Cited by 275Hormonal and reproductive studiesBone health and osteoporosis researchMenopause: Health Impacts and Treatments

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Testosterone Use in Men and Its Effects on Bone Health. A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials

Tracz, Michal J., Sideras, Kostandinos, Boloña, Enrique R., Haddad, Rudy M., Kennedy, Cassie C., Uraga, Maria V., Caples, Sean M., Erwin, Patricia J., Montori, Victor M.·2006·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2006-0036

Open this paper in CoChat — free account

Abstract

CONTEXT: Androgen-deficient men are at increased risk of osteoporosis. The extent to which testosterone can prevent and treat osteoporosis in men remains unclear. OBJECTIVE AND DESIGN: We performed a systematic review and meta-analysis of randomized placebo-controlled trials in men to estimate the effect of testosterone use on bone health outcomes. DATA SOURCES: The review encompassed librarian-designed search strategies using MEDLINE (1966 to March 2005), EMBASE (1988 to March 2005), and Cochrane CENTRAL (inception to March 2005); a review of reference lists from included studies; and content expert files. DATA COLLECTION: Independently and in duplicate, we assessed the methodological quality of the eligible trials and collected data on bone mineral density and bone fractures at the longest point of complete follow-up. DATA SYNTHESIS: We included eight trials enrolling 365 patients. Two trials followed patients for more than 1 yr. Meta-analysis of these trials showed that, compared with placebo, im testosterone was associated with an 8% (95% confidence interval, 4%, 13%) gain in lumbar bone mineral density and transdermal testosterone had no significant impact. Testosterone use was associated with a nonsignificant 4% (95% confidence interval, -2%, 9%) gain in femoral neck bone mineral density with unexplained differences in results across trials (26% of these differences were not explained by chance alone). No trials measured or reported the effect of testosterone on fractures. CONCLUSIONS: Intramuscular testosterone moderately increased lumbar bone density in men; the results on femoral neck bone density are inconclusive. Without bone fracture data, the available trials offer weak and indirect inferences about the clinical efficacy of testosterone on osteoporosis prevention and treatment in men.

Integrity signals

Registry

Crossref · 10.1210/jc.2006-0036

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763
Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement
Moher, D., Cook, D. J., Eastwood, S., Olkin, I., Rennie, D., & Stroup, D. F. (1999) · The Lancet · doi:10.1016/s0140-6736(99)04149-5 · Cited by 4,826
Interaction revisited: the difference between two estimates.
Altman, D. G., & Bland, J. M. (2003) · BMJ · doi:10.1136/bmj.326.7382.219 · Cited by 3,203
Alendronate for the Treatment of Osteoporosis in Men
ORWOLL, E. S., Ettinger, M. P., Weiss, S. R., Miller, P. D., Kendler, D. L., Graham, J., Adami, S., Weber, K., Lorenc, R. S., Pietschmann, P., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008313430902 · Cited by 971
Testosterone Replacement in Older Hypogonadal Men: A 12-Month Randomized Controlled Trial
Sih, R., Morley, J. E., Kaiser, F. E., Perry, H. M., Patrick, P., & Ross, C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.3988 · Cited by 920
Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men
Falahati-Nini, A., Riggs, B. L., Atkinson, E. J., O’Fallon, W. M., Eastell, R., & Khosla, S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10942 · Cited by 757
Adverse Events Associated With Testosterone Replacement in Middle-Aged and Older Men: A Meta-Analysis of Randomized, Placebo-Controlled Trials
Calof, O. M., Singh, A. B., Lee, M. L., Kenny, A. M., Urban, R. J., Tenover, J. L., & Bhasin, S. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.11.1451 · Cited by 728
Androgens and Bone
Vanderschueren, D., Vandenput, L., Boonen, S., Lindberg, M. K., Bouillon, R., & Ohlsson, C. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0003 · Cited by 717
Effects of testosterone supplementation in the aging male.
Tenover, J. S. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.4.1400877 · Cited by 702
Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis
Isidori, A. M., Giannetta, E., Greco, E. A., Gianfrilli, D., Bonifacio, V., Isidori, A., Lenzi, A., & Fabbri, A. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02339.x · Cited by 695

