Catecholamine response to exercise in children with attention deficit hyperactivity disorder.
Open accessAbstract
The objective of this study was to examine differences in catecholamine (CA) response to exercise between children who had received a diagnosis of attention-deficit/hyperactivity disorder (ADHD) and age- and gender-matched controls. On the basis of the notion of a CA dysfunction in ADHD, we reasoned that the normal robust increase in circulating CA seen in response to exercise would be blunted in children with ADHD. To test this, we recruited 10 treatment-naïve children with newly diagnosed ADHD and 8 age-matched controls (all male) and measured CA response to an exercise test in which the work was scaled to each subject's physical capability. After exercise, epinephrine and norepinephrine increased in both control and ADHD subjects (p = 0.006 and p = 0.002, respectively), but the responses were substantially blunted in the ADHD group (p = 0.018) even though the work performed did not differ from controls. Circulating dopamine increased significantly in the control subjects (p < 0.016), but no increase was noted in the subjects with ADHD. Finally, a significant attenuation in the lactate response to exercise was found in ADHD (between groups, p < 0.005). Our data suggest that CA excretion after exercise challenges in children with ADHD is deficient. This deficiency can be detected using a minimally invasive, nonpharmacologic challenge.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Exercise is natural, quantifiable in terms of workload and duration, and a known stimulus of the adrenal medulla and systemic sympathetic nervous system.
“Although several physical stressors are capable of eliciting physiological responses in the body, exercise is natural, quantifiable in terms of workload and duration, and a known stimulus of the adrenal medulla and systemic sympathetic nervous system (6).”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
CDC growth charts: United States.
Kuczmarski, R. J., Ogden, C. L., Grummer‐Strawn, L. M., Flegal, K. M., Guo, S. S., Wei, R. X., Mei, Z., Curtin, L. R., Roche, A. F., & Johnson, C. L. (2000) · PubMed · Cited by 5,298 · see citing works
Exercise and the immune system: regulation, integration, and adaptation
Pedersen, B. K., & Hoffman-Goetz, L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.1055 · Cited by 1,710 · see citing works
The level and tempo of children???s physical activities: an observational study
Bailey, R. C., Olson, J., Pepper, S. L., Pórszász, J., Barstow, T. J., & Cooper, D. M. (1995) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199507000-00012 · Cited by 978 · see citing works
Self-citationSolanto, M. V. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00175-7 · Cited by 677 · see citing works
Attention-deficit hyperactivity disorder and hyperkinetic disorder
Jm, S., Sergeant, J. A., Taylor, E. A., Sonuga-Barke, E. J. S., Jensen, P. S., & Dp, C. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11450-7 · Cited by 602 · see citing works
Attention-deficit hyperactivity disorder and hyperkinetic disorder
Swanson, J. M., Sergeant, J. A., Taylor, E., Sonuga-Barke, E. J. S., Jensen, P. S., & Cantwell, D. P. (2001) · Routledge eBooks · doi:10.4324/9781315054315-2 · Cited by 573 · see citing works
Self-citationCatecholamines in Attention-Deficit Hyperactivity Disorder: Current Perspectives
Pliszka, S. R., McCracken, J. T., & Maas, J. W. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199603000-00006 · Cited by 440 · see citing works
Aerobic parameters of exercise as a function of body size during growth in children
Cooper, D. M., Weiler‐Ravell, D., Whipp, B. J., & Wasserman, K. (1984) · Journal of Applied Physiology · doi:10.1152/jappl.1984.56.3.628 · Cited by 431 · see citing works
Self-citationNeurobiology of Attention Deficit Disorder With Hyperactivity: Where Have We Come in 50 Years?
