Impact of obstructive sleep apnea on insulin resistance and glucose tolerance in women with polycystic ovary syndrome
Open accessAbstract
CONTEXT: Insulin resistance, impaired glucose tolerance, and type 2 diabetes are common in women with polycystic ovary syndrome (PCOS). Obstructive sleep apnea (OSA) has been linked to metabolic dysfunction. We studied women with and without PCOS to determine the extent to which OSA is responsible for insulin resistance and glucose intolerance in PCOS. METHODS: In a prospective design, 52 women with PCOS and 21 women without PCOS of similar age and body mass index had an overnight polysomnogram and a 75-g oral glucose tolerance test. RESULTS: Twenty-nine women (56%) with PCOS had OSA compared with four controls (19%) (adjusted odds ratio 7.1; 95% confidence interval, 1.7-45.7; P = 0.01). PCOS women with OSA were more insulin resistant than those without OSA [homeostasis model assessment (HOMA) index 5.7 +/- 0.4 vs. 3.5 +/- 0.4; P = 0.006] after controlling for age, body mass index, and ethnicity. Impaired glucose tolerance was found in 16 of 29 (55%) PCOS women with OSA and only six of 23 (26%) of those without OSA (unadjusted P = 0.049). Insulin resistance and glucose intolerance were highly correlated with the presence and severity of OSA. Among PCOS women with normal glucose tolerance, the presence of OSA was associated with a nearly 2-fold higher fasting insulin level and HOMA index. The severity of OSA was a highly significant predictor of the fasting concentrations of glucose and insulin as well as the 2-h glucose concentration and HOMA index. CONCLUSIONS: OSA is a highly prevalent and important determinant of insulin resistance, glucose intolerance, and type 2 diabetes in PCOS.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The present meta-analysis reported, for the first time, a ~5-fold higher effect estimate for AHI≥5 with symptoms compared to AHI≥5 only outcomes among individuals with PCOS (OR 17.95 vs OR 3.90).
“The present meta-analysis reported, for the first time, a ~5-fold higher effect estimate for AHI≥5 with symptoms compared to AHI≥5 only outcomes among individuals with PCOS (OR: 17.95 vs. OR: 3.90) (15, 17–21, 40).”
From Obstructive sleep apnea syndrome in polycystic ovary syndrome: a systematic review and meta-analysis (2025) · cites this paper as [17]
The Polysomnography section defines OSA as AHI ≥5 without a symptom requirement. The Results report higher odds of OSA in women with PCOS than in controls (OR 7.7), so this study is relevant to the AHI≥5-only outcome. It does not report the meta-analysis’s comparison with a symptomatic outcome or its ORs of 17.95 and 3.90 (pages not available in our copy). (LLM, conf=0.88)
Experimental — accuracy not yet measuredPast cross-sectional studies have shown that obstructive sleep apnea syndrome (OSAS) is highly prevalent in women with polycystic ovary syndrome (PCOS) compared with the general population of reproductive-aged women (17-75% vs. 9-28%).
“Past cross-sectional studies have shown that OSAS is highly prevalent in women with PCOS (15–19) compared with the general population of reproductive-aged women (17-75% vs. 9-28%) (9, 10), with lower rates in adolescents with PCOS (0-57%) (20, 21).”
From Obstructive sleep apnea syndrome in polycystic ovary syndrome: a systematic review and meta-analysis (2025) · cites this paper as [17]
All eight included studies employed polysomnography (PSG) to measure obstructive sleep apnea (OSA).
“All eight studies employed PSG to measure OSAS (as this was an inclusion criterion) (15–21, 40), five of which also assessed the presence of other OSAS-related symptoms such as excessive daytime sleepiness (15, 16, 18, 19, 21).”
From Obstructive sleep apnea syndrome in polycystic ovary syndrome: a systematic review and meta-analysis (2025) · cites this paper as [17]
Only five of the eight included studies adjusted or matched their control group by age, body mass index (BMI) and/or ethnicity.
“with only five of the eight studies having adjusted or matched their control group by age, BMI and/or ethnicity (15, 17, 18, 21, 40).”
