Fibroblast Growth Factor 21 Regulates Lipolysis in White Adipose Tissue But Is Not Required for Ketogenesis and Triglyceride Clearance in Liver

FGF-21 as a novel metabolic regulator

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Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting

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Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

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Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

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Fuel Metabolism in Starvation

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Fibroblast Growth Factor 21 Corrects Obesity in Mice

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A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: The PPARα-null mouse as a model of fatty acid oxidation disorders

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Identification of a novel FGF, FGF-21, preferentially expressed in the liver

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Functions and regulations of fibroblast growth factor signaling during embryonic development

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Circulating FGF21 Levels in Human Health and Metabolic Disease

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Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice

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Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action

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Ketogenic Diet Impairs FGF21 Signaling and Promotes Differential Inflammatory Responses in the Liver and White Adipose Tissue

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Stressed Liver and Muscle Call on Adipocytes with FGF21

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Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones

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Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia

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Fibroblast growth factor 21, the endocrine FGF pathway and novel treatments for metabolic syndrome

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Molecular mechanisms underlying metabolic syndrome: the expanding role of the adipocyte

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Effects of fibroblast growth factor 21 on the heart

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Human FGF-21 Is a Substrate of Fibroblast Activation Protein

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CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis

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Fasting-induced hormonal regulation of lysosomal function

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The Nuanced Metabolic Functions of Endogenous FGF21 Depend on the Nature of the Stimulus, Tissue Source, and Experimental Model

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The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-α agonist-induced amelioration of metabolic disorders in obese mice

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Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents

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Repletion of branched chain amino acids reverses mTORC1 signaling but not improved metabolism during dietary protein dilution

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Hepatocyte-specific fibroblast growth factor 21 overexpression ameliorates high-fat diet-induced obesity and liver steatosis in mice

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Liver Fat But Not Other Adiposity Measures Influence Circulating FGF21 Levels in Healthy Young Adult Twins

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Fibroblast growth factors in control of lipid metabolism: from biological function to clinical application

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Deletion of hepatic carbohydrate response element binding protein (ChREBP) impairs glucose homeostasis and hepatic insulin sensitivity in mice

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Regulator of G Protein Signaling (RGS16) Inhibits Hepatic Fatty Acid Oxidation in a Carbohydrate Response Element-binding Protein (ChREBP)-dependent Manner

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CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα

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Fibroblast Growth Factor 21 Protects Against High Glucose Induced Cellular Damage and Dysfunction of Endothelial Nitric-Oxide Synthase in Endothelial Cells

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Physiological modulation of circulating FGF21: relevance of free fatty acids and insulin

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β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue

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Chronic high-sucrose diet increases fibroblast growth factor 21 production and energy expenditure in mice

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The impact of keto-adaptation on exercise performance and the role of metabolic-regulating cytokines

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Myokines: Metabolic regulation in obesity and type 2 diabetes

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Hormone-like fibroblast growth factors and metabolic regulation

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FGF21 ameliorates diabetic cardiomyopathy by activating the AMPK-paraoxonase 1 signaling axis in mice

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Rush to the fire: FGF21 extinguishes metabolic stress, metaflammation and tissue damage

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Fibroblast growth factor 21 protects against lipotoxicity-induced pancreatic β-cell dysfunction via regulation of AMPK signaling and lipid metabolism

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Fgf21 Impairs Adipocyte Insulin Sensitivity in Mice Fed a Low-Carbohydrate, High-Fat Ketogenic Diet

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Chronic Over-expression of Fibroblast Growth Factor 21 Increases Bile Acid Biosynthesis by Opposing FGF15/19 Action

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The effects of fibroblast growth factor-21 knockdown and over-expression on its signaling pathway and glucose–lipid metabolism in vitro

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Lipid sensing by PPARα: Role in controlling hepatocyte gene regulatory networks and the metabolic response to fasting

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Serum FGF21 levels are elevated in association with lipodystrophy, insulin resistance and biomarkers of liver injury in HIV-1-infected patients

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Rapid increase in fibroblast growth factor 21 in protein malnutrition and its impact on growth and lipid metabolism

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Fibroblast growth factor 21: a novel biomarker for human muscle-manifesting mitochondrial disorders

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Fibroblast Growth Factor 21 Suppresses Adipogenesis in Pig Intramuscular Fat Cells

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Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects

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Association Between Serum Fibroblast Growth Factor 21 and Mortality Among Patients With Coronary Artery Disease

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Independent links between plasma xanthine oxidoreductase activity and levels of adipokines

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Clinical significance of neutrophil–lymphocyte ratio and monocyte–lymphocyte ratio in women with hyperglycemia

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Metabolic Effects of Ketogenic Diets: Exploring Whole-Body Metabolism in Connection with Adipose Tissue and Other Metabolic Organs

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Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK

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Effects of fibroblast growth factor 21 on cell damage in vitro and atherosclerosis in vivo

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Current perspective on the role of insulin and glucagon in the pathogenesis and treatment of type 2 diabetes mellitus

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Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress

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Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding

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Fibroblast growth factor 21 regulates foam cells formation and inflammatory response in Ox-LDL-induced THP-1 macrophages

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Butyrate attenuated fat gain through gut microbiota modulation in db/db mice following dapagliflozin treatment

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FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice

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Toward reconciling the roles of FGF21 in protein appetite, sweet preference, and energy expenditure

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Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21

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The physiology of MASLD: molecular pathways between liver and adipose tissues

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β-Klotho promotes glycolysis and glucose-stimulated insulin secretion via GP130

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Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice

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Stress Signaling Between Organs in Metazoa

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Dietary Manipulations That Induce Ketosis Activate the HPA Axis in Male Rats and Mice: A Potential Role for Fibroblast Growth Factor-21

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Can we predict a favourable response to Ketogenic Diet Therapies for drug-resistant epilepsy?

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Fibroblast Growth Factor 21 Exerts its Anti‐inflammatory Effects on Multiple Cell Types of Adipose Tissue in Obesity

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Low-protein diet induces, whereas high-protein diet reduces hepatic FGF21 production in mice, but glucose and not amino acids up-regulate FGF21 in cultured hepatocytes

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Protein metabolism and related body function: mechanistic approaches and health consequences

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Mitochondrial complex I inhibition triggers NAD+-independent glucose oxidation via successive NADPH formation, “futile” fatty acid cycling, and FADH2 oxidation

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Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations

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Cardioprotective mechanisms activated in response to myocardial ischemia.

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Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state

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Emerging Structure–Function Paradigm of Endocrine FGFs in Metabolic Diseases

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The Autophagy Inducer Spermidine Protects Against Metabolic Dysfunction During Overnutrition

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Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity

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Role of fibroblast growth factors in elicitation of cell responses

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ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21

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Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance

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Metabolic actions of FGF21: molecular mechanisms and therapeutic implications

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Glucagon receptor signaling regulates weight loss via central KLB receptor complexes

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Hepatokines: unveiling the molecular and cellular mechanisms connecting hepatic tissue to insulin resistance and inflammation

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