewicz, G., Tamilarasan, K. P., Kumari, P., Trauner, M., et al. (2011) · Science · doi:10.1126/science.1198973 · Cited by 594
Self-citationThe effects of glucocorticoids on adipose tissue lipid metabolism
Peckett, A. J., Wright, D. C., & Riddell, M. C. (2011) · Metabolism · doi:10.1016/j.metabol.2011.06.012 · Cited by 569
Not Just Fat: The Structure and Function of the Lipid DropletPreprint
Fujimoto, T., & Parton, R. G. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004838 · Cited by 506
Yang, X., Lü, X., Lombès, M., Rha, G. B., Chi, Y., Guerin, T. M., Smart, E. J., & Liu, J. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.003 · Cited by 490
Guo, X., Yin, X., Liu, Z., & Wang, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415489 · Cited by 465
Houde, V. P., Brûlé, S., Festuccia, W. T., Blanchard, P.-G., Bellmann, K., Deshaies, Y., & Marette, A. (2010) · Diabetes · doi:10.2337/db09-1324 · Cited by 456
Boron Containing Compounds as Protease Inhibitors
Smoum, R., Rubinstein, A., Dembitsky, V. M., & Srebnik, M. (2012) · Chemical Reviews · doi:10.1021/cr608202m · Cited by 454
Regulation of adipocyte lipolysis
Frühbeck, G., Méndez-Giménez, L., Fernández‐Formoso, J. A., Fernández, S., & Rodrı́guez, A. (2014) · Nutrition Research Reviews · doi:10.1017/s095442241400002x · Cited by 447
A lipase-independent pathway of lipid release and immune modulation by adipocytes
Flaherty, S. E., Grijalva, A., Xu, X., Ables, E., Nomani, A., & Ferrante, A. W. (2019) · Science · doi:10.1126/science.aaw2586 · Cited by 395
Role of lipids in the formation and maintenance of the cutaneous permeability barrier
Feingold, K. R., & Elias, P. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.11.007 · Cited by 383
Li‐Beisson, Y., Shorrosh, B. S., Beisson, F., Andersson, M. X., Arondel, V., Bates, P. D., Baud, S., Bird, D. A., DeBono, A., Durrett, T. P., et al. (2010) · The Arabidopsis Book · doi:10.1199/tab.0133 · Cited by 383
Perilipins: a diversity of intracellular lipid droplet proteins
Itabe, H., Yamaguchi, T., Nimura, S., & Sasabe, N. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0473-y · Cited by 373
Biochemistry and pathophysiology of intravascular and intracellular lipolysisPreprint
Young, S. G., & Zechner, R. (2013) · Genes & Development · doi:10.1101/gad.209296.112 · Cited by 367
Self-citationMammalian Triacylglycerol Metabolism: Synthesis, Lipolysis, and Signaling
Coleman, R., & Mashek, D. G. (2011) · Chemical Reviews · doi:10.1021/cr100404w · Cited by 348
Kienesberger, P. C., Oberer, M., Lass, A., & Zechner, R. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800082-jlr200 · Cited by 334
Self-citationTargeting SREBP-1-driven Lipid Metabolism to Treat Cancer
Guo, D., Bell, E. H., Mischel, P. S., & Chakravarti, A. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990486 · Cited by 333
The pharmacological landscape and therapeutic potential of serine hydrolases
Bachovchin, D. A., & Cravatt, B. F. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3620 · Cited by 317
Regulatory enzymes of mitochondrial β‐oxidation as targets for treatment of the metabolic syndrome
Schreurs, M., Kuipers, F., & van der Leij, F. R. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00642.x · Cited by 304
Lipid droplet autophagy in the yeast Saccharomyces cerevisiae
van Zutphen, T., Todde, V., de Boer, R., Kreim, M., Hofbauer, H. F., Wolinski, H., Marten Veenhuis, A., van der Klei, I. J., & Kohlwein, S. D. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-08-0448 · Cited by 301
Ren, G., Kim, J. Y., & Smas, C. M. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00084.2012 · Cited by 261
Kimmel, A. R., & Sztalryd, C. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071813-105410 · Cited by 297
