The DOI matches its Crossref record; 68 of the 69 references it cites were found in a registry or an index.
Leptin Levels Are Dependent on Sleep Duration: Relationships with Sympathovagal Balance, Carbohydrate Regulation, Cortisol, and Thyrotropin
Open accessAbstract
Sleep plays an important role in energy homeostasis. The present study tests the hypothesis that circulating levels of leptin, a hormone that signals energy balance to the brain, are influenced by sleep duration. We also analyzed associations between leptin and sympathovagal balance, cortisol, TSH, glucose, and insulin under different bedtime conditions. Twenty-four-hour hormonal and glucose profiles were sampled at frequent intervals, and sympathovagal balance was estimated from heart rate variability in 11 subjects studied after 6 d of 4-h bedtimes (mean +/- sem of sleep duration during last 2 d: 3 h and 49 +/- 2 min) and after 6 d of 12-h bedtimes (sleep: 9 h and 03 +/- 15 min). A study with 8-h bedtimes was performed 1 yr later (sleep: 6 h and 52 +/- 10 min). Caloric intake and activity levels were carefully controlled in all studies. Mean levels, maximal levels, and rhythm amplitude of leptin were decreased (-19%, -26%, and -20%, respectively) during sleep restriction compared with sleep extension. The decrease in leptin levels was concomitant with an elevation of sympathovagal balance. The effects of sleep duration on leptin were quantitatively associated with alterations of the cortisol and TSH profiles and were accompanied by an elevation of postbreakfast homeostasis model assessment values. Measures of perceived stress were not increased during sleep restriction. During the study with 8-h bedtimes, hormonal and metabolic parameters were intermediate between those observed with 4-h and 12-h bedtimes. In conclusion, sleep modulates a major component of the neuroendocrine control of appetite.
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In the citing paper
“sleep loss, resulting from either acute total sleep deprivation or severe recurrent sleep restriction (≤5, 5 h/ night) resulted in elevated evening cortisol levels, often associated with a slower decline of cortisol concentrations across the day.[8][9][10][11][12][13][14][15][16][17]”
From Effects of Insufficient Sleep on Pituitary–Adrenocortical Response to CRH Stimulation in Healthy Men (2017) · cites this paper as [10]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These data implicate reduced leptin as a hormonal mechanism by which sleep restriction can worsen insulin sensitivity, increase circulating lipids, and lead to obesity and abdominal obesity via disruption of energy balance and increased cravings for carbohydrate rich foods.”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [17]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This prompted the hypothesis that sleep restriction is linked with obesity via disruption of leptin and increased cravings for carbohydrate rich foods [17].”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [17]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Both these pathways also have been proposed as possible mediators of the impairments in glucose tolerance associated with sleep restriction (22,44–48).”
From Sleep Restriction for 1 Week Reduces Insulin Sensitivity in Healthy Men (2010) · cites this paper as [47]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Severe sleep restriction results in elevated evening cortisol levels.”
From Effects of Insufficient Sleep on Pituitary–Adrenocortical Response to CRH Stimulation in Healthy Men (2017) · cites this paper as [10]
The cited source says what the claim attributes to it.
In the citing paper
“Some studies showed that sleep restriction significantly increases plasma cortisol levels during the late afternoon to early evening hours [17], [18], whereas others showed little to no changes [16], [21], [23], [27].”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [17]
The cited source says what the claim attributes to it.
In the citing paper
“Early studies investigating the relationship between sleep restriction and leptin showed that sleep restriction decreased leptin levels [17], [19], and increased self-reported appetite and hunger [19].”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [17]
The cited source says what the claim attributes to it.
In the citing paper
“Early experimental studies exploring the relationship between sleep restriction and the adipose-derived hormone leptin found decreases after both two [19] and six [17] nights of sleep restriction to 4 h TIB.”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [17]
The cited source says what the claim attributes to it.
In the citing paper
“several others have found elevated cortisol in the latter part of the day instead of the usual diurnal decline [17], [18], [54].”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [17]
The cited source says what the claim attributes to it.
