Cited by 203Regulation of Appetite and ObesityAdrenal Hormones and DisordersStress Responses and Cortisol

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Leptin Inhibits Directly Glucocorticoid Secretion by Normal Human and Rat Adrenal Gland**This work was supported by a grant from the Swiss National Science Foundation (No. 3100–050748.97/1).

Pralong, François P., Roduit, Raphaël, Waeber, Gérard, Castillo, Einar, Mosimann, François, Thorens, Bernard, Gaillard, Rolf C.·1998·Endocrinology

DOI 10.1210/endo.139.10.6254

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Abstract

Different interactions have been described between glucocorticoids and the product of the ob gene leptin. Leptin can inhibit the activation of the hypothalamo-pituitary-adrenal axis by stressful stimuli, whereas adrenal glucocorticoids stimulate leptin production by the adipocyte. The present study was designed to investigate the potential direct effects of leptin to modulate glucocorticoid production by the adrenal. Human adrenal glands from kidney transplant donors were dissociated, and isolated primary cells were studied in vitro. These cells were preincubated with recombinant leptin (10(-10)-10(-7) M) for 6 or 24 h, and basal or ACTH-stimulated cortisol secretion was subsequently measured. Basal cortisol secretion was unaffected by leptin, but a significant and dose-dependent inhibition of ACTH-stimulated cortisol secretion was observed [down by 29 +/- 0.1% of controls with the highest leptin dose, P < 0.01 vs. CT (unrelated positive control)]. This effect of leptin was also observed in rat primary adrenocortical cells, where leptin inhibited stimulated corticosterone secretion in a dose-dependent manner (down by 46 +/- 0.1% of controls with the highest leptin dose, P < 0.001 vs. CT). These effects of leptin in adrenal cells are likely mediated by the long isoform of the leptin receptor (OB-R), because its transcript was found to be expressed in the adrenal tissue and leptin had no inhibitory effect in adrenal glands obtained from db/db mice. Therefore, leptin inhibits directly stimulated cortisol secretion from human and rat adrenal glands, and this may represent an important mechanism to modulate glucocorticoid levels in various metabolic states.

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243
Role of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117
The role of neuropeptide Y in the antiobesity action of the obese gene product
Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., et al. (1995) · Nature · doi:10.1038/377530a0 · Cited by 1,498
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.
Vaisse, C., Halaas, J. L., Horvath, C. M., Darnell, J. E., Stoffel, M., & Friedman, J. M. (1996) · Nature Genetics · doi:10.1038/ng0996-95 · Cited by 1,086
The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.
Baumann, H., Morella, K. K., White, D. W., Dembski, M., Bailon, P., Kim, H., Lai, C. F., & Tartaglia, L. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8374 · Cited by 827

