The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Use of a Comprehensive Geriatric Assessment for the Management of Elderly Patients With Advanced Non–Small-Cell Lung Cancer: The Phase III Randomized ESOGIA-GFPC-GECP 08-02 Study
Abstract
Purpose: Comprehensive geriatric assessment (CGA) is recommended to assess the vulnerability of elderly patients, but its integration in cancer treatment decision making has never been prospectively evaluated. Here, in elderly patients with advanced non–small-cell lung cancer (NSCLC), we compared a standard strategy of chemotherapy allocation on the basis of performance status (PS) and age with an experimental strategy on the basis of CGA. Patients and Methods: In a multicenter, open-label, phase III trial, elderly patients ≥ 70 years old with a PS of 0 to 2 and stage IV NSCLC were randomly assigned between chemotherapy allocation on the basis of PS and age (standard arm: carboplatin-based doublet if PS ≤ 1 and age ≤ 75 years; docetaxel if PS = 2 or age > 75 years) and treatment allocation on the basis of CGA (CGA arm: carboplatin-based doublet for fit patients, docetaxel for vulnerable patients, and best supportive care for frail patients). The primary end point was treatment failure free survival (TFFS). Secondary end points were overall survival (OS), progression-free survival, tolerability, and quality of life. Results: Four hundred ninety-four patients were randomly assigned (standard arm, n = 251; CGA arm, n = 243). Median age was 77 years. In the standard and CGA arms, 35.1% and 45.7% of patients received a carboplatin-based doublet, 64.9% and 31.3% received docetaxel, and 0% and 23.0% received best supportive care, respectively. In the standard and CGA arms, median TFFS times were 3.2 and 3.1 months, respectively (hazard ratio, 0.91; 95% CI, 0.76 to 1.1), and median OS times were 6.4 and 6.1 months, respectively (hazard ratio, 0.92; 95% CI, 0.79 to 1.1). Patients in the CGA arm, compared with standard arm patients, experienced significantly less all grade toxicity (85.6% v 93.4%, respectively P = .015) and fewer treatment failures as a result of toxicity (4.8% v 11.8%, respectively; P = .007). Conclusion: In elderly patients with advanced NSCLC, treatment allocation on the basis of CGA failed to improve the TFFS or OS but slightly reduced treatment toxicity.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Models based on GA have been developed to predict chemotherapy toxicity and may aid therapeutic decisions in older patients.”
In the citing paper
“the frailty index determined from a CGA provides a summary measure which could prove useful to oncologists who are increasingly seeking to use the concept of frailty to direct treatment decisions (20).”
From Frailty as determined by a comprehensive geriatric assessment-derived deficit-accumulation index in older patients with cancer who receive chemotherapy (2016) · cites this paper as [20]
In the citing paper
“a recently published phase III trial did not demonstrate an improvement in survival outcomes of elderly patients with advanced NSCLC deriving from CGA-based allocation of chemotherapy [76].”
From Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (2016) · cites this paper as [76]
Citations
Cites
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
Ferlay, J., Shin, H., Bray, F., Forman, D., Mathers, C. D., & Parkin, D. M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25516 · Cited by 21,468
Wildiers, H. P. M. W., Heeren, P., Puts, M. T. E., Topinková, E., Janssen-Heijnen, M. L. G., Extermann, M., Falandry, C., Artz, A. S., Brain, E. G. C., Colloca, G. A., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.54.8347 · Cited by 1,854
Pfister, D. G., Johnson, D. H., Azzoli, C. G., Sause, W. T., Smith, T. J., Baker, S., Olak, J., Stover, D. E., Strawn, J. R., Turrisi, A. T., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2004.09.053 · Cited by 1,411
Management of Cancer in the Older Person: A Practical Approach
Balducci, L., & Extermann, M. (2000) · The Oncologist · doi:10.1634/theoncologist.5-3-224 · Cited by 937
Azzoli, C. G., Baker, S., Temin, S., Pao, W., Aliff, T., Brahmer, J., Johnson, D. H., Laskin, J. L., Masters, G., Milton, D., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.23.5622 · Cited by 915
Repetto, L., Fratino, L., Audisio, R. A., Venturino, A., Gianni, W., Vercelli, M., Parodi, S., Lago, D. D., Gioia, F., Monfardini, S., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.2.494 · Cited by 912
