The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Differential Effects of Androgens and Estrogens on Bone Turnover in Normal Men
Abstract
The physiologic role of androgens and estrogens in the maintenance of normal bone turnover in men is a fundamental issue in bone biology. To address this question, we randomized 70 men between the ages of 20 and 44 yr to receive one of three treatment regimens. Group 1 (n = 25) received a GnRH analog (goserelin acetate 3.6 mg by sc injection every 4 wk) alone for 12 wk to suppress endogenous gonadal steroids to prepubertal levels. Group 2 (n = 22) received goserelin plus transdermal testosterone (Androderm 5 mg topically daily) to normalize circulating testosterone and estradiol levels. Group 3 (n = 23) received goserelin plus testosterone plus an aromatase inhibitor (anastrozole 1 mg orally daily) to induce selective estrogen deficiency. The selective effects of androgens and estrogens on skeletal homeostasis were then assessed by measuring changes in biochemical markers of bone turnover and analyzing the between-group differences. Bone resorption markers increased in both the hypogonadal group (group 1) and in the group with selective estrogen deficiency (group 3). Urinary deoxypyridinoline excretion increased more in group 1 than in group 3 (P = 0.023), suggesting a significant effect of androgens on bone resorption, whereas serum N-telopeptide levels increased more in group 3 than in group 2 (P = 0.037), suggesting a significant effect of estrogen on bone resorption. Bone formation markers initially declined in all groups and then increased in groups 1 and 3. The between-group comparisons were consistent for all formation markers. Bone formation markers increased more in group 1 than in group 2 (P = 0.001, 0.037, 0.005 for osteocalcin, carboxy-terminal propeptide of type I procollagen, and amino-terminal propeptide of type I procollagen, respectively). Bone formation markers also increased more in group 1 than in group 3 but these differences were not statistically significant (P = 0.065 0.073, 0.099 for osteocalcin, carboxy-terminal propeptide of type I procollagen, and amino-terminal propeptide of type I procollagen, respectively). Taken together, these data suggest that both androgens and estrogens play independent and fundamental roles in regulating bone resorption in men. These data also suggest that androgens may play an important role in the regulation of bone formation in men.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It is well known that aromatase inhibition results in a dramatic reduction of tumor estrogen concentrations [66].”
From Aromatase inhibitors in men: effects and therapeutic options (2011) · cites this paper as [66]
Citations
Cites
Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man
Smith, E. P., Boyd, J., Frank, G. R., Takahashi, H., Cohen, R. M., Specker, B., Williams, T. C., Lubahn, D. B., & Korach, K. S. (1994) · New England Journal of Medicine · doi:10.1056/nejm199410203311604 · Cited by 2,471
Morishima, A., Grumbach, M. M., Simpson, E. R., Fisher, C., & Qin, K. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.12.8530621 · Cited by 1,416
Evidence of Estrogen Receptors in Normal Human Osteoblast-Like Cells
Eriksen, E. F., Colvard, D. S., Berg, N. J., Graham, M. L., Mann, K. G., Spelsberg, T. C., & Riggs, B. L. (1988) · Science · doi:10.1126/science.3388021 · Cited by 1,227
Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors
Kousteni, S., Bellido, T., Plotkin, L. I., O’Brien, C. A., Bodenner, D., Li, H., Han, K., Gregorio, G. B. D., Katzenellenbogen, J. A., Katzenellenbogen, B. S., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00268-9 · Cited by 1,163
Effect of testosterone and estradiol in a man with aromatase deficiency
Carani, C., Qin, K., Simoni, M., Faustini-Fustini, M., Serpente, S., Boyd, J., Korach, K. S., & Simpson, E. R. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707103370204 · Cited by 1,151
Falahati-Nini, A., Riggs, B. L., Atkinson, E. J., O’Fallon, W. M., Eastell, R., & Khosla, S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10942 · Cited by 757
Self-citationPamidronate to Prevent Bone Loss during Androgen-Deprivation Therapy for Prostate Cancer
Smith, M. R., McGovern, F. J., Zietman, A. L., Fallon, M. A., Hayden, D. L., Schoenfeld, D., Kantoff, P. W., & Finkelstein, J. S. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010845 · Cited by 695
Self-citationIncreased Bone Mass as a Result of Estrogen Therapy in a Man with Aromatase Deficiency
Bilezikian, J. P., Morishima, A., Bell, J., & Grumbach, M. M. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808273390905 · Cited by 622
