Phagocyte migration and cellular stress induced in liver, lung, and intestine during sleep loss and sleep recovery
Open accessAbstract
Sleep is understood to possess recuperative properties and, conversely, sleep loss is associated with disease and shortened life span. Despite these critical attributes, the mechanisms and functions by which sleep and sleep loss impact health still are speculative. One of the most consistent, if largely overlooked, signs of sleep loss in both humans and laboratory rats is a progressive increase in circulating phagocytic cells, mainly neutrophils. The destination, if any, of the increased circulating populations has been unknown and, therefore, its medical significance has been uncertain. The purpose of the present experiment was to determine the content and location of neutrophils in liver and lung tissue of sleep-deprived rats. These are two principal sites affected by neutrophil migration during systemic inflammatory illness. The content of neutrophils in the intestine also was determined. Sleep deprivation in rats was produced for 5 and 10 days by the Bergmann-Rechtschaffen disk method, which has been validated for its high selectivity under freely moving conditions and which was tolerated and accompanied by a deep negative energy balance. Comparison groups included basal conditions and 48 h of sleep recovery after 10 days of sleep loss. Myeloperoxidase (MPO), an enzyme constituent of neutrophils, was extracted from liver, lung, and intestinal tissues, and its activity was determined by spectrophotometry. Leukocytes were located in vasculature and interstitial spaces in the liver and the lung by immunohistochemistry. Heme oxygenase-1, also known as heat shock protein-32 and a marker of cellular stress, and corticosterone also were measured. The results indicate neutrophil migration into extravascular liver and lung tissue concurrent with cell stress and consistent with tissue injury or infection induced by sleep loss. Plasma corticosterone was unchanged. Recovery sleep was marked by increased lung heme oxygenase-1, increased intestinal MPO activity, and abnormally low corticosterone, suggesting ongoing reactive processes as a result of prior sleep deprivation.
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Applying the same method of sleep deprivation leads to a breakdown of host defense indicated by a systemic bacterial infection.
“a breakdown of host defense indicated by a systemic bacterial infection was reported after applying the same method of sleep deprivation (172, 175).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [175]
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The Sleep-Immune Crosstalk in Health and Disease
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“However, myeloperoxidase activity in the intestines was increased after recovery sleep compared with baseline and sleepdeprivation levels, suggesting ongoing reactive processes during recovery sleep subsequent to sleep deprivation (174).”
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- Authors
- Everson, C. A., Thalacker, C. D., & Hogg, N.
- Affiliations
- Medical College of Wisconsin (US)
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2008-12
- Volume
- 295
- Issue
- 6
- Pages
- R2067-R2074
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- PMC
- PMC2685300
- OpenAlex
- W1967173369
- Cited by
- 35
- References
- 79
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2020: 3 · 2019: 3 · 2018: 1 · 2016: 2 · 2015: 4 · 2014: 3 · 2012: 4
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (38733, 080744, 59271)
- National Heart, Lung, and Blood Institute
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, sleep recovery, neutrophil migration, phagocytes, myeloperoxidase, heme oxygenase-1, cellular stress, corticosterone, liver, lung, intestine, tissue damage, systemic inflammation
- MeSH terms
- Animals, Cell Movement, Corticosterone, Disease Models, Animal, Heme Oxygenase (Decyclizing), Immunohistochemistry, Intestines, Liver, Lung, Male, Peroxidase, Neutrophils, Sleep, Sleep Deprivation, Stress, Physiological, Time Factors, Rats, Sprague-Dawley, Recovery of Function, Neutrophil Infiltration, Rats
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