In the citing paper
“other published findings in the field which have previously documented decreases in leptin and increases in hunger and appetite following sleep restriction [17], [19].”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [17]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“The approximate 30% reduction in cellular insulin signaling in adipocytes induced by 4 nights of sleep restriction lies within the range of the difference in insulin sensitivity in adipocytes from obese versus lean participants (30) and from diabetic patients versus nondiabetic participants (31).”
From Impaired Insulin Signaling in Human Adipocytes After Experimental Sleep Restriction: A Randomized, Crossover Study (2012) · cites this paper as [31]
Experimental — accuracy not yet measuredIn the citing paper
“Multiple studies have observed that sleep loss, either from acute partial or total sleep deprivation or from recurrent sleep curtailment or insomnia, results in elevated evening cortisol levels (12–19).”
From Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men (2014) · cites this paper as [15]
In the citing paper
“Consistent with our previous study of 6 nights of sleep restriction (15), we found that levels of perceived stress in the present study remained low and were not affected by sleep loss.”
From Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men (2014) · cites this paper as [15]
In the citing paper
“Three studies assessed leptin at more than 2 time points in a rested sleep condition and in a sleep restriction condition in normal-weight men after similar food intake had been enforced in both conditions. All found decreased levels of anorexigenic leptin after sleep loss [62, 161, 162].”
From Sleep and metabolic function (2012) · cites this paper as [161]
In the citing paper
“In a study that assessed the 24-h leptin profiles after 6 days of 4-, 8-, and 12-h bedtimes in healthy lean young men under conditions of stable caloric intake and activity levels, all characteristics of the 24-h leptin profile (overall mean, nocturnal maximum, and amplitude) gradually increased from the 4- to the 12-h bedtime condition [161].”
From Sleep and metabolic function (2012) · cites this paper as [161]
In the citing paper
“Interestingly, cortisol evening levels observed under 8-hour bedtime condition were intermediate between those measured under 4-hour and 12-hour bedtime conditions [84] (Figure 5).”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [84]
In the citing paper
“short sleep duration (6 hours or less), and especially very short sleep duration (less than 5 hours) is associated with increased cardiometabolic morbidity and mortality, including weight gain and obesity, hypertension, hyperlipidemia, and diabetes.”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [30]
In the citing paper
“insufficient sleep has been linked to lower energy expenditure, altered glucose homeostasis and alterations in hormones that mediate hunger(24, 25, 27-31).”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [30]
In the citing paper
“SG was 30% lower in the state of sleep debt.”
From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [19]
In the citing paper
“AIRg was reduced by more than 30% after sleep restriction despite a trend for decreased SI.”
From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [19]
In the citing paper
“Glucose tolerance, assessed during an intravenous glucose tolerance test (ivGTT) and a high-carbohydrate breakfast, was lower in the sleep-debt condition than in the fully rested condition.”
From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [19]
In the citing paper
“For all these variables, clear changes are observed in a dose-response relationship with sleep duration.”
From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [19]
In the citing paper
“For instance, Panels D of Figure 2 show that all characteristics of the 24-h leptin profile (overall mean, nocturnal maximum, amplitude) gradually increased from the 4h to the 12h bedtime, signaling the brain an unnecessary need for extra caloric intake in a state of sleep debt.”
From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [19]
In the citing paper
“In a study that assessed the 24-h leptin profiles after 6 days of 4-h, 8-h, and 12-h bedtimes in healthy lean young men under conditions of stable caloric intake and activity levels, all characteristics of the 24-h leptin profile (overall mean, nocturnal maximum, amplitude) gradually increased from the 4-h to the 12-h bedtime condition [19] (Figure 2; panels D).”
From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [19]
In the citing paper
“HOMA levels post-breakfast increased from the 12-h to the 4-h in bed condition indicating a decrease in glucose tolerance and/or a decrease in SI proportional to the severity of sleep loss (Figure 2; panels A).”