Zametkin, A. J., & Rapoport, J. L. (1987) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198709000-00011 · Cited by 348 · see citing works
Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Franceschi, D., Maynard, L., Ding, Y., Gatley, S. J., Gifford, A., Zhu, W., et al. (2002) · Synapse · doi:10.1002/syn.10038 · Cited by 321 · see citing works
Self-citationThe Dopamine Theory of Attention Deficit Hyperactivity Disorder (ADHD)
Levy, F. (1991) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048679109077746 · Cited by 234 · see citing works
Behavior and circulating catecholamines
Frankenhaeuser, M. (1971) · Brain Research · doi:10.1016/0006-8993(71)90180-6 · Cited by 209 · see citing works
The effects of exercise on children with attention-deficit hyperactivity disorder
Tantillo, M., Kesick, C. M., Hynd, G. W., & Dishman, R. K. (2002) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200202000-00004 · Cited by 154 · see citing works
A more sensitive and specific radioenzymatic assay for catecholamines
Kennedy, B. P., & Ziegler, M. G. (1990) · Life Sciences · doi:10.1016/0024-3205(90)90314-h · Cited by 153 · see citing works
Self-citationAttention-deficit hyperactivity disorder and the stress response
King, J. A., Barkley, R. A., & Barrett, S. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00507-6 · Cited by 151 · see citing works
Habitual Physical Activity and Academic Performance
Shephard, R. J. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1996.tb03896.x · Cited by 135 · see citing works
Plasma dopamine: regulation and significance.
Gr, V. L. (1983) · PubMed · Cited by 113 · see citing works
Kraemer, W. J., Fleck, S. J., Maresh, C. M., Ratamess, N. A., Gordon, S. E., Goetz, K. L., Harman, E. A., Frykman, P., Volek, J. S., MAZZETTI, S. A., et al. (1999) · Canadian Journal of Applied Physiology · doi:10.1139/h99-034 · Cited by 112 · see citing works
Urhausen, A., Weiler, B., Coen, B., & Kindermann, W. (1994) · European Journal of Applied Physiology and Occupational Physiology · doi:10.1007/bf00867921 · Cited by 109 · see citing works
Fitness, Acute Exercise, and Anabolic and Catabolic Mediators in Cystic Fibrosis
Tirakitsoontorn, P., Nussbaum, E., Moser, C., HILL, M., & Cooper, D. M. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.8.2102045 · Cited by 87 · see citing works
Self-citationInteractive effects of mental and physical stress on cardiovascular control
Wasmund, W. L., Westerholm, E. C., Watenpaugh, D. E., Wasmund, S. L., & Smith, M. L. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00019.2001 · Cited by 70 · see citing works
Nagao, F., Suzui, M., Takeda, K., Yagita∥, H., & Okumura, K. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.4.r1251 · Cited by 69 · see citing works
Urinary Catecholamines in Attention-Deficit Hyperactivity Disorder with and without Comorbid Anxiety
Pliszka, S. R., Maas, J. W., Javors, M. A., Rogeness, G. A., & BAKER, J. (1994) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199410000-00012 · Cited by 64 · see citing works
Stratton, J. R., & Halter, J. B. (1985) · The American Journal of Cardiology · doi:10.1016/0002-9149(85)90582-x · Cited by 60 · see citing works
Oral [13C]bicarbonate measurement of CO2 stores and dynamics in children and adults
Armon, Y., Cooper, D. M., Springer, C., Barstow, T. J., Rahimizadeh, H., Landaw, E. M., & Epstein, S. (1990) · Journal of Applied Physiology · doi:10.1152/jappl.1990.69.5.1754 · Cited by 49 · see citing works
Self-citationUrinary Catecholamine Excretion and Behavioral Differences in ADHD and Normal Boys
Hanna, G. L., Ornitz, E. M., & Hariharan, M. (1996) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.1996.6.63 · Cited by 41 · see citing works
