The Role of NFAT in Osteoclast Formation

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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.

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Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

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Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.

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Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families

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A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.

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Genetic regulation of osteoclast development and function

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The roles of Orai and Stim in bone health and disease

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Specific RANK Cytoplasmic Motifs Drive Osteoclastogenesis

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The Coumarin Derivative 5′-Hydroxy Auraptene Suppresses Osteoclast Differentiation via Inhibiting MAPK and c-Fos/NFATc1 Pathways

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THIAZOLIDINEDIONES INHIBIT TNF-α-MEDIATED OSTEOCLAST DIFFERENTIATION OF RAW264.7 MACROPHAGES AND MOUSE BONE MARROW CELLS THROUGH DOWNREGULATION OF NFATc1

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WHI-131 Promotes Osteoblast Differentiation and Prevents Osteoclast Formation and Resorption in Mice

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Streptococcus gordonii induces bone resorption by increasing osteoclast differentiation and reducing osteoblast differentiation

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Cytoplasmic PCNA is located in the actin belt and involved in osteoclast differentiation

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A review on interleukins: The key manipulators in rheumatoid arthritis

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Nuclear Receptors in Skeletal Homeostasis

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Idelalisib inhibits osteoclast differentiation and pre-osteoclast migration by blocking the PI3Kδ-Akt-c-Fos/NFATc1 signaling cascade

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Insights into the Notch signaling pathway in degenerative musculoskeletal disorders: Mechanisms and perspectives

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The mechanism of action of indole-3-propionic acid on bone metabolism

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Inhibitory Effects of N-[2-(4-acetyl-1-piperazinyl) phenyl]-2-(2-chlorophenoxy) acetamide on Osteoclast Differentiation In Vitro via the Downregulation of TRAF6

Chen, Z., Cho, E., Lee, J., Lee, S., & Lee, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205196 · Cited by 21

Inhibitory effects of Atlantic cod ( Gadus morhua ) peptides on RANKL-induced osteoclastogenesis in vitro and osteoporosis in ovariectomized mice

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Pasteurella multocida toxin – lessons learned from a mitogenic toxin

Kubatzky, K. F. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1058905 · Cited by 27

The Effects of Aronia melanocarpa ‘Viking’ Extracts in Attenuating RANKL-Induced Osteoclastic Differentiation by Inhibiting ROS Generation and c-FOS/NFATc1 Signaling

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Adiponectin inhibits osteoclastogenesis by suppressing NF-κB and p38 signaling pathways

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Homer2 and Homer3 modulate RANKL-induced NFATc1 signaling in osteoclastogenesis and bone metabolism

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Sclareol prevents ovariectomy-induced bone loss in vivo and inhibits osteoclastogenesis in vitro via suppressing NF-κB and MAPK/ERK signaling pathways

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Tubeimoside I suppresses diabetes-induced bone loss in rats, osteoclast formation, and RANKL-induced nuclear factor-κB pathway

Yang, M., Xie, J. W., Lei, X., Song, Z., Gong, Y., Liu, H., & Zhou, L. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106202 · Cited by 21

Decitabine represses osteoclastogenesis through inhibition of RANK and NF-κB

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Nmp4/CIZ Suppresses the Response of Bone to Anabolic Parathyroid Hormone by Regulating Both Osteoblasts and Osteoclasts

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Autoregulation of RANK ligand in oral squamous cell carcinoma tumor cells

Sambandam, Y., Ethiraj, P., Hathaway‐Schrader, J. D., Novince, C. M., Panneerselvam, E., Sundaram, K., & Reddy, S. V. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26456 · Cited by 23

Bone Disease in Primary Hyperparathyroidism—Changes Occurring in Bone Metabolism and New Potential Treatment Strategies

Iwanowska, M., Kochman, M., Szatko, A., Zgliczyński, W., & Glinicki, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111639 · Cited by 20

CCAAT/Enhancer-binding Protein α (C/EBPα) Is Important for Osteoclast Differentiation and Activity

Jules, J., Chen, W., Feng, X., & Li, Y. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.674598 · Cited by 20

Breast Cancer: A Molecular and Redox Snapshot

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Pim‐2 is a critical target for treatment of osteoclastogenesis enhanced in myeloma

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Inhibitory Effects of 2N1HIA (2-(3-(2-Fluoro-4-Methoxyphenyl)-6-Oxo-1(6H)-Pyridazinyl)-N-1H-Indol-5-Ylacetamide) on Osteoclast Differentiation via Suppressing Cathepsin K Expression

Ahn, S. H., Chen, Z., Lee, J., Lee, S., Min, S. H., Kim, N. D., & Lee, T. (2018) · Molecules · doi:10.3390/molecules23123139 · Cited by 20

Inhibition of osteoclasts differentiation by CDC2-induced NFATc1 phosphorylation

Kim, H. M., He, L., Lee, S., Park, C., Kim, D. H., Han, H.-J., Han, J., Hwang, J., Cha‐Molstad, H., Lee, K. H., et al. (2019) · Bone · doi:10.1016/j.bone.2019.115153 · Cited by 20

Ortho-silicic Acid Inhibits RANKL-Induced Osteoclastogenesis and Reverses Ovariectomy-Induced Bone Loss In Vivo

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FAEE exerts a protective effect against osteoporosis by regulating the MAPK signalling pathway

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Pasteurella multocida Toxin Triggers RANKL-Independent Osteoclastogenesis

Chakraborty, S., Kloos, B., Harre, U., Schett, G., & Kubatzky, K. F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00185 · Cited by 20

Regulator of Calcineurin 3 Ameliorates Autoimmune Arthritis by Suppressing Th17 Cell Differentiation

