Cited by 516Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 68 of the 69 references it cites were found in a registry or an index.

GLP-1 Neurons in the Nucleus of the Solitary Tract Project Directly to the Ventral Tegmental Area and Nucleus Accumbens to Control for Food Intake

Open access

Alhadeff, Amber L., Rupprecht, Laura E., Hayes, Matthew R.·2012·Endocrinology

DOI 10.1210/en.2011-1443PMC PMC3275387

Open this paper in CoChat — free account Open PDF

Abstract

Central glucagon-like-peptide-1 (GLP-1) receptor activation reduces food intake; however, brain nuclei and mechanism(s) mediating this effect remain poorly understood. Although central nervous system GLP-1 is produced almost exclusively in the nucleus of the solitary tract in the hindbrain, GLP-1 receptors (GLP-1R) are expressed throughout the brain, including nuclei in the mesolimbic reward system (MRS), e.g. the ventral tegmental area (VTA) and the nucleus accumbens (NAc). Here, we examine the MRS as a potential site of action for GLP-1-mediated control of food intake and body weight. Double immunohistochemistry for Fluorogold (monosynaptic retrograde tracer) and GLP-1 neuron immunoreactivity indicated that GLP-1-producing nucleus tractus solitarius neurons project directly to the VTA, the NAc core, and the NAc shell. Pharmacological data showed that GLP-1R activation in the VTA, NAc core, and NAc shell decreased food intake, especially of highly-palatable foods, and body weight. Moreover, blockade of endogenous GLP-1R signaling in the VTA and NAc core resulted in a significant increase in food intake, establishing a physiological relevance for GLP-1 signaling in the MRS. Current data highlight these nuclei within the MRS as novel sites for GLP-1R-mediated control of food intake and body weight.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1210/en.2011-1443

Cites

68 of 68 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Biology of Incretins: GLP-1 and GIP
Baggio, L. L., & Drucker, D. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.054 · Cited by 3,639
The Physiology of Glucagon-like Peptide 1
Holst, J. J. (2007) · Physiological Reviews · doi:10.1152/physrev.00034.2006 · Cited by 3,371
A role for glucagon-like peptide-1 in the central regulation of feeding
Turton, M. D., O'Shea, D., Gunn, I., Beak, S. A., Edwards, C. M. B., Meeran, K., Choi, S. J., Taylor, G. M., Heath, M. M., Lambert, P. D., et al. (1996) · Nature · doi:10.1038/379069a0 · Cited by 1,950
Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
Buse, J. B., Rosenstock, J., Sesti, G., Schmidt, W. E., Montanya, E., Brett, J. H., Zychma, M., & Blonde, L. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60659-0 · Cited by 1,503
Effects of exenatide (Exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
Buse, J. B., Henry, R. R., Han, J., Kim, D. D., Fineman, M. S., Baron, A. D., & for the Exenatide-113 Clinical Study Group (2004) · Diabetes Care · doi:10.2337/diacare.27.11.2628 · Cited by 1,346
Effects of liraglutide in the treatment of obesity: A randomised, double-blind, placebo-controlled study
Astrup, A., Rössner, S., Van Gaal, L., Rissanen, A., Niskanen, L., Al Hakim, M., Madsen, J., Rasmussen, M. F., & Lean, M. E. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61375-1 · Cited by 1,163
Neurobiology of addiction
Wise, R. A. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80079-1 · Cited by 1,072
Conditioned Aversion to Saccharin Resulting from Exposure to Gamma Radiation
García, J., Kimeldorf, D. J., & Koelling, R. A. (1955) · Science · doi:10.1126/science.122.3160.157 · Cited by 1,011
Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Hommel, J. D., Trinko, R., Sears, R. M., Georgescu, D., Liu, Z.-W., Gao, X.-B., Thurmon, J. J., Marinelli, M., & DiLeone, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.023 · Cited by 902

Flagged first, then by citations

Show all 69 references

1 of the 69 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Hayes, 2011, Intracellular signals mediating the food intake suppressive effects of hindbrain glucagon-like-peptide-1 receptor activation., Cell Metab, 13, 320, 10.1016/j.cmet.2011.02.001 · DOI