A Comparison of the Blood Lactate and Plasma Catecholamine Thresholds in Untrained Male Subjects
Schneider, D., McGuiggin, M. E., & Kamimori, G. H. (1992) · International Journal of Sports Medicine · doi:10.1055/s-2007-1024565 · Cited by 39 · see citing works
Effects of d-amphetamine on urinary metabolites of dopamine and norepinephrine in hyperactive boys
Shekim, W. O., Javaid, J. I., Dekirmenjian, H., Chapel, J. L., & Davis, J. M. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.4.485 · Cited by 37 · see citing works
Adrenomedullary Function During Cognitive Testing in Attention-Deficit/Hyperactivity Disorder
Anderson, G. M., Dover, M., Yang, B. P.-S., Holahan, J. M., Shaywitz, S. E., Marchione, K. E., Hall, L. M., Fletcher, J. M., & Shaywitz, B. A. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200005000-00018 · Cited by 30 · see citing works
Blunted Catecholamine Responses after Glucose Ingestion in Children with Attention Deficit Disorder
Girardi, N. L., Shaywitz, S. E., Shaywitz, B. A., Marchione, K. E., Fleischman, S. J., Jones, T. W., & Tamborlane, W. V. (1995) · Pediatric Research · doi:10.1203/00006450-199510000-00011 · Cited by 29 · see citing works
Shekim, W. O., Sinclair, E., Glaser, R., Horwitz, E., Javaid, J., & Bylund, D. B. (1987) · Journal of Child Neurology · doi:10.1177/088307388700200110 · Cited by 25 · see citing works
Changes in breath 13CO2/12CO2 consequent to exercise and hypoxia
Barstow, T. J., Cooper, D. M., Epstein, S., & Wasserman, K. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.66.2.936 · Cited by 23 · see citing works
Self-citationAdrenaline and the relationship between neurosomatism, aerobic fitness and mental task performance
van Zijderveld, G. A., van Doornen, L. J. P., van Faassen, I., Orlebeke, J. F., van Dyck, R., & Tilders, F. J. H. (1993) · Biological Psychology · doi:10.1016/0301-0511(93)90016-2 · Cited by 13 · see citing works
The Effect of Exercise on the Hypothalamo—Pituitary—Adrenal Axis
Wittert, G. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-016-2_3 · Cited by 12 · see citing works
Performance and metabolic effects of benzodiazepine during submaximal exercise
Collomp, K., Fortier, M., Cooper, S., Long, A. M., Ahmaidi, S., Prefaut, C., Wright, F., Picot, M., & Côté, M. G. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.2.828 · Cited by 11 · see citing works
Wo, S., Dekirmenjian, H., & Jl, C. (1978) · PubMed · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [31]31. Brown GL, Ebert MH, Minichiello MD 1985 Biochemical and pharmacological aspects of attention deficit disorder. In: LM Bloomingdale (ed) Attention Deficit Disorder: Identification, Course, and Rationale. Spectrum Press Medical and Scien- tific Books, New York, pp 93-130
- [32]32. Maas JW, Leckman JF 1983 Relationship between central nervous system noradren- ergic function and plasma and urinary MHPG and other norepinephrine metabolites. In: Maas JW (ed) MHPG: Basic Mechanisms and Psychopathology. Academic Press, London, pp 33-44
Cited by
Sorted by citations
Cerrillo‐Urbina, A. J., García‐Hermoso, A., Sánchez‐López, M., Pardo‐Guijarro, M. J., Santos Gómez, J. L., & Martínez‐Vizcaíno, V. (2015) · Child: Care, Health and Development · doi:10.1111/cch.12255 · Cited by 284 · see citing works
Halperin, J. M., & Healey, D. M. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.07.006 · Cited by 237 · see citing works
Biomarkers and Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analyses
Scassellati, C., Bonvicini, C., Faraone, S. V., & Gennarelli, M. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.08.015 · Cited by 235 · see citing works
