Cited by 331Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthParaoxonase enzyme and polymorphisms

The metabolism and anti-atherogenic properties of HDL

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Rye, Kerry-Anne, Bursill, Christina A., Lambert, Gilles, Tabet, Fatiha, Barter, Philip J.·2009·Journal of Lipid Research

Abstract

Population studies have shown that plasma HDL levels correlate inversely with cardiovascular disease risk. In recent years there has been intense interest in developing strategies for exploiting these cardioprotective properties by increasing HDL levels. While this approach has considerable merit, it is important to recognize that HDL are structurally and functionally diverse and consist of numerous, highly dynamic subpopulations of particles that do not all inhibit atherosclerosis to the same extent. For this reason it is essential to assess HDL subpopulation distribution and functionality when considering therapeutic interventions that raise HDL levels. This review documents what is known about the relationship between the metabolism and function of HDL subpopulations and how this affects their cardioprotective properties.

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Crossref · 10.1194/jlr.r800034-jlr200

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Authors
Rye, K.-A., Bursill, C. A., Lambert, G., Tabet, F., & Barter, P. J.
Affiliations
  • The University of Sydney (AU)
  • The Heart Research Institute (AU)
Corresponding author
Rye, Kerry-Anne
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2009-04
Volume
50
Pages
S195-S200
ISSN
0022-2275 (ISSN-L)
OpenAlex
W1967702791
Cited by
331
References
51
Citations by year
2026: 13 · 2025: 14 · 2024: 12 · 2023: 17 · 2022: 15 · 2021: 16 · 2020: 16 · 2019: 17 · 2018: 21 · 2017: 13 · 2016: 9 · 2015: 27 · 2014: 21 · 2013: 48 · 2012: 20
FWCI
2.90
Type
journal article
Language
en
Open access
Locations
  • Journal of Lipid Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords
HDL metabolism, HDL subpopulations, atherosclerosis, cardioprotection, cardiovascular risk, HDL function, HDL-targeted therapy
MeSH terms
Animals, Antioxidants, Humans, Inflammation, Cholesterol, HDL, Genetic Heterogeneity, Atherosclerosis

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