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Cited by 149Hormonal and reproductive studiesSexual Differentiation and DisordersAdrenal Hormones and Disorders

The DOI matches its Crossref record; 51 of the 53 references it cites were found in a registry or an index.

Effects of Testosterone on Mood, Aggression, and Sexual Behavior in Young Men: A Double-Blind, Placebo-Controlled, Cross-Over Study

O’Connor, Daryl B., Archer, John, Wu, Frederick C. W.·2004·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2003-031354
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Abstract

The prospects of wider application of testosterone (T) in novel indications such as male contraception have prompted renewed interest in the investigation of nonreproductive actions and safety of androgens. This study investigated potential changes in mood and behavior in response to elevations in circulating T concentrations produced by the new long-acting preparation, T undecanoate (TU). Twenty-eight eugonadal men were randomized into one of two treatment groups: A1) active, receiving 1000 mg TU im followed by A2) washout, followed by A3) placebo, receiving 4 ml castor oil im; B1) placebo, 4 ml castor oil im; B2) washout followed by B3) active, receiving 1000 mg TU im. Mood, self- and partner-reported physical and verbal aggression, anger, hostility, irritability, assertiveness, self-esteem, and sexual function were assessed. A single injection of 1000 mg TU im increased plasma T concentrations from 20.7 ± 1.5 to 37.5 ± 2.2 nmol/liter at wk 1 and 31.6 ± 1.5 nmol/liter at wk 2, and estradiol from 74.0 ± 4.9 to 120.4 ± 10.7 pmol/liter at wk 1, and 100.0 ± 6.3 pmol/liter at wk 2. The T increment was associated with detectable but minor mood changes. Increased circulating T was associated with significant increases in anger-hostility from baseline (mean score = 7.48) to wk 2 (mean score = 10.71) accompanied by an overall reduction in fatigue-inertia (treatment = 6.21 vs. placebo = 7.84). TU treatment did not increase aggressive behavior or induce any changes in nonaggressive or sexual behavior. Changes in estradiol were not associated with any behavioral alterations. Our results suggest that exogenous TU-induced elevation of circulating T, to the range likely to be used in hormonal male contraception, has limited psychological effects. Future research should investigate the implications of these minor mood changes.

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  1. Parrott, 1994, Anabolic steroid use by amateur athletes: effects upon hostility and aggression., J Sports Med Phys Fitness, 34, 292

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Metadata

Authors
O’Connor, D. B., Archer, J., & Wu, F. C. W.
Affiliations
  • Department of Endocrinology (D.B.O., F.C.W.W.), Manchester Royal Infirmary, Manchester M13 9WL, United Kingdom
  • University of Lancashire (GB)
  • Manchester Royal Infirmary (GB)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2004-06-01
Volume
89
Issue
6
Pages
2837-2845
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2003-031354
OpenAlex
W2119920700
Cited by
149
References
53
Citations by year
2026: 3 · 2025: 2 · 2024: 6 · 2023: 9 · 2022: 4 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 8 · 2015: 9 · 2014: 10 · 2013: 6 · 2012: 6
FWCI
5.31
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
testosterone undecanoate, testosterone, mood, aggression, anger-hostility, sexual behavior, male contraception, androgen effects, estradiol, self-esteem, young men
MeSH terms
Adult, Aggression, Androgens, Double-Blind Method, Estradiol, Follicle Stimulating Hormone, Humans, Irritable Mood, Luteinizing Hormone, Male, Placebos, Surveys and Questionnaires, Self Concept, Sexual Behavior, Testosterone, Cross-Over Studies

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