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Cited by 39Circadian rhythm and melatoninDiet, Metabolism, and DiseaseRegulation of Appetite and Obesity

Impact of carbohydrate-rich meals on plasma epinephrine levels: dysregulation with aging.

Penev, Plamen, Spiegel, Karine, Marcinkowski, Teresa, Van Cauter, Eve·2005·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2005-0415
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Abstract

CONTEXT: Plasma norepinephrine (NE) and epinephrine (E) levels are indicators of peripheral sympathetic and adrenomedullary activities, respectively. The sympathoadrenomedullary system is involved in the metabolic response to carbohydrate intake and is affected by aging; however, the relationship between glucose metabolism and adrenomedullary activity in older adults remains poorly defined. OBJECTIVE: The objective of this study was to examine the changes in the impact of carbohydrate-rich meals on circulating catecholamines with aging. DESIGN: After iv glucose tolerance testing and 1 d of habituation, blood samples were collected every 10-30 min for 24 h. Daytime hours were spent at bed rest. Sleep was scheduled between 2300 and 0700 h with polygraphic monitoring. SETTING: The study was performed at a general clinical research center. PARTICIPANTS: Nine young (age, 20-28 yr) and eight older (age, 50-69 yr) healthy men participated in this study. INTERVENTION: Identical mixed meals (62% carbohydrate) were given at 0900, 1400, and 1900 h. MAIN OUTCOME MEASURES: The main outcome measures were 24-h plasma E and NE measurements. RESULTS: The profiles of E and NE were characterized by clear day-night differences, which were preserved in the older group. Young subjects showed a clear dissociation between postprandial adrenomedullary and sympathetic activities characterized by a rapid decline in plasma E and increased NE levels. There was an overall increase in NE levels and markedly dampened postprandial variation in plasma E in the older men. CONCLUSIONS: In young adults, postprandial E levels follow a biphasic pattern that is inversely related to that of glucose and insulin. Aging is associated with a dysregulation of this response.

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  • Short-term decreases in sleep quantity or quality alter amount and timing of catabolic hormones (glucocorticoids, catecholamines).

    “alter the amount and timing of catabolic hormones (glucocorticoids [23], catecholamines, [30])”

    From Metabolic effects of sleep disruption, links to obesity and diabetes (2014) · cites this paper as [30]

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Authors
Penev, P., Spiegel, K., Marcinkowski, T., & Van Cauter, E.
Affiliations
  • University of Chicago (US)
  • Université Libre de Bruxelles (BE)
ORCID
Spiegel, Karine
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2005-11
Volume
90
Issue
11
Pages
6198-6206
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2005-0415
OpenAlex
W2080588312
Semantic Scholar
e66c507440c5946bf5ea7af8d2843c9583753100
Cited by
39
References
38
Citations by year
2023: 1 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 2
FWCI
0.60
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Funders
NIH Clinical Center
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
plasma epinephrine, plasma norepinephrine, carbohydrate-rich meal, aging, glucose metabolism, insulin, diurnal variation, older men
MeSH terms
Adult, Aged, Aging, Blood Glucose, Dietary Carbohydrates, Epinephrine, Glucose Tolerance Test, Humans, Insulin, Male, Middle Aged, Sleep, Postprandial Period

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