Cited by 268Pregnancy and preeclampsia studiesBirth, Development, and HealthGestational Diabetes Research and Management

Maternal High-Fat Diet Disturbs Uteroplacental Hemodynamics and Increases the Frequency of Stillbirth in a Nonhuman Primate Model of Excess Nutrition

Open access
Frias, Antonio E., Morgan, Terry K., Evans, Anne E., Rasanen, Juha, Oh, Karen Y., Thornburg, Kent L., Grove, Kevin L.·2011·Endocrinology

Abstract

Prepregnancy maternal obesity confers an increased risk of stillbirth, but the mechanisms are unknown. Maternal obesity is associated with placental inflammation. We considered that maternal diet may predispose to the increased risk of placental inflammation and stillbirth. We hypothesized that a chronic high-fat diet (HFD) is associated with abnormal uteroplacental circulation and placental inflammation. Here we used a nonhuman primate model to determine the effect of chronic HFD on the uterine and placental hemodynamics, placental histology, and inflammation in a prospective, observational study of 24 Japanese macaques. Overall, there was a statistically significant (38-56%) reduction in uterine volume blood flow from HFD animals, whether they were lean or obese. Consumption of a HFD, independent of obesity, increased placental inflammatory cytokines and the expression of Toll-like receptor 4. We show that HFD consumption by obese mothers with hyperinsulinemia also reduced volume blood flow on the fetal side of the placenta and significantly increased the frequency of both placental infarctions and stillbirth. These results suggest that a HFD, independent of obesity, decreases uterine volume blood flow. Maternal obesity and insulin resistance further exacerbates the placental dysfunction and results in an increased frequency of stillbirth.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1210/en.2010-1332

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In non-human primates, feeding a high fat diet increases placental infarction and reduces utero-placental blood flow, more pronounced in mothers that become obese than in those who remained lean on the diet.

    “In non-human primates, there are increases in placental infarction and reductions in utero-placental blood flow in response to feeding a high fat diet, which are more pronounced in mothers that become obese than in those who remained lean on the diet (200).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [200]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Frias, A. E., Morgan, T. K., Evans, A. E., Rasanen, J., Oh, K. Y., Thornburg, K. L., & Grove, K. L.
Affiliations
  • Oregon National Primate Research Center (US)
  • Oregon Health & Science University (US)
Corresponding author
Frias, Antonio E.
Venue
Endocrinology
Published
2011-03-29
Volume
152
Issue
6
Pages
2456-2464
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
OpenAlex
W1964355822
Cited by
268
References
44
Citations by year
2026: 10 · 2025: 11 · 2024: 9 · 2023: 9 · 2022: 16 · 2021: 12 · 2020: 19 · 2019: 16 · 2018: 26 · 2017: 16 · 2016: 24 · 2015: 35 · 2014: 19 · 2013: 22 · 2012: 17
FWCI
26.19
Type
journal article
Language
en
Open access
Locations
  • Endocrinology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (R24DK090964, R01DK079194, R24 DK0909640-01, P30DK020593)
  • National Center for Research Resources (P51RR000163, K01RR000163)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD034430, K12HD001243, K12HD043488)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords
maternal high-fat diet, stillbirth, uteroplacental hemodynamics, placental inflammation, maternal obesity, Japanese macaque, placental infarction, hyperinsulinemia, insulin resistance, TLR4, uterine blood flow
MeSH terms
Animals, Dietary Fats, Disease Models, Animal, Female, Hemodynamics, Humans, Macaca, Obesity, Placenta, Pregnancy, Pregnancy Complications, Regional Blood Flow, Uterus, Cytokines, Prenatal Nutritional Physiological Phenomena, Stillbirth

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review