van den Beld, A. W., de Jong, F. H., Grobbee, D. E., Pols, H. A. P., & Lamberts, S. W. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6825 · Cited by 618
Endogenous Sex Steroids and Bone Mineral Density in Older Women and Men: The Rancho Bernardo Study
Greendale, G. A., Edelstein, S. L., & Barrett-Connor, E. L. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.11.1833 · Cited by 550
Cited by
Sorted by citations
Khosla, S., Amin, S., & ORWOLL, E. S. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0002 · Cited by 943
Estrogens and androgens in skeletal physiology and pathophysiology
Almeida, M., Laurent, M. R., Dubois, V., Claessens, F., O'Brien, C. A., Bouillon, R., Vanderschueren, D., & Manolagas, S. C. (2017) · Physiological Reviews · doi:10.1152/physrev.00033.2015 · Cited by 860
Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men
Finkelstein, J. S., Lee, H., Burnett-Bowie, S.-A. M., Pallais, J. C., Yu, E. W., Borges, L. F., Jones, B. F., Barry, C. V., Wulczyn, K. E., Thomas, B. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1206168 · Cited by 782
Self-citationVanderschueren, D., Vandenput, L., Boonen, S., Lindberg, M. K., Bouillon, R., & Ohlsson, C. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0003 · Cited by 717
Osteoporosis in Men: An Endocrine Society Clinical Practice Guideline
Watts, N. B., Adler, R. A., Bilezikian, J. P., Drake, M. T., Eastell, R., Orwoll, E. S., & Finkelstein, J. S. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3045 · Cited by 611
Self-citationAging and bone loss: new insights for the clinician
Demontiero, O., Vidal, C., & Duque, G. (2011) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x11430858 · Cited by 602
Amory, J. K., Watts, N. B., Easley, K. A., Sutton, P. R., Anawalt, B. D., Matsumoto, A. M., Bremner, W. J., & Tenover, J. L. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031110 · Cited by 475
Mechanisms of sex steroid effects on bone
Syed, F., & Khosla, S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.097 · Cited by 380
Pathophysiology of Age-Related Bone Loss and Osteoporosis
Khosla, S., & Riggs, B. L. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2005.07.009 · Cited by 376
Snyder, P. J., Kopperdahl, D. L., Stephens-Shields, A. J., Ellenberg, S. S., Cauley, J. A., Ensrud, K. E., Lewis, C. E., Barrett-Connor, E., Schwartz, A. V., Lee, D. C., et al. (2017) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.9539 · Cited by 363
Khosla, S., Melton, L. J., & Riggs, B. L. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.262 · Cited by 344
MANAGEMENT OF ENDOCRINE DISEASE: Secondary osteoporosis: pathophysiology and management
Mirza, F., & CANALIS, E. M. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0118 · Cited by 343
Sex Steroid Actions in Male Bone
Vanderschueren, D., Laurent, M. R., Claessens, F., Gielen, E., Lagerquist, M. K., Vandenput, L., Börjesson, A. E., & Ohlsson, C. (2014) · Endocrine Reviews · doi:10.1210/er.2014-1024 · Cited by 327
A concise review of testosterone and bone health
Mohamad, N.-V., Soelaiman, I. N., & Chin, K. (2016) · Clinical Interventions in Aging · doi:10.2147/cia.s115472 · Cited by 305
Older Men With Low Serum Estradiol and High Serum SHBG Have an Increased Risk of Fractures
Mellström, D., Vandenput, L., Mallmin, H., Holmberg, A. H., Lorentzon, M., Odén, A., Johansson, H., Orwoll, E. S., Labrie, F., Karlsson, M. K., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080518 · Cited by 279
Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned
Drake, M. T., Clarke, B. L., Oursler, M. J., & Khosla, S. (2017) · Endocrine Reviews · doi:10.1210/er.2015-1114 · Cited by 291
Clarke, B. L., & Khosla, S. (2010) · Radiologic Clinics of North America · doi:10.1016/j.rcl.2010.02.014 · Cited by 221
Smith, M. R., Fallon, M. A., Lee, H., & Finkelstein, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032058 · Cited by 248
Self-citationCharatcharoenwitthaya, N., Khosla, S., Atkinson, E. J., McCready, L. K., & Riggs, B. L. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070207 · Cited by 235
Longitudinal Association between Sex Hormone Levels, Bone Loss, and Bone Turnover in Elderly Men
Gennari, L., Merlotti, D., Martini, G., Gonnelli, S., Franci, B., Campagna, S., Lucani, B., Dal Canto, N., Valenti, R., Gennari, C., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030736 · Cited by 235
Regulation of circulating sclerostin levels by sex steroids in women and in men
Mödder, U. I., Clowes, J. A., Hoey, K. A., Peterson, J. M., McCready, L. K., Oursler, M. J., Riggs, B. L., & Khosla, S. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.128 · Cited by 231