From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [19]
In the citing paper
“Following partial sleep deprivation, mean daytime values of leptin were approximately 18% lower compared to the rested state.104,105”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [105]
In the citing paper
“After two 4-h nights, there was a 24% increase in daytime appetite ratings;105 in addition, sleep deprivation specifically increased appetite for sweet and salty foods.”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [105]
In the citing paper
“Similarly, 4 hours in bed per night for 6 days significantly decreased leptin’s amplitude by 20% when compared with 12 hours in bed per night for 6 nights in 11 lean men [39].”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [39]
In the citing paper
“obstructive sleep apnea, which stimulates the SNS; 41,43,44”
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Citations
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
Robust Locally Weighted Regression and Smoothing Scatterplots
Cleveland, W. S. (1979) · Journal of the American Statistical Association · doi:10.1080/01621459.1979.10481038 · Cited by 11,594
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190
Hobson, J. A. (1969) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(69)90021-2 · Cited by 5,215
Spectral Analysis and its Applications.
Freiberger, W. F., Jenkins, G. M., & Watts, D. G. (1969) · Journal of the American Statistical Association · doi:10.2307/2286100 · Cited by 4,990
Impact of sleep debt on metabolic and endocrine function
Spiegel, K., Leproult, R., & Van Cauter, E. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01376-8 · Cited by 3,668
Self-citationSympathetic neural mechanisms in obstructive sleep apnea.
Somers, V. K., Dyken, M. E., Clary, M. P., & Abboud, F. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118235 · Cited by 2,527
Taheri, S., Lin, L., Austin, D., Young, T., & Mignot, E. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010062 · Cited by 2,477 · cited 1×
“Preliminary findings from a population study involving 1024 subjects are, however, in complete agreement with our observations, because restricted sleep duration was found to be associated with reduced leptin levels independently of BMI ( 45 ).”
ResultSpiegel, K., Tasali, E., Penev, P., & Cauter, E. V. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-11-200412070-00008 · Cited by 2,459
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- Buxton OM, Spiegel K, Van Cauter E 2002 Chapter 8: Modulation of endocrine function and metabolism by sleep and sleep loss. In: Lee-Chiong TL, Sateia MJ, Carskadon MA, eds. Sleep Medicine. Handley, Philadelphia: Belfus, Inc.; 59 -69
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Nakamura, Y., Nakano, M., Suzuki, T., Sato, J., Kato, H., Takahashi, J. A., & Shiraki, M. (2019) · Bone · doi:10.1016/j.bone.2020.115404 · Cited by 39
Najafian, J., Toghianifar, N., Mohammadifard, N., & Nouri, F. (2011) · Europe PMC (PubMed Central) · Cited by 39
McHill, A. W., Hull, J. T., McMullan, C. J., & Klerman, E. B. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00319 · Cited by 38
Dinevari, M. F., Sanaie, S., Rasouli, K., Faramarzi, E., & Molani‐Gol, R. (2023) · BMC Endocrine Disorders · doi:10.1186/s12902-023-01515-y · Cited by 38
No Association Between Leptin Levels and Sleep Duration or Quality in Obese Adults
Knutson, K. L., Galli, G., Zhao, X., Mattingly, M., Cizza, G., & Study, ;. F. T. N. S. E. (2011) · Obesity · doi:10.1038/oby.2011.248 · Cited by 38
Collomp, K., Baillot, A., Forget, H., Coquerel, A., Rieth, N., & Vibarel-Rebot, N. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.05.039 · Cited by 41
Fleary, S. A. (2017) · Journal of School Health · doi:10.1111/josh.12481 · Cited by 38
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Gutiérrez‐Repiso, C., Soriguer, F., Rubio‐Martín, E., Esteva, I., de Adana, M. S. R., Almaraz, M. C., Olveira, G., Morcillo, S., Valdés, S., Lago-Sampedro, A. M., et al. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2014.06.014 · Cited by 37
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Hall, M. H., Lee, L., & Matthews, K. A. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2014.10.005 · Cited by 43
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Pizinger, T., Aggarwal, B., & St‐Onge, M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00392 · Cited by 36