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Puerarin Exerts Protective Effects on Wear Particle-Induced Inflammatory Osteolysis

Yang, C., Li, J., Zhu, K., Yuan, X., Cheng, T., Qian, Y., & Zhang, X. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01113 · Cited by 19

Senkyunolide H attenuates osteoclastogenesis and postmenopausal osteoporosis by regulating the NF-κB, JNK and ERK signaling pathways

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MKP-1 signaling events are required for early osteoclastogenesis in lineage defined progenitor populations by disrupting RANKL-induced NFATc1 nuclear translocation

Valerio, M. S., Herbert, B. A., Griffin, A. C., Wan, Z., Hill, E. G., & Kirkwood, K. L. (2013) · Bone · doi:10.1016/j.bone.2013.11.012 · Cited by 19

Activation of the liver X receptor-β potently inhibits osteoclastogenesis from lipopolysaccharide-exposed bone marrow-derived macrophages

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Fluid shear force and hydrostatic pressure jointly promote osteogenic differentiation of BMSCs by activating YAP1 and NFAT2

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The multi-faceted role of retinoid X receptor in bone remodeling

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Molecular and cellular characterizations of human cherubism: disease aggressiveness depends on osteoclast differentiation

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Urolithin B suppresses osteoclastogenesis via inhibiting RANKL‐induced signalling pathways and attenuating ROS activities

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The role of secreted osteoclastogenic factor of activated T cells in bone remodeling

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Osteoblast-derived Laminin-332 is a novel negative regulator of osteoclastogenesis in bone microenvironments

Uehara, N., Kukita, A., Kyumoto‐Nakamura, Y., Yamaza, T., Yasuda, H., & Kukita, T. (2017) · Laboratory Investigation · doi:10.1038/labinvest.2017.55 · Cited by 17

Cumambrin A prevents OVX‐induced osteoporosis via the inhibition of osteoclastogenesis, bone resorption, and RANKL signaling pathways

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Effects of omega‐3 fatty acids and aspirin on Porphyromonas gingivalis‐induced periodontitis in rats

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Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in Mice

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Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling

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Celastrol Attenuates RANKL-Induced Osteoclastogenesis in vitro and Reduces Titanium Particle-Induced Osteolysis and Ovariectomy-Induced Bone Loss in vivo

Xu, Q., Chen, G., Xu, H., Xia, G., Zhu, M., Zhan, H., Zhang, B., Dai, M., Fan, H., & Liu, X. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.682541 · Cited by 17

RCANs regulate the convergent roles of NFATc1 in bone homeostasis

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HIV-1-Infected Human Macrophages, by Secreting RANK-L, Contribute to Enhanced Osteoclast Recruitment

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Molecular Signaling Pathways and Essential Metabolic Elements in Bone Remodeling: An Implication of Therapeutic Targets for Bone Diseases

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The Physiology and Pathophysiology of the Osteoclast

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Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption

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Effect of Usnic Acid on Osteoclastogenic Activity

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NFATc1 marks articular cartilage progenitors and negatively determines articular chondrocyte differentiation

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Humanin suppresses receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation via AMP-activated protein kinase activation

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PSTP-3,5-Me Inhibits Osteoclast Differentiation and Bone Resorption

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Sestrin2 Regulates Osteoclastogenesis via the p62-TRAF6 Interaction

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NFATc1 and TNFα expression in giant cell lesions of the jaws

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Piezo1 protects against inflammatory bone loss via a unique Ca2+-independent mechanism in osteoclasts

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Cedrol, a Ginger-derived sesquiterpineol, suppresses estrogen-deficient osteoporosis by intervening NFATc1 and reactive oxygen species

Xu, C., Jin, S., Jin, S., Dai, Z.-H., Wu, Y., He, G.-L., Ma, H., Xu, C.-Y., & Fang, W. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109893 · Cited by 16

Current and future treatments of bone metastases

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Physiological role of receptor activator nuclear factor-kB (RANK) in denervation-induced muscle atrophy and dysfunction

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Liver X receptors and skeleton: Current state-of-knowledge

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Eriodicyol inhibits osteoclast differentiation and ovariectomy-induced bone loss in vivo

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The inhibitory effect of beta-lapachone on RANKL-induced osteoclastogenesis

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Hdac3 regulates bone modeling by suppressing osteoclast responsiveness to RANKL

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A Novel Small Molecule Which Increases Osteoprotegerin Expression and Protects Against Ovariectomy-Related Bone Loss in Rats

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Design, synthesis and SARs of novel salicylanilides as potent inhibitors of RANKL-induced osteoclastogenesis and bone resorption

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Effects and Mechanisms of Rhus chinensis Mill. Fruits on Suppressing RANKL-Induced Osteoclastogenesis by Network Pharmacology and Validation in RAW264.7 Cells

Zheng, Y., Zhao, L., Yi, J., & Cai, S. (2022) · Nutrients · doi:10.3390/nu14051020 · Cited by 14

Gene expression of transcription factor NFATc1 in periodontal diseases

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L-type Ca2+ channel agonist inhibits RANKL-induced osteoclast formation via NFATc1 down-regulation

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Inhibition of osteoclast differentiation by overexpression of NDRG2 in monocytes

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Ethanolic extract of Schizonepeta tenuifolia attenuates osteoclast formation and activation in vitro and protects against lipopolysaccharide-induced bone loss in vivo

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Thiaplakortone B attenuates RANKL‐induced NF‐κB and MAPK signaling and dampens OVX‐induced bone loss in mice

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TRAFD1 (FLN29) Interacts with Plekhm1 and Regulates Osteoclast Acidification and Resorption

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Calcineurin Plays an Important Role in the Shell Formation of Pearl Oyster (Pinctada fucata)

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