Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 45

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Hormonal Basis of Biological Sex Differences in Human Athletic Performance

Senefeld, Jonathon W, Hunter, Sandra K·2024·Endocrinology

Abstract

Biological sex is a primary determinant of athletic human performance involving strength, power, speed, and aerobic endurance and is more predictive of athletic performance than gender. This perspective article highlights 3 key medical and physiological insights related to recent evolving research into the sex differences in human physical performance: (1) sex and gender are not the same; (2) males and females exhibit profound differences in physical performance with males outperforming females in events and sports involving strength, power, speed, and aerobic endurance; (3) endogenous testosterone underpins sex differences in human physical performance with questions remaining on the roles of minipuberty in the sex differences in performance in prepubescent youth and the presence of the Y chromosome (SRY gene expression) in males, on athletic performance across all ages. Last, females are underrepresented as participants in biomedical research, which has led to a historical dearth of information on the mechanisms for sex differences in human physical performance and the capabilities of the female body. Collectively, greater effort and resources are needed to address the hormonal mechanisms for biological sex differences in human athletic performance before and after puberty.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1210/endocr/bqae036

Cites

9 of 9 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 9 references

Research works printed but not linked: 30

  1. Miller, 2016, Sex as a biological variable: now what?!, Physiology, 31, 78, 10.1152/physiol.00058.2015 · DOI
  2. James, 2023, Underrepresentation of women in exercise science and physiology research is associated with authorship gender, J Appl Physiol (1985), 135, 932, 10.1152/japplphysiol.00377.2023 · DOI
  3. Anderson, 2008, Gender differences in pharmacological response, Int Rev Neurobiol, 83, 1, 10.1016/S0074-7742(08)00001-9 · DOI · Paper page
  4. Nokoff, 2023, Sex differences in athletic performance: perspectives on transgender athletes, Exerc Sport Sci Rev, 51, 85, 10.1249/JES.0000000000000317 · DOI
  5. Handelsman, 2018, Circulating testosterone as the hormonal basis of sex differences in athletic performance, Endocr Rev, 39, 803, 10.1210/er.2018-00020 · DOI · Paper page
  6. Armstrong, 2023, Performance of non-binary athletes in mass-participation running events, BMJ Open Sport Exerc Med, 9, e001662, 10.1136/bmjsem-2023-001662 · DOI
  7. Schärer, 2012, Anisogamy, chance and the evolution of sex roles, Trends Ecol Evol, 27, 260, 10.1016/j.tree.2011.12.006 · DOI
  8. Mauvais-Jarvis, 2020, Sex and gender: modifiers of health, disease, and medicine, Lancet, 396, 565, 10.1016/S0140-6736(20)31561-0 · DOI · Paper page
  9. Short, 2013, Sex, gender, genetics, and health, Am J Public Health, 103, S93, 10.2105/AJPH.2013.301229 · DOI
  10. Clayton, 2016, Studying both sexes: a guiding principle for biomedicine., FASEB J, 30, 519, 10.1096/fj.15-279554 · DOI · Paper page
  11. Hamilton, 2021, Integrating transwomen athletes into elite competition: the case of elite archery and shooting, Eur J Sport Sci, 21, 1500, 10.1080/17461391.2021.1938692 · DOI
  12. Berta, 1990, Genetic evidence equating SRY and the testis-determining factor, Nature, 348, 448, 10.1038/348448a0 · DOI · Paper page
  13. Senefeld, 2019, Sex differences in youth elite swimming, PLoS One, 14, e0225724, 10.1371/journal.pone.0225724 · DOI