The FATP1–DGAT2 complex facilitates lipid droplet expansion at the ER–lipid droplet interface
Xu, N., Zhang, S. O., Cole, R. A., McKinney, S., Guo, F., Haas, J. T., Bobba, S., Farese, R. V., & Mak, H. Y. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201201139 · Cited by 292
Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease
Chen, R., Zhang, J., Wu, Y., Wang, D., Feng, G., Tang, Y., Teng, Z., & Chen, C. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.09.030 · Cited by 277
Schweiger, M., Lass, A., Zimmermann, R., Eichmann, T. O., & Zechner, R. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00099.2009 · Cited by 272
Self-citationCoatomer-dependent protein delivery to lipid droplets
Soni, K. G., Mardones, G. A., Sougrat, R., Smirnova, E., Jackson, C. L., & Bonifacino, J. S. (2009) · Journal of Cell Science · doi:10.1242/jcs.045849 · Cited by 258
Mechanisms of triglyceride accumulation in activated macrophages
Feingold, K. R., Shigenaga, J. K., Kazemi, M. R., McDonald, C. M., Patzek, S. M., Cross, A. S., Moser, A. H., & Grünfeld, C. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.1111537 · Cited by 257
Metabolic consequences of intermittent hypoxia: Relevance to obstructive sleep apnea
Drager, L. F., Jun, J. C., & Polotsky, V. Y. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.08.011 · Cited by 256
Understanding the factors that effect maximal fat oxidation.
Purdom, T., Kravitz, L., Dokladny, K., & Mermier, C. (2018) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-018-0207-1 · Cited by 247
Kuramoto, K., Okamura, T., Yamaguchi, T., Nakamura, T. Y., Wakabayashi, S., Morinaga, H., Nomura, M., Yanase, T., Otsu, K., Usuda, N., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.328708 · Cited by 243
Chakrabarti, P., English, T., Shi, J., Smas, C. M., & Kandror, K. V. (2010) · Diabetes · doi:10.2337/db09-1602 · Cited by 242
Chakrabarti, P., & Kandror, K. V. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.c800241200 · Cited by 233
Causes and mechanisms of adipocyte enlargement and adipose expansion
Haczeyni, F., Bell-Anderson, K. S., & Farrell, G. C. (2017) · Obesity Reviews · doi:10.1111/obr.12646 · Cited by 231
Intermittent Hypoxia Exacerbates Metabolic Effects of Diet‐Induced Obesity
Drager, L. F., Li, J., Reinke, C., Bevans‐Fonti, S., Jun, J. C., & Polotsky, V. Y. (2011) · Obesity · doi:10.1038/oby.2011.240 · Cited by 208
Schweiger, M., Eichmann, T. O., Taschler, U., Zimmermann, R., Zechner, R., & Lass, A. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-800280-3.00010-4 · Cited by 203
Self-citationThe resurgence of Hormone-Sensitive Lipase (HSL) in mammalian lipolysis
Lampidonis, A. D., Rogdakis, E., Voutsinas, G. E., & Stravopodis, D. J. (2011) · Gene · doi:10.1016/j.gene.2011.01.007 · Cited by 202
Kelly, A. A., Quettier, A., Shaw, E., & Eastmond, P. J. (2011) · PLANT PHYSIOLOGY · doi:10.1104/pp.111.181784 · Cited by 198
Suzuki, M., Shinohara, Y., Ohsaki, Y., & Fujimoto, T. (2011) · Microscopy · doi:10.1093/jmicro/dfr016 · Cited by 197
Crystal Structure of the Human Monoacylglycerol Lipase, a Key Actor in Endocannabinoid Signaling
Labar, G., Bauvois, C., Borel, F., Ferrer, J.-L., Wouters, J., & Lambert, D. M. (2009) · ChemBioChem · doi:10.1002/cbic.200900621 · Cited by 194
Nonalcoholic fatty liver disease: A comprehensive review of a growing epidemic
Hassan, K. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i34.12082 · Cited by 192
Chakrabarti, P., Kim, J. Y., Singh, M., Shin, Y., Kim, J., Kumbrink, J., Wu, Y., Lee, M., Kirsch, K. H., Fried, S. K., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01584-12 · Cited by 188
SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL
