Mechanisms of endothelial dysfunction in obesity.

Avogaro, Angelo; de Kreutzenberg, Saula Vigili

doi:10.1016/j.cccn.2005.04.020

Cited by 188Nitric Oxide and Endothelin EffectsCardiovascular Disease and AdiposityAdipokines, Inflammation, and Metabolic Diseases

Mechanisms of endothelial dysfunction in obesity.

Avogaro, Angelo, de Kreutzenberg, Saula Vigili·2005·Clinica Chimica Acta

DOI 10.1016/j.cccn.2005.04.020

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Abstract

Obesity is a chronic disease, whose incidence is alarmingly growing, affecting not only adults but also children and adolescents. It is associated with severe metabolic abnormalities and increased cardiovascular morbidity and mortality. Adipose tissue secretes a great number of hormones and cytokines that not only regulate substrate metabolism but may deeply and negatively influence endothelial physiology, a condition which may lead to the formation of the atherosclerotic plaque. In this review, the physiology of the endothelium is summarised and the mechanisms by which obesity, through the secretory products of adipose tissue, influences endothelial function are explained. A short description of methodological approaches to diagnose endothelial dysfunction is presented. The possible pathogenetic links between obesity and cardiovascular disease, mediated by oxidative stress, inflammation and endothelial dysfunction are described as well.

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Authors: Avogaro, A., & de Kreutzenberg, S. V.
Affiliations: University of Padua (IT)
Corresponding author: Avogaro, Angelo
ORCID: Avogaro, Angelo
Venue: Clinica Chimica Acta
Publisher: Elsevier BV
Published: 2005-10
Volume: 360
Issue: 1-2
Pages: 9-26
ISSN: 0009-8981 (ISSN-L)
DOI: 10.1016/j.cccn.2005.04.020
OpenAlex: W2015806050
Cited by: 188
References: 158
Citations by year: 2026: 2 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 9 · 2021: 9 · 2020: 10 · 2019: 7 · 2018: 11 · 2017: 6 · 2016: 10 · 2015: 10 · 2014: 14 · 2013: 13 · 2012: 7
FWCI: 1.42
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinica Chimica Acta (publishedVersion)
PubMed (publishedVersion)
Padua Research Archive (University of Padova) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords: endothelial dysfunction, obesity, adipose tissue hormones, adipokines, cytokines, endothelial physiology, atherosclerosis, cardiovascular disease, oxidative stress, inflammation
MeSH terms: Adipose Tissue, Endothelium, Vascular, Humans, Inflammation, Obesity, Oxidative Stress

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