Testosterone replacement therapy: current trends and future directions
Nieschlag, E., Behre, H. M., Bouchard, P., Corrales, J. J., Jones, T. H., Stalla, G. K., Webb, S. M., & Wu, F. C. W. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh035 · Cited by 224
Clarke, B. L., & Khosla, S. (2008) · Steroids · doi:10.1016/j.steroids.2008.10.003 · Cited by 229
Pathogenesis of Age-Related Bone Loss in Humans
Khosla, S. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls163 · Cited by 222
Gonadal steroid–dependent effects on bone turnover and bone mineral density in men
Finkelstein, J. S., Lee, H., Leder, B. Z., Burnett-Bowie, S.-A. M., Goldstein, D. W., Hahn, C. W., Hirsch, S. C., Linker, A., Perros, N., Servais, A. B., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84137 · Cited by 198
Self-citationAromatase Activity and Bone Homeostasis in Men
Gennari, L., Nuti, R., & Bilezikian, J. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1717 · Cited by 191
Smith, M. R., Goode, M., Zietman, A. L., McGovern, F. J., Lee, H., & Finkelstein, J. S. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.01.174 · Cited by 188
Self-citationKhosla, S. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1740 · Cited by 174
Khosla, S., Melton, L. J., Robb, R. A., Camp, J. J., Atkinson, E. J., Oberg, A. L., Rouleau, P. A., & Riggs, B. L. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.041228 · Cited by 161
Androgen deprivation therapy for prostate cancer: new concepts and concerns
Smith, M. R. (2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32814db88c · Cited by 157
Aromatase inhibitors in men: effects and therapeutic options
de Ronde, W., & de Jong, F. H. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-93 · Cited by 155
Golds, G., Houdek, D., & Arnason, T. (2017) · International Journal of Endocrinology · doi:10.1155/2017/4602129 · Cited by 150
Effects of Aromatase Inhibition in Elderly Men with Low or Borderline-Low Serum Testosterone Levels
Leder, B. Z., Rohrer, J. L., Rubin, S. D., Gallo, J., & Longcope, C. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031467 · Cited by 149
Self-citationRegulation of adult bone turnover by sex steroids
Frenkel, B., Hong, A., Baniwal, S. K., Coetzee, G. A., Ohlsson, C., Khalid, O. S., & Gabet, Y. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22159 · Cited by 150
Lee, H., McGovern, K., Finkelstein, J. S., & Smith, M. R. (2005) · Cancer · doi:10.1002/cncr.21381 · Cited by 148
Self-citationPhysiology of the Hypothalamic Pituitary Gonadal Axis in the Male
Corradi, P. F., Corradi, R. B., & Greene, L. W. (2016) · Urologic Clinics of North America · doi:10.1016/j.ucl.2016.01.001 · Cited by 162
Burnett-Bowie, S.-A. M., McKay, E. A., Lee, H., & Leder, B. Z. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0739 · Cited by 146
Self-citationSecondary Osteoporosis: A Review of The Recent Evidence
Painter, S., Kleerekoper, M., & Camacho, P. M. (2006) · Endocrine Practice · doi:10.4158/ep.12.4.436 · Cited by 138
Hormone Replacement Therapy and Physical Function in Healthy Older Men. Time to Talk Hormones?
Giannoulis, M. G., Martin, F. C., Nair, K. S., Umpleby, A. M., & Sonksen, P. (2012) · Endocrine Reviews · doi:10.1210/er.2012-1002 · Cited by 132
Towards a diagnostic and therapeutic consensus in male osteoporosis
Kanis, J. А., Bianchi, G., Bilezikian, J. P., Kaufman, J.-M., Khosla, S., ORWOLL, E. S., & Seeman, E. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1632-z · Cited by 132
Estrogens as regulators of bone health in men
Vandenput, L., & Ohlsson, C. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.112 · Cited by 133
Adynamic bone in patients with chronic kidney disease
Andress, D. L. (2008) · Kidney International · doi:10.1038/ki.2008.60 · Cited by 129
Age‐related changes in testosterone and the role of replacement therapy in older men
Allan, C. A., & McLachlan, R. I. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02002.x · Cited by 128
Amin, S., & Felson, D. T. (2001) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70186-1 · Cited by 123
Sims, N. A., & Vrahnas, C. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.05.015 · Cited by 132
Mineralization and Bone Resorption Are Regulated by the Androgen Receptor in Male Mice
Chiang, C. Y., Chiu, M. W. S., Moore, A., Anderson, P., Ghasemzadeh, A., McManus, J. F., Ma, C., Seeman, E., Clemens, T. L., Morris, H. A., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081217 · Cited by 121
Aromatase inhibitors in pediatrics
Wit, J. M., Hero, M. T., & Nuñez, S. B. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.161 · Cited by 119
Andropause: is androgen replacement therapy indicated for the aging male?
