Randomized clinical trial of telephone-administered cognitive-behavioral therapy to reduce post-traumatic stress disorder and distress symptoms after hematopoietic stem-cell transplantation
Open accessAbstract
Purpose: A significant number of survivors of hematopoietic stem-cell transplantation (HSCT) report enduring adverse effects of treatment, including illness-related post-traumatic stress disorder (PTSD) symptoms and general distress. We report results of a randomized clinical trial that tested the effects of a 10-session, telephone-administered cognitive-behavioral therapy (CBT) intervention on PTSD, depression, and distress symptoms. Methods: Survivors who had undergone HSCT 1 to 3 years earlier (N = 408) were assessed for study eligibility. Those who met study eligibility criteria (n = 89) completed a baseline assessment that included a clinical interview and self-report measures of PTSD symptoms (the primary outcome) and depression and general distress (the secondary outcomes). Next, they were randomly assigned to CBT or an assessment-only condition. Survivors in the CBT group completed 10 individual telephone-based CBT sessions (T-CBT) that included strategies to reduce PTSD symptoms, depression, and general distress. Follow-up assessments occurred at 6, 9, and 12 months after the baseline assessment. Results: Linear mixed-model analyses revealed that, compared with HSCT survivors in the assessment-only condition, survivors who completed T-CBT reported fewer illness-related PTSD symptoms, including less avoidance (P < .001) and fewer intrusive thoughts (P < .05) as well as less general distress and fewer depressive symptoms (P < .05) even after controlling for potential demographic and medical covariates. These results were consistent across the three follow-up assessments. Conclusion: A brief, telephone-administered CBT intervention developed for HSCT survivors is an efficacious treatment for reducing illness-related PTSD symptoms and general distress.
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The way in which individuals approach and manage difficult thoughts, emotions, and physical sensations has been shown to hinder or facilitate psychological functioning, including the development of traumatic stress symptoms, and to affect the experience and expression of physical symptoms.
“The way in which individuals approach and manage difficult thoughts, emotions, and physical sensations has been shown to hinder or facilitate psychological functioning, including the development of traumatic stress symptoms, and to affect the experience and expression of physical symptoms [12-16]”
From Mindfulness, Experiential Avoidance, and Recovery From Hematopoietic Stem Cell Transplantation. (2019) · cites this paper as [12]
The PTSD Symptoms: Cluster Subscales section reports that telephone-administered CBT reduced intrusive thoughts and avoidance in stem-cell transplant survivors, supporting the claim that how people manage difficult experiences can affect traumatic-stress symptoms. The paper does not show that these approaches affect the experience or expression of physical symptoms, and its findings concern treatment of existing symptoms rather than their development. Page numbers are not available in our copy. (LLM, conf=0.85)
Experimental — accuracy not yet measuredThe HSCT patient population experiences a particularly high level of psychological distress and related sequelae.