Sorted by citations

Items 101–200 of 516

Incretins and Amylin: Neuroendocrine Communication Between the Gut, Pancreas, and Brain in Control of Food Intake and Blood Glucose
Hayes, M. R., Mietlicki‐Baase, E. G., Kanoski, S. E., & Jonghe, B. C. D. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161201 · Cited by 94
Self-citation
Central GLP-1 receptor activation modulates cocaine-evoked phasic dopamine signaling in the nucleus accumbens core
Fortin, S. M., & Roitman, M. F. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.019 · Cited by 88
Integration of Satiety Signals by the Central Nervous System
Chambers, A. P., Sandoval, D. A., & Seeley, R. J. (2013) · Current Biology · doi:10.1016/j.cub.2013.03.020 · Cited by 98
Dopamine signaling in the amygdala, increased by food ingestion and GLP-1, regulates feeding behavior
Anderberg, R. H., Anefors, C., Bergquist, F., Nissbrandt, H., & Skibicka, K. P. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.02.026 · Cited by 96
A novel mouse model of glucagon‐like peptide‐1 receptor expression: A look at the brain
Graham, D. L., Durai, H. H., Trammell, T. S., Noble, B. L., Mortlock, D. P., Galli, A., & Stanwood, G. D. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.24905 · Cited by 90
GLP-1 and estrogen conjugate acts in the supramammillary nucleus to reduce food-reward and body weight
Vogel, H., Wolf, S., Rabasa, C., Rodriguez-Pacheco, F., Babaei, C. S., Stöber, F., Goldschmidt, J., DiMarchi, R. D., Finan, B., Tschöp, M. H., et al. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.039 · Cited by 86
Glucocorticoids, stress and eating: The mediating role of appetite‐regulating hormones
Kuckuck, S., van der Valk, E. S., Scheurink, A. J. W., van der Voorn, B., Iyer, A. M., Visser, J. A., Delhanty, P. J. D., van den Berg, S. A. A., & van Rossum, E. F. C. (2022) · Obesity Reviews · doi:10.1111/obr.13539 · Cited by 99
Brain region specific glucagon-like peptide-1 receptors regulate alcohol-induced behaviors in rodents
Vallöf, D., Kalafateli, A. L., & Jerlhag, E. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.02.006 · Cited by 87
Appetite problem in cancer patients: Pathophysiology, diagnosis, and treatment
Hariyanto, T. I., & Kurniawan, A. (2021) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2021.100336 · Cited by 89
Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress
Diz-Chaves, Y., Herrera-Pérez, S., González-Matías, L. C., Lamas, J. A., & Mallo, F. (2020) · Nutrients · doi:10.3390/nu12113304 · Cited by 84
Brain glucose sensing in homeostatic and hedonic regulation
Steinbusch, L. K. M., Labouèbe, G., & Thorens, B. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.06.005 · Cited by 95
Vagal Interoceptive Modulation of Motivated Behavior
Maniscalco, J. W., & Rinaman, L. (2018) · Physiology · doi:10.1152/physiol.00036.2017 · Cited by 83
Nucleus accumbens GLP-1 receptors influence meal size and palatability
Dossat, A. M., Diaz, R., Gallo, L. K., Panagos, A., Kay, K. E., & Williams, D. L. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00137.2013 · Cited by 81
The therapeutic potential of glucagon-like peptide-1 for persons with addictions based on findings from preclinical and clinical studies
Jerlhag, E. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1063033 · Cited by 80
The Functional and Neurobiological Properties of Bad Taste
Schier, L. A., & Spector, A. C. (2018) · Physiological Reviews · doi:10.1152/physrev.00044.2017 · Cited by 77
Role of lateral septum glucagon-like peptide 1 receptors in food intake
Terrill, S. J., Jackson, C. M., Greene, H. E., Lilly, N., Maske, C. B., Vallejo, S., & Williams, D. L. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00460.2015 · Cited by 80
Activation of glucagon‐like peptide‐1 receptors in the nucleus accumbens attenuates cocaine seeking in rats
Hernandez, N. S., O’Donovan, B., Ortinski, P. I., & Schmidt, H. D. (2017) · Addiction Biology · doi:10.1111/adb.12583 · Cited by 83
Central & peripheral glucagon-like peptide-1 receptor signaling differentially regulate addictive behaviors