Hijazi, R. A., & Cunningham, G. R. (2005) · Annual Review of Medicine · doi:10.1146/annurev.med.56.082103.104518 · Cited by 105
Khosla, S., Riggs, B. L., Robb, R. A., Camp, J. J., Achenbach, S. J., Oberg, A. L., Rouleau, P. A., & Melton, L. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0396 · Cited by 98
The physiology of male reproduction: Impact of drugs and their abuse on male fertility
Ajayi, A. F., & Akhigbe, R. E. (2020) · Andrologia · doi:10.1111/and.13672 · Cited by 100
What does testosterone do for red deer males?
Malo, A. F., Roldán, E. R. S., Garde, J. J., Soler, A. J., Vicente, J., Gortázar, C., & Gomendio, M. (2008) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2008.1367 · Cited by 96
Bone density in peripubertal boys with Autism Spectrum Disorders
Neumeyer, A. M., Gates, A., Ferrone, C., Lee, H., & Misra, M. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1709-3 · Cited by 91
Idan, A., Griffiths, K. A., Harwood, D. T., Seibel, M. J., Turner, L., Conway, A. J., & Handelsman, D. J. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-153-10-201011160-00004 · Cited by 89
Araujo, A. B., Travison, T. G., Leder, B. Z., & McKinlay, J. B. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1469 · Cited by 86
Self-citationGielen, E., Vanderschueren, D., Callewaert, F., & Boonen, S. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.08.012 · Cited by 85
Wiren, K. M., Zhang, X.-W., Toombs, A. R., Kasparcova, V., Gentile, M. A., Harada, S.-I., & Jepsen, K. J. (2004) · Endocrinology · doi:10.1210/en.2003-1016 · Cited by 80
Relationship of Estrogen Receptor Genotypes to Bone Mineral Density and to Rates of Bone Loss in Men
Khosla, S., Riggs, B. L., Atkinson, E. J., Oberg, A. L., Mavilia, C., Monte, F. D., Melton, L. J., & Brandi, M. L. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031448 · Cited by 78
Testosterone and the Male Skeleton: A Dual Mode of Action
Sinnesael, M., Boonen, S., Claessens, F., Gielen, E., & Vanderschueren, D. (2011) · Journal of Osteoporosis · doi:10.4061/2011/240328 · Cited by 78
Cancer Treatment-Induced Bone Loss: Pathophysiology and Clinical Perspectives
Brufsky, A. (2008) · The Oncologist · doi:10.1634/theoncologist.2007-0152 · Cited by 72
Baniwal, S. K., Khalid, O. S., Sir, D., Buchanan, G., Coetzee, G. A., & Frenkel, B. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0470 · Cited by 71
Crosstalk Between the Neuroendocrine System and Bone Homeostasis
Zhao, Y., Peng, X., Wang, Q., Zhang, Z., Wang, L., Xu, Y., Yang, H., Bai, J., & Geng, D. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad025 · Cited by 75
Secondary osteoporosis: Pathophysiology & diagnosis
Emkey, G. R., & Epstein, S. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.07.002 · Cited by 71
Wiren, K. M., Semirale, A. A., Zhang, X.-W., Woo, A., Tommasini, S. M., Price, C., Schaffler, M. B., & Jepsen, K. J. (2008) · Bone · doi:10.1016/j.bone.2008.04.026 · Cited by 65
Treatment-Related Osteoporosis in Men with Prostate Cancer
Smith, M. R. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0846 · Cited by 63
Bone Health in Men Receiving Androgen Deprivation Therapy for Prostate Cancer
Eastham, J. A. (2006) · The Journal of Urology · doi:10.1016/j.juro.2006.08.089 · Cited by 61
Hero, M., Mäkitie, O., Kröger, H., Nousiainen, E., Toiviainen-Salo, S., & Dunkel, L. (2009) · Hormone Research in Paediatrics · doi:10.1159/000208803 · Cited by 60
Role of sex steroids in the regulation of bone morphology in men. The MINOS study
Szulc, P., Uusi‐Rasi, K., Claustrat, B., Marchand, F., Beck, T., & Delmas, P. D. (2004) · Osteoporosis International · doi:10.1007/s00198-004-1635-0 · Cited by 60
New Insights Into Androgen and Estrogen Receptor Regulation of the Male Skeleton
Khosla, S. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2529 · Cited by 58
