Cited by 516Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

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GLP-1 Neurons in the Nucleus of the Solitary Tract Project Directly to the Ventral Tegmental Area and Nucleus Accumbens to Control for Food Intake

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Alhadeff, Amber L., Rupprecht, Laura E., Hayes, Matthew R.·2012·Endocrinology

DOI 10.1210/en.2011-1443PMC PMC3275387

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Abstract

Central glucagon-like-peptide-1 (GLP-1) receptor activation reduces food intake; however, brain nuclei and mechanism(s) mediating this effect remain poorly understood. Although central nervous system GLP-1 is produced almost exclusively in the nucleus of the solitary tract in the hindbrain, GLP-1 receptors (GLP-1R) are expressed throughout the brain, including nuclei in the mesolimbic reward system (MRS), e.g. the ventral tegmental area (VTA) and the nucleus accumbens (NAc). Here, we examine the MRS as a potential site of action for GLP-1-mediated control of food intake and body weight. Double immunohistochemistry for Fluorogold (monosynaptic retrograde tracer) and GLP-1 neuron immunoreactivity indicated that GLP-1-producing nucleus tractus solitarius neurons project directly to the VTA, the NAc core, and the NAc shell. Pharmacological data showed that GLP-1R activation in the VTA, NAc core, and NAc shell decreased food intake, especially of highly-palatable foods, and body weight. Moreover, blockade of endogenous GLP-1R signaling in the VTA and NAc core resulted in a significant increase in food intake, establishing a physiological relevance for GLP-1 signaling in the MRS. Current data highlight these nuclei within the MRS as novel sites for GLP-1R-mediated control of food intake and body weight.

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Hayes, 2011, Intracellular signals mediating the food intake suppressive effects of hindbrain glucagon-like-peptide-1 receptor activation., Cell Metab, 13, 320, 10.1016/j.cmet.2011.02.001 · DOI

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Authors: Alhadeff, A. L., Rupprecht, L. E., & Hayes, M. R.
Affiliations: University of Pennsylvania (US)
Corresponding author: Hayes, Matthew R.
ORCID: Alhadeff, Amber L.
Rupprecht, Laura E.
Hayes, Matthew R.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2012-02-01
Volume: 153
Issue: 2
Pages: 647-658
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2011-1443
PMC: PMC3275387
OpenAlex: W2140625608
Cited by: 515
References: 69
Citations by year: 2026: 66 · 2025: 45 · 2024: 38 · 2023: 26 · 2022: 33 · 2021: 36 · 2020: 33 · 2019: 34 · 2018: 25 · 2017: 28 · 2016: 34 · 2015: 31 · 2014: 34 · 2013: 37 · 2012: 13
FWCI: 12.59
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Endocrinology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Pennsylvania
National Institutes of Health
U.S. Public Health Service (NIDDK 085435)
National Institute of Diabetes and Digestive and Kidney Diseases (K01DK085435)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: glucagon-like peptide-1, GLP-1 receptor, nucleus tractus solitarius, ventral tegmental area, nucleus accumbens, mesolimbic reward system, food intake regulation, body weight, palatable food, monosynaptic projection, hindbrain neurons
MeSH terms: Glucagon-Like Peptide-1 Receptor, Exenatide, Animals, Dose-Response Relationship, Drug, Eating, Gene Expression Regulation, Hypoglycemic Agents, Male, Neurons, Nucleus Accumbens, Peptides, Venoms, Signal Transduction, Rats, Sprague-Dawley, Solitary Nucleus, Ventral Tegmental Area, Receptors, Glucagon, Rats, Glucagon-Like Peptide 1

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GLP-1 Neurons in the Nucleus of the Solitary Tract Project Directly to the Ventral Tegmental Area and Nucleus Accumbens to Control for Food Intake

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