Flagged first, then by citations

Show all 29 references

Sorted by citations

The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gotzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · BMJ · doi:10.1136/bmj.b2700 · Cited by 17,648
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2009.06.006 · Cited by 10,578
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00136 · Cited by 10,349
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · Italian Journal of Public Health · doi:10.2427/5768 · Cited by 3,374
Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society Clinical Practice Guideline
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2354 · Cited by 1,954
Self-citation
Estrogens and androgens in skeletal physiology and pathophysiology
Almeida, M., Laurent, M. R., Dubois, V., Claessens, F., O'Brien, C. A., Bouillon, R., Vanderschueren, D., & Manolagas, S. C. (2017) · Physiological Reviews · doi:10.1152/physrev.00033.2015 · Cited by 860
European Association of Urology Guidelines on Sexual and Reproductive Health—2021 Update: Male Sexual Dysfunction
Salonia, A., Bettocchi, C., Boeri, L., Capogrosso, P., Carvalho, J., Çilesiz, N. C., Cocci, A., Corona, G., Dimitropoulos, K., Gül, M., et al. (2021) · European Urology · doi:10.1016/j.eururo.2021.06.007 · Cited by 858
Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials
Xu, L., Freeman, G., Cowling, B. J., & Schooling, C. M. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-108 · Cited by 569
Effect of Testosterone Supplementation on Functional Mobility, Cognition, and Other Parameters in Older Men: A Randomized Controlled Trial
Emmelot-Vonk, M. H., Verhaar, H. J. J., Nakhai Pour, H. R., Aleman, A., Lock, T. M. T. W., Bosch, J. L. H. R., Grobbee, D. E., & van der Schouw, Y. T. (2008) · JAMA · doi:10.1001/jama.2007.51 · Cited by 518
Estrogen and bone health in men and women
Cauley, J. A. (2014) · Steroids · doi:10.1016/j.steroids.2014.12.010 · Cited by 484
European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: Endorsing organization: European Society of Endocrinology
Corona, G., Goulis, D. G., Huhtaniemi, I., Zitzmann, M., Toppari, J., Forti, G., Vanderschueren, D., & Wu, F. C. (2020) · Andrology · doi:10.1111/andr.12770 · Cited by 431
The benefits and risks of testosterone replacement therapy: a review
Morley, J. E. (2009) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s3025 · Cited by 381
Secondary Osteoporosis
Ebeling, P. R., Nguyen, H. H., Aleksova, J., Vincent, A. J., Wong, P., & Milat, F. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab028 · Cited by 368
Sex Steroid Actions in Male Bone
Vanderschueren, D., Laurent, M. R., Claessens, F., Gielen, E., Lagerquist, M. K., Vandenput, L., Börjesson, A. E., & Ohlsson, C. (2014) · Endocrine Reviews · doi:10.1210/er.2014-1024 · Cited by 327
Male hypogonadism
Basaria, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61126-5 · Cited by 328
Low Free Testosterone Predicts Frailty in Older Men: The Health in Men Study
Hyde, Z., Flicker, L., Almeida, O. P., Hankey, G. J., McCaul, K. A., Chubb, S. A. P., & Yeap, B. B. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2754 · Cited by 286
Paediatric and adult-onset male hypogonadism
Salonia, A., Rastrelli, G., Hackett, G., Seminara, S. B., Huhtaniemi, I. T., Rey, R. A., Hellstrom, W. J. G., Palmert, M. R., Corona, G., Dohle, G. R., et al. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0087-y · Cited by 286
Testosterone Deficiency in Men: Systematic Review and Standard Operating Procedures for Diagnosis and Treatment
Buvat, J., Maggi, M., Guay, A. T., & Torres, L. O. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02783.x · Cited by 285
Patient-Important Outcomes in Registered Diabetes Trials
Gandhi, G. Y. (2008) · JAMA · doi:10.1001/jama.299.21.2543 · Cited by 251
Onset of effects of testosterone treatment and time span until maximum effects are achieved
Saad, F., Aversa, A., Isidori, A. M., Zafalon, L., Zitzmann, M., & Gooren, L. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0221 · Cited by 232