“it is not surprising that this patient population experiences a particularly high level of psychological distress and related sequelae [11, 12]”
From Mindfulness, Experiential Avoidance, and Recovery From Hematopoietic Stem Cell Transplantation. (2019) · cites this paper as [12]
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Cites
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032 · see citing works
Cognitive Therapy for Depression
(2012) · PsycEXTRA Dataset · doi:10.1037/e675542012-001 · Cited by 9,678 · see citing works
The development of a Clinician-Administered PTSD Scale
Blake, D. D., Weathers, F. W., Nagy, L. M., Kaloupek, D. G., Gusman, F. D., Charney, D. S., & Keane, T. M. (1995) · Journal of Traumatic Stress · doi:10.1002/jts.2490080106 · Cited by 5,024 · see citing works
Cognitive Therapy of Depression
HOLLON, S. D., & BECK, A. T. (1979) · Cognitive-Behavioral Interventions · doi:10.1016/b978-0-12-404480-7.50012-5 · Cited by 4,685 · see citing works
Goycoolea, A. (1997) · Cited by 3,612 · see citing works
Hematopoietic Stem-Cell Transplantation
Copelan, E. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052638 · Cited by 2,522 · see citing works
Six-item screener to identify cognitive impairment among potential subjects for clinical research
Callahan, C. M., Unverzagt, F. W., Hui, S. L., Perkins, A. J., & Hendrie, H. C. (2002) · Medical Care · doi:10.1097/00005650-200209000-00007 · Cited by 1,499 · see citing works
A clinician rating scale for assessing current and lifetime PTSD. The CAPS-1
Blake, D. D., Weathers, F. W., Nagy, L., Kaloupek, D. G., Klauminzer, G. W., Charney, D. S., & Keane, T. M. (1990) · Behavior Therapy · Cited by 1,123 · see citing works
Foa, E. B., Dancu, C. V., Hembree, E. A., Jaycox, L. H., Meadows, E. A., & Street, G. P. (1999) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.67.2.194 · Cited by 1,060 · see citing works
Antoni, M. H., Lehman, J. M., Kilbourn, K. M., Boyers, A. E., Culver, J. L., Alferi, S. M., Yount, S. E., McGregor, B. A., Arena, P. L., Harris, S. D., et al. (2001) · Health Psychology · doi:10.1037/0278-6133.20.1.20 · Cited by 1,011 · see citing works
Antoni, M. H., Lehman, J. M., Klibourn, K. M., Boyers, A. E., Culver, J. L., Alferi, S. M., Yount, S., McGregor, B. A., Arena, P. L., Harris, S. D., et al. (2001) · Health Psychology · doi:10.1037//0278-6133.20.1.20 · Cited by 1,008 · see citing works
Foa, E. B., Dancu, C. V., Hembree, E. A., Jaycox, L. H., Meadows, E. A., & Street, G. P. (1999) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.67.2.194 · Cited by 808 · see citing works
Psychosocial treatments for posttraumatic stress disorder: a critical review.
Foa, E., & Meadows, E. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.449 · Cited by 725 · see citing works
Critical Review of Psychosocial Interventions in Cancer Care
Fawzy, F. I. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950140018003 · Cited by 559 · see citing works
Foa, E. B., Hearst‐Ikeda, D., & Perry, K. J. (1995) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.63.6.948 · Cited by 448 · see citing works
Foa, E. B., Hearst-Ikeda, D., & Perry, K. J. (1995) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.63.6.948 · Cited by 448 · see citing works
Tatrow, K., & Montgomery, G. H. (2006) · Journal of Behavioral Medicine · doi:10.1007/s10865-005-9036-1 · Cited by 349 · see citing works
Forbes, D., Creamer, M. C., Phelps, A. J., Bryant, R. A., McFARLANE, A. C., Devilly, G. J., Matthews, L. R., Raphael, B., Doran, C. M., Merlin, T., et al. (2007) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670701449161 · Cited by 336 · see citing works
The partner relationship in psychological response to breast cancer
Pistrang, N., & Barker, C. (1995) · Social Science & Medicine · doi:10.1016/0277-9536(94)00136-h · Cited by 329 · see citing works
Mosher, C. E., Redd, W. H., Rini, C. M., Burkhalter, J. E., & DuHamel, K. N. (2009) · Psycho-Oncology · doi:10.1002/pon.1399 · Cited by 315 · see citing works
Self-citationGuidelines for treatment of PTSD
Foa, E. B., Keane, T. M., & Friedman, M. J. (2000) · Journal of Traumatic Stress · doi:10.1023/a:1007802031411 · Cited by 255 · see citing works
A two-item conjoint screen for alcohol and other drug problems.
