Relationship of Adolescent Polycystic Ovary Syndrome to Parental Metabolic Syndrome
Abstract
CONTEXT: We determined the relationship of metabolic syndrome (MBS) to polycystic ovary syndrome (PCOS). OBJECTIVE: We tested the hypothesis that parental MBS is related to the PCOS phenotype in their offspring. DESIGN/SETTING: We phenotyped for MBS and PCOS in our General Clinical Research Center. PATIENTS: Girls with PCOS, 12-19 yr old (n = 36, including one pair of siblings), and their parents (35 mothers, 19 fathers) were recruited from the Pediatric Endocrinology Clinic. Healthy girls, 12-19 yr old (n = 21), were recruited as a reference population. INTERVENTIONS: We measured anthropometrics, blood pressure, fasting lipids and androgens, oral glucose tolerance, and ultrasonographically determined polycystic ovary status. MAIN OUTCOME MEASURES: MBS in parents, and PCOS features in mothers, were related to the presence of PCOS features in probands. RESULTS: Fathers had strikingly high prevalence of excess adiposity (94% were obese or overweight) and MBS (79%). Premenopausal mothers more commonly had MBS (36%) than features of PCOS (< or =22%). Polycystic ovaries in proband offspring of premenopausal mothers were associated with maternal polycystic ovaries only in a minority of cases. Proband polycystic ovary status was completely concordant to fathers' MBS status (P = 0.008), but not their own or their mothers' MBS status, in families whose premenopausal mothers lacked polycystic ovaries. Proband prevalence of MBS was 27.8%, 3-fold greater than expected for obesity status. CONCLUSION: Familial factors related to paternal MBS seem to be fundamental to the pathogenesis of PCOS.
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Fasting insulin and 24-hour insulin concentrations as well as stimulated insulin responses to intravenous glucose are elevated in adolescent girls at risk for polycystic ovary syndrome even after adjusting for body mass index.
“Fasting insulin and 24-hour insulin concentrations as well as stimulated insulin responses to intravenous glucose are elevated in adolescent girls at risk for PCOS even after adjusting for BMI [113]”
From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [113]
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Hyperandrogenism, Hirsutism, and Polycystic Ovary Syndrome
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- Authors
- Leibel, N. I., Baumann, E. E., Kocherginsky, M., & Rosenfield, R. L.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Rosenfield, Robert L.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2006-04
- Volume
- 91
- Issue
- 4
- Pages
- 1275-1283
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2129794022
- Cited by
- 118
- References
- 83
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 10 · 2017: 2 · 2016: 3 · 2015: 8 · 2014: 9 · 2013: 12 · 2012: 2
- FWCI
- 9.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- University of Chicago
- U.S. Public Health Service (U54-041859)
- Pfizer Pharmaceuticals
- National Center for Research Resources (RR-00055)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-39267, R01HD039267)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- polycystic ovary syndrome, metabolic syndrome, adolescent girls, parental influence, paternal obesity, family transmission, maternal metabolic syndrome, androgens, insulin resistance, hyperandrogenism
- MeSH terms
- Adolescent, Adult, Androgens, Anthropometry, Blood Pressure, Child, Fathers, Female, Glucose Tolerance Test, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Parents, Phenotype, Polycystic Ovary Syndrome, Metabolic Syndrome, Dyslipidemias, Lipid Metabolism
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