Endocrine Aspects of Male Sexual Dysfunctions
Buvat, J., Maggi, M., Gooren, L., Guay, A. T., Kaufman, J., Morgentaler, A., Schulman, C., Tan, H. M., Torres, L. O., Yassin, A., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01780.x · Cited by 221
Late-onset hypogonadism: Current concepts and controversies of pathogenesis, diagnosis and treatment
Huhtaniemi, I. T. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.122336 · Cited by 203
Endocrinology of the aging male
de Araújo, A. B., & Wittert, G. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.11.004 · Cited by 184
Effect of pubertal suppression and cross-sex hormone therapy on bone turnover markers and bone mineral apparent density (BMAD) in transgender adolescents
Vlot, M. C., Klink, D. T., den Heijer, M., Blankenstein, M. A., Rotteveel, J., & Heijboer, A. C. (2016) · Bone · doi:10.1016/j.bone.2016.11.008 · Cited by 181
Diagnosis and treatment of late-onset hypogonadism: Systematic review and meta-analysis of TRT outcomes
Corona, G., Rastrelli, G., & Maggi, M. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.05.002 · Cited by 177
New horizons in treatment of osteoporosis
Tabatabaei‐Malazy, O., Salari, P., Khashayar, P., & Larijani, B. A. (2017) · DARU Journal of Pharmaceutical Sciences · doi:10.1186/s40199-017-0167-z · Cited by 164
GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background
Sinnott-Armstrong, N., Naqvi, S., Rivas, M. A., & Pritchard, J. K. (2021) · eLife · doi:10.7554/elife.58615 · Cited by 149
Risks and benefits of testosterone therapy in older men
Spitzer, M., Huang, G., Basaria, S., Travison, T. G., & Bhasin, S. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.73 · Cited by 154
Adult- and late-onset male hypogonadism: the clinical practice guidelines of the Italian Society of Andrology and Sexual Medicine (SIAMS) and the Italian Society of Endocrinology (SIE)
Isidori, A. M., Aversa, A., Calogero, A. E., Ferlin, A., Francavilla, S., Lanfranco, F., Pivonello, R., Rochira, V., Corona, G., & Maggi, M. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-022-01859-7 · Cited by 163
Hypogonadism in the Aging Male Diagnosis, Potential Benefits, and Risks of Testosterone Replacement Therapy
Surampudi, P. N., Wang, C., & Swerdloff, R. S. (2012) · International Journal of Endocrinology · doi:10.1155/2012/625434 · Cited by 154
Testosterone and Bone Health in Men: A Narrative Review
Shigehara, K., Izumi, K., Kadono, Y., & Mizokami, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030530 · Cited by 159
Aging and the Male Reproductive System
Kaufman, J., Lapauw, B., Mahmoud, A., T'Sjoen, G. G., & Huhtaniemi, I. T. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00178 · Cited by 150
Trends in non-medical use of anabolic steroids by U.S. college students: Results from four national surveys
McCabe, S. E., Brower, K. J., West, B. T., Nelson, T. F., & Wechsler, H. (2007) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2007.04.004 · Cited by 143
Targeting metabolic disorders by natural products
Tabatabaei‐Malazy, O., Larijani, B. A., & Abdollahi, M. R. (2015) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/s40200-015-0184-8 · Cited by 136
INTERDISCIPLINARY CLINICAL PRACTICE GUIDELINES "MANAGEMENT OF OBESITY AND ITS COMORBIDITIES"
Dedov, I. I., Shestakova, M. V., Mel'nichenko, G. A., Mazurina, N. V., Andreeva, E. N., Bondarenko, I. Z., Руслановна, Г. З., Dzgoeva, F. K., Елисеев, М. С., Ershova, E. V., et al. (2021) · Obesity and metabolism · doi:10.14341/omet12714 · Cited by 163
Cardiovascular risks and elevation of serum DHT vary by route of testosterone administration: a systematic review and meta-analysis
Borst, S. E., Shuster, J. J., Zou, B., Ye, F., Jia, H., Wokhlu, A., & Yarrow, J. F. (2014) · BMC Medicine · doi:10.1186/s12916-014-0211-5 · Cited by 128
Update in Testosterone Therapy for Men (CME)
Corona, G., Rastrelli, G., Forti, G., & Maggi, M. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.02200.x · Cited by 124
