Polymeric Micelles for Multi-Drug Delivery in Cancer
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Drug combinations are common in cancer treatment and are rapidly evolving, moving beyond chemotherapy combinations to combinations of signal transduction inhibitors. For the delivery of drug combinations, i.e., multi-drug delivery, major considerations are synergy, dose regimen (concurrent versus sequential), pharmacokinetics, toxicity, and safety. In this contribution, we review recent research on polymeric micelles for multi-drug delivery in cancer. In concurrent drug delivery, polymeric micelles deliver multi-poorly water-soluble anticancer agents, satisfying strict requirements in solubility, stability, and safety. In sequential drug delivery, polymeric micelles participate in pretreatment strategies that "prime" solid tumors and enhance the penetration of secondarily administered anticancer agent or nanocarrier. The improved delivery of multiple poorly water-soluble anticancer agents by polymeric micelles via concurrent or sequential regimens offers novel and interesting strategies for drug combinations in cancer treatment.
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Polymeric micelles can improve drug bioavailability and produce a controlled and targeted drug release, useful for reducing side effects.
“They can improve drug bioavailability and produce a controlled and targeted drug release, useful for reducing side effects [45,46].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [46]
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- Authors
- Cho, H., Lai, T. C., Tomoda, K., & Kwon, G. S.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Cho, Hyunah
- Venue
- AAPS PharmSciTech
- Published
- 2014-12-11
- Volume
- 16
- Issue
- 1
- Pages
- 10-20
- ISSN
- 1530-9932 (ISSN-L)
- PMC
- PMC4309804
- OpenAlex
- W2081911649
- Cited by
- 159
- References
- 71
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 10 · 2023: 16 · 2022: 13 · 2021: 28 · 2020: 22 · 2019: 16 · 2018: 10 · 2017: 11 · 2016: 9 · 2015: 6
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AAPS PharmSciTech (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation
- National Research Foundation of Korea
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- polymeric micelles, multidrug delivery, cancer chemotherapy, combination therapy, signal transduction inhibitors, sequential drug delivery, drug synergy, pharmacokinetics, nanocarriers
- MeSH terms
- Animals, Antineoplastic Combined Chemotherapy Protocols, Diffusion, Drug Compounding, Humans, Micelles, Neoplasms, Particle Size, Polymers, Nanocapsules
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