Comprehensive geriatric assessment for older patients with cancer
Extermann, M., & Hurria, A. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.10.6559 · Cited by 875
Elderly Lung Cancer Vinorelbine Italian Study Group (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.1.66 · Cited by 867
Gridelli, C., Perrone, F., Gallo, C., Cigolari, S., Rossi, A., Piantedosi, F., Barbera, S., Ferrau, F., Piazza, E., Rosetti, F., et al. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.5.362 · Cited by 781
Quoix, E., Zalcman, G., Oster, J.-P., Westeel, V., Pichon, E., Lavolé, A., Dauba, J., Debieuvre, D., Souquet, P.-J., Bigay-Game, L., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60780-0 · Cited by 566
Repetto, L., Fratino, L., Audisio, R. A., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.2.494 · Cited by 551
Maione, P., Perrone, F., Gallo, C., Manzione, L., Piantedosi, F., Barbera, S., Cigolari, S., Rosetti, F., Piazza, E., Robbiati, S. F., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.527 · Cited by 477
Frasci, G., Lorusso, V., Panza, N., Comella, P., Nicolella, G. P., Bianco, A., Cataldis, G. D., Iannelli, A., Bilancia, D., Belli, M., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.13.2529 · Cited by 447
Kudoh, S., Takeda, K., Nakagawa, K., Takada, M., Katakami, N., Matsui, K., Shinkai, T., Sawa, T., Goto, I., Semba, H., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.1044 · Cited by 360 · cited 1×
“Singleagent therapy consisted of weekly docetaxel because previous studies have demonstrated its efficacy and favorable safety profile.(14,20,21)”
Asmis, T. R., Ding, K., Seymour, L., Shepherd, F. A., Leighl, N. B., Winton, T. L., Whitehead, M., Spaans, J. N., Graham, B., & Goss, G. D. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.12.8322 · Cited by 332
Wildiers, H. P. M. W., Mauer, M. E. L., Pallis, A. G., Hurria, A., Mohile, S. G., Luciani, A., Curigliano, G., Extermann, M., Lichtman, S. M., Ballman, K. V., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2013.49.6125 · Cited by 322
An update on a systematic review of the use of geriatric assessment for older adults in oncology
Puts, M. T. E., dos Santos, B. S., Hardt, J., Monette, J., Girre, V., Atenafu, E. G., Springall, E., & Alibhai, S. M. H. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt386 · Cited by 254
Zukin, M., Barrios, C. H., Rodrigues Pereira, J., De Albuquerque Ribeiro, R., de Mendonça Beato, C. A., do Nascimento, Y. N., Murad, A., Franke, F. A., Precivale, M., de Lima Araujo, L. H., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.48.1911 · Cited by 235
Kanesvaran, R., Li, H., Koo, K.-N., & Poon, D. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.32.0796 · Cited by 203
Does a Geriatric Oncology Consultation Modify the Cancer Treatment Plan for Elderly Patients?
Girre, V., Falcou, M.-C., Gisselbrecht, M., Gridel, G., Mosseri, V., Bouleuc, C., Poinsot, R., Védrine, L., Ollivier, L., Garabige, V., et al. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.7.724 · Cited by 188
Pallis, A. G., Gridelli, C., Wedding, U., Finn, C. F., Veronesi, G., Jaklitsch, M. T., Luciani, A., & O'Brien, M. E. R. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu022 · Cited by 186
Predictive value of geriatric assessment for patients older than 70 years, treated with chemotherapy
Aaldriks, A. A., Maartense, E., le Cessie, S., Giltay, E. J., Verlaan, H. A. C. M., van der Geest, L. G., Kloosterman-Boele, W. M., Peters-Dijkshoorn, M. T., Blansjaar, B. A., van Schaick, H. W., et al. (2010) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2010.05.009 · Cited by 175
Belani, C. P., & Fossella, F. V. (2005) · Cancer · doi:10.1002/cncr.21495 · Cited by 144
Handbook of Statistics in Clinical Oncology
(2005) · Chapman & Hall/CRC eBooks · doi:10.1201/9781420027761 · Cited by 122
Gridelli, C., Maione, P., Illiano, A., Piantedosi, F. V., Favaretto, A. G., Bearz, A., Robbiati, S. F., Filipazzi, V., Lorusso, V., Carrozza, F., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.12.5708 · Cited by 79
Ansari, R., Socinski, M. A., Edelman, M. J., Belani, C. P., Gonin, R., Catalano, R. B., Marinucci, D. M., Comis, R. L., Obasaju, C. K., Chen, R., et al. (2010) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2010.03.003 · Cited by 50
the GFPC 0504 Team, LeCaer, H., Barlési, F., Corre, R., Jullian, H., Bota, S., Falchero, L., Vergnenégre, A., Dujon, C., Delhoume, J. Y., et al. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.331 · Cited by 26