Androgens and Androgen Receptor Actions on Bone Health and Disease: From Androgen Deficiency to Androgen Therapy
Chen, J., Lin, P., Tsai, Y.-R., Yang, Y.-C., & Kang, H. (2019) · Cells · doi:10.3390/cells8111318 · Cited by 129
Outcomes of androgen replacement therapy in adult male hypogonadism: recommendations from the Italian society of endocrinology
Isidori, A. M., Balercia, G., Calogero, A. E., Corona, G., Ferlin, A., Francavilla, S., Santi, D., & Maggi, M. (2014) · Journal of Endocrinological Investigation · doi:10.1007/s40618-014-0155-9 · Cited by 118
Metabolic effects of testosterone replacement therapy on hypogonadal men with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials
Wang, K., Cai, X., Tian, Y., Wu, T., Cao, C., & Li, H. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.122346 · Cited by 113
Why Is Androgen Replacement in Males Controversial?
Cunningham, G. R., & Toma, S. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0266 · Cited by 111
Therapies for Musculoskeletal Disease: Can we Treat Two Birds with One Stone?
Girgis, C. M., Mokbel, N., & DiGirolamo, D. J. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0204-5 · Cited by 110
Testosterone and ill-health in aging men
Yeap, B. B. (2009) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet1050 · Cited by 112
Effects of long-acting testosterone undecanoate on bone mineral density in middle-aged men with late-onset hypogonadism and metabolic syndrome: Results from a 36 months controlled study
Aversa, A., Bruzziches, R., Francomano, D., Greco, E. A., Fornari, R., Luigi, L. D., Lenzi, A., & Migliaccio, S. (2012) · The Aging Male · doi:10.3109/13685538.2011.631230 · Cited by 108
Testosterone deficiency in the aging male
McBride, J. A., Carson, C. C., & Coward, R. M. (2015) · Therapeutic Advances in Urology · doi:10.1177/1756287215612961 · Cited by 109
Impact of Exogenous Testosterone on Mood: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials
Amanatkar, H. R., Chibnall, J. T., Seo, B.-W., Manepalli, J. N., & Grossberg, G. T. (2014) · Annals of Clinical Psychiatry · doi:10.1177/104012371402600103 · Cited by 106
Risks and Benefits of Late Onset Hypogonadism Treatment: An Expert Opinion
Corona, G., Vignozzi, L., Sforza, A., & Maggi, M. (2013) · The World Journal of Men s Health · doi:10.5534/wjmh.2013.31.2.103 · Cited by 101
Musculoskeletal and prostate effects of combined testosterone and finasteride administration in older hypogonadal men: A randomized, controlled trial
Borst, S. E., Yarrow, J. F., Conover, C. F., Nseyo, U., Meuleman, J. R., Lipinska, J. A., Braith, R. W., Beck, D. T., Martin, J. S., Morrow, M., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00592.2013 · Cited by 98
Osteoporosis in Men
Gennari, L., & Bilezikian, J. P. (2007) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2007.03.008 · Cited by 98
Testosterone replacement therapy: for whom, when and how?
Tsametis, C. P., & Isidori, A. M. (2018) · Metabolism · doi:10.1016/j.metabol.2018.03.007 · Cited by 96
Andropause: Current concepts
Singh, P. (2013) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.123552 · Cited by 98
Male sex hormones, aging, and inflammation
Ketchem, J. M., Bowman, E. J., & Isales, C. M. (2023) · Biogerontology · doi:10.1007/s10522-022-10002-1 · Cited by 94
EAA clinical guideline on management of bone health in the andrological outpatient clinic
Rochira, V., Antonio, L., & Vanderschueren, D. (2018) · Andrology · doi:10.1111/andr.12470 · Cited by 90
Guías de práctica clínica en la osteoporosis posmenopáusica, glucocorticoidea y del varón. Sociedad Española de Investigación Ósea y del Metabolismo Mineral
Macías, J. G., Gay, N. G., Alonso, C. G., Barquero, L. M. D. R., Torres, M. M., Delgado‐Rodríguez, M., Pérez-Edo, L., López, J. B. D., Gimeno, E. J., & Carranza, F. H. (2008) · Revista Clínica Española · doi:10.1016/s0014-2565(08)71780-6 · Cited by 84
Male late-onset hypogonadism: pathogenesis, diagnosis and treatment
Huhtaniemi, I., & Forti, G. (2011) · Nature Reviews Urology · doi:10.1038/nrurol.2011.47 · Cited by 88