From Obstructive sleep apnea syndrome in polycystic ovary syndrome: a systematic review and meta-analysis (2025) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,769 · see citing works
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2002) · Diabetes Care · doi:10.2337/diacare.25.2007.s5 · Cited by 10,320 · see citing works
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) · Diabetes Care · doi:10.2337/diacare.20.7.1183 · Cited by 6,220 · see citing works
Principles and Practice of Sleep Medicine
Kryger, M. H., Roth, T. G., & Dement, W. C. (2011) · Elsevier eBooks · doi:10.1016/c2009-0-59875-3 · Cited by 5,118 · see citing works
Marin, J. M., Carrizo, S. J., Vicente, E., & Agusti, A. G. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71141-7 · Cited by 4,678 · see citing works
McNicholas, W. T., Strohl, K. P., White, D. P., Levy, P. A., Schmidt, W., Wheatley, J. R., Redline, S. S., Carley, D. W., Buysse, D. J., Young, T. B., et al. (1999) · PubMed · Cited by 3,665 · see citing works
The Diagnosis of Polycystic Ovary Syndrome during Adolescence
Witchel, S. F., Oberfield, S., Rosenfield, R. L., Codner, E., Bonny, A., Ibáñez, L., Pena, A., Horikawa, R., Gomez-Lobo, V., Joel, D., et al. (2015) · Hormone Research in Paediatrics · doi:10.1159/000375530 · Cited by 3,113 · see citing works
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis
Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.6.0318 · Cited by 2,761 · see citing works
Franks, S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509283331307 · Cited by 2,463 · see citing works
EEG Arousals: Scoring Rules and Examples
(1992) · SLEEP · doi:10.1093/sleep/15.2.173 · Cited by 2,117 · see citing works
Longitudinal Study of Moderate Weight Change and Sleep-Disordered Breathing
Peppard, P. E. (2000) · JAMA · doi:10.1001/jama.284.23.3015 · Cited by 2,020 · see citing works
Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome
Dunaif, A., Segal, K. R., Futterweit, W., & Dobrjansky, A. (1989) · Diabetes · doi:10.2337/diab.38.9.1165 · Cited by 1,967 · see citing works
Ehrmann, D. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041536 · Cited by 1,884 · see citing works
Self-citationLegro, R. S. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.1.165 · Cited by 1,743 · see citing works
Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome.
Ehrmann, D. A., Barnes, R. B., Rosenfield, R. L., Cavaghan, M. K., & Imperial, J. (1999) · Diabetes Care · doi:10.2337/diacare.22.1.141 · Cited by 1,257 · see citing works
Self-citationPunjabi, N. M. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh261 · Cited by 1,107 · see citing works
Sleep-disordered Breathing and Insulin Resistance in Middle-aged and Overweight Men
Punjabi, N. M., Sorkin, J. D., Katzel, L. I., Goldberg, A. P., Schwartz, A. R., & SMITH, P. L. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.5.2104087 · Cited by 955 · see citing works
Slow-wave sleep and the risk of type 2 diabetes in humans
Tasali, E., Leproult, R., Ehrmann, D. A., & Van Cauter, E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706446105 · Cited by 921 · see citing works
Self-citationSleep duration as a risk factor for the development of type 2 diabetes
Yaggi, H. K., Araujo, A. B., & McKinlay, J. B. (2006) · Diabetes Care · doi:10.2337/diacare.29.03.06.dc05-0879 · Cited by 790 · see citing works
Harsch, I. A., Schahin, S. P., Radespiel-Tröger, M., Weintz, O., Jahreiß, H., Fuchs, F. S., Wiest, G. H., Hahn, E. G., Lohmann, T., Konturek, P. C., et al. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200302-206oc · Cited by 583 · see citing works
Sleep Apnea and Sleep Disruption in Obese Patients
Vgontzas, A. N. (1994) · Archives of Internal Medicine · doi:10.1001/archinte.1994.00420150073007 · Cited by 470 · see citing works
Babu, A. R., Herdegen, J., Fogelfeld, L., Shott, S., & Mazzone, T. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.4.447 · Cited by 453 · see citing works
West, S. D., Nicoll, D. J., Wallace, T. M., Matthews, D. R., & Stradling, J. R. (2007) · Thorax · doi:10.1136/thx.2006.074351 · Cited by 408 · see citing works
Obstructive Sleep Apnea and Type 2 Diabetes
Tasali, E., Mokhlesi, B., & Van Cauter, E. (2008) · Chest · doi:10.1378/chest.07-0828 · Cited by 371 · see citing works
Self-citationVgontzas, A. N., Legro, R. S., Bixler, E. O., Grayev, A., Kales, A., & Chrousos, G. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7185 · Cited by 371 · see citing works
Obstructive sleep apnea and type 2 diabetes
Rasche, K., Keller, T., Tautz, B., Hader, C., Hergenç, G., Antosiewicz, J., Giulio, C. D., & Pokorski, M. (2010) · European journal of medical research · doi:10.1186/2047-783x-15-s2-152 · Cited by 366 · see citing works
Obstructive Sleep Apnea and Metabolic Syndrome: Alterations in Glucose Metabolism and Inflammation
Tasali, E., & Ip, M. S. M. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200708-139mg · Cited by 365 · see citing works
Self-citationFogel, R. B., Malhotra, A., Pillar, G., Pittman, S. D., Dunaif, A., & White, D. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7316 · Cited by 274 · see citing works
Ehrmann, D. A., Kasza, K., Azziz, R., Legro, R. S., & Ghazzi, M. N. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0229 · Cited by 205 · see citing works
Self-citationSeicean, S., Kirchner, H. L., Gottlieb, D. J., Punjabi, N. M., Resnick, H. E., SANDERS, M. H., Budhiraja, R., Singer, M. E., & Redline, S. S. (2008) · Diabetes Care · doi:10.2337/dc07-2003 · Cited by 190 · see citing works
Gopal, M., Duntley, S. P., Uhles, M., & Attarian, H. P. (2002) · Sleep Medicine · doi:10.1016/s1389-9457(02)00033-3 · Cited by 141 · see citing works
Effects of sleep deprivation and exercise on glucose tolerance.
