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Cited by 59Hormonal and reproductive studiesMenopause: Health Impacts and TreatmentsSexual function and dysfunction studies

Late-Life Onset Hypogonadism: A Review

Bassil, Nazem, Morley, John E.·2010·Clinics in Geriatric Medicine
DOI 10.1016/j.cger.2010.02.003
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Abstract

Increased longevity and population aging will increase the number of men with late-onset hypogonadism, a common condition that is often under diagnosed and under treated. The indication of testosterone replacement therapy (TRT) treatment requires the presence of low testosterone level and symptoms and signs of hypogonadism. Although there is a lack of large-scale, long-term studies assessing the benefits and risks of TRT in men with hypogonadism, reports indicate that TRT may produce a wide range of benefits that include improvement in libido and sexual function, bone density, muscle mass, body composition, mood, erythropoiesis, cognition, quality of life, and cardiovascular disease. Perhaps the most controversial area is the issue of risk, especially the possible stimulation of prostate cancer by testosterone, even though there is no evidence to support this risk. Other possible risks include worsening symptoms of benign prostatic hypertrophy, liver toxicity, hyperviscosity, erythrocytosis, worsening untreated sleep apnea, or severe heart failure. Despite this controversy, testosterone supplementation in the United States has increased substantially in the past several years. The physician should discuss with the patient the potential benefits and risks of TRT. This review discusses the benefits and risks of TRT.

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Authors
Bassil, N., & Morley, J. E.
Affiliations
  • Saint Louis University (US)
  • St. Louis VA Medical Center (US)
Corresponding author
Morley, John E.
ORCID
Morley, John E.
Venue
Clinics in Geriatric Medicine
Publisher
Elsevier BV
Published
2010-05
Volume
26
Issue
2
Pages
197-222
ISSN
0749-0690 (ISSN-L)
DOI
10.1016/j.cger.2010.02.003
OpenAlex
W2165214316
Cited by
59
References
215
Citations by year
2026: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 3 · 2014: 8 · 2013: 7 · 2012: 5
FWCI
1.01
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinics in Geriatric Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Keywords
testosterone replacement therapy, androgen deficiency, older men, prostate cancer risk, benign prostatic hyperplasia, hepatotoxicity, erythrocytosis, sleep apnea, cardiovascular risk, sexual function, bone mineral density, quality of life
MeSH terms
Aging, Androgens, Humans, Hypogonadism, Male, Risk Factors, Testosterone, Treatment Outcome, Age of Onset, Hormone Replacement Therapy

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