Musculoskeletal Disorders in Chronic Obstructive Pulmonary Disease
Cielen, N., Maes, K., & Gayan‐Ramirez, G. (2014) · BioMed Research International · doi:10.1155/2014/965764 · Cited by 86
Natesto ™ , a novel testosterone nasal gel, normalizes androgen levels in hypogonadal men
Rogol, A. D., Tkachenko, N., & Bryson, N. (2015) · Andrology · doi:10.1111/andr.12137 · Cited by 87
Muscular responses to testosterone replacement vary by administration route: a systematic review and meta‐analysis
Skinner, J. W., Otzel, D. M., Bowser, A., Nargi, D., Agarwal, S., Peterson, M. D., Zou, B., Borst, S. E., & Yarrow, J. F. (2018) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12291 · Cited by 76
Interventions to prevent and treat corticosteroid-induced osteoporosis and prevent osteoporotic fractures in Duchenne muscular dystrophy
Bell, J. M., Shields, M. D., Watters, J., Hamilton, A., Beringer, T. R. O., Elliott, M., Quinlivan, R. C. M., Tirupathi, S., & Blackwood, B. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010899.pub2 · Cited by 77
Effect of Testosterone Treatment on Bone Microarchitecture and Bone Mineral Density in Men: A 2-Year RCT
Fui, M. N. T., Hoermann, R., Bracken, K., Handelsman, D. J., Inder, W. J., Stuckey, B. G. A., Yeap, B. B., Ghasemzadeh, A., Robledo, K. P., Jesudason, D. R., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab149 · Cited by 80
Testosterone Therapy: What We Have Learned From Trials
Corona, G., Torres, L. O., & Maggi, M. (2020) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2019.11.270 · Cited by 78
Are declining testosterone levels a major risk factor for ill-health in aging men?
Yeap, B. B. (2008) · International Journal of Impotence Research · doi:10.1038/ijir.2008.60 · Cited by 75
Compounded Bioidentical Hormones in Endocrinology Practice: An Endocrine Society Scientific Statement
Santoro, N. F., Braunstein, G. D., Butts, C. L., Martin, K. A., McDermott, M., & Pinkerton, J. V. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1271 · Cited by 75
Benefits and Risks of Testosterone Treatment in Men with Age-Related Decline in Testosterone
dos Santos, M. R., & Bhasin, S. (2020) · Annual Review of Medicine · doi:10.1146/annurev-med-050219-034711 · Cited by 71
Management of Osteoporosis in Men: A Narrative Review
Vescini, F., Chiodini, I., Falchetti, A., Palermo, A., Salcuni, A. S., Bonadonna, S., Geronimo, V. D., Cesareo, R., Giovanelli, L., Brigo, M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413640 · Cited by 71
Testosterone supplementation and bone parameters: a systematic review and meta-analysis study
Corona, G., Vena, W., Pizzocaro, A., Giagulli, V. A., Francomano, D., Rastrelli, G., Mazziotti, G., Aversa, A., Isidori, A. M., Pivonello, R., et al. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01702-5 · Cited by 71
Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone
Weiss, E. P., Shah, K. N., Fontana, L., Lambert, C. P., Holloszy, J. O., & Villareal, D. T. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27265 · Cited by 66
Sclerostin Inhibition Prevents Spinal Cord Injury-Induced Cancellous Bone Loss
Beggs, L. A., Ye, F., Ghosh, P., Beck, D. T., Conover, C. F., Balaez, A., Miller, J. R., Phillips, E. G., Zheng, N. N., Williams, A. A., et al. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2396 · Cited by 67
Testosterone treatment in male patients with Klinefelter syndrome: a systematic review and meta-analysis
Pizzocaro, A., Vena, W., Condorelli, R. A., Radicioni, A. F., Rastrelli, G., Pasquali, D., Selice, R., Ferlin, A., Foresta, C., Jannini, E. A., et al. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01299-1 · Cited by 64
Bone Mineral Status and Bone Loss Over Time in Men with Chronic Systolic Heart Failure and Their Clinical and Hormonal Determinants
Jankowska, E. A., Jakubaszko, J., Cwynar, A., Majda, J., Ponikowska, B., Kustrzycka−Kratochwil, D., Reczuch, K. W., Borodulin-Nadzieja, L., Banasiak, W., Poole-Wilson, P. A., et al. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfn004 · Cited by 63