Self-citationKarampeazis, A., Vamvakas, L. N., Agelidou, A., Kentepozidis, N. K., Chainis, K., Chandrinos, V., Vardakis, N., Pallis, A. G., Christophyllakis, C., & Georgoulias, V. (2011) · Clinical Lung Cancer · doi:10.1016/j.cllc.2011.03.015 · Cited by 24
LeCaer, H., Greillier, L., Corre, R., Jullian, H., Créquit, J., Falchero, L., Dujon, C., Berard, H., Vergnenégre, A., & CHOUAID, C. (2012) · Lung Cancer · doi:10.1016/j.lungcan.2012.02.004 · Cited by 24
Self-citationLeCaer, H., Fournel, P., Jullian, H., CHOUAID, C., Letreut, J., Thomas, P. A., Paillotin, D., Pérol, M., Gimenez, C., & Vergnenégre, A. (2007) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2007.06.008 · Cited by 21
Self-citationQuoix, É., Breton, J.-L., Ducoloné, A., Mennecier, B., Depierre, A., Lemarié, É., Moro‐Sibilot, D., Germa, C., & Neidhardt, A.-C. (2004) · Lung Cancer · doi:10.1016/j.lungcan.2004.08.012 · Cited by 21
LeCaer, H., Barlési, F., Robinet, G., Fournel, P., Geriniere, L., Bombaron, P., Falchero, L., Auliac, J. B., Créquit, J., & CHOUAID, C. (2007) · Lung Cancer · doi:10.1016/j.lungcan.2007.02.012 · Cited by 18
Self-citationZhu, J., Sharma, D. B., Chen, A. B., Johnson, B. E., Weeks, J. C., & Schrag, D. (2013) · Cancer · doi:10.1002/cncr.28022 · Cited by 17
Flagged first, then by citations
Cited by
Sorted by citations
Novello, S., Barlesi, F., Califano, R., Cufer, T., Ekman, S., Levra, M. G., Kerr, K., Popat, S., Reck, M., Senan, S., et al. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw326 · Cited by 2,631
Planchard, D., Popat, S., Kerr, K., Novello, S., Smit, E. F., Faivre-Finn, C., Mok, T. S., Reck, M., Van Schil, P. E., Hellmann, M. D., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy275 · Cited by 2,274
Mohile, S. G., Dale, W., Somerfield, M. R., Schonberg, M. A., Boyd, C. M., Burhenn, P. S., Canin, B., Cohen, H. J., Holmes, H. M., Hopkins, J. O., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2018.78.8687 · Cited by 1,479
Hendriks, L. E. L., Kerr, K. M., Menis, J., Mok, T. S. K., Nestle, U., Passaro, A., Peters, S., Planchard, D., Smit, E. F., Solomon, B., et al. (2023) · Annals of Oncology · doi:10.1016/j.annonc.2022.12.013 · Cited by 685
Mohile, S. G., Mohamed, M., Xu, H., Culakova, E., Loh, K. P., Magnuson, A. M., Flannery, M. A., Obrecht, S., Gilmore, N. J., Ramsdale, E. E., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)01789-x · Cited by 622
Metadata
- Authors
- Corre, R., Greillier, L., Le Caër, H., Audigier-Valette, C., Baize, N., Bérard, H., Falchero, L., Monnet, I., Dansin, E., Vergnenègre, A., Marcq, M., Decroisette, C., Auliac, J.-B., Bota, S., Lamy, R., Massuti, B., Dujon, C., Pérol, M., Daurès, J.-P., Descourt, R., Léna, H., Plassot, C., & Chouaïd, C.
- Affiliations
- Centre Hospitalier Universitaire d'Angers (FR)
- Romain Corre and Hervé Léna, Centre Hospitalier Universitaire de Rennes, Rennes; Laurent Greillier, Université de Médecine, Marseille; Hervé Le Caër, Centre Hospitalier de Draguignan, Draguignan; Clarisse Audigier-Valette, Centre Hospitalier Intercommunal de Toulon; Henri Bérard, Hôpital Inter Armées Sainte-Anne, Toulon; Nathalie Baize, Centre Hospitalier Universitaire d’Angers, Angers; Lionel Falchero, Centre Hospitalier de Villefranche sur Saône, Villefranche sur Saône; Isabelle Monnet and Christos...
- ORCID
- Venue
- Journal of Clinical Oncology
- Published
- 2016-05-01
- Volume
- 34
- Issue
- 13
- Pages
- 1476-1483
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2281930375
- Cited by
- 403
- References
- 32
- Citations by year
- 2026: 18 · 2025: 11 · 2024: 37 · 2023: 35 · 2022: 47 · 2021: 40 · 2020: 50 · 2019: 40 · 2018: 56 · 2017: 43 · 2016: 23
- FWCI
- 31.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- American Society of Clinical Oncology
- Centre Hospitalier Universitaire de Rennes
- National Cancer Institute
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Keywords
- comprehensive geriatric assessment, advanced non-small cell lung cancer, elderly patients, frailty, performance status, docetaxel, treatment toxicity, overall survival, best supportive care, geriatric oncology, treatment decision-making, quality of life, treatment tolerability
- MeSH terms
- Pemetrexed, Docetaxel, Gemcitabine, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Deoxycytidine, Female, Follow-Up Studies, Humans, Lung Neoplasms, Male, Neoplasm Staging, Prognosis, Quality of Life, Geriatric Assessment, Survival Rate, Carboplatin, Paclitaxel, Taxoids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