Chakrabarti, P., English, T., Karki, S., Qiang, L., Tao, R., Kim, J., Luo, Z., Farmer, S. R., & Kandror, K. V. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m014647 · Cited by 182
Muscle Lipid Metabolism: Role of Lipid Droplets and Perilipins
Morales, P. E., Bucarey, J. L., & Espinosa, A. (2017) · Journal of Diabetes Research · doi:10.1155/2017/1789395 · Cited by 179
Thiam, A. R., Antonny, B., Wang, J., Delacotte, J., Wilfling, F., Walther, T. C., Beck, R., Rothman, J. E., & Pincet, F. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307685110 · Cited by 175
Rajbhandari, P., Arneson, D. V., Hart, S. K., Ahn, I. S., Diamante, G., SANTOS, L. V. D. S., Zaghari, N., Feng, A., Thomas, B. J., Vergnes, L., et al. (2019) · eLife · doi:10.7554/elife.49501 · Cited by 173
Lipid oversupply, selective insulin resistance, and lipotoxicity: Molecular mechanisms
Chavez, J. A., & Summers, S. A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.09.015 · Cited by 169
Ontogenesis of muscle and adipose tissues and their interactions in ruminants and other species
Bonnet, M., Cassar‐Malek, I., Chilliard, Y., & Picard, B. B. (2010) · animal · doi:10.1017/s1751731110000601 · Cited by 168
Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges
Silva, H. M., Báfica, A. L. B., Rodrigues-Luiz, G. F., Chi, J., Santos, P. D. A., Reis, B. S., van Konijnenburg, D. P. H., Crane, A., Arifa, R. D. D. N., Martin, P. K., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181049 · Cited by 168
Maus, M., Ćuk, M., Patel, B., Lian, J., Ouimet, M. I., Kaufmann, U., Yang, J. J. J., Horváth, R., Hornig‐Do, H., Chrzanowska‐Lightowlers, Z. M., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.021 · Cited by 161
Protein Crowding Is a Determinant of Lipid Droplet Protein Composition
Kory, N., Thiam, A. R., Farese, R. V., & Walther, T. C. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.06.007 · Cited by 160
Jeong, J. Y., Kwon, E.-G., Im, S. K., Seo, K.-S., & Baik, M. (2012) · Journal of Animal Science · doi:10.2527/jas.2011-4753 · Cited by 158
Yin, K., Liao, D., & Tang, C. (2010) · Molecular Medicine · doi:10.2119/molmed.2010.00004 · Cited by 158
Villanueva, C. J., Vergnes, L., Wang, J., Drew, B. G., Hong, C., Tu, Y., Hu, Y., Xu, P., Xu, F., Sáez, E., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.016 · Cited by 152
Parvy, J.-P., Napal, L., Rubin, T., Poidevin, M., Perrin, L., Wicker, C., & Montagne, J. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002925 · Cited by 149
Genetic determinants of hepatic steatosis in man
Hooper, A. J., Adams, L. A., & Burnett, J. R. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r008896 · Cited by 149
Melatonin regulates lipid metabolism in porcine oocytes
Jin, J., Lee, S., Taweechaipaisankul, A., Kim, G. A., & Lee, B. C. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12388 · Cited by 149
Fatty Acid Signaling: The New Function of Intracellular Lipases
Papáčková, Z., & Cahová, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16023831 · Cited by 144
Shui, G., Guan, X. L., Low, C. P., Chua, G. H., Goh, J. S. Y., Yang, H., & Wenk, M. R. (2010) · Molecular BioSystems · doi:10.1039/b913353d · Cited by 144
D’Aquila, T., Hung, Y.-H., Carreiro, A. L., & Buhman, K. K. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.04.012 · Cited by 142
Lipid metabolism in sarcopenia
Al Saedi, A., Debruin, D. A., Hayes, A., & Hamrick, M. (2022) · Bone · doi:10.1016/j.bone.2022.116539 · Cited by 140
Comparative and functional genomics of lipases in holometabolous insects
Horne, I. M., Haritos, V. S., & Oakeshott, J. G. (2009) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2009.06.002 · Cited by 138
Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused?