Sirohi, S., Schurdak, J. D., Seeley, R. J., Benoit, S. C., & Davis, J. F. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.04.013 · Cited by 77
Neural integration of satiation and food reward: Role of GLP-1 and orexin pathways
Williams, D. L. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.03.013 · Cited by 74
Neuronal and intracellular signaling pathways mediating GLP-1 energy balance and glycemic effects
Hayes, M. R. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.02.017 · Cited by 73
Self-citation
Hindbrain Oxytocin Receptors Contribute to the Effects of Circulating Oxytocin on Food Intake in Male Rats
Ho, J. M., Anekonda, V. T., Thompson, B. W., Zhu, M., Curry, R. W., Hwang, B. H., Morton, G. J., Schwartz, M. W., Baskin, D. G., Appleyard, S. M., et al. (2014) · Endocrinology · doi:10.1210/en.2014-1148 · Cited by 74
Weight suppression in bulimia nervosa: Associations with biology and behavior.
Bodell, L. P., & Keel, P. K. (2015) · Journal of Abnormal Psychology · doi:10.1037/abn0000077 · Cited by 78
Glucagon-like peptide-1 receptor agonist treatment does not reduce abuse-related effects of opioid drugs
Bornebusch, A. B., Fink-Jensen, A., Wörtwein, G., Seeley, R. J., & Thomsen, M. (2019) · eneuro · doi:10.1523/eneuro.0443-18.2019 · Cited by 72
GLP-1 signaling and alcohol-mediated behaviors; preclinical and clinical evidence
Jerlhag, E. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.013 · Cited by 72
Association of Semaglutide With Tobacco Use Disorder in Patients With Type 2 Diabetes: Target Trial Emulation Using Real-World Data
Wang, W., Volkow, N. D., Berger, N. A., Davis, P. B., Kaelber, D. C., & Xu, R. (2024) · Annals of Internal Medicine · doi:10.7326/m23-2718 · Cited by 72
Exendin-4 Protected against Cognitive Dysfunction in Hyperglycemic Mice Receiving an Intrahippocampal Lipopolysaccharide Injection
Huang, H.-J., Chen, Y., Liang, K., Jheng, Y.-S., Jhao, J.-J., Su, M., Lee‐Chen, G., & Hsieh‐Li, H. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039656 · Cited by 75
Body weight loss, reduced urge for palatable food and increased release of GLP-1 through daily supplementation with green-plant membranes for three months in overweight women
Montelius, C., Erlandsson, D., Vitija, E., Stenblom, E.-L., Egecioglu, E., & Erlanson‐Albertsson, C. (2014) · Appetite · doi:10.1016/j.appet.2014.06.101 · Cited by 72
Effects of the GLP ‐1 Agonist Exendin‐4 on Intravenous Ethanol Self‐Administration in Mice
Sørensen, G., Caine, S. B., & Thomsen, M. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13199 · Cited by 70
GLP-1 receptor signaling in the laterodorsal tegmental nucleus attenuates cocaine seeking by activating GABAergic circuits that project to the VTA
Hernandez, N. S., Weir, V. R., Ragnini, K., Merkel, R., Zhang, Y., Mace, K. D., Rich, M. T., Pierce, R. C., & Schmidt, H. D. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00957-3 · Cited by 73
Vagal Afferents Mediate Early Satiation and Prevent Flavour Avoidance Learning in Response to Intraperitoneally Infused Exendin‐4
Labouesse, M. A., Weber‐Stadlbauer, U., Weber, E., Arnold, M., Langhans, W., & Pacheco‐López, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02364.x · Cited by 71
Mesolimbic dopamine and its neuromodulators in obesity and binge eating
Naef, L., Pitman, K. A., & Borgland, S. L. (2015) · CNS Spectrums · doi:10.1017/s1092852915000693 · Cited by 70
Enteroendocrine hormones – central effects on behavior
Skibicka, K. P., & Dickson, S. L. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.09.004 · Cited by 69
GOAT induced ghrelin acylation regulates hedonic feeding
Davis, J. F., Perelló, M., Choi, D. L., Magrisso, I. J., Kirchner, H., Pfluger, P. T., Tschoep, M. H., Zigman, J. M., & Benoit, S. C. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.08.009 · Cited by 68
Vagal mediation of GLP-1's effects on food intake and glycemia
Krieger, J.-P., Langhans, W., & Lee, S. J. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.06.001 · Cited by 67
Amylin activates distributed CNS nuclei to control energy balance