den Heijer, A. E., Groen, Y., Tucha, L., Fuermaier, A. B. M., Koerts, J., Lange, K. W., Thome, J., & Tucha, O. M. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1593-7 · Cited by 201 · see citing works
The effects of physical activity on attention deficit hyperactivity disorder symptoms: The evidence
Gapin, J. I., Labban, J. D., & Etnier, J. L. (2011) · Preventive Medicine · doi:10.1016/j.ypmed.2011.01.022 · Cited by 201 · see citing works
Pilot Physical Activity Intervention Reduces Severity of ADHD Symptoms in Young Children
Smith, A. L., Hoza, B., Linnea, K. S., McQuade, J. D., Tomb, M. F., Vaughn, A. J., Shoulberg, E. K., & Hook, H. (2011) · Journal of Attention Disorders · doi:10.1177/1087054711417395 · Cited by 177 · see citing works
Ng, Q. X., Ho, C. Y. X., Chan, H. W., Yong, B. Z. J., & Yeo, W. S. (2017) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2017.08.018 · Cited by 179 · see citing works
Exercise impact on sustained attention of ADHD children, methylphenidate effects
Medina, J. A., Netto, T. L. B., Muszkat, M., Medina, A. C., Botter, D. A., Orbetelli, R., Scaramuzza, L. F. C., Sinnes, E. G., Vilela, M., & Miranda, M. C. (2010) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-009-0018-y · Cited by 155 · see citing works
Exercise Interventions in Children and Adolescents With ADHD: A Systematic Review
Neudecker, C., Mewes, N., Reimers, A. K., & Wöll, A. (2015) · Journal of Attention Disorders · doi:10.1177/1087054715584053 · Cited by 149 · see citing works
Christiansen, L., Beck, M. M., Bilenberg, N., Wienecke, J., Astrup, A. V., & Lundbye‐Jensen, J. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060841 · Cited by 148 · see citing works
Physical activity as the main therapeutic tool for metabolic syndrome in childhood
Brambilla, P., Pozzobon, G. C., & Pietrobelli, A. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.255 · Cited by 121 · see citing works
Kadri, A., Slimani, M., Bragazzi, N. L., Tod, D., & Azaiez, F. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16020204 · Cited by 113 · see citing works
Eliakim, A., Nemet, D., Zaldivar, F. P., McMurray, R. G., Culler, F. L., Galassetti, P. R., & Cooper, D. M. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01072.2005 · Cited by 98 · see citing works
Self-citationExercise: Applications to Childhood ADHD
Wigal, S. B., Emmerson, N., Gehricke, J.-G., & Galassetti, P. (2013) · Journal of Attention Disorders · doi:10.1177/1087054712454192 · Cited by 93 · see citing works
Self-citationSport participation and anxiety in children with ADHD
Kiluk, B. D., Weden, S., & Culotta, V. P. (2009) · Journal of Attention Disorders · doi:10.1177/1087054708320400 · Cited by 90 · see citing works
Zhu, F., Zhu, X., Bi, X., Kuang, D., Liu, B., Zhou, J., Yang, Y., & Ren, Y. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1133727 · Cited by 89 · see citing works
Mehren, A., Reichert, M., Coghill, D., Müller, H. H. O., Braun, N., & Philipsen, A. (2020) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/s40479-019-0115-2 · Cited by 86 · see citing works
Xie, Y., Gao, X., Song, Y., Zhu, X., Chen, M., Yang, L., & Ren, Y. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.706625 · Cited by 86 · see citing works
Halperin, J. M., Berwid, O. G., & O’Neill, S. (2014) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2014.05.005 · Cited by 75 · see citing works
Galassetti, P. R., Iwanaga, K., Crisostomo, M. M., Zaldivar, F. P., Larson, J. K., & Pescatello, A. (2006) · Pediatric Diabetes · doi:10.1111/j.1399-543x.2006.00140.x · Cited by 61 · see citing works
Characterizing the ADHD phenotype for genetic studies.
