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Cited by 79Thermoregulation and physiological responsesThermal Regulation in MedicineCardiovascular and exercise physiology

Altered reflex control of cutaneous circulation by female sex steroids is independent of prostaglandins

Charkoudian, Nisha, Johnson, John M.·1999·American Journal of Physiology-Heart and Circulatory Physiology
DOI 10.1152/ajpheart.1999.276.5.h1634
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Abstract

We tested the hypothesis that the shift in the cutaneous vasodilator response to hyperthermia seen with elevated female reproductive hormones is a prostaglandin-dependent resetting of thermoregulation to higher internal temperatures, similar to that seen in the febrile response to bacterial infection. Using water-perfused suits to control body temperature, we conducted heat stress experiments in resting women under conditions of low and high progesterone and estrogen and repeated these experiments after an acute dose of ibuprofen (800 mg). In six women the hormones were exogenous (oral contraceptives); three women had regular menstrual cycles and were tested in the early follicular and midluteal phases. Resting oral temperature (T or) was significantly elevated with high hormone status ( P < 0.05); this was not affected by ibuprofen treatment ( P > 0.2). The T or threshold for cutaneous vasodilation was significantly increased by high hormone status (+0.27 ± 0.07°C, P < 0.02); the shift was not affected by ibuprofen treatment (with ibuprofen: +0.29 ± 0.08°C, P > 0.2 vs. control experiments). The T or threshold for sweating was similarly increased by high hormone status (+0.22 ± 0.05°C, P < 0.05); this shift was not influenced by ibuprofen (with ibuprofen: +0.35 ± 0.05, P > 0.1 vs. control experiments). Thus the shift in thermoregulatory control of skin blood flow and sweating mediated by female reproductive steroids is not sensitive to ibuprofen; it therefore appears that this shift is independent of prostaglandins.

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Crossref · 10.1152/ajpheart.1999.276.5.h1634

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  • Women taking oral contraceptives containing an estrogen and progestin (active phase) have elevated core body temperatures while awake at rest compared with the placebo phase.

    “Studies of women taking oral contraceptives containing an estrogen and progestin (active phase) have shown they have elevated core body temperatures while awake at rest compared with the placebo phase [105,106].”

    From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [105]

  • Reflex thermoregulatory control of vasoconstriction is shifted to a higher core body temperature, at least by exogenous female steroid hormones in oral contraceptives.

    “it has been shown that reflex thermoregulatory control of vasoconstriction also is shifted to a higher core body temperature, at least by exogenous female steroid hormones in oral contraceptives [105].”

    From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [105]

  • Ibuprofen has no effect on sweating responses in the high hormone phase.

    “Ibuprofen had no effect on the upward shift in short-term resting core body temperature, cutaneous vascular conductance and sweating responses in the high hormone phase (luteal phase/active pill).”

    From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [105]

  • Ibuprofen has no effect on the upward shift in short-term resting core body temperature in the high hormone phase (luteal phase/active pill).

    “Ibuprofen had no effect on the upward shift in short-term resting core body temperature, cutaneous vascular conductance and sweating responses in the high hormone phase (luteal phase/active pill).”

    From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [105]

  • Ibuprofen has no effect on cutaneous vascular conductance responses in the high hormone phase.

    “Ibuprofen had no effect on the upward shift in short-term resting core body temperature, cutaneous vascular conductance and sweating responses in the high hormone phase (luteal phase/active pill).”

    From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [105]

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Authors
Charkoudian, N., & Johnson, J. M.
Affiliations
The University of Texas at San Antonio Health Science Center (US)
ORCID
Charkoudian, Nisha
Venue
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Published
1999-05-01
Volume
276
Issue
5
Pages
H1634-H1640
ISSN
  • 0363-6135 (ISSN-L)
  • 1522-1539
DOI
10.1152/ajpheart.1999.276.5.h1634
OpenAlex
W2337055558
Cited by
79
References
30
Citations by year
2026: 4 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 2 · 2012: 3
FWCI
2.27
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5t32ag000205-12)
  • National Institute on Aging (T32 AG0-0205)
  • National Heart, Lung, and Blood Institute (HL 59166, R01HL059166)
Topics
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
female sex hormones, progesterone, estrogen, cutaneous vasodilation, thermoregulation, hyperthermia, skin blood flow, sweating, prostaglandins, ibuprofen, oral temperature, menstrual cycle, water-perfused suit
MeSH terms
Adult, Contraceptives, Oral, Combined, Contraceptives, Oral, Synthetic, Drug Combinations, Female, Heart Rate, Hot Temperature, Humans, Ibuprofen, Mestranol, Norethindrone, Norgestrel, Prostaglandins, Reflex, Skin, Stress, Physiological, Sweating, Vasodilation, Cyclooxygenase Inhibitors, Estradiol Congeners

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