Mietlicki‐Baase, E. G., & Hayes, M. R. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.01.013 · Cited by 65
Self-citation
Satiation and Stress-Induced Hypophagia: Examining the Role of Hindbrain Neurons Expressing Prolactin-Releasing Peptide or Glucagon-Like Peptide 1
Maniscalco, J. W., Kreisler, A. D., & Rinaman, L. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00199 · Cited by 68
The neural basis of sugar preference
Liu, W. W., & Bohórquez, D. V. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00613-5 · Cited by 65
An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking
Merkel, R., Hernandez, N. S., Weir, V. R., Zhang, Y., Caffrey, A., Rich, M. T., Crist, R. C., Reiner, B. C., & Schmidt, H. D. (2025) · Science Advances · doi:10.1126/sciadv.adr5051 · Cited by 66
Central GLP-1 receptors: Novel molecular targets for cocaine use disorder
Hernandez, N. S., & Schmidt, H. D. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.03.026 · Cited by 66
Glucagon-like peptide-1 receptors within the nucleus of the solitary tract regulate alcohol-mediated behaviors in rodents
Vallöf, D., Vestlund, J., & Jerlhag, E. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.02.020 · Cited by 62
Peripheral interleukin-2 level is associated with negative symptoms and cognitive performance in schizophrenia
Asevedo, E. D. M., Rizzo, L. B., Gadelha, A., Mansur, R. B., Ota, V., Berberian, A. D. A., Scarpato, B. S., Teixeira, A. L., Bressan, R. A., & Brietzke, E. M. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.02.032 · Cited by 63
The therapeutic potential of GLP-1 analogues for stress-related eating and role of GLP-1 in stress, emotion and mood: a review
Guerrero-Hreins, E., Goldstone, A. P., Brown, R. M., & Sumithran, P. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110303 · Cited by 62
Amylin-mediated control of glycemia, energy balance, and cognition
Mietlicki‐Baase, E. G. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.02.034 · Cited by 66
Glucagon-like peptide-1 receptor agonist, exendin-4, reduces reinstatement of heroin-seeking behavior in rats
Douton, J. E., Augusto, C. M., Stoltzfus, B., Carkaci‐Salli, N., Vrana, K. E., & Grigson, P. S. (2020) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000609 · Cited by 63
Brain Site-Specific Inhibitory Effects of the GLP-1 Analogue Exendin-4 on Alcohol Intake and Operant Responding for Palatable Food
Colvin, K. J., Killen, H. S., Kanter, M. J., Halperin, M. C., Engel, L., & Currie, P. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249710 · Cited by 62
Leptin Signaling in the Medial Nucleus Tractus Solitarius Reduces Food Seeking and Willingness to Work for Food
Kanoski, S. E., Alhadeff, A. L., Fortin, S. M., Gilbert, J. R., & Grill, H. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.235 · Cited by 61
Self-citation
Potential role of glucagon-like peptide-1 (GLP-1) receptor agonists in substance use disorder: A systematic review of randomized trials
Martinelli, S., Mazzotta, A. D., Longaroni, M., & Petrucciani, N. (2024) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2024.112424 · Cited by 66
Endogenous GLP-1 in lateral septum promotes satiety and suppresses motivation for food in mice
Terrill, S. J., Holt, M. K., Maske, C. B., Abrams, N., Reimann, F. M., Trapp, S., & Williams, D. L. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.04.008 · Cited by 55
GLP-1 programs the neurovascular landscape
Chen, B., Yu, X., HORVATH-DIANO, C., Ortuño, M. J., Tschöp, M. H., Jastreboff, A. M., & Schneeberger, M. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.09.003 · Cited by 58
Effects of liraglutide in hypothalamic arcuate nucleus of obese mice
Vianna, A. R. D. C. B., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2016) · Obesity · doi:10.1002/oby.21387 · Cited by 60
The Role of the Melanocortin System in Metabolic Disease: New Developments and Advances
Hill, J. W., & Faulkner, L. D. (2016) · Neuroendocrinology · doi:10.1159/000450649 · Cited by 57
Phasic dopamine responses to a food-predictive cue are suppressed by the glucagon-like peptide-1 receptor agonist Exendin-4