Brown, R. L., Leonard, T., Saunders, L. A., & Papasouliotis, O. (2001) · PubMed · Cited by 237 · see citing works
Walker, L., Walker, M. B., Ogston, K. N., Heys, S. D., Ah-See, A. K., Miller, I. D., Hutcheon, A. W., Sarkar, T. K., & Eremin, O. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690349 · Cited by 219 · see citing works
Validation of the PTSD checklist–civilian version in survivors of bone marrow transplantation
Smith, M. Y., Redd, W. H., DuHamel, K. N., Vickberg, S. M. J., & Ricketts, P. (1999) · Journal of Traumatic Stress · doi:10.1023/a:1024719104351 · Cited by 213 · see citing works
Self-citationCHERPITEL, C. J. S. (2000) · Journal of Studies on Alcohol · doi:10.15288/jsa.2000.61.447 · Cited by 180 · see citing works
Posttraumatic Stress Disorder Symptoms After Bone Marrow Transplantation for Breast Cancer
Jacobsen, P. B., Widows, M. R., Hann, D. M., Andrykowski, M. A., Kronish, L. E., & Fields, K. K. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199805000-00026 · Cited by 158 · see citing works
Jacobsen, P. B., Sadler, I. J., Booth‐Jones, M., Soety, E. M., Weitzner, M. A., & Fields, K. K. (2002) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.70.1.235 · Cited by 144 · see citing works
DuHamel, K. N., Ostroff, J. S., Ashman, T. A., Winkel, G. H., Mundy, E. A., Keane, T. M., Morasco, B. J., Vickberg, S. M. J., Hurley, K. E., Burkhalter, J. E., et al. (2004) · Psychological Assessment · doi:10.1037/1040-3590.16.3.255 · Cited by 144 · see citing works
Self-citationSocial‐cognitive correlates of adjustment to prostate cancer
Roberts, K. J., Lepore, S., & Helgeson, V. (2006) · Psycho-Oncology · doi:10.1002/pon.934 · Cited by 135 · see citing works
Spouse support, coping, and mood among individuals with cancer
Manne, S. L., Pape, S. J., Taylor, K. L., & Dougherty, J. (1999) · Annals of Behavioral Medicine · doi:10.1007/bf02908291 · Cited by 124 · see citing works
Jacobsen, P. B., Sadler, I. J., Booth‐Jones, M., et al. (2002) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.70.1.235 · Cited by 118 · see citing works
Social Support, Intrusive Thoughts, and Quality of Life in Breast Cancer Survivors
Lewis, J., Manne, S. L., DuHamel, K. N., Vickberg, S. M. J., Bovbjerg, D. H., Currie, V. E., Winkel, G. H., & Redd, W. H. (2001) · Journal of Behavioral Medicine · doi:10.1023/a:1010714722844 · Cited by 108 · see citing works
Self-citationMundy, E. A., Blanchard, E. B., Cirenza, E., Gargiulo, J., Maloy, B., & Blanchard, C. G. (2000) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(99)00144-8 · Cited by 104 · see citing works
Hopelessness as a predictor of depressive symptoms for breast cancer patients coping with recurrence
Brothers, B. M., & Andersen, B. L. (2008) · Psycho-Oncology · doi:10.1002/pon.1394 · Cited by 83 · see citing works
Physical and psychosocial functioning of 117 survivors of bone marrow transplantation.