Muoio, D. M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.11.007 · Cited by 137
Fatty acid metabolism and the basis of brown adipose tissue function
Calderón‐Domínguez, M., Mir, J. F., Fucho, R., Weber, M., Serra, D., & Herrero, L. (2015) · Adipocyte · doi:10.1080/21623945.2015.1122857 · Cited by 134
The G0/G1 switch gene 2 (G0S2): Regulating metabolism and beyond
Heckmann, B. L., Zhang, X., Xie, X., & Liu, J. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.09.016 · Cited by 133
Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells
Dichlberger, A., Schlager, S., Maaninka, K., Schneider, W. J., & Kovanen, P. T. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m048553 · Cited by 131
An Overview of Hormone-Sensitive Lipase (HSL)
Althaher, A. R. (2022) · The Scientific World Journal · doi:10.1155/2022/1964684 · Cited by 129
Gong, Z., Li, Q., Shi, J., Liu, E. T., Shultz, L. D., & Ren, G. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.003 · Cited by 129
Dulermo, T., Tréton, B., Béopoulos, A., Gnankon, A. P. K., Haddouche, R., & Nicaud, J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.07.001 · Cited by 126
Differential control of ATGL-mediated lipid droplet degradation by CGI-58 and G0S2
Lü, X., Yang, X., & Liu, J. (2010) · Cell Cycle · doi:10.4161/cc.9.14.12181 · Cited by 125
Kolditz, C.-I., & Langin, D. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32833bed6a · Cited by 124
Acute Stimulation of White Adipocyte Respiration by PKA-Induced Lipolysis
Yehuda‐Shnaidman, E., Buehrer, B. M., Pi, J., Kumar, N., & Collins, S. (2010) · Diabetes · doi:10.2337/db10-0245 · Cited by 118
Gruber, A., Cornaciu, I., Lass, A., Schweiger, M., POESCHL, M., Eder, C., Kumari, M., Schoiswohl, G., Wolinski, H., Kohlwein, S. D., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.064469 · Cited by 117
Self-citationDemonstrated and inferred metabolism associated with cytosolic lipid droplets
Goodman, J. M. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r001446 · Cited by 116
Hynynen, R., Suchanek, M., Spandl, J., Bäck, N., Thiele, C., & Olkkonen, V. M. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800661-jlr200 · Cited by 116
Markgraf, D. F., Klemm, R. W., Junker, M., Hannibal‐Bach, H. K., Ejsing, C. S., & Rapoport, T. A. (2014) · Cell Reports · doi:10.1016/j.celrep.2013.11.046 · Cited by 115
Emerging Role of Lipid Droplets in Host/Pathogen Interactions
Herker, E., & Ott, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.300202 · Cited by 115
Phospholipase A2 regulation of lipid droplet formation
Guijas, C., Rodríguez, J. P., Rubio, J. M., Balboa, M. A., & Balsinde, J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.10.004 · Cited by 113
Kolnes, K. J., Petersen, M. H., Lien-Iversen, T., Højlund, K., & Jensen, J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.737709 · Cited by 112
Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism
Simmons, G. E., Jr., Pruitt, W. M., & Pruitt, K. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16010950 · Cited by 111
A Review on the Monoacylglycerol Lipase: At the Interface Between Fat and Endocannabinoid Signalling
Labar, G., Wouters, J., & Lambert, D. M. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710791859414 · Cited by 111
Aging-associated exacerbation in fatty degeneration and infiltration after rotator cuff tear
Gumucio, J. P., Korn, M. A., Saripalli, A. L., Flood, M. D., Phan, A. C., Roche, S. M., Lynch, E. B., Claflin, D. R., Bedi, A., & Mendias, C. L. (2013) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2013.04.011 · Cited by 109
Obesity and Cancer Progression: Is There a Role of Fatty Acid Metabolism?