Konanur, V., Hsu, T. M., Kanoski, S. E., Hayes, M. R., & Roitman, M. F. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112771 · Cited by 59
Self-citation
GLP-1 modulates the supramammillary nucleus-lateral hypothalamic neurocircuit to control ingestive and motivated behavior in a sex divergent manner
López‐Ferreras, L., Eerola, K., Mishra, D., Shevchouk, O. T., Richard, J. E., Nilsson, F. H., Hayes, M. R., & Skibicka, K. P. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.11.005 · Cited by 57
Self-citation
Gastric Sensory and Motor Functions and Energy Intake in Health and Obesity—Therapeutic Implications
Cifuentes, L., Camilleri, M., & Acosta, A. J. (2021) · Nutrients · doi:10.3390/nu13041158 · Cited by 61
Glucagon-Like Peptide-1 Receptor Signaling in the Lateral Dorsal Tegmental Nucleus Regulates Energy Balance
Reiner, D. J., Leon, R. M., McGrath, L. E., Koch‐Laskowski, K., Hahn, J. D., Kanoski, S. E., Mietlicki‐Baase, E. G., & Hayes, M. R. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.225 · Cited by 58
Self-citation
Parallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons
Hsu, T. M., McCutcheon, J. E., & Roitman, M. F. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00410 · Cited by 59
The effect of glucagon-like peptide-1 (GLP-1) receptor agonists on substance use disorder (SUD)-related behavioural effects of drugs and alcohol: A systematic review
Brunchmann, A., Thomsen, M., & Fink‐Jensen, A. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.03.029 · Cited by 63
Gut microbes and food reward: From the gut to the brain
d’Oplinter, A. D. W., Huwart, S. J. P., Cani, P. D., & Everard, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.947240 · Cited by 57
The incretin hormone glucagon‐like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage‐dependent potassium channel
Thiebaud, N., Llewellyn‐Smith, I. J., Gribble, F. M., Reimann, F. M., Trapp, S., & Fadool, D. A. (2016) · The Journal of Physiology · doi:10.1113/jp272322 · Cited by 60
The pleiotropic of GLP-1/GLP-1R axis in central nervous system diseases
Zhang, L., Zhang, W., & Tian, X. (2023) · International Journal of Neuroscience · doi:10.1080/00207454.2021.1924707 · Cited by 54
Resveratrol Modulates the Gut-Brain Axis: Focus on Glucagon-Like Peptide-1, 5-HT, and Gut Microbiota
Chung, J. Y., Jeong, J., & Song, J. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.588044 · Cited by 56
GLP-1 action in the mouse bed nucleus of the stria terminalis
Williams, D. L., Lilly, N., Edwards, I. J., Yao, P., Richards, J. E., & Trapp, S. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.007 · Cited by 51
Alcohol-mediated behaviours and the gut-brain axis; with focus on glucagon-like peptide-1
Jerlhag, E. (2020) · Brain Research · doi:10.1016/j.brainres.2019.146562 · Cited by 53
GLP-1 Suppresses Feeding Behaviors and Modulates Neuronal Electrophysiological Properties in Multiple Brain Regions
Chen, X.-Y., Chen, L., Yang, W., & Xie, A.-M. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.793004 · Cited by 52
Accumbal ghrelin and glucagon-like peptide 1 signaling in alcohol reward in female rats
Abtahi, S., Howell, E., & Currie, P. J. (2018) · Neuroreport · doi:10.1097/wnr.0000000000001071 · Cited by 52
Tirzepatide suppresses palatable food intake by selectively reducing preference for fat in rodents
Geisler, C. E., Antonellis, M. P., Trumbauer, W., Martin, J. A., Coskun, T., Samms, R. J., & Hayes, M. R. (2023) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14843 · Cited by 51
Self-citation
The hormonal signature of energy deficit: Increasing the value of food reward
Lockie, S. H., & Andrews, Z. B. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.08.003 · Cited by 50
Alcohol
Engel, J. A., & Jerlhag, E. (2014) · Progress in brain research · doi:10.1016/b978-0-444-63425-2.00009-x · Cited by 53
Memory and eating: A bidirectional relationship implicated in obesity
Parent, M. B., Higgs, S., Cheke, L. G., & Kanoski, S. E. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.051 · Cited by 54