Prieto, J. M., Saez, R. A., Carreras, E., Atala, J., Sierra, J., Rovira, M., Batlle, M., Blanch, J., Escobar, R. J., Vieta, E., et al. (1996) · PubMed · Cited by 78 · see citing works
Manne, S. L., & Andrykowski, M. A. (2006) · Annals of Behavioral Medicine · doi:10.1207/s15324796abm3202_4 · Cited by 72 · see citing works
Barriers to mental health service use among hematopoietic SCT survivors
Mosher, C. E., DuHamel, K. N., Rini, C. M., Li, Y., Isola, L., Labay, L., Rowley, S., Papadopoulos, E., Moskowitz, C., Scigliano, E., et al. (2010) · Bone Marrow Transplantation · doi:10.1038/bmt.2009.166 · Cited by 41 · see citing works
Self-citationCwikel, J., Behar, L. C., & Rabson-Hare, J. (2000) · Research on Social Work Practice · doi:10.1177/15527581-00010001-02 · Cited by 31 · see citing works
Trauma-focused intervention after bone marrow transplantation: A case study
DuHamel, K. N., Ostroff, J. S., Bovbjerg, D. H., Pfeffer, M., Morasco, B. J., Papadopoulos, E. B., & Redd, W. H. (2000) · Behavior Therapy · doi:10.1016/s0005-7894(00)80010-6 · Cited by 22 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [21]21. First MB, Spitzer RL, Gibbon M, et al: Struc- tured Clinical Interview for DSM-IV-TR Axis I Disor- ders, Research Version, Patient Edition With Psychotic Screen (SCID-I/P W/PSY SCREEN). New York, NY, Biometrics Research, New York State Psychiatric Institute, 2002
Cited by
Sorted by citations
Psychological therapies for chronic post-traumatic stress disorder (PTSD) in adults
Bisson, J. I., Roberts, N. P., Andrew, M., Cooper, R., & Lewis, C. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003388.pub4 · Cited by 829 · see citing works
Post-traumatic stress disorder and cancer
Cordova, M. J., Riba, M. B., & Spiegel, D. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30014-7 · Cited by 442 · see citing works
Cognitive behavioral therapy for the treatment of post-traumatic stress disorder: A review
Kar, N. (2011) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s10389 · Cited by 266 · see citing works
What Happens Now? Psychosocial Care for Cancer Survivors After Medical Treatment Completion
Stanton, A. L. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.39.7406 · Cited by 229 · see citing works
Bevans, M., El-Jawahri, A., Tierney, D. K., Wiener, L., Wood, W. A., Hoodin, F., Kent, E. E., Jacobsen, P. B., Lee, S. J., Hsieh, M. M., et al. (2017) · Biology of Blood and Marrow Transplantation · doi:10.1016/j.bbmt.2016.09.011 · Cited by 166 · see citing works
Barnett, P., Goulding, L., Casetta, C., Jordan, H., Sheridan-Rains, L., Steare, T., Williams, J., Wood, L., Gaughran, F., & Johnson, S. (2021) · Journal of Medical Internet Research · doi:10.2196/26492 · Cited by 136 · see citing works
Greer, J. A., Traeger, L., Bemis, H., Solis, J., Hendriksen, E. S., Park, E. R., Pirl, W. F., Temel, J. S., Prigerson, H. G., & Safren, S. A. (2012) · The Oncologist · doi:10.1634/theoncologist.2012-0041 · Cited by 111 · see citing works
Wade, D., Varker, T., Kartal, D., Hetrick, S., O'Donnell, M., & Forbes, D. (2016) · Psychological Trauma: Theory, Research, Practice, and Policy · doi:10.1037/tra0000110 · Cited by 111 · see citing works
Syrjala, K. L., Yi, J. C., Artherholt, S. B., Romano, J. M., Crouch, M.-L., Fiscalini, A. S., Hegel, M. T., Flowers, M. E. D., Martin, P. J., & Leisenring, W. M. (2018) · Journal of Cancer Survivorship · doi:10.1007/s11764-018-0693-9 · Cited by 76 · see citing works
Evidence of phone vs video-conferencing for mental health treatments: A review of the literature.
Chen, P. V., Helm, A., Caloudas, S. G., Ecker, A., Day, G., Hogan, J., & Lindsay, J. (2022) · Current Psychiatry Reports · doi:10.1007/s11920-022-01359-8 · Cited by 73 · see citing works
Distance-delivered interventions for PTSD: A systematic review and meta-analysis
Olthuis, J. V., Wozney, L., Asmundson, G. J. G., Cramm, H., Lingley-Pottie, P., & McGrath, P. J. (2016) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2016.09.010 · Cited by 64 · see citing works
Psychological Symptoms in Advanced Cancer
Bail, J. R., Traeger, L., Pirl, W. F., & Bakitas, M. A. (2018) · Seminars in Oncology Nursing · doi:10.1016/j.soncn.2018.06.005 · Cited by 34 · see citing works
Grossman, P., Zwahlen, D., Halter, J. P., Passweg, J. R., Steiner, C., & Kiss, A. (2015) · Supportive Care in Cancer · doi:10.1007/s00520-014-2452-4 · Cited by 36 · see citing works
Mindfulness, Experiential Avoidance, and Recovery From Hematopoietic Stem Cell Transplantation.