Vinstrup, J., Jakobsen, M. D., Calatayud, J., Jay, K., & Andersen, L. L. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00968 · Cited by 37
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Self-citationEverson, C. A., Thalacker, C. D., & Hogg, N. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90623.2008 · Cited by 35
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Smith, S. S., Waight, C., Doyle, G., Rossa, K. R., & Sullivan, K. A. (2014) · Appetite · doi:10.1016/j.appet.2014.03.019 · Cited by 35
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Setting adolescents up for success: Promoting a policy to delay high school start times
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Hartescu, I., Stensel, D. J., Thackray, A. E., King, J. A., Dorling, J. L., Rogers, E. N., Hall, A. P., Brady, E. M., Davies, M. J., Yates, T. E., et al. (2021) · Journal of Sleep Research · doi:10.1111/jsr.13469 · Cited by 33
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Kim, S. J., Han, K., Jang, S., Yoo, K.-B., & Kim, S. J. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15122648 · Cited by 33
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Muscogiuri, G., Tuccinardi, D., Nicastro, V., Barrea, L., Colao, A., & Savastano, S. (2020) · International Journal of Obesity Supplements · doi:10.1038/s41367-020-0019-z · Cited by 34
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Kim, D. J., Mun, S. J., Choi, J. S., Kim, J., Lee, G.-H., Kim, H.-W., Park, M., & Cho, J. W. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.09.025 · Cited by 33
Markwald, R. R., & Wright, K. P. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3492-4_8 · Cited by 33
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Murase, K., Tabara, Y., Ito, H., Kobayashi, M., Takahashi, Y., Setoh, K., Kawaguchi, T., Muro, S., Kadotani, H., Kosugi, S., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140058 · Cited by 33
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Self-citationGrigg-Damberger, M. M. (2006) · Journal of Clinical Neurophysiology · doi:10.1097/01.wnp.0000201077.44102.80 · Cited by 32
Hart, C. N., Carskadon, M. A., Demos, K. E., Reen, E. V., Sharkey, K. M., Raynor, H. A., Considine, R. V., Jones, R. N., & Wing, R. R. (2014) · Behavioral Sleep Medicine · doi:10.1080/15402002.2014.940105 · Cited by 31
Gruber, R. (2013) · Canadian Psychology/Psychologie canadienne · doi:10.1037/a0030936 · Cited by 31
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Olson, C. A., Hamilton, N. A., & Somers, V. K. (2016) · Journal of Sleep Research · doi:10.1111/jsr.12394 · Cited by 29
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Hersoug, L.-G., Sjödin, A. M., & Astrup, A. V. (2012) · Nutrition and Diabetes · doi:10.1038/nutd.2012.2 · Cited by 30
Insomnia and risk of nonalcoholic fatty liver disease
Wijarnpreecha, K., Thongprayoon, C., Panjawatanan, P., & Ungprasert, P. (2017) · Journal of Postgraduate Medicine · doi:10.4103/jpgm.jpgm_140_17 · Cited by 28
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Marques, C. G., Quaresma, M. V. L. D. S., Nakamoto, F. P., Magalhães, A. C. O., Lucin, G. A., & dos Santos, R. V. T. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.705545 · Cited by 30
Infant sleep problems and childhood overweight: Effects of three definitions of sleep problems
Alamian, A., Wang, L., Hall, A. M., Pitts, M., & Ikekwere, J. C. (2016) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2016.08.017 · Cited by 31
Human Circadian Timing System and Sleep-Wake Regulation
Czeisler, C. A., & Buxton, O. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00035-0 · Cited by 32
Kim, Y.-I., Kim, E., Lee, Y., & Park, J. (2025) · Physical Activity and Nutrition · doi:10.20463/pan.2025.0003 · Cited by 31
Siart, B., Nimmerichter, A., Vidotto, C., & Wallner, B. (2017) · Scientific Reports · doi:10.1038/s41598-017-06461-z · Cited by 27
Heart rate variability rebound following exposure to persistent and repetitive sleep restriction
Yang, H., Haack, M., Dang, R., Gautam, S., Simpson, N. S., & Mullington, J. M. (2018) · SLEEP · doi:10.1093/sleep/zsy226 · Cited by 27
Jarrin, D. C., McGrath, J. J., Poirier, P., & QUALITY Cohort Collaborative Group (2014) · Journal of Youth and Adolescence · doi:10.1007/s10964-014-0235-3 · Cited by 27
Sleep loss as a risk factor for obesity and diabetes
Spiegel, K. (2008) · International Journal of Pediatric Obesity · doi:10.1080/17477160802404681 · Cited by 27
Self-citationNight Shift Work, Sleep Quality, and Obesity.