Serum sex steroid hormones and frailty in older American men of the Third National Health and Nutrition Examination Survey (NHANES III)
Eichholzer, M., Barbir, A., Basaria, S. S., Dobs, A. S., Feinleib, M., Güallar, E., Menke, A., Nelson, W. G., Rifai, N., Platz, E. A., et al. (2012) · The Aging Male · doi:10.3109/13685538.2012.705366 · Cited by 62
Injection of testosterone may be safer and more effective than transdermal administration for combating loss of muscle and bone in older men
Borst, S. E., & Yarrow, J. F. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00111.2015 · Cited by 63
Therapeutic approaches to osteosarcopenia: insights for the clinician
Fatima, M., Brennan-Olsen, S. L., & Duque, G. (2019) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x19867009 · Cited by 84
Testosterone treatment in the aging male: myth or reality?
Nigro, N., & Christ‐Crain, M. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2012.13539 · Cited by 59
Late-Life Onset Hypogonadism: A Review
Bassil, N., & Morley, J. E. (2010) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2010.02.003 · Cited by 59
Genetically predicted sex hormone levels and health outcomes: phenome-wide Mendelian randomization investigation
Yuan, S., Wang, L., Sun, J., Yu, L., Zhou, X., Yang, J., Zhu, Y., Gill, D., Burgess, S., Denny, J. C., et al. (2022) · International Journal of Epidemiology · doi:10.1093/ije/dyac036 · Cited by 60
The aging population – Is there a role for endocrine interventions?
Nass, R. M., Johannsson, G., Christiansen, J. S., Kopchick, J. J., & Thorner, M. O. (2008) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2008.09.002 · Cited by 56
Effect of testosterone therapy on lumbar spine and hip mineral density in elderly men
Basurto, L., Zárate, A., Gómez, R. N. M. M., Vargas, C. D. V., Saucedo, R., & Galván, R. E. (2008) · The Aging Male · doi:10.1080/13685530802273715 · Cited by 56
Anabolic-Androgenic Steroid Use in Sports, Health, and Society
Bhasin, S., Hatfield, D. L., Hoffman, J. R., Kraemer, W. J., LaBotz, M., Phillips, S. M., & Ratamess, N. A. (2021) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002670 · Cited by 63
Associations of insulin‐like growth factor‐I and its binding proteins and testosterone with frailty in older men
Yeap, B. B., Paul Chubb, S. A., Lopez, D., Ho, K. K. Y., Hankey, G. J., & Flicker, L. (2013) · Clinical Endocrinology · doi:10.1111/cen.12052 · Cited by 53
Do low testosterone levels contribute to ill-health during male ageing?
Yeap, B. B., de Araújo, A. B., & Wittert, G. (2012) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2012.725461 · Cited by 53
Transdermal testosterone replacement therapy in men
Koch, C. A., Ullah, M. I., & Riche, D. M. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s43475 · Cited by 54
Androgen Physiology, Pharmacology, and Abuse
Handelsman, D. J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00138-4 · Cited by 54
Late-Onset Hypogonadism
Bassil, N. (2011) · Medical Clinics of North America · doi:10.1016/j.mcna.2011.03.001 · Cited by 50
Osteoporosis in older men: Recent advances in pathophysiology and treatment
Laurent, M. R., Gielen, E., Claessens, F., Boonen, S., & Vanderschueren, D. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.04.010 · Cited by 51
Supraphysiological testosterone enanthate administration prevents bone loss and augments bone strength in gonadectomized male and female rats
Yarrow, J. F., Conover, C. F., Purandare, A. V., Bhakta, A. M., Zheng, N. N., Conrad, B. P., Altman, M. K., Franz, S. E., Wronski, T. J., & Borst, S. E. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90640.2008 · Cited by 51
National Athletic Trainers' Association Position Statement: Anabolic-Androgenic Steroids
Kersey, R. D., Elliot, D. L., Goldberg, L., Kanayama, G., Leone, J. E., Pavlovich, M., & Pope, H. G. (2012) · Journal of Athletic Training · doi:10.4085/1062-6050-47.5.08 · Cited by 73