VanHelder, T., Symons, J. D., & Radomski, M. W. (1993) · PubMed · Cited by 119 · see citing works
Differences in Polysomnography Predictors for Hypertension and Impaired Glucose Tolerance
Sulit, L., Storfer‐Isser, A., Kirchner, H. L., & Redline, S. S. (2006) · SLEEP · doi:10.1093/sleep/29.6.777 · Cited by 116 · see citing works
Polycystic Ovary Syndrome and Obstructive Sleep Apnea
Tasali, E., Cauter, E. V., & Ehrmann, D. A. (2008) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.11.001 · Cited by 108 · see citing works
Self-citationPrevalence and Severity of Sleep Apnea in a Group of Morbidly Obese Patients
Daltro, C., Gregório, P. B., Alves, E. S., Abreu, M., Bomfim, D., Chicourel, M. H., Araújo, L. M. B., & Cotrim, H. P. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9147-6 · Cited by 77 · see citing works
Schahin, S. P., Nechanitzky, T., Dittel, C., Fuchs, F. S., Hahn, E. G., Konturek, P. C., Ficker, J. H., & Harsch, I. A. (2008) · PubMed · Cited by 66 · see citing works
Practice patterns of screening for sleep apnea in physicians treating PCOS patients
Subramanian, S., Desai, A. D., Joshipura, M., & Surani, S. (2007) · Sleep And Breathing · doi:10.1007/s11325-007-0120-3 · Cited by 25 · see citing works
Lee-Chiong, T. L., & Polnitsky, C. A. (2007) · Elsevier eBooks · doi:10.1016/b978-075067563-5.10004-5 · Cited by 15 · see citing works
Sleep Apnea and Neuroendocrine Function
Liu, P. Y., Yee, B. J., Phillips, C. L., & Grunstein, R. R. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.03.008 · Cited by 12 · see citing works
(2006) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2006.00540_29.x · Cited by 1 · see citing works
Flagged first, then by citations
6 of the 49 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Lim, S. S., Davies, M. J., Norman, R. J., & Moran, L. J. (2012) · Human Reproduction Update · doi:10.1093/humupd/dms030 · Cited by 939 · see citing works
Effects of poor and short sleep on glucose metabolism and obesity risk
Spiegel, K., Tasali, E., Leproult, R., & Van Cauter, E. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.23 · Cited by 857 · see citing works
Self-citationThe polycystic ovary syndrome: a position statement from the European Society of Endocrinology
Conway, G., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Franks, S., Gambineri, A., Kelestimur, F., Macut, D., Micic, D., Pasquali, R., et al. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0253 · Cited by 676 · see citing works
Obesity and polycystic ovary syndrome
Barber, T., McCarthy, M. I., Wass, J. A. H., & Franks, S. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02587.x · Cited by 655 · see citing works
Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies
Barber, T. M., Hanson, P., Weickert, M. O., & Franks, S. (2019) · Clinical Medicine Insights: Reproductive Health · doi:10.1177/1179558119874042 · Cited by 411 · see citing works
Obesity and polycystic ovary syndrome
Barber, T. M., & Franks, S. (2021) · Clinical Endocrinology · doi:10.1111/cen.14421 · Cited by 385 · see citing works
Endocrine Aspects of Obstructive Sleep Apnea
Attal, P. D., & Chanson, P. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1912 · Cited by 256 · see citing works
Lifestyle management in polycystic ovary syndrome – beyond diet and physical activity
Cowan, S., Lim, S. S., Alycia, C., Pirotta, S., Thomson, R. L., Gibson‐Helm, M. E., Blackmore, R., Naderpoor, N., Bennett, C., Ee, C., et al. (2023) · BMC Endocrine Disorders · doi:10.1186/s12902-022-01208-y · Cited by 285 · see citing works
The sympathetic nervous system in polycystic ovary syndrome: a novel therapeutic target?
Lansdown, A., & Rees, A. (2012) · Clinical Endocrinology · doi:10.1111/cen.12003 · Cited by 165 · see citing works
Fernandez, R., Moore, V., Van Ryswyk, E., Varcoe, T., Rodgers, R., March, W., Moran, L., Avery, J., McEvoy, D., & Davies, M. (2018) · Nature and Science of Sleep · doi:10.2147/nss.s127475 · Cited by 137 · see citing works
Sleep apnoea and visceral adiposity in middle-aged male and female subjects
Kritikou, I., Basta, M., Tappouni, R. F. R., Pejovic, S., Fernández‐Mendoza, J., Nazir, R., Shaffer, M., Liao, D., Bixler, E. O., Chrousos, G. P., et al. (2012) · European Respiratory Journal · doi:10.1183/09031936.00183411 · Cited by 131 · see citing works
Tasali, E., Chapotot, F., Leproult, R., Whitmore, H. R., & Ehrmann, D. A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1187 · Cited by 126 · see citing works
Self-citationHelvaci, N., Karabulut, E., Demir, A. U., & Yildiz, B. O. (2017) · Endocrine Connections · doi:