Fat Oxidation before and after a High Fat Load in the Obese Insulin-Resistant State
Open accessAbstract
BACKGROUND: Obesity may be associated with a lowered use of fat as a fuel, which may contribute to the enlarged adipose tissue stores. AIM: The aim of the present study was to study fatty acid use in the fasting state and in response to a high fat load in a large cohort of obese subjects (n = 701) and a lean reference group (n = 113). METHODS: Subjects from eight European centers underwent a test meal challenge containing 95 en% fat [energy content 50% of estimated resting energy expenditure (EE)]. Fasting and postprandial fat oxidation and circulating metabolites and hormones were determined over a 3-h period. RESULTS: Postprandial fat oxidation (as percent of postprandial EE, adjusted for fat mass, age, gender, center, and energy content of the meal) decreased with increasing body mass index (BMI) category (P < 0.01), an effect present only in those obese subjects with a relatively low fasting fat oxidation (below median, interaction BMI category x fasting fat oxidation, P < 0.001). Fasting fat oxidation increased with increasing BMI category (P < 0.001), which was normalized after adjustment for fat-free mass and fat mass. Furthermore, insulin resistance was positively associated with postprandial fat oxidation (P < 0.05) and negatively associated with fasting fat oxidation (expressed as percent of EE), independent of body composition. CONCLUSIONS: The present data indicate an impaired capacity to regulate fat oxidation in the obese insulin-resistant state, which is hypothesized to play a role in the etiology of both obesity and insulin resistance.
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The relationship between fasting RQ and insulin sensitivity has not always been observed.
“The relationship between fasting RQ and insulin sensitivity, however, has not always been observed.”
From Metabolic flexibility and insulin resistance (2008) · cites this paper as [4]
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- Authors
- Blaak, E. E., Hul, G., Verdich, C., Stich, V., Martinez, A., Petersen, M., Feskens, E. F. M., Patel, K., Oppert, J. M., Barbe, P., Toubro, S., Anderson, I., Polak, J., Astrup, A., Macdonald, I. A., Langin, D., Holst, C., Sørensen, T. I., & Saris, W. H. M.
- Affiliations
- Maastricht University (NL)
- Copenhagen University Hospital (DK)
- University of Nottingham (GB)
- Hôtel-Dieu de Paris (FR)
- Université Toulouse III - Paul Sabatier (FR)
- Karolinska Institutet (SE)
- Charles University (CZ)
- Corresponding author
- Blaak, Ellen E.
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2006-04
- Volume
- 91
- Issue
- 4
- Pages
- 1462-1469
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2112041847
- Cited by
- 97
- References
- 35
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 13 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 7 · 2012: 5
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Rivm (National Institute for Public Health and the Environment) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- fat oxidation, obesity, insulin resistance, body mass index, postprandial energy expenditure, fat-free mass, fat mass, adipose tissue, energy metabolism
- MeSH terms
- Adult, Body Composition, Body Weight, Dietary Fats, Female, Humans, Hydrocortisone, Insulin Resistance, Insulin-Like Growth Factor I, Male, Middle Aged, Obesity, Oxidation-Reduction, Sex Characteristics, Body Mass Index, Area Under Curve, Leptin
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