Cited by 572Stress Responses and CortisolHeart Rate Variability and Autonomic ControlSalivary Gland Disorders and Functions

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Salivary α‐Amylase in Biobehavioral Research: Recent Developments and Applications

GRANGER, DOUGLAS A., KIVLIGHAN, KATIE T., El‐SHEIKH, MONA, GORDIS, ELANA B., STROUD, LAURA R.·2007·Annals of the New York Academy of Sciences

DOI 10.1196/annals.1384.008

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Abstract

Abstract: In the history of science, technical advances often precede periods of rapid accumulation of knowledge. Within the past three decades, discoveries that enabled the noninvasive measurement of the psychobiology of stress (in saliva) have added new dimensions to the study of health and human development. This widespread enthusiasm has led to somewhat of a renaissance in behavioral science. At the cutting edge, the focus is on testing innovative theoretical models of individual differences in behavior as a function of multilevel biosocial processes in the context of everyday life. Several new studies have generated renewed interest in salivary α‐amylase (sAA) as a surrogate marker of the autonomic/sympathetic nervous system component of the psychobiology of stress. This article reviews sAA's properties and functions; presents illustrative findings relating sAA to stress and the physiology of stress, behavior, cognitive function, and health; and provides practical information regarding specimen collection and assay. The overarching intent is to accelerate the learning curve such that investigators avoid potential pitfalls associated with integrating this unique salivary analyte into the next generation of biobehavioral research.

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Exercise upregulates salivary amylase in humans (Review)
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Higher locus coeruleus MRI contrast is associated with lower parasympathetic influence over heart rate variability
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Transdermal neuromodulation of noradrenergic activity suppresses psychophysiological and biochemical stress responses in humans
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Background
Methodological considerations in the use of salivary α‐amylase as a stress marker in field research
DeCaro, J. A. (2008) · American Journal of Human Biology · doi:10.1002/ajhb.20795 · Cited by 74
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“One explanation could be that the diurnal profile of sAA is relatively robust against momentary and moderate levels of stress, in contrast to momentary levels of sAA, which are highly sensitive to acute physical and psychological stress (e.g., Granger et al., 2007; Nater and Rohleder, 2009).”
Self-citation
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Self-citation
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FMRI response to acute psychological stress differentiates patients with psychogenic non-epileptic seizures from healthy controls – A biochemical and neuroimaging biomarker study
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Salivary alpha‐amylase and cortisol among pentecostals on a worship and nonworship day
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In the Wake of the Great Recession: Economic Uncertainty, Communication, and Biological Stress Responses in Families
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Authors: GRANGER, D. A., KIVLIGHAN, K. T., El‐SHEIKH, M., GORDIS, E. B., & STROUD, L. R.
Affiliations: Pennsylvania State University (US)
Johns Hopkins University (US)
Auburn University (US)
University at Albany, State University of New York (US)
Brown University (US)
Corresponding author: GRANGER, DOUGLAS A.
ORCID: GRANGER, DOUGLAS A.
KIVLIGHAN, KATIE T.
El‐SHEIKH, MONA
GORDIS, ELANA B.
STROUD, LAURA R.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2007-03
Volume: 1098
Issue: 1
Pages: 122-144
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1196/annals.1384.008
OpenAlex: W2118909914
Cited by: 572
References: 50
Citations by year: 2026: 17 · 2025: 14 · 2024: 28 · 2023: 30 · 2022: 22 · 2021: 17 · 2020: 28 · 2019: 35 · 2018: 34 · 2017: 43 · 2016: 50 · 2015: 35 · 2014: 45 · 2013: 30 · 2012: 36
FWCI: 9.26
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 32 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: Pennsylvania State University
Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23HD041428, P01 HD 39667-01A1, P01HD039667)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Physiology (medical) › Salivary Gland Disorders and Functions
Keywords: salivary amylase, stress physiology, autonomic nervous system, sympathetic nervous system, non-invasive biomarkers, individual differences in behavior, cognitive function, sample collection
MeSH terms: alpha-Amylases, Behavior, Humans, Saliva, Salivary Proteins and Peptides, Biomarkers

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Salivary α‐Amylase in Biobehavioral Research: Recent Developments and Applications

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