The neurobiology of overeating
Stuber, G. D., Schwitzgebel, V., & Lüscher, C. (2025) · Neuron · doi:10.1016/j.neuron.2025.03.010 · Cited by 66
Nucleus accumbens melanin-concentrating hormone signaling promotes feeding in a sex-specific manner
Terrill, S. J., Subramanian, K. S., Lan, R., Liu, C. M., Cortella, A. M., Noble, E. E., & Kanoski, S. E. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108270 · Cited by 48
Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis
Berland, C., Castel, J., Terrasi, R., Montalban, E., Foppen, E., Martin, C., Muccioli, G. G., Luquet, S. H., & Gangarossa, G. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01428-z · Cited by 58
Glucagon‐like peptide ‐1 receptor agonist ‐based agents and weight loss composition: Filling the gaps
Dubin, R. L., Heymsfield, S. B., Ravussin, E., & Greenway, F. L. (2024) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15913 · Cited by 47
Review Article: GLP ‐1 Receptor Agonists and Glucagon/ GIP / GLP ‐1 Receptor Dual or Triple Agonists—Mechanism of Action and Emerging Therapeutic Landscape in MASLD
Zafer, M., Tavaglione, F., Romero‐Gómez, M., & Loomba, R. (2025) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70196 · Cited by 47
A comparative transcriptomic analysis of glucagon-like peptide-1 receptor- and glucose-dependent insulinotropic polypeptide receptor-expressing cells in the hypothalamus
Smith, C., Patterson-Cross, R., Woodward, O. R. M., Lewis, J. E., Chiarugi, D., Merkle, F. T., Gribble, F. M., Reimann, F. M., & Adriaenssens, A. E. (2022) · Appetite · doi:10.1016/j.appet.2022.106022 · Cited by 47
The glucagon-like peptide-1 system is modulated by acute and chronic alcohol exposure: Findings from human laboratory experiments and a post-mortem brain study
Farokhnia, M., Browning, B. D., Crozier, M. E., Sun, H., Akhlaghi, F., & Leggio, L. (2022) · Addiction Biology · doi:10.1111/adb.13211 · Cited by 46
Long Term Exendin-4 Treatment Reduces Food Intake and Body Weight and Alters Expression of Brain Homeostatic and Reward Markers
Yang, Y., Moghadam, A. A., Cordner, Z. A., Liang, N., & Moran, T. H. (2014) · Endocrinology · doi:10.1210/en.2014-1052 · Cited by 44
Glucagon-like peptide-1 mediates effects of oral galactose in streptozotocin-induced rat model of sporadic Alzheimer’s disease
Knezović, A., Barilar, J. O., Perhoč, A. B., Bagarić, R., Farkaš, V., Riederer, P. F., & Šalković‐Petrišić, M. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.02.027 · Cited by 45
Glucagon-Like Peptide 1 in the Brain: Where Is It Coming From, Where Is It Going?
Daniels, D., & Mietlicki‐Baase, E. G. (2018) · Diabetes · doi:10.2337/dbi18-0045 · Cited by 49
Ghrelin and Glucagon-Like Peptide-1: A Gut-Brain Axis Battle for Food Reward
Décarie-Spain, L., & Kanoski, S. E. (2021) · Nutrients · doi:10.3390/nu13030977 · Cited by 49
Metabolic hormone action in the VTA: Reward-directed behavior and mechanistic insights
Geisler, C. E., & Hayes, M. R. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114236 · Cited by 51
Self-citation
Possible Mechanisms of Circulating PYY-Induced Satiation in Male Rats
Weber‐Stadlbauer, U., Arnold, M., Weber, E., & Langhans, W. (2012) · Endocrinology · doi:10.1210/en.2012-1956 · Cited by 44
Liraglutide prevents metabolic side-effects and improves recognition and working memory during antipsychotic treatment in rats
Babic, I., Gorak, A., Engel, M., Sellers, D., Else, P. L., Osborne, A. L., Pai, N. B., Huang, X., Nealon, J. R., & Weston–Green, K. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118756061 · Cited by 44
THE INTRIGUING LIGAND-DEPENDENT AND LIGAND-INDEPENDENT ACTIONS OF THE GROWTH HORMONE SECRETAGOGUE RECEPTOR ON REWARD-RELATED BEHAVIORS
Cornejo, M. P., Mustafá, E. R., Barrile, F., Cassano, D., Francesco, P. N. D., Raingo, J., & Perelló, M. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.10.017 · Cited by 46
Association between glucagon-like peptide-1 receptor agonists use and change in alcohol consumption: a systematic review