Stevenson, J., Asherson, P., Hay, D., Levy, F., Swanson, J., Thapar, A., & Willcutt, E. (2005) · Developmental Science · doi:10.1111/j.1467-7687.2005.00398.x · Cited by 76 · see citing works
Self-citationThe Effect of Physical Activity on Children With ADHD: A Quantitative Review of the Literature
Cornelius, C., Fedewa, A. L., & Ahn, S. (2017) · Journal of Applied School Psychology · doi:10.1080/15377903.2016.1265622 · Cited by 57 · see citing works
Kamp, C. F., Sperlich, B., & Holmberg, H. (2014) · Acta Paediatrica · doi:10.1111/apa.12628 · Cited by 53 · see citing works
Jang, B., Song, J., Kim, J., Kim, S., Lee, J.-Y., Shin, H.-Y., Kwon, J., Kim, Y., & Joung, Y. (2015) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2015.0067 · Cited by 52 · see citing works
Angeli, E., Korpa, T., Johnson, E. O., Apostolakou, F., Papassotiriou, I., Chrousos, G. P., & Pervanidou, P. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.02.026 · Cited by 52 · see citing works
Green-Golan, L., Yates, C., Drinkard, B., VanRyzin, C., Eisenhofer, G., Weise, M., & Merke, D. P. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0493 · Cited by 50 · see citing works
Mayer, J. S., Hees, K., Medda, J., Grimm, O., Asherson, P., Bellina, M., Colla, M., Ibáñez, P., Koch, E., Martinez-Nicolas, A., et al. (2018) · Trials · doi:10.1186/s13063-017-2426-1 · Cited by 48 · see citing works
Fitness Level and Gross Motor Performance of Children With Attention-Deficit Hyperactivity Disorder
Verret, C., Gardiner, P. F., & Béliveau, L. (2010) · Adapted Physical Activity Quarterly · doi:10.1123/apaq.27.4.337 · Cited by 48 · see citing works
Protection from genetic diathesis in ADHD: Possible complementary roles of exercise
Rommel, A.-S., Halperin, J., Mill, J., Asherson, P., & Kuntsi, J. (2013) · Journal of the American Academy of Child and Adolescent Psychiatry · doi:10.1016/j.jaac.2013.05.018 · Cited by 41 · see citing works
Effect of prior hyperglycemia on IL-6 responses to exercise in children with type 1 diabetes
Galassetti, P. R., Iwanaga, K., Pontello, A. M., Zaldivar, F. P., Flores, R. L., & Larson, J. K. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00445.2005 · Cited by 39 · see citing works
The association between physical education and symptoms of attention deficit hyperactivity disorder.
Barnard-Brak, L., Davis, T. N., Sulak, T., & Brak, V. (2011) · Journal of Physical Activity and Health · doi:10.1123/jpah.8.7.964 · Cited by 35 · see citing works
Updates in technology-based interventions for attention deficit hyperactivity disorder
Lim, C. G., Lim-Ashworth, N., & Fung, D. S. S. (2020) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000643 · Cited by 34 · see citing works
Parental perceptions of the effects of exercise on behavior in children and adolescents with ADHD
Gapin, J. I., & Etnier, J. L. (2013) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2013.03.002 · Cited by 33 · see citing works
Barranco-Ruíz, Y., Etxabe, B. E., Ramírez-Vélez, R., & Villa-González, E. (2019) · Medicina · doi:10.3390/medicina55070325 · Cited by 28 · see citing works
Medin, T., Medin, H., Hefte, M. B., Storm‐Mathisen, J., & Bergersen, L. H. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.12.023 · Cited by 29 · see citing works
Enhanced Physical Activity Improves Selected Outcomes in Children With ADHD
Song, M., Lauseng, D. L., Lee, S., Nordstrom, M., & Katch, V. L. (2016) · Western Journal of Nursing Research · doi:10.1177/0193945916649954 · Cited by 29 · see citing works
Gallego-Méndez, J., Pérez‐Gómez, J., Calzada-Rodríguez, J. I., Denche-Zamorano, Á. M., Mendoza-Muñoz, M., Carlos‐Vivas, J., García-Gordillo, M. Á., & Adsuar, J. C. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17082804 · Cited by 30 · see citing works
Lee, S.-K., Lee, C.-M., & Park, J. (2015) · Journal of Physical Therapy Science · doi:10.1589/jpts.27.2915 · Cited by 25 · see citing works
Mahon, A. D., Stephens, B. R., & Cole, A. S. (2008) · Journal of Attention Disorders · doi:10.1177/1087054707308484 · Cited by 24 · see citing works
Peng, S., Fang, Y., Othman, A. T., & Liang, J. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.940977 · Cited by 26 · see citing works
Soori, R., Goodarzvand, F., Akbarnejad, A., Effatpanah, M., Ramezankhani, A., Teixeira, A. L., & Ghram, A. (2020) · Science & Sports · doi:10.1016/j.scispo.2019.08.002 · Cited by 21 · see citing works
Nazeer, A., Mansour, M., & Gross, K. A. (2014) · Frontiers in Public Health · doi:10.3389/fpubh.2014.00046 · Cited by 19 · see citing works
A systematic review of acute exercise as a coadjuvant treatment of ADHD in young people
Villa-González, R., Olmedillas, H., Soto, M. D. V., Crespo, I., & Villalba-Heredia, L. (2020) · Psicothema · doi:10.7334/psicothema2019.211 · Cited by 18 · see citing works
Reeves, M. J., & Bailey, R. P. (2014) · Education 3-13 · doi:10.1080/03004279.2014.918160 · Cited by 18 · see citing works
Biochemical markers and genetic research of ADHD.
