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Cited by 168Lipid metabolism and biosynthesisMuscle metabolism and nutritionFatty Acid Research and Health

Changes in fat oxidation in response to a high-fat diet

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Schrauwen, P, van Marken Lichtenbelt, WD, Saris, WH, Westerterp, KR·1997·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/66.2.276
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Abstract

Intervention studies have shown that the adaptation of fat oxidation to fat intake, when the dietary fat content is changed, is not abrupt. This study was conducted to measure the time course of adaptation of oxidation rates to increases in the fat content of the diet while subjects were fed at energy balance. Twelve healthy, nonobese males and females [age: 26 +/- 2 y, body mass index (in kg/m2): 21.4 +/- 0.5; and habitual fat intake: 29 +/- 1% of energy] consumed a low-fat diet for 6 d (days 1-6) followed by a high-fat diet for 7 d (days 7-13). Days 5-9 and 13 were spent in a respiration chamber. After adjustment for energy intake to 24-h energy expenditure on day 5, subjects were in energy balance (range: -0.15 to 0.23 kJ/d) on days 6-9 and 13. Fat balance was zero on day 6 but became positive after subjects changed to the high-fat diet (1.06 +/- 0.15, 0.75 +/- 0.15, and 0.55 +/- 0.14 MJ/d for days 7, 8, and 9, respectively, P < 0.05), reaching a new balance on day 13, 7 d afterward. In conclusion, when in energy balance, lean subjects are capable of adjusting fat oxidation to fat intake within 7 d of when dietary fat content is increased.

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Crossref · 10.1093/ajcn/66.2.276

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  • The rate at which fat oxidation adjusts to high fat intake is variable among individuals.

    “The rate at which fat oxidation adjusts to high fat intake is variable among individuals ([21](#r21), [53](#r53)), but only scarce evidence exists about which factors determine this variability.”

    From Metabolic flexibility and insulin resistance (2008) · cites this paper as [53]

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Authors
Schrauwen, P., van Marken Lichtenbelt, W., Saris, W., & Westerterp, K.
Affiliations
Maastricht University (NL)
Corresponding author
Schrauwen, P
ORCID
Schrauwen, P
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
1997-08
Volume
66
Issue
2
Pages
276-282
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/66.2.276
OpenAlex
W1871281387
Cited by
168
References
28
Citations by year
2026: 2 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 7 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 7
FWCI
3.80
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
fat oxidation, high-fat diet, energy balance, fat balance, pulmonary gas exchange, energy expenditure
MeSH terms
Adaptation, Physiological, Adult, Basal Metabolism, Body Composition, Calorimetry, Dietary Fats, Energy Metabolism, Female, Humans, Male, Obesity, Sex Factors, Exercise, Diet Records

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