Ko, S. B. (2013) · Europe PMC (PubMed Central) · Cited by 27
Impact of leptin on memory function and hippocampal structure in mild cognitive impairment
Witte, A. V., Köbe, T., Graunke, A., Schuchardt, J. P., Hahn, A., Tesky, V. A., Pantel, J., & Flöel, A. (2016) · Human Brain Mapping · doi:10.1002/hbm.23327 · Cited by 27
Biological rhythms, metabolic syndrome and current depressive episode in a community sample
Moreira, F. P., Jansen, K., Mondin, T. C., Cardoso, T. D. A., Magalhães, P. V. D. S., Kapczinski, F. P., Frey, B. N., Oses, J. P., Souza, L. D. D. M., da Silva, R. A., et al. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.06.007 · Cited by 28
Cauter, E. V. (2005) · Elsevier eBooks · doi:10.1016/b0-72-160797-7/50029-x · Cited by 27
A Population‐Based Twin Study on Sleep Duration and Body Composition
Liu, R., Liu, X., Arguelles, L. M., Patwari, P. P., Zee, P. C., Chervin, R. D., Ouyang, F., Christoffel, K. K., Zhang, S., Hong, X., et al. (2012) · Obesity · doi:10.1038/oby.2011.274 · Cited by 26
Is poor sleep associated with obesity in older adults? A narrative review of the literature
Norton, M. C., Eleuteri, S., Cerolini, S., Ballesio, A., Conte, S. C., Falaschi, P., & Lucidi, F. (2017) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-017-0453-2 · Cited by 27
Obesity: novel and unusual predisposing factors
Hanson, P., Weickert, M. O., & Barber, T. M. (2020) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018820922018 · Cited by 28
Is time of eating associated with BMI and obesity? A population-based study
Crispim, C. A., Rinaldi, A. E. M., Azeredo, C. M., Skene, D. J., & Moreno, C. R. D. C. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03282-x · Cited by 26
Leptin Replacement Restores Supraspinal Cholinergic Antinociception in Leptin-Deficient Obese Mice
Wang, W., Baghdoyan, H. A., & Lydic, R. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.02.003 · Cited by 26
Donjacour, C. E. H. M., Pardi, D., Aziz, N. A., Frölich, M., Roelfsema, F., Overeem, S., Pijl, H., & Lammers, G. J. (2013) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.2924 · Cited by 26
Johansson, A., Windahl, M., Svanborg, E., Fredrichsen, M., Swahn, E., Uhlin, P. Y., & Edéll‐Gustafsson, U. (2007) · Scandinavian Journal of Caring Sciences · doi:10.1111/j.1471-6712.2007.00496.x · Cited by 26
Sleep Extension: A Potential Target for Obesity Treatment
Hoddy, K. K., Potts, K. S., Bazzano, L., & Kirwan, J. P. (2020) · Current Diabetes Reports · doi:10.1007/s11892-020-01360-6 · Cited by 27
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Borgland, S. L. (2021) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.210036 · Cited by 27
Polysomnographic Sleep, Growth Hormone Insulin‐like Growth Factor‐I Axis, Leptin, and Weight Loss
Rasmussen, M. H., Wildschiødtz, G., Juul, A., & Hilsted, J. (2008) · Obesity · doi:10.1038/oby.2008.249 · Cited by 25
Sleep loss effects on physiological and cognitive responses to systemic environmental hypoxia
Fabries, P. A., Gomez-Mérino, D., Sauvet, F., Malgoyre, A., Koulmann, N., & Chennaoui, M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1046166 · Cited by 25
Potential biochemical pathways for the relationship between sleep duration and mortality
Li, Y., Sato, Y., & Yamaguchi, N. (2012) · Sleep Medicine · doi:10.1016/j.sleep.2012.08.020 · Cited by 25
de Castro, M. A., Garcez, M. R., Pereira, J. L., & Fisberg, R. M. (2019) · Appetite · doi:10.1016/j.appet.2019.02.020 · Cited by 25
Hong, J., He, Y., Fu, R., Si, Y.-X., Xu, B., Xu, J., Li, X., & Mao, F. (2022) · Open Medicine · doi:10.1515/med-2022-0470 · Cited by 29