Larson, A. G., Morris, K. J., Juckett, M. B., Coe, C. L., Broman, A. T., & Costanzo, E. S. (2019) · Annals of Behavioral Medicine · doi:10.1093/abm/kay097 · Cited by 27 · see citing works
Nenova, M., Morris, L., Paul, L., Li, Y., Applebaum, A., & DuHamel, K. (2013) · Journal of Cognitive Psychotherapy · doi:10.1891/0889-8391.27.3.258 · Cited by 26 · see citing works
Self-citationSmith, S. K., Somers, T. J., Kuhn, E., Laber, E., Sung, A. D., Syrjala, K. L., Feger, B., Kelleher, S. A., Majestic, C., Gebert, R., et al. (2021) · Contemporary Clinical Trials · doi:10.1016/j.cct.2021.106569 · Cited by 14 · see citing works
Acute Cancer Cognitive Therapy
Levin, T. T., & Applebaum, A. J. (2014) · Cognitive and Behavioral Practice · doi:10.1016/j.cbpra.2014.03.003 · Cited by 14 · see citing works
Problem‐focussed interactive telephone therapy for cancer patients: a phase II feasibility trial
Watson, M., White, C., Davolls, S., Mohammed, A., Lynch, A., & Mohammed, K. (2013) · Psycho-Oncology · doi:10.1002/pon.3194 · Cited by 14 · see citing works
- Authors
- DuHamel, K. N., Mosher, C. E., Winkel, G., Labay, L. E., Rini, C., Meschian, Y. M., Austin, J., Greene, P. B., Lawsin, C. R., Rusiewicz, A., Grosskreutz, C. L., Isola, L., Moskowitz, C. H., Papadopoulos, E. B., Rowley, S., Scigliano, E., Burkhalter, J. E., Hurley, K. E., Bollinger, A. R., & Redd, W. H.
- Affiliations
- William Paterson University (US)
- From Memorial Sloan-Kettering Cancer Center; Mount Sinai School of Medicine; and Graduate Center of the City University of New York, New York, NY; Hackensack University Medical Center, Hackensack; and William Paterson University, Wayne, NJ; and Dominican University of California, San Rafael, CA.
- ORCID
- Venue
- Journal of Clinical Oncology
- Published
- 2010-08-10
- Volume
- 28
- Issue
- 23
- Pages
- 3754-3761
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- PMC
- PMC2917309
- OpenAlex
- W2111471105
- Semantic Scholar
- 5ab068f7134ec6d7f5a3dd33203474846b88098c
- Cited by
- 151
- References
- 40
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 9 · 2021: 13 · 2020: 11 · 2019: 13 · 2018: 7 · 2017: 10 · 2016: 7 · 2015: 12 · 2014: 12 · 2013: 11 · 2012: 14
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Oncology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Cancer Society (PF-01-018-01-CPPB)
- National Institutes of Health
- National Cancer Institute (K07CA109236, F32CA130600, CA093609, R01CA093609, P30CA008748)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Telemedicine and Telehealth Implementation
- Keywords
- post-traumatic stress disorder, hematopoietic stem cell transplantation, depression, distress, transplant survivors, avoidance, intrusive thoughts, psychological intervention
- MeSH terms
- Adult, Aged, Depression, Female, Humans, Male, Middle Aged, Stress Disorders, Post-Traumatic, Telephone, Cognitive Behavioral Therapy, Single-Blind Method, Hematopoietic Stem Cell Transplantation, Young Adult
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