Rotter, I., Kosik-Bogacka, D. I., Dołęgowska, B., Safranow, K., Kuczyńska, M., & Laszczyńska, M. (2015) · Environmental Geochemistry and Health · doi:10.1007/s10653-015-9758-0 · Cited by 55
Cancer-treatment-induced bone loss, part 1
Michaud, L. B., & Goodin, S. (2006) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp050045.p1 · Cited by 54
Impact of occupational cadmium exposure on bone in sewage workers
Taha, M. M., Mahdy-Abdallah, H., Shahy, E. M., Ibrahim, K. S., & Elserougy, S. (2018) · International Journal of Occupational and Environmental Health · doi:10.1080/10773525.2018.1518745 · Cited by 53
Bisphenol A exposure disturbs the bone metabolism: An evolving interest towards an old culprit
Thent, Z. C., Froemming, G. R. A., & Muid, S. A. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.02.013 · Cited by 53
Male Osteoporosis: Deadly, but Ignored
Gruntmanis, U. (2007) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200702000-00004 · Cited by 52
Morovat, A., Catchpole, A., Meurisse, A., Carlisi, A., Bekaert, A.-C., Rousselle, O., Paddon, M., James, T., & Cavalier, E. (2013) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2012-0531 · Cited by 51
Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men
Schooling, C. M., Himmelstein, D. U., & Woolhandler, S. J. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1313169 · Cited by 54
Brent, M. B. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108383 · Cited by 52
Andropause: invention, prevention, rejuvenation
Handelsman, D. J., & Liu, P. Y. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.01.002 · Cited by 49
Effect of Risedronate on Bone in Renal Transplant Recipients
Coco, M., Pullman, J. M., Cohen, H. W., Lee, S., Shapiro, C., Solórzano, C., Greenstein, S., & Glicklich, D. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011060623 · Cited by 48
Kim, D. K., Lee, J. Y., Kim, K. J., Hong, N., Kim, J. W., Hah, Y. S., Koo, K. C., Kim, J. H., & Cho, K. S. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8010113 · Cited by 48
Herrera, A. (2012) · World Journal of Orthopedics · doi:10.5312/wjo.v3.i12.223 · Cited by 48
Androgens and bone growth: it's location, location, location
Wiren, K. M. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.06.003 · Cited by 49
Neuropeptide Y and sex hormone interactions in humoral and neuronal regulation of bone and fat
Zengin, A., Zhang, L., Herzog, H., Baldock, P. A. J., & Sainsbury, A. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.02.004 · Cited by 47
Wiren, K. M., Zhang, X.-W., Olson, D. A., Turner, R. T., & Iwaniec, U. T. (2012) · Bone · doi:10.1016/j.bone.2012.08.111 · Cited by 47
Estrogen and bone: Insights from estrogen-resistant, aromatase-deficient, and normal men
Khosla, S. (2008) · Bone · doi:10.1016/j.bone.2008.05.005 · Cited by 47
Shanbhogue, V. V., Hansen, S. G., Jørgensen, N. R., Brixen, K., & Gravholt, C. H. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2272 · Cited by 45
Effect of aromatase inhibition on bone metabolism in elderly hypogonadal men
Leder, B. Z., & Finkelstein, J. S. (2005) · Osteoporosis International · doi:10.1007/s00198-005-1890-8 · Cited by 44
Self-citationCirculatory pattern of cytokines, adipokines and bone markers in postmenopausal women with low BMD
Azizieh, F. Y., Shehab, D. K., Al-Jarallah, K. F., Mojiminiyi, O. A., Gupta, R., & Raghupathy, R. (2019) · Journal of Inflammation Research · doi:10.2147/jir.s203590 · Cited by 44
Osteocalcin and its forms respond similarly to exercise in males and females
Hiam, D., Landen, S., Jacques, M., Voisin, S. A. C., Alvarez‐Romero, J., Byrnes, E., Chubb, P., Levinger, I., & Eynon, N. (2020) · Bone · doi:10.1016/j.bone.2020.115818 · Cited by 42
Disposition and Metabolism of LY2452473, a Selective Androgen Receptor Modulator, in Humans