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“Cortisol increases or stimulates production of leptin in adipose tissue (44).”
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Self-citation
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Guha, P. K., Villarreal, D., Reams, G. P., & Freeman, R. H. (2003) · Progress in experimental cardiology · doi:10.1007/978-1-4419-9232-1_17 · Cited by 5
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Manzar, M. D., & Hussain, M. E. (2010) · Biological Rhythm Research · doi:10.1080/09291011003759558 · Cited by 5
Glucocorticoids contribute to the heritability of leptin in Scottish adult female twins
Wallace, A. M., Banfield, E. C., Ingram, M. C., Fräser, R., Swan, L., Hillis, W. S., & Connell, J. M. C. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02068.x · Cited by 5
Homeostatic Joint Amplification of Pulsatile and 24-Hour Rhythmic Cortisol Secretion by Fasting Stress in Midluteal Phase Women: Concurrent Disruption of Cortisol-Growth Hormone, Cortisol-Luteinizing Hormone, and Cortisol-Leptin Synchrony1
Bergendahl, M., Iranmanesh, A., Pastor, C. L., Evans, W. S., & Veldhuis, J. D. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.11.6945 · Cited by 5
Neuroendocrine-immune interactions : impact of gender, negative energetic balance condition, and developmental stage on the mechanisms of the acute phase response of the inflammatory process in mammals.
Spinedi, E., Pérez, N., & Gaillard, R. C. (2004) · IRIS · Cited by 5
Self-citation
Effects of bariatric surgery upon the sympathetic nervous system and hypothalamic-pituitary-adrenal axis in obese humans
Ziegler, A. K., Christensen, M., Jørgensen, H. L., Fenger, M., Myrup, S. F., Dirksen, C., & Madsbad, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-14537-4 · Cited by 5
Leptin exerts a bone protective effect in ovariectomized rats by inhibiting osteoclastogenesis
Said, M. A., Abdel-Kareem, H., & Abdallah, H. A. (2020) · Bulletin of Egyptian Society for Physiological Sciences · doi:10.21608/besps.2019.14749.1033 · Cited by 4
Leptin/leptin receptor system in the regulation of reproductive functions and stress response in the European beaver
Chojnowska, K., Czerwińśka, J., Kamiński, T., Kamińska, B., Kurzyńska, A., & Bogacka, I. (2018) · Current Zoology · doi:10.1093/cz/zoy030 · Cited by 4
Hormonal regulation of the mouse adrenal melanocortinergic system
Soltani, Y., Doghman, M., Gout, J., Rebuffet, V., Vigier, M., Bekkouche, F. H., Naville, D., & Bégeot, M. (2009) · Journal of Endocrinological Investigation · doi:10.1007/bf03345678 · Cited by 3
An acute method to test leptin responsiveness in rats
Desai, B. N., & Harris, R. B. S. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00548.2013 · Cited by 3
Basic Experimental and Clinical Advances in the Mechanisms Underlying Abnormal Pregnancy Outcomes
Regnault, T. R. H., Nijland, M. J., Budge, H., & Morrison, J. L. (2013) · Journal of Pregnancy · doi:10.1155/2013/327638 · Cited by 3
Modulatory Role of the Ovarian Function in Neuroimmunoendocrine Axis Activity
Perelló, M., Giovambattista, A., Castrogiovanni, D. C., Gaillard, R. C., & Spinedi, E. (2010) · NeuroImmunoModulation · doi:10.1159/000314608 · Cited by 2
Self-citation
Physiological and Hormonal Factors that Influence Leptin Production
Dagogo-Jack, S. E. (2014) · Springer eBooks · doi:10.1007/978-3-319-09915-6_5 · Cited by 2
Leptin and Other Endocrine Systems
Considine, R. V. (2006) · Springer eBooks · doi:10.1007/978-0-387-31416-7_6 · Cited by 2
Analysis of angiotensin II- and ACTH-driven mineralocorticoid functions and omental adiposity in a non-genetic, hyperadipose female rat phenotype
Perelló, M., Cónsole, G. M., Gaillard, R. C., & Spinedi, E. (2010) · Endocrine · doi:10.1007/s12020-010-9335-3 · Cited by 1
Self-citation
Brain Melanocortin Receptors are Involved In CRH-Mediated HPA Axis Activity And Thermogenesis
de Vries, K. (2011) · The Open Neuroendocrinology Journal · doi:10.2174/1876528901104010127 · Cited by 1
Tetraploid genes of leptin (leptin-AI, -AII, -BI and -BII) in goldfish: Molecular cloning, bioinformatics analysis, tissue distribution and differential regulation of transcript expression by glucocorticoids
Yan, A., Li, J., Liu, L., Zhu, X., Ren, C., Hu, C., Tang, D., & Chen, T. (2022) · Aquaculture Reports · doi:10.1016/j.aqrep.2022.101191 · Cited by 1
Pathogenesis of Pheochromocytoma
Isobe, K., Takekoshi, K., Kawakami, Y., & Nakai, T. (2003) · KARGER eBooks · doi:10.1159/000074655 · Cited by 1
Aberrant Hormone Receptors
Lacroix, A., Tremblay, J., & Hamet, P. (2002) · Springer eBooks · doi:10.1007/978-1-4615-1103-8_10 · Cited by 1
Leptin and the Hypothalamopituitary-Adrenal Axis
Pralong, F. P., & Gaillard, R. C. (2003) · Endocrine updates · doi:10.1007/978-1-4615-0501-3_10 · Cited by 1
Self-citation
Dynamic Leptin Secretion in Obesity and Diabetes
Dagogo-Jack, S. E. (2014) · Springer eBooks · doi:10.1007/978-3-319-09915-6_15
Cushing’s Syndrome due to Aberrant Adrenal Hormone Receptors
Bourdeau, I., N’Diaye, N., Mircescu, H., Tremblay, J., Hamet, P., & Lacroix, A. (2003) · Endocrine updates · doi:10.1007/978-1-4615-0501-3_11
Non‐invasive measure of corticosterone in food restricted rats
Amara, C. E., Cole, D. C., Bellem, A., Civitarese, R., & Boonstra, R. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.937.25
Leptin in the perinatal period
Hytinantti, T. K. (2001) · Työväentutkimus Vuosikirja
Characteristics of glucocorticoid synthesis-related factors in the adrenals of obese Zucker rats (Short communication)
Harikai, N., & Yamada, M. (2012) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.99.2012.2.9
LEPTIN RESISTANCE REDUCES GROWTH HORMONE SECRETION AND CONTRIBUTES TO THE PATHOGENESIS OF OBESITY
Martin, R. L. (2000) · University Microfilms International eBooks
Long-Term Hypoxia Regulates Cortisol Biosynthesis in the Ovine Fetal Adrenal Cortex
Vargas, V. E. (2010) · The Scholars Repository - LLU (Loma Linda University)
and onset of obesity
Roberge, C., Carpentier, A. C., Langlois, M., Baillargeon, J., Ardilouze, J., & Gallo‐Payet, N. (2007)
The relationships between changes in weight status, leptin, cortisol, growth hormone and insulin resistance in youth
Ondrak, K. S. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/pf5k-jz84
FUNCIÓN MEDULAR ADRENAL EN PACIENTES CON HIPERPLASIA SUPRARRENAL CONGÉNITA POR DÉFICIT DE 21-HIDROXILASA
Medicina, F. D. (2010)