Paclt, I., Koudelová, J., Křepelová, A., Uhlíková, P., Gazdíková, M., & Bauer, P. O. (2005) · PubMed · Cited by 18 · see citing works
Angulo-Kinzler, R. M., Ferrer-Uris, B., & Busquets, A. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02000 · Cited by 13 · see citing works
Chueh, T., Hsieh, S., Tsai, Y.-J., Yu, C.-L., Huang, C., & Hung, T. (2021) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2021.104063 · Cited by 12 · see citing works
Wymbs, F. A., Wymbs, B. T., Margherio, S. M., & Burd, K. A. (2021) · Journal of Child and Family Studies · doi:10.1007/s10826-020-01880-5 · Cited by 12 · see citing works
Feng, L., Li, B., Yong, S. S., & Tian, Z. (2024) · Journal of Science in Sport and Exercise · doi:10.1007/s42978-024-00295-8 · Cited by 11 · see citing works
Effect of Stimulant Medication Use by Children With ADHD on Heart Rate and Perceived Exertion
Mahon, A. D., Woodruff, M. E., Horn, M. P., Marjerrison, A. D., & Cole, A. S. (2012) · Adapted Physical Activity Quarterly · doi:10.1123/apaq.29.2.151 · Cited by 10 · see citing works
Exercise outcomes in prevalent users of stimulant medications
Westover, A. N., Nakonezny, P. A., Barlow, C. E., Vongpatanasin, W., Adinoff, B. H., Brown, E. S., Mortensen, E. M., Halm, E. A., & DeFina, L. F. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.03.011 · Cited by 9 · see citing works
Hattabi, S., Bouallegue, M., Mhenni, T., Halouani, J., & Chtourou, H. (2021) · International journal of Sport Studies for Health · doi:10.5812/intjssh.118756 · Cited by 10 · see citing works
Santiago-Rodríguez, M. E., Ramer, J. D., Márquez, D. X., Frazier, S. L., Davis, C. L., & Bustamante, E. E. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19074032 · Cited by 9 · see citing works
Bustamante, E. E., Santiago-Rodríguez, M. E., Ramer, J. D., Balbim, G. M., Mehta, T. G., & Frazier, S. L. (2019) · Pensar en Movimiento Revista de Ciencias del Ejercicio y la Salud · doi:10.15517/pensarmov.v17i1.37863 · Cited by 9 · see citing works
Nemet, D., Ben‐Zaken, S., Eliakim, R. A., & Eliakim, A. (2022) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2022.101485 · Cited by 6 · see citing works
Self-citationBustamante, E. E., Santiago-Rodríguez, M. E., Ramer, J. D., Balbim, G. M., Mehta, T. G., & Frazier, S. L. (2019) · Pensar en Movimiento Revista de Ciencias del Ejercicio y la Salud · doi:10.15517/pensarmov.v17i1.34662 · Cited by 6 · see citing works
The Impact of an Adapted Climbing Program on Children with Attention-Deficit/Hyperactivity Disorder
Angelini, E., Oriel, K. N., Myers, G. M., Cook, K. D. A., Drawbaugh, R. M., & Price, J. (2020) · International Journal of Physical Education Fitness and Sports · doi:10.34256/ijpefs2047 · Cited by 5 · see citing works
Kano, M., Uchiyama, H., Ohta, M., & Ohtani, N. (2015) · Journal of Veterinary Behavior · doi:10.1016/j.jveb.2014.12.009 · Cited by 5 · see citing works
The Exercise–Cognition Interaction and ADHD
