The DOI matches its Crossref record; 21 of the 26 references it cites were found in a registry or an index.
Leptin Treatment Rescues the Sterility of Genetically Obese ob/ob Males*
Abstract
Leptin, a hormone secreted from white adipose tissue, has been shown to normalize the body weight of ob/ob but not db/db mice as postulated by Coleman in his classical parabiosis experiments. The major effect of leptin is therefore to decrease food intake, thus resulting in a breakdown of fat stores. Recently, we have suggested that leptin plays a role in reproductive physiology based on the observation that leptin treatment but not food restriction rescues the sterility of ob/ob females. In the present communication, we treated sterile ob/ob males with leptin and asked whether fertility could be induced, thus selecting their reproductive ability as the endpoint of the experiment. Our results show that all food-restricted ob/ob males are unable to impregnate normal C57BL/6J females. However, all leptin-treated ob/ob males fertilized normal females mice that carried out normal pregnancies and deliveries, demonstrating that the reproductive capacity of ob/ob males was corrected only with leptin treatment. Furthermore, reproductive indices such as testicular weight and histology are normalized in leptin-treated animals. Therefore, as in ob/ob females, leptin plays a significant role in the male mouse reproductive pathways.
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“and corrects the sterility of leptin-deficient ob/ob mice (29, 30).”
From The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men (2003) · cites this paper as [30]
Citations
Cites
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Leptin is a metabolic signal to the reproductive system
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OBESE, A NEW MUTATION IN THE HOUSE MOUSE*
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Investigation into the hypogonadism of the obese mouse (genotype ob/ob)
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ENDOCRINE ACTIVITY OF THE TESTIS IN OBESE-HYPERGLYCAEMIC MICE
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Genetically determined obesity and sterility in the mouse.
Jones (1957) · Stud Fertil
UnresolvedInherited hypofunction of the female pituitary in the sterile-obese syndrome in the mouse.
Runner (1954) · Genetics
UnresolvedTransplantation of ovaries of the obese mouse.
Hummel (1957) · Anat Rec
UnresolvedThe association of obesity with infertility and related menstrual abnormalities in women.
Hartz (1979) · Int J Obes
UnresolvedHypothalamic and pituitary dysfunction in obese males.
Amatruda (1982) · Int J Obes
Unresolved
Cited by
Sorted by citations
Perspectives on fish gonadotropins and their receptors
Levavi‐Sivan, B., Bogerd, J., Mañanós, E. L., Gómez, A., & Lareyre, J. (2009) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2009.07.019 · Cited by 610
Chan, J. L., Heist, K., DePaoli, A. M., Veldhuis, J. D., & Mantzoros, C. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17490 · Cited by 697
Impact of obesity on male fertility, sperm function and molecular composition
Palmer, N. O., Bakos, H. W., Fullston, T., & Lane, M. (2012) · Spermatogenesis · doi:10.4161/spmg.21362 · Cited by 403
Chan, J. L., & Mantzoros, C. S. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66830-4 · Cited by 382
Donato, J., Cravo, R. M., Frazão, R., Gautron, L., Scott, M. M., Lachey, J. L., de Castro, I. A., Margatho, L. O., Lee, S., Lee, C., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci45106 · Cited by 367
Metadata
- Authors
- Mounzih, K., Lu, R., & Chehab, F. F.
- Affiliations
- University of California, San Francisco (US)
- ORCID
- Lu, Ronghua
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1997-03-01
- Volume
- 138
- Issue
- 3
- Pages
- 1190-1193
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W1997157145
- Cited by
- 482
- References
- 26
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 9 · 2023: 6 · 2022: 7 · 2021: 11 · 2020: 14 · 2019: 10 · 2018: 21 · 2017: 19 · 2016: 17 · 2015: 11 · 2014: 20 · 2013: 24 · 2012: 20
- FWCI
- 26.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California, San Francisco
- National Heart, Lung, and Blood Institute (HLS-53762)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- leptin, ob/ob mice, male infertility, reproductive capacity, dietary restriction, testicular histology, testicular weight, obesity, reproductive physiology
- MeSH terms
- Animals, Body Weight, Eating, Female, Fertility, Infertility, Male, Obesity, Organ Size, Proteins, Testis, Leptin, Mice
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