17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone) exhibits tissue selective anabolic activity: effects on muscle, bone, adiposity, hemoglobin, and prostate
Yarrow, J. F., Conover, C. F., McCoy, S. C., Lipinska, J. A., Santillana, C. A., Hance, J. M., Cannady, D. F., VanPelt, T. D., Sanchez, J., Conrad, B. P., et al. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00440.2010 · Cited by 47
The Current Understanding of Sarcopenia
Delmonico, M. J., & Beck, D. T. (2015) · American Journal of Lifestyle Medicine · doi:10.1177/1559827615594343 · Cited by 53
Gender-Affirming Hormone Treatment Decreases Bone Turnover in Transwomen and Older Transmen
Vlot, M. C., Wiepjes, C. M., de Jongh, R. T., T'Sjoen, G. G., Heijboer, A. C., & den Heijer, M. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3762 · Cited by 48
Effects of oral testosterone undecanoate therapy on bone mineral density and body composition in 322 aging men with symptomatic testosterone deficiency: a 1-year, randomized, placebo-controlled, dose-ranging study
Bouloux, P. M., Legros, J., Elbers, J. M. H., Geurts, T. B. P., Kaspers, M. J. G. H., Meehan, A. G., MEULEMAN, E. J. H., & and for the Study 43203 Investigators (2013) · The Aging Male · doi:10.3109/13685538.2013.773420 · Cited by 46
An update on male hypogonadism therapy
Surampudi, P. N., Swerdloff, R. S., & Wang, C. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.913022 · Cited by 46
Pharmacological management of late-onset hypogonadism
Rastrelli, G., Maggi, M., & Corona, G. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1445969 · Cited by 46
Late‐onset Hypogonadism: Bone health
Rochira, V. (2020) · Andrology · doi:10.1111/andr.12827 · Cited by 49
Management of Osteoporosis in CKD Stages 3 to 5
Gordon, P., & Frassetto, L. A. (2010) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2010.02.338 · Cited by 43
Integrated Therapies for Osteoporosis and Sarcopenia: From Signaling Pathways to Clinical Trials
Girgis, C. M. (2015) · Calcified Tissue International · doi:10.1007/s00223-015-9956-x · Cited by 43
Role of Testosterone in the Pathogenesis, Progression, Prognosis and Comorbidity of Men With Chronic Kidney Disease
Dousdampanis, P., Trigka, K., Fourtounas, C., & Bargman, J. M. (2013) · Therapeutic Apheresis and Dialysis · doi:10.1111/1744-9987.12101 · Cited by 44
Late-onset hypogonadism
Dudek, P., Kozakowski, J., & Zgliczyński, W. (2017) · Menopause Review/Przegląd Menopauzalny · doi:10.5114/pm.2017.68595 · Cited by 43
Dimethandrolone (7α,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone are not converted to aromatic A-ring products in the presence of recombinant human aromatase
Attardi, B., Pham, T. C., Radler, L. M., Burgenson, J., Hild, S. A., & Reel, J. R. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.11.009 · Cited by 40

Authors: Tracz, M. J., Sideras, K., Boloña, E. R., Haddad, R. M., Kennedy, C. C., Uraga, M. V., Caples, S. M., Erwin, P. J., & Montori, V. M.
Affiliations: Mayo Clinic (US)
ORCID: Tracz, Michal J.
Sideras, Kostandinos
Kennedy, Cassie C.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2006-06
Volume: 91
Issue: 6
Pages: 2011-2016
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2006-0036
OpenAlex: W1985066712
Cited by: 275
References: 29
Citations by year: 2026: 8 · 2025: 4 · 2024: 6 · 2023: 12 · 2022: 14 · 2021: 11 · 2020: 14 · 2019: 9 · 2018: 16 · 2017: 15 · 2016: 8 · 2015: 16 · 2014: 24 · 2013: 24 · 2012: 19
FWCI: 1.86
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: Mayo Clinic
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: testosterone, androgen deficiency, male osteoporosis, bone mineral density, lumbar spine, femoral neck, transdermal testosterone, intramuscular testosterone, bone fractures, men's health
MeSH terms: Glucocorticoids, Humans, Male, Osteoporosis, Testosterone, Bone Density, Randomized Controlled Trials as Topic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Testosterone Use in Men and Its Effects on Bone Health. A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks