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Cited by 146Aortic Disease and Treatment ApproachesConnective tissue disorders researchCongenital Heart Disease Studies

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

A Comparison of Echocardiography and Magnetic Resonance Imaging in Cardiovascular Screening of Adults with Turner Syndrome

Ostberg, Julia E., Brookes, Jocelyn A. S., McCarthy, Carolyn, Halcox, Julian, Conway, Gerard S.·2004·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2004-1090
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Abstract

The high mortality rate from aortic dissection of women with Turner syndrome (TS) achieving ovum donation pregnancies has highlighted the need for a refinement of cardiac screening protocols. Echocardiography and magnetic resonance imaging (MRI) are used to assess the risk factors, aortic root dilatation, bicuspid aortic valve, and coarctation, but the relative merits of each modality are unclear. Cardiovascular screening was performed in 128 unselected women with TS (mean age +/- SD, 31.1 +/- 8.5 yr) using echocardiography (n = 120) and MRI (n = 115) and in 36 age-matched normal control women. Clinical history, anthropometric measurements, blood pressure, and metabolic parameters were recorded. Echocardiography was normal in 53% of women with TS; MRI was normal in 34%. Aortic root dilatation was identified in 16% of women by echocardiography, 33% on MRI criteria, and 7% by both modalities. Height-adjusted echocardiographic aortic root dimensions were greater in TS than controls (2.90 vs. 2.62 cm; P = 0.010). Bicuspid aortic valve and increasing age were associated with greater aortic dimensions; the latter effect was more marked in TS than controls. On MRI, ascending aortic diameter was greater in TS than control women (2.83 vs. 2.52 cm; P = 0.029), but descending aortic diameter and ascending/descending aortic ratio were not, because these may be affected by the presence of coarctation. The two techniques are complementary and identify different aspects of cardiovascular pathology. Ascending/descending ratio on MRI circumvents issues of stature, but may be influenced by descending aortic abnormalities. We present reference ranges for absolute aortic dimensions in a TS population to aid future interpretation of these measurements.

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Metadata

Authors
Ostberg, J. E., Brookes, J. A. S., McCarthy, C., Halcox, J., & Conway, G. S.
Affiliations
University College Hospital (GB)
Corresponding author
Conway, Gerard S.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2004-12
Volume
89
Issue
12
Pages
5966-5971
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2004-1090
OpenAlex
W1992965424
Semantic Scholar
98d416e67e5b845f6a430d0879abc7bbb45d0982
Cited by
146
References
15
Citations by year
2025: 2 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 7 · 2018: 7 · 2017: 7 · 2016: 7 · 2015: 8 · 2014: 10 · 2013: 11 · 2012: 10
FWCI
9.38
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Aortic Disease and Treatment Approaches
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
Keywords
Turner syndrome, cardiovascular screening, aortic root dilatation, aortic dissection, bicuspid aortic valve, coarctation of the aorta, echocardiography, cardiac magnetic resonance imaging, aortic dimensions, reference values, oocyte donation, aortic root dimensions
MeSH terms
Adult, Aorta, Aortic Coarctation, Cardiovascular Diseases, Echocardiography, Female, Humans, Magnetic Resonance Imaging, Middle Aged, Turner Syndrome, Vasodilation, Case-Control Studies

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