Balaban, S., Lee, L. S., Schreuder, M., & Hoy, A. J. (2015) · BioMed Research International · doi:10.1155/2015/274585 · Cited by 107
Zienkiewicz, A., Zienkiewicz, K., Poliner, E., Pulman, J. A., Du, Z., Stefano, G., Tsai, C., Horn, P. J., Feußner, I., Farré, E. M., et al. (2019) · PLANT PHYSIOLOGY · doi:10.1104/pp.19.00854 · Cited by 103
Brindley, D. N., Kok, B. P., Kienesberger, P. C., Lehner, R. S., & Dyck, J. R. B. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00509.2009 · Cited by 102
Self-citationZhang, X., Xie, X., Heckmann, B. L., Saarinen, A. M., Czyzyk, T. A., & Liu, J. (2013) · Diabetes · doi:10.2337/db13-1422 · Cited by 102
Lipid droplets as fat storage organelles in Caenorhabditis elegans
Mak, H. Y. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r021006 · Cited by 102
Johnson, S. M., Bao, H., McMahon, C. E., Chen, Y., Burr, S. D., Anderson, A. M., Madeyski-Bengtson, K., Lindén, D., Han, X., & Liu, J. (2024) · Nature Communications · doi:10.1038/s41467-024-49224-x · Cited by 100
Contreras, G. A., Strieder‐Barboza, C., & Koster, J. D. (2017) · Journal of Dairy Science · doi:10.3168/jds.2017-13340 · Cited by 100
Understanding the brown adipocyte as a contributor to energy homeostasis
Chechi, K., Carpentier, A. C., & Richard, D. (2013) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.04.002 · Cited by 99
Rajakumari, S., & Daum, G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.076331 · Cited by 97
MacPherson, R. E. K., Ramos, S. V., Vandenboom, R., Roy, B. D., & Peters, S. J. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00418.2012 · Cited by 97
Nguyen, L. N., Bormann, J., Le, G. T. T., Stärkel, C., Olsson, S., Nosanchuk, J. D., Giese, H., & Schäfer, W. (2010) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2010.11.004 · Cited by 96
Metadata
- Authors
- Zechner, R., Kienesberger, P. C., Haemmerle, G., Zimmermann, R., & Lass, A.
- Affiliations
- University of Graz (AT)
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 50
- Issue
- 1
- Pages
- 3-21
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2055651091
- Cited by
- 576
- References
- 218
- Citations by year
- 2026: 17 · 2025: 17 · 2024: 33 · 2023: 26 · 2022: 28 · 2021: 23 · 2020: 17 · 2019: 28 · 2018: 22 · 2017: 34 · 2016: 33 · 2015: 35 · 2014: 36 · 2013: 55 · 2012: 45
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- adipose triglyceride lipase, hormone-sensitive lipase, monoglyceride lipase, lipolysis, lipid droplets, triacylglycerol mobilization, CGI-58, energy homeostasis, fatty acid mobilization
- MeSH terms
- Adipose Tissue, Animals, Sterol Esterase, Fatty Acids, Humans, Hydrolases, Hydrolysis, Lipase, Lipids, Lipolysis, Metabolism, Monoacylglycerol Lipases, Mutation, Phenotype, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