Yi, P., Rehmel, J., Cassidy, K. C., Hadden, C. E., Campanale, K. M., Patel, N. J., & Johnson, J. T. (2012) · Drug Metabolism and Disposition · doi:10.1124/dmd.112.047613 · Cited by 41
Gonadal sex steroid status and bone health in middle-aged and elderly European men
The EMAS Study Group, Vanderschueren, D., Pye, S. R., Venken, K., Borghs, H., Gaytant, J., Huhtaniemi, I. T., Adams, J. E., Ward, K. A., Bártfai, G., et al. (2009) · Osteoporosis International · doi:10.1007/s00198-009-1144-2 · Cited by 39
Duan, Y., Tan, Z., Yang, M., Li, J., Liu, C., Wang, C., Zhang, F., Jin, Y., Wang, Y., & Zhu, L. (2019) · BioMed Research International · doi:10.1155/2019/8650846 · Cited by 40
Cerrito, P., Bailey, S. E., Hu, B., & Bromage, T. G. (2020) · Scientific Reports · doi:10.1038/s41598-020-62177-7 · Cited by 39
Causes, consequences, and treatment of osteoporosis in men
Banu, J. (2013) · Drug Design Development and Therapy · doi:10.2147/dddt.s46101 · Cited by 40
Fracture healing: From basic science to role of nutrition
Maria, G. G. (2014) · Frontiers in bioscience · doi:10.2741/4273 · Cited by 38
Mukaddam, M. A., Rajapakse, C. S., Bhagat, Y. A., Wehrli, F. W., Guo, W.-S., Peachey, H., LeBeau, S. O., Zemel, B. S., Wang, C., Swerdloff, R. S., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3665 · Cited by 41
Bone Health and Associated Metabolic Complications in Neuromuscular Diseases
Joyce, N. C., Hache, L. P., & Clemens, P. R. (2012) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2012.08.005 · Cited by 41
Aromatase Activity and Bone Loss in Men
Merlotti, D., Gennari, L., Stolakis, K., & Nuti, R. (2011) · Journal of Osteoporosis · doi:10.4061/2011/230671 · Cited by 41
Endocrine regulation of bone turnover in men
Meier, C., Liu, P. Y., Handelsman, D. J., & Seibel, M. J. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02333.x · Cited by 36
Testosterone and Male Bone Health: A Puzzle of Interactions
Tenuta, M., Hasenmajer, V., Gianfrilli, D., & Isidori, A. M. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf191 · Cited by 42
Sex steroids and bone turnover markers in men with symptomatic vertebral fractures
Tuck, S. P., Scane, A. C., Fraser, W. D., Diver, M. J., Eastell, R., & Francis, R. M. (2008) · Bone · doi:10.1016/j.bone.2008.08.123 · Cited by 37
Self-citation
Metadata
- Authors
- Leder, B. Z., LeBlanc, K. M., Schoenfeld, D. A., Eastell, R., & Finkelstein, J. S.
- Affiliations
- Massachusetts General Hospital (US)
- Northern General Hospital (GB)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2003-01
- Volume
- 88
- Issue
- 1
- Pages
- 204-210
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2143514874
- Cited by
- 283
- References
- 41
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 9 · 2021: 4 · 2020: 11 · 2019: 7 · 2018: 9 · 2017: 10 · 2016: 17 · 2015: 6 · 2014: 15 · 2013: 16 · 2012: 17
- FWCI
- 17.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5f32ar008574-02)
- National Institute of Diabetes and Digestive and Kidney Diseases (K24DK02759, K24DK002759)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (F32-AR08574)
- National Center for Research Resources (K23 RR 16310, M01RR001066, K23RR016310, RR-1066)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- androgens, estrogen, bone turnover, bone resorption, bone formation, testosterone, estradiol, aromatase inhibition, goserelin, GnRH analogues, hypogonadism, men, bone turnover markers, deoxypyridinoline, N-telopeptide, osteocalcin, type I procollagen, skeletal homeostasis
- MeSH terms
- Anastrozole, Administration, Cutaneous, Adult, Androgens, Bone Resorption, Drug Synergism, Enzyme Inhibitors, Estrogens, Hormones, Humans, Injections, Subcutaneous, Gonadotropin-Releasing Hormone, Male, Nitriles, Osteogenesis, Testosterone, Triazoles, Biomarkers, Bone Remodeling, Goserelin, Aromatase Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
