Cited by 230Pancreatic function and diabetesDiabetes and associated disordersDiabetes Treatment and Management

beta-cell turnover: its assessment and implications.

Open access
Bonner-Weir, S·2001·Diabetes

Abstract

The pancreatic beta-cells are responsible for the maintenance of the body's glucose levels within a very narrow range; their population is dynamic and undergoes compensatory changes to maintain euglycemia. The structural parameters that allow mass changes (replication, neogenesis, cell volume changes, and cell death) can now be assessed and have proved to be powerful tools. Changes in one parameter can dramatically affect the beta-cell mass. Unfortunately, conclusions are often drawn on measurements that do not assess beta-cell mass but only relative volumes. Throughout the lifetime of a mammal, low levels of beta-cell replication and apoptosis are balanced and result in a slowly increasing mass. The balance allows gradual replacement of the beta-cell population; thus, beta-cells should be considered a slowly renewed tissue. Two major implications of beta-cell turnover are that 1) at any time, the beta-cells would be at different ages and 2) any limitation on replacement could have dire consequences for glucose homeostasis.

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Crossref · 10.2337/diabetes.50.2007.s20

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  • β-Cell mass can slowly expand in adult rodents in response to increased insulin requirements or during pregnancy.

    “β-Cell mass can slowly expand in adult rodents in response to increased insulin requirements (3) or during pregnancy (4).”

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Authors
Bonner-Weir, S.
Affiliations
Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA. susan.bonner-weir@joslin.harvard.edu
Venue
Diabetes
Published
2001-02-01
Volume
50
Issue
suppl_1
Pages
S20
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
OpenAlex
W2132667679
Cited by
230
References
26
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 4 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 6 · 2015: 7 · 2014: 11 · 2013: 7 · 2012: 14
Type
conference abstract
Language
en
Open access
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
beta-cell turnover, beta-cell mass, beta-cell proliferation, beta-cell neogenesis, beta-cell apoptosis, glucose homeostasis, pancreatic islets
MeSH terms
Animals, Cell Count, Cell Division, Female, Humans, Insulin Resistance, Islets of Langerhans, Male, Rats, Zucker, Cell Death, Apoptosis, In Situ Nick-End Labeling, Models, Animal, Rats

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