Subhani, M., Dhanda, A., King, J. A., Warren, F. C., Creanor, S., Davies, M. J., Eldeghaidy, S., Bawden, S., Gowland, P. A., Bataller, R. A., et al. (2024) · EClinicalMedicine · doi:10.1016/j.eclinm.2024.102920 · Cited by 48
Insulin in the ventral tegmental area reduces cocaine‐evoked dopamine in the nucleus accumbens in vivo
Naef, L., Seabrook, L. T., Hsiao, J., Li, C., & Borgland, S. L. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14291 · Cited by 42
GLP-1 Analogues in the Neurobiology of Addiction: Translational Insights and Therapeutic Perspectives
Marquez-Meneses, J. D., Olaya-Bonilla, S. A., Barrera-Carreño, S., Tibaduiza-Arévalo, L. C., Forero-Cárdenas, S., Carrillo-Vaca, L., Rojas-Rodríguez, L. C., Calderón‐Ospina, C., & Rodríguez, J. H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115338 · Cited by 50
Estradiol and the control of feeding behavior
Rivera, H. M., & Stincic, T. L. (2017) · Steroids · doi:10.1016/j.steroids.2017.11.011 · Cited by 46
Neuroprotective effects of glucagon-like peptide-1 (GLP-1) analogues in epilepsy and associated comorbidities
Manavi, M. A. (2022) · Neuropeptides · doi:10.1016/j.npep.2022.102250 · Cited by 41
Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP
Chepurny, O. G., Matsoukas, M., Liapakis, G., Leech, C. A., Milliken, B. T., Doyle, R. P., & Holz, G. G. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005682 · Cited by 40
The science of safety: adverse effects of GLP-1 receptor agonists as glucose-lowering and obesity medications
Jalleh, R. J., Talley, N. J., Horowitz, M., & Nauck, M. A. (2026) · Journal of Clinical Investigation · doi:10.1172/jci194740 · Cited by 40
“The Journal of Clinical Investigation The nucleus tractus solitarii projects to multiple regions of the CNS involved in the regulation of appetite, including the hypothalamus, ventral tegmental area, lateral parabrachial nucleus, and nucleus accumbens (58, 59).”
Review article: Pharmacologic management of obesity ‐ updates on approved medications, indications and risks
Lupianez‐Merly, C., Dilmaghani, S., Vosoughi, K., & Camilleri, M. (2024) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.17856 · Cited by 41
The Aversive Agent Lithium Chloride Suppresses Phasic Dopamine Release Through Central GLP-1 Receptors
Fortin, S. M., Chartoff, E. H., & Roitman, M. F. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.220 · Cited by 42
GLP-1: benefits beyond pancreas
Muscogiuri, G., Cignarelli, A., Giorgino, F., Prodram, F., Santi, D., Tirabassi, G., Balercia, G., Modica, R., Faggiano, A., & Colao, A. (2014) · Journal of Endocrinological Investigation · doi:10.1007/s40618-014-0137-y · Cited by 41
Spinally projecting preproglucagon axons preferentially innervate sympathetic preganglionic neurons
Llewellyn‐Smith, I. J., Marina, N., Manton, R. N., Reimann, F. M., Gribble, F. M., & Trapp, S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.10.043 · Cited by 40
GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans
Hanßen, R., Kretschmer, A. C., Rigoux, L., Albus, K., Thanarajah, S. E., Sitnikow, T., Melzer, C., Cornely, O. A., Brüning, J. C., & Tittgemeyer, M. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101163 · Cited by 42
Gut peptide regulation of food intake – evidence for the modulation of hedonic feeding
Woodward, O. R. M., Gribble, F. M., Reimann, F., & Lewis, J. E. (2021) · The Journal of Physiology · doi:10.1113/jp280581 · Cited by 46
Liraglutide, leptin and their combined effects on feeding: additive intake reduction through common intracellular signalling mechanisms
Kanoski, S. E., Ong, Z. Y., Fortin, S. M., Schlessinger, E. S., & Grill, H. J. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12423 · Cited by 41
Brain regulation of hunger and motivation: The case for integrating homeostatic and hedonic concepts and its implications for obesity and addiction
Morales, I. (2022) · Appetite · doi:10.1016/j.appet.2022.106146 · Cited by 39
G lucagon‐Like Peptide‐1 Receptor in the Brain: Role in Neuroendocrine Control of Energy Metabolism and Treatment Target for Obesity
Lockie, S. H. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12039 · Cited by 38