Authors: Pralong, F. P., Roduit, R., Waeber, G., Castillo, E., Mosimann, F., Thorens, B., & Gaillard, R. C.
Affiliations: Division of Endocrinology, Diabetology and Metabolism (F.P.P., E.C., R.C.G.), University Hospital, 1011 Lausanne, Switzerland
Institute of Pharmacology and Toxicology (R.R., B.T.), University Hospital, 1011 Lausanne, Switzerland
Service of Internal Medicine B (G.W.) University Hospital, 1011 Lausanne, Switzerland
Centre Hospitalier Universitaire Vaudois (CH)
Department of Surgery (F.M.), University Hospital, 1011 Lausanne, Switzerland
ORCID: Thorens, Bernard
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 1998-10-01
Volume: 139
Issue: 10
Pages: 4264-4268
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo.139.10.6254
OpenAlex: W2050930379
Cited by: 202
References: 40
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 6 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 7 · 2016: 2 · 2015: 2 · 2014: 11 · 2013: 5 · 2012: 7
FWCI: 6.37
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: leptin, glucocorticoid secretion, adrenal cortex, cortisol, ACTH stimulation test, corticosterone, adrenocortical cells, leptin receptor, hypothalamic-pituitary-adrenal axis, db/db mice, adipokines
MeSH terms: Adrenal Glands, Adrenocorticotropic Hormone, Animals, Corticosterone, Dose-Response Relationship, Drug, Female, Humans, Hydrocortisone, Proteins, Rats, Wistar, Leptin, Rats

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Leptin Inhibits Directly Glucocorticoid Secretion by Normal Human and Rat Adrenal Gland**This work was supported by a grant from the Swiss National Science Foundation (No. 3100–050748.97/1).

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