The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
High-Fat Diet Causes Lipotoxicity Responses in Cumulus–Oocyte Complexes and Decreased Fertilization Rates
Abstract
In obesity, accumulation of lipid in nonadipose tissues, or lipotoxicity, is associated with endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and ultimately apoptosis. We have previously shown that obese women have increased triglycerides in follicular fluid; thus, the present study examined whether high-fat diet–induced obesity causes lipotoxicity in granulosa cells and the cumulus–oocyte complex (COC). Oocytes of mice fed a high-fat diet had dramatically increased lipid content and reduced mitochondrial membrane potential compared to those of mice fed a control diet. COCs from mice fed a high-fat diet had increased expression of ER stress marker genes ATF4 and GRP78. Apoptosis was increased in granulosa and cumulus cells of mice fed a high-fat diet. Mice fed a high-fat diet also exhibited increased anovulation and decreased in vivo fertilization rates. Thus, lipid accumulation, ER stress, mitochondrial dysfunction, and apoptosis are markedly increased in ovarian cells of mice fed a high-fat diet. ER stress markers were also analyzed in granulosa cells and follicular fluid from women with varying body mass indices (BMI). ATF4 was increased in granulosa cells and [Ca2+] in follicular fluid from obese women compared to nonobese women. These results indicate that lipotoxicity may be occurring in ovarian cells of obese women and may contribute to the reduced pregnancy rates observed in response to obesity.
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Citations
Cites
Oxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes
Schrauwen, P., & Hesselink, M. K. C. (2004) · Diabetes · doi:10.2337/diabetes.53.6.1412 · Cited by 408
Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis
Ilieva, E. V., Ayala, V., Jove, M., Dalfo, E., Cacabelos, D., Povedano, M., Bellmunt, M. J., Ferrer, I., Pamplona, R., & Portero-Otin, M. (2007) · Brain · doi:10.1093/brain/awm190 · Cited by 358
Mitochondrial dysfunction and lipotoxicity
Schrauwen, P., Schrauwen-Hinderling, V., Hoeks, J., & Hesselink, M. K. C. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.09.011 · Cited by 268
Protein Folding in the Endoplasmic Reticulum and the Unfolded Protein Response
Zhang, K., & Kaufman, R. J. (2005) · Handbook of Experimental Pharmacology · doi:10.1007/3-540-29717-0_3 · Cited by 152
Li, N., Frigerio, F., & Maechler, P. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360930 · Cited by 114
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Obesity and female infertility: potential mediators of obesity's impact
Broughton, D. E., & Moley, K. H. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.01.017 · Cited by 845
Female infertility: which role for obesity?
on behalf of the Obesity Programs of nutrition, E., Gambineri, A., Laudisio, D., Marocco, C., Radellini, S., Colao, A., & Savastano, S. (2019) · International Journal of Obesity Supplements · doi:10.1038/s41367-019-0009-1 · Cited by 114
Epigenetic inheritance through the female germ-line: The known, the unknown, and the possible
Clarke, H. J., & Vieux, K.-F. (2015) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2015.07.003 · Cited by 79
Kazemi, M., Jarrett, B. Y., Vanden Brink, H., Lin, A. W., Hoeger, K. M., Spandorfer, S. D., & Lujan, M. E. (2020) · Nutrients · doi:10.3390/nu12071953 · Cited by 53
Calcaterra, V., Magenes, V. C., Massini, G., De Sanctis, L., Fabiano, V., & Zuccotti, G. (2024) · Nutrients · doi:10.3390/nu16070938 · Cited by 35
Wołodko, K., Castillo-Fernandez, J., Kelsey, G., & Galvão, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084270 · Cited by 31
Wang, S., Yang, H., Fu, Y., Teng, X., Wang, C., & Xu, W. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7982344 · Cited by 19
Metadata
- Authors
- Wu, L. L.-Y., Dunning, K. R., Yang, X., Russell, D. L., Lane, M., Norman, R. J., & Robker, R. L.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2010-09-22
- Volume
- 151
- Issue
- 11
- Pages
- 5438-5445
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2046230257
- Cited by
- 358
- References
- 5
- FWCI
- 12.22
- Type
- journal article
- Language
- en
- Open access
- closed
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