Qiu, C., Sánchez, S. E., Gelaye, B., Enquobahrie, D. A., Ananth, C. V., & Williams, M. A. (2014) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2014.916682 · Cited by 25
Rao, R., Somvanshi, P. R., Klerman, E. B., Marmar, C. R., & Doyle, F. J. (2021) · Metabolites · doi:10.3390/metabo11080483 · Cited by 24
Behavioral Medicine and Sleep: Concepts, Measures, and Methods
Hall, M. H. (2010) · Springer eBooks · doi:10.1007/978-0-387-09488-5_49 · Cited by 24
Impact of menstrual cycle phase on endocrine effects of partial sleep restriction in healthy women
LeRoux, A., Wright, L., Perrot, T. S., & Rusak, B. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.06.002 · Cited by 24
Ekstedt, M. (2005) · Figshare · Cited by 24
Su, C.-H., Ko, L., Juang, J.-C., & Hsu, C. (2021) · Processes · doi:10.3390/pr9122265 · Cited by 23
Ariza, C., Sánchez‐Martínez, F., Serral, G., Valmayor, S., Juárez, O., Pasarín, M. I., Castell, C., Rajmil, L., & López, M. J. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy259 · Cited by 27
Sleep deprivation induces oxidative stress in the liver and pancreas in young and aging rats
Santiago, K. H., –López, A. L. L., Sánchez‐Muñoz, F., Cortes-Altamirano, J. L., Alfaro-Rodríguez, A., & Bonilla‐Jaime, H. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e06466 · Cited by 23
Primack, C. (2021) · Nursing Clinics of North America · doi:10.1016/j.cnur.2021.07.012 · Cited by 25
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Abreu, G. D. A., Barufaldi, L. A., Bloch, K. V., & Szklo, M. (2015) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20150121 · Cited by 23
Sleep disturbances in anorexia nervosa
Vieira, F. P., & Afonso, P. (2016) · Advances in Eating Disorders · doi:10.1080/21662630.2016.1175958 · Cited by 23
Jones, S. G., & Benca, R. M. (2012) · Wiley eBooks · doi:10.1002/9781118133880.hop203013 · Cited by 23
Disruption of the circadian rhythms and its relationship with pediatric obesity
Kawai, M. (2021) · Pediatrics International · doi:10.1111/ped.14992 · Cited by 22
Metadata
- Authors
- Spiegel, K., Leproult, R., L’Hermite-Balériaux, M., Copinschi, G., Penev, P. D., & Van Cauter, E.
- Affiliations
- Université Libre de Bruxelles (BE)
- University of Chicago (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-11
- Volume
- 89
- Issue
- 11
- Pages
- 5762-5771
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2115505164
- Cited by
- 1,006
- References
- 69
- Citations by year
- 2026: 18 · 2025: 29 · 2024: 28 · 2023: 52 · 2022: 48 · 2021: 40 · 2020: 50 · 2019: 30 · 2018: 42 · 2017: 41 · 2016: 57 · 2015: 57 · 2014: 61 · 2013: 78 · 2012: 74
- FWCI
- 9.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- University of Chicago
- National Institutes of Health
- National Institute on Aging (P01AG011412, AG-11412)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 20595, DK-41814, R01DK041814)
- National Center for Research Resources (M01-RR 00055, M01RR000055)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- leptin, sleep duration, sleep restriction, sleep extension, sympathovagal balance, heart rate variability, cortisol, thyroid-stimulating hormone, glucose, insulin, HOMA, carbohydrate regulation, energy homeostasis, appetite regulation, neuroendocrine regulation, perceived stress
- MeSH terms
- Adult, Homeostasis, Humans, Hydrocortisone, Male, Sleep, Sympathetic Nervous System, Thyrotropin, Time Factors, Vagus Nerve, Leptin, Carbohydrate Metabolism
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