O’Neill, S. C., Berwid, O. G., & Bedard, A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800778-5.00018-9 · Cited by 5 · see citing works
Réol, L. A. (2022) · International Journal of Disability Development and Education · doi:10.1080/1034912x.2022.2150837 · Cited by 4 · see citing works
The Novel Use of Objective Laboratory School Tasks to Measure Stress Responses in Children with ADHD
Wigal, S. B., Truong, C., & Stehli, A. (2012) · Postgraduate Medicine · doi:10.3810/pgm.2012.09.2593 · Cited by 4 · see citing works
Self-citationAttention Deficit/Hyperactivity Disorder (ADHD) in Athletes
Kreher, J. B. (2012) · International Journal of Athletic Therapy & Training · doi:10.1123/ijatt.17.3.15 · Cited by 5 · see citing works
Association of exercise and ADHD symptoms: Analysis within an adult general population sample
Tucker, R., Williams, C., & Reed, P. (2025) · PLoS ONE · doi:10.1371/journal.pone.0314508 · Cited by 3 · see citing works
Li, H., Meng, Q., Zhang, P., & Zhen, Z.-P. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.09.044 · Cited by 2 · see citing works
Meßler, C. F. (2019) · B&G Bewegungstherapie und Gesundheitssport · doi:10.1055/a-0860-2053 · Cited by 2 · see citing works
Hattabi, S., Bouallegue, M., Mhenni, T., Halouani, J., & Chtourou, H. (2021) · International journal of Sport Studies for Health · doi:10.61838/kman.intjssh.4.1.4 · Cited by 2 · see citing works
Alşen, S., Resmi, H., Erkuran, H. Ö., Tufan, A. E., Bülbül, M., & Akay, A. P. (2015) · Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology · doi:10.5455/bcp.20150802050349 · Cited by 2 · see citing works
Der Einfluss von Sport auf kognitive Funktionen bei Kindern mit ADHS
Lehnert, K. (2014) · Zeitschrift für Sportpsychologie · doi:10.1026/1612-5010/a000124 · Cited by 2 · see citing works
Suárez-Manzano, S. (2018) · International Journal of Developmental and Educational Psychology Revista INFAD de psicología · doi:10.17060/ijodaep.2018.n1.v3.1271 · Cited by 2 · see citing works
Nemet, D., Ben‐Zaken, S., & Eliakim, A. (2024) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2024.101596 · Cited by 1 · see citing works
Self-citationA comprehensive overview of the biological foundations of ADHD
Folego-Temoteo, I., Lima, Y. C., Grevet, E. H., Vidor, M. V., Tavares, M. E., da Silva, B. S., Bau, C. H. D., & Rovaris, D. L. (2026) · Bioscience Reports · doi:10.1042/bsr20254061 · Cited by 1 · see citing works
EFEITOS DO EXERCÍCIO FÍSICO SOBRE O SISTEMA IMUNE PHYSICAL EXERCISES EFFECT ON THE IMMUNE SYSTEM
Prestes, J., Foschini, D., & Donatto, F. F. (2006) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · doi:10.13037/rbcs.vol4n7.448 · Cited by 1 · see citing works
Galassetti, P. R., Cooper, D. M., Eliakim, A., Nemet, D., Zaldivar, F. P., McMurray, R. G., Culler, F. L., Duque, J. S. R., Flores, R. L., Oliver, S. R., et al. (2013) · Cited by 1 · see citing works
Self-citationActividad física y atención en escolares diagnosticados TDAH: revisión de estudios longitudinales.