Authors: Alhadeff, A. L., Rupprecht, L. E., & Hayes, M. R.
Affiliations: University of Pennsylvania (US)
Corresponding author: Hayes, Matthew R.
ORCID: Alhadeff, Amber L.
Rupprecht, Laura E.
Hayes, Matthew R.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2012-02-01
Volume: 153
Issue: 2
Pages: 647-658
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2011-1443
PMC: PMC3275387
OpenAlex: W2140625608
Cited by: 515
References: 69
Citations by year: 2026: 66 · 2025: 45 · 2024: 38 · 2023: 26 · 2022: 33 · 2021: 36 · 2020: 33 · 2019: 34 · 2018: 25 · 2017: 28 · 2016: 34 · 2015: 31 · 2014: 34 · 2013: 37 · 2012: 13
FWCI: 12.59
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Endocrinology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Pennsylvania
National Institutes of Health
U.S. Public Health Service (NIDDK 085435)
National Institute of Diabetes and Digestive and Kidney Diseases (K01DK085435)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: glucagon-like peptide-1, GLP-1 receptor, nucleus tractus solitarius, ventral tegmental area, nucleus accumbens, mesolimbic reward system, food intake regulation, body weight, palatable food, monosynaptic projection, hindbrain neurons
MeSH terms: Glucagon-Like Peptide-1 Receptor, Exenatide, Animals, Dose-Response Relationship, Drug, Eating, Gene Expression Regulation, Hypoglycemic Agents, Male, Neurons, Nucleus Accumbens, Peptides, Venoms, Signal Transduction, Rats, Sprague-Dawley, Solitary Nucleus, Ventral Tegmental Area, Receptors, Glucagon, Rats, Glucagon-Like Peptide 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

GLP-1 Neurons in the Nucleus of the Solitary Tract Project Directly to the Ventral Tegmental Area and Nucleus Accumbens to Control for Food Intake

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks