The Role of NFAT in Osteoclast Formation

Osteoclast differentiation and activation

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Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

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Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.

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Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

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Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.

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Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families

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A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.

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Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

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Genetic regulation of osteoclast development and function

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The Effect of Phytoestrogens on Bone and T Cells Differentiation and Activity

Karieb, S. S. (2012) · PEARL (University of Plymouth) · doi:10.24382/1814

Ο ρόλος κυτταροκινών και βιοχημικών οδών ενδοκυττάριας σηματοδότησης στην παθογένεια των φλεγμονωδών αρθρίτιδων

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The Role of microRNAs in Osteoclastogenesis

Franceschetti, T. (2014) · OpenCommons at University of Connecticut (University of Connecticut)

Coordinated effect of IL-17A and IL-27 on osteoclast differentiation of RANKL-stimulated RAW264.7 cells

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Cinética de expressão de moléculas co-estimulatórias de osteoclastos no desenvolvimento da doença periodontal experimental e sua modulação por citocinas

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Regulatory mechanisms of the Ca2+-dependent transcription factor NFAT in sensory neurons

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Production of Recombinant Receptor Activator of Nuclear Factor κ B Ligand for in vitro Osteoclastogenesis

Machauer, S. (2013)

Avaliação do efeito do hormônio tireodiano na estrutura e fisiologia óssea de camundongos com inativação do gene do adrenoceptor α2C.

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c-Jun-centred Regulatory Network of Signalling Pathways in Bone Stem Cells and Applications to Bone Repair

Fernández‐Rueda, J., Jakobsson, E., Dorronsoro, A., & Trigueros, C. (2013) · CRC Press eBooks · doi:10.1201/b14590-12

Effects of Digestive Diseases on Bone Metabolism

Sylvester, F. A. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4377-0774-8.10091-0

CD166 modulates disease progression and osteolytic disease in multiple myeloma

Xu, L. (2016) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1742

Article Open Access

Lawford‐Smith, H. (2015)

Physiopathology of osteoporosis and action mechanism of PTH

Macías, J. G., González Macías, J., & Jm, O. M. (2010)

Piperlongumine suppressed osteoclastogenesis in RAW264.7 macrophages

Jin, S., Kang, H., Park, D., Yu, S., Kim, I., & Park, B.-S. (2019) · International Journal of Oral Biology · doi:10.11620/ijob.2019.44.3.89

Avaliação da ação do receptor de estrógeno beta e a função de NOX2 na osteoclastogênese e na atividade de osteoclastos.

Uehara, I. A. (2020) · doi:10.14393/ufu.di.2020.399

EKSPRESI Nuclear Factor of Activated T cells c-1 (NFATc-1) DAN OSTEOKALSIN PADA KERUSAKAN TULANG PERIAPIKAL AKIBAT INDUKSI BAKTERI Enterococcus faecalis

Hadi, A., Roelianto, M., Subiyanto, A., & Yuanita, T. (2019) · Conservative Dentistry Journal · doi:10.20473/cdj.v7i2.2017.138-144

N‐[2‐(4‐benzoyl‐1‐piperazinyl)phenyl]‐2‐(4‐chlorophenoxy) acetamide is a novel inhibitor of resorptive bone loss in mice

Chen, Z., Cho, E., Ding, M., Seong, J., Che, X., Lee, S., Park, B., Choi, J., & Lee, T. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16228

Effects of pulsed electromagnetic fields on the expression of NFATc1 and CAII in mouse osteoclast-like cells

HeYongsheng, J., Zhangjian, C., ZhengHui, S., & Dong, H. (2015)

Bushenhuoxue formula inhibits osteoclastogenesis and bone resorption on rabbit steroid-related osteonecrosis of the femoral head by suppressing NF-κB/NFATc1 pathwayPreprint

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Faculty Opinions recommendation of HIV-1-Infected Human Macrophages, by Secreting RANK-L, Contribute to Enhanced Osteoclast Recruitment.

Cambi, A. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737901608.793584009

Inflammatory Bowel Disease and Bone

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NCX1 Disturbs Calcium Homeostasis, and Promotes RANKL-Induced Osteoclast Differentiation by Regulating JMK/ C-Fos/NFATc1 Signaling Pathway in Multiple MyelomaPreprint

Li, T., Qiu, D., Chen, Q., Yang, A., Chen, J., & Zeng, Z. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4149831

The Effect of Water Extract of Betaone against Osteoporosis in OVX mice by Inhibiting MAP Kinase SignalingPreprint

Lee, Y., Lee, H.-J., Kim, K., Shin, H.-B., Ham, J. R., Lee, M., Lee, M., & Son, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-2348694/v1

Sodium hydrogen sulfide alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via the inhibition of the ubiquitination and degradation of IKB-αPreprint

Fei, W., Tong, W., Ke Cheng, X. U., Huo, Z., Hong, Y., & Li, Y. (2023) · Research Square · doi:10.21203/rs.3.rs-2599716/v1

Data from β3 Integrin Subunit Mediates the Bone-Resorbing Function Exerted by Cultured Myeloma Plasma Cells

