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Cited by 203Regulation of Appetite and ObesityAdrenal Hormones and DisordersStress Responses and Cortisol

The DOI matches its Crossref record, with a small difference in title or year; 38 of the 40 references it cites were found in a registry or an index.

Leptin Inhibits Directly Glucocorticoid Secretion by Normal Human and Rat Adrenal Gland**This work was supported by a grant from the Swiss National Science Foundation (No. 3100–050748.97/1).

Pralong, François P., Roduit, Raphaël, Waeber, Gérard, Castillo, Einar, Mosimann, François, Thorens, Bernard, Gaillard, Rolf C.·1998·Endocrinology
DOI 10.1210/endo.139.10.6254
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Abstract

Different interactions have been described between glucocorticoids and the product of the ob gene leptin. Leptin can inhibit the activation of the hypothalamo-pituitary-adrenal axis by stressful stimuli, whereas adrenal glucocorticoids stimulate leptin production by the adipocyte. The present study was designed to investigate the potential direct effects of leptin to modulate glucocorticoid production by the adrenal. Human adrenal glands from kidney transplant donors were dissociated, and isolated primary cells were studied in vitro. These cells were preincubated with recombinant leptin (10(-10)-10(-7) M) for 6 or 24 h, and basal or ACTH-stimulated cortisol secretion was subsequently measured. Basal cortisol secretion was unaffected by leptin, but a significant and dose-dependent inhibition of ACTH-stimulated cortisol secretion was observed [down by 29 +/- 0.1% of controls with the highest leptin dose, P < 0.01 vs. CT (unrelated positive control)]. This effect of leptin was also observed in rat primary adrenocortical cells, where leptin inhibited stimulated corticosterone secretion in a dose-dependent manner (down by 46 +/- 0.1% of controls with the highest leptin dose, P < 0.001 vs. CT). These effects of leptin in adrenal cells are likely mediated by the long isoform of the leptin receptor (OB-R), because its transcript was found to be expressed in the adrenal tissue and leptin had no inhibitory effect in adrenal glands obtained from db/db mice. Therefore, leptin inhibits directly stimulated cortisol secretion from human and rat adrenal glands, and this may represent an important mechanism to modulate glucocorticoid levels in various metabolic states.

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Metadata

Authors
Pralong, F. P., Roduit, R., Waeber, G., Castillo, E., Mosimann, F., Thorens, B., & Gaillard, R. C.
Affiliations
  • Division of Endocrinology, Diabetology and Metabolism (F.P.P., E.C., R.C.G.), University Hospital, 1011 Lausanne, Switzerland
  • Institute of Pharmacology and Toxicology (R.R., B.T.), University Hospital, 1011 Lausanne, Switzerland
  • Service of Internal Medicine B (G.W.) University Hospital, 1011 Lausanne, Switzerland
  • Centre Hospitalier Universitaire Vaudois (CH)
  • Department of Surgery (F.M.), University Hospital, 1011 Lausanne, Switzerland
ORCID
Thorens, Bernard
Venue
Endocrinology
Publisher
The Endocrine Society
Published
1998-10-01
Volume
139
Issue
10
Pages
4264-4268
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
DOI
10.1210/endo.139.10.6254
OpenAlex
W2050930379
Cited by
202
References
40
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 6 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 7 · 2016: 2 · 2015: 2 · 2014: 11 · 2013: 5 · 2012: 7
FWCI
6.37
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
leptin, glucocorticoid secretion, adrenal cortex, cortisol, ACTH stimulation test, corticosterone, adrenocortical cells, leptin receptor, hypothalamic-pituitary-adrenal axis, db/db mice, adipokines
MeSH terms
Adrenal Glands, Adrenocorticotropic Hormone, Animals, Corticosterone, Dose-Response Relationship, Drug, Female, Humans, Hydrocortisone, Proteins, Rats, Wistar, Leptin, Rats

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