THE EFFECTS OF DOSAGE, AND OF ESTROGEN, ANDROGEN OR SALICYLATE ADMINISTRATION ON THE DEGREE OF BODY TEMPERATURE ELEVATION INDUCED BY PROGESTERONE
Abstract
THE literature concerning the thermogenic effect of progesterone has by now attained sizeable proportions (see the review by Palmer, 1949), yet with the exception of the study of Isreal and Schneller (1950), and those reported in abstract by Permian (1948), and Nieburgs and Greenblatt (1948), practically no attempt has been made to study either the quantitative aspects of this effect, or the essential physiologic processes involved. Isreal and Schneller (1950) and Perlman (1948) indicate that the rise in body temperature is related to the dose of progesterone. Nieburgs and Greenblatt (1948) state that in rats the effect is present in the absence of ovaries, adrenals and thyroids. In the main, concomitant administration of estrogens does not alter the thermogenic effect of progesterone (Buxton and Atkinson, 1948; Davis and Fugo, 1948; Isreal and Schneller, 1950) although estrogens alone are almost uniformly claimed to have a temperature depressing effect.
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The thermogenic action of progesterone was shown in early studies in which progesterone was administered to men or to women with anovulatory cycles or amenorrhea, or in the follicular phase or luteal phase, or post-menopause.
“The thermogenic action of progesterone was shown in early studies in which progesterone was administered to men [98] (Figure 3) or to women with anovulatory cycles or amenorrhea, or in the follicular phase or luteal phase, or post-menopause [62,63,99].”
From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [98]
Administration of salicylates together with progesterone across multiple days in men has inconsistent effects on basal body temperature.
“Administration of salicylates together with progesterone across multiple days in men had inconsistent effects on basal body temperature [98].”
From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [98]
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- Authors
- ROTHCHILD, I., & BARNES, A. C.
- Affiliations
- The Ohio State University (US)
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1952-04
- Volume
- 50
- Issue
- 4
- Pages
- 485-496
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2089346206
- Cited by
- 59
- References
- 0
- Citations by year
- 2023: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 2
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- progesterone, thermogenesis, body temperature elevation, estrogen, androgens, salicylates, dose-response relationship, hormone crosstalk, rats
- MeSH terms
- Androgens, Body Temperature, Pharmaceutical Preparations, Estrogens, Progesterone, Salicylates
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