Tucci, M., Palma, R. D., Lombardi, L., Rodolico, G., Berrino, L., Dammacco, F., & Silvestris, F. (2023) · doi:10.1158/0008-5472.c.6499046

Data from β3 Integrin Subunit Mediates the Bone-Resorbing Function Exerted by Cultured Myeloma Plasma Cells

Tucci, M., Palma, R. D., Lombardi, L., Rodolico, G., Berrino, L., Dammacco, F., & Silvestris, F. (2023) · doi:10.1158/0008-5472.c.6499046.v1

Avaliação dos efeitos do tabagismo na constituição do tecido ósseo

Kohler, J. B. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2023.tde-09052023-114015

Induction of S100A7 expression from mechanical stress-induced human dental pulp cells and its effect on osteoclastogenesis

Charoenpong, H., & Ritprajak, P. (2017) · doi:10.58837/chula.the.2017.390

CR6-Interacting Factor-1 Promotes Osteoclastogenesis Through the NF-κB Signaling Pathway after Irradiation

Xiang, L., Li, F., Xiang, Y., Zhang, W., Shi, D., Zhang, X., Chen, L., Ran, Q., & Li, Z. (2023) · Radiation Research · doi:10.1667/rade-22-00066.1

Herbal medicine Ninjinyoeito inhibits RANKL-induced osteoclast differentiation and bone resorption activity by regulating NF-κB and MAPK pathway

Htike, K., Yoshida, K., Eguchi, T., Takebe, K., Li, X., Qu, Y., Sakai, E., Tsukuba, T., & Okamoto, K. (2024) · Journal of Oral Biosciences · doi:10.1016/j.job.2024.09.007

Alternating electrical fields to stimulate osteogenic cells and biomimetic calcium phosphate-coated titanium substrates–A combinatorial approach to bone regeneration

Kreller, T., Boccaccini, A. R., Jonitz‐Heincke, A., & Detsch, R. (2025) · Biomaterials Advances · doi:10.1016/j.bioadv.2025.214191

PEX5 acts as a negative regulator of RANKL-induced osteoclastogenesis in vitro and inflammatory calvarial bone destruction in vivo

Eun, S. Y., Cheon, Y., Lee, C. H., Chung, C. H., Lee, M. S., & Kim, J. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151924

Sodium Hydrosulfide Alleviates Osteoporosis by Suppressing Osteoclastogenesis via the Inhibition of the NF-κB Signaling

Tong, W., Fei, W., Ke Cheng, X. U., Hong, Y., & Li, Y. (2025) · Discovery Medicine · doi:10.24976/discov.med.202537201.207

The immune thrombocytopenia therapeutic Avatrombopag alleviates osteoporosis by targeting NFATc1 signaling

Hu, Y., Chen, Z., Hu, S., Zhou, C., Chen, X., Wei, S., Wang, D., Liang, K., Wu, P., Chen, L., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178377

Interleukin-17 inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing nuclear factor-κB p65 phosphorylation and nuclear factor of activated T cells c1 expressionPreprint

Kobuchi, S., Inoue, H., Sougawa, N., Goda, S., & Nishiura, A. (2025) · Research Square · doi:10.21203/rs.3.rs-8121955/v1

Inhibitory Effects of Polygonati Odorati Rhizoma on Osteoclast Differentiation and Bone Resorption

Joo, B. D., Shin, W. J., Kim, S., Kim, E. J., Park, S. Y., Lee, H. J., Jung, H., Kim, E., & Sohn, Y. (2025) · Korean Journal of Acupuncture · doi:10.14406/acu.2025.026 · Cited by 1

Fluid shear stress activates c-Src and promotes RANKL localization in the plasma membrane in osteoblast-like MC3T3-E1 cells

Matsubara, T., Yoshimura, A., & Kokabu, S. (2026) · BBA Advances · doi:10.1016/j.bbadva.2026.100185

Research Progress on the Mechanisms by Which Strontium Regulates Bone Metabolism

熊, 缄. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.1631185

Etude de la transmission intercellulaire du VIH-1 vers les macrophages par fusion cellule-cellule

Mascarau, R. (2022) · theses.fr (ABES) · doi:10.70675/2e3aacaazcd4fz49a5zb350zcd4933447d78

Liensinine-loaded extracellular vesicles mitigate osteoporosis through inhibition of NF-κB signaling and calcium oscillations in osteoclasts

Jiang, Y., Wang, M., Zheng, P., & Cao, Z. (2026) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-026-05701-z

Genetic and epigenetic contributors to cleft laterality: evidence from monozygotic mirror twins and replication cohorts

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Preclinical Mouse Models of Rheumatoid Arthritis: Comparative Insights into Inflammatory Mediators and Immune Cells

Lubamba, B. A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27209037

Novel osteoclast signaling mechanisms

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The molecular understanding of osteoclast differentiation

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Mechanistic insight into osteoclast differentiation in osteoimmunology

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Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J.-I., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00369-6 · Cited by 2,701

Ca 2+ ‐NFATc1 signaling is an essential axis of osteoclast differentiation

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