Suárez-Manzano, S., Ruiz‐Ariza, A., López-Serrano, S., & López, E. J. M. (2018) · Innovación educativa · doi:10.15304/ie.28.4571 · Cited by 1 · see citing works
Role of physical exercise in attention deficit hyperactivity disorder
Mitra, S. (2022) · International Journal of Physiology Nutrition and Physical Education · doi:10.22271/journalofsport.2022.v7.i2b.2555 · Cited by 1 · see citing works
The Influences of Therapeutic Horse Riding Program on Psychology of the Children with ADHD
이종구, 조효구, 한덕현, & 정태운 (2015) · 한국특수체육학회지 · doi:10.17006/kjapa.2015.23.4.141 · Cited by 1 · see citing works
Eliakim, A., & Nemet, D. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780198757672.003.0005 · Cited by 1 · see citing works
Self-citationEndocrine responses to exercise
Eliakim, A., & Nemet, D. (2023) · Oxford University Press eBooks · doi:10.1093/med/9780192843968.003.0009 · Cited by 1 · see citing works
Self-citationHammoud, N. M. (2014) · Purdue e-Pubs (Purdue University System)
EFFEKTEN AV FYSISK AKTIVITET FÖR SYMPTOM HOS INDIVIDER MED ADHD
Stenland, J., & Svensson, M. (2014) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Ranada, Å. L. (2015) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Galassetti, P. R. (2009) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2009.22.11.987
(2012) · Wiley eBooks · doi:10.1002/9781119977452.refs
Eroğlu, M., Yakşi, N., Gundogdu, U., Demirkapi, E., & Degirmencioglu, E. (2023) · Turkish Journal of Child and Adolescent Mental Health · doi:10.4274/tjcamh.galenos.2022.20591
Körperliche Aktivität bei spezifischen psychischen Erkrankungen
Bendau, A., Petzold, M. B., & Ströhle, A. (2023) · Springer eBooks · doi:10.1007/978-3-662-66208-3_12
Okonkwo, U. P., Nwose, J. C., Akosile, C. O., Chukwuemeka, U. M., Mbanuzuru, A. V., Igwe, S. E., Okafor, C. N., & Umunnah, J. O. (2024) · Bulletin of Faculty of Physical Therapy · doi:10.1186/s43161-024-00174-x
A KATP channel theory of attention-deficit hyperactivity disorder
Rappoport, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-44-345008-2.00012-6
Li, Y., Ma, Z., Falchi, W., Huang, L., Chen, Z., & Hai, W. (2026) · Complementary Medicine Research · doi:10.1159/000552870
Blanco-Martínez, N., Diz-Gómez, J. C., Outeda-Monteagudo, B., Carballo-Afonso, R., & Ayán, C. (2026) · Archives de Pédiatrie · doi:10.1016/j.arcped.2026.105583
Kavyani, M., toosi, F. A., Farsi, A., & Keshvari, F. (2026) · Psychiatric Quarterly · doi:10.1007/s11126-026-10305-3
- Authors
- Wigal, S. B., Nemet, D., Swanson, J. M., Regino, R., Trampush, J., Ziegler, M. G., & Cooper, D. M.
- Affiliations
- University of California, Irvine (US)
- University of California San Diego (US)
- Corresponding author
- Cooper, Dan M
- Venue
- Pediatric Research
- Published
- 2003-05
- Volume
- 53
- Issue
- 5
- Pages
- 756-761
- ISSN
- 0031-3998 (ISSN-L)
- 1530-0447
- OpenAlex
- W2058913720
- Semantic Scholar
- 291c77959298e4b5ba1f3220f877b21c790a35ce
- Cited by
- 92
- References
- 36
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 7 · 2018: 5 · 2017: 3 · 2016: 2 · 2015: 10 · 2014: 7 · 2013: 3 · 2012: 6
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pediatric Research (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (5k23mh002042-05, RR00827)
- National Institute of Mental Health (MH02042)
- National Center for Research Resources (M-01RR00827, M01RR000827)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD23969)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- attention deficit hyperactivity disorder, catecholamines, exercise response, epinephrine, norepinephrine, dopamine, lactate response, children, exercise challenge
- MeSH terms
- Attention Deficit Disorder with Hyperactivity, Catecholamines, Child, Dopamine, Epinephrine, Exercise Test, Heart Rate, Humans, Male, Norepinephrine, Oxygen Consumption, Lactic Acid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