  14. Senefeld, 2016, Sex differences in elite swimming with advanced age are less than marathon running, Scand J Med Sci Sports, 26, 17, 10.1111/sms.12412 · DOI
  15. Petek, 2023, Impact of sex on cardiovascular adaptations to exercise. JACC review topic of the week, J Am Coll Cardiol, 82, 1030, 10.1016/j.jacc.2023.05.070 · DOI
  16. Senefeld, 2021, Sex-based limits to running speed in the human, horse and dog: the role of sexual dimorphisms, FASEB J, 35, e21562, 10.1096/fj.202100161R · DOI
  17. Handelsman, 2017, Sex differences in athletic performance emerge coinciding with the onset of male puberty, Clin Endocrinol (Oxf), 87, 68, 10.1111/cen.13350 · DOI · Paper page
  18. Senefeld, 2020, Divergence in timing and magnitude of testosterone levels between male and female youths, JAMA, 324, 99, 10.1001/jama.2020.5655 · DOI
  19. Kong, 2019, Dehydroepiandrosterone sulfate and free testosterone but not estradiol are related to muscle strength and bone microarchitecture in older adults, Calcif Tissue Int, 105, 285, 10.1007/s00223-019-00566-5 · DOI
  20. Patel, 2018, Estrogen: the necessary evil for human health, and ways to tame it, Biomed Pharmacother, 102, 403, 10.1016/j.biopha.2018.03.078 · DOI
  21. Russell, 2019, MECHANISMS IN ENDOCRINOLOGY: estradiol as a male hormone, Eur J Endocrinol, 181, R23, 10.1530/EJE-18-1000 · DOI
  22. Hansen, 2018, Female hormones: do they influence muscle and tendon protein metabolism?, Proc Nutr Soc, 77, 32, 10.1017/S0029665117001951 · DOI
  23. Atkinson, 2023, Sex differences in performance of elite youth track and field athletes, Med Sci Sports Exerc, 55, 851, 10.1249/01.mss.0000987852.95964.b7 · DOI
  24. Becker, 2020, Minipuberty: why does it happen?, Horm Res Paediatr, 93, 76, 10.1159/000508329 · DOI
  25. Kiviranta, 2016, Transient postnatal gonadal activation and growth velocity in infancy, Pediatrics, 138, e20153561, 10.1542/peds.2015-3561 · DOI
  26. Davis, 2019, Sex differences in infant body composition emerge in the first 5 months of life, J Pediatr Endocrinol Metab, 32, 1235, 10.1515/jpem-2019-0243 · DOI
  27. Sartorio, 2002, The impact of gender, body dimension and body composition on hand-grip strength in healthy children, J Endocrinol Invest, 25, 431, 10.1007/BF03344033 · DOI
  28. Franke, 1997, Hormonal doping and androgenization of athletes: a secret program of the German Democratic Republic government, Clin Chem, 43, 1262, 10.1093/clinchem/43.7.1262 · DOI · Paper page
  29. Nielsen, 2023, Higher myonuclei density in muscle fibers persists among former users of anabolic androgenic steroids, J Clin Endocrinol Metab, 109, e266, 10.1210/clinem/dgad432 · DOI
  30. Pataky, 2023, Impact of biological sex and sex hormones on molecular signatures of skeletal muscle at rest and in response to distinct exercise training modes, Cell Metab, 35, 1996, 10.1016/j.cmet.2023.10.010 · DOI

Cited by

See all 45

Metadata

Authors
Senefeld, J. W., & Hunter, S. K.
Affiliations
  • Department of Health and Kinesiology, University of Illinois Urbana-Champaign , Urbana, IL 61801 , USA
  • Exercise Science Program, Department of Physical Therapy, Marquette University , Milwaukee, WI 53201 , USA
Venue
Endocrinology
Published
2024-03-29
Volume
165
Issue
5
ISSN
1945-7170
Cited by
45
References
9
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Hormonal Basis of Biological Sex Differences in Human Athletic Performance. https://app.cochat.ai/papers/10.1210/endocr/bqae036
The paper
Senefeld, J. W., & Hunter, S. K. (2024). Hormonal Basis of Biological Sex Differences in Human Athletic Performance. Endocrinology. https://doi.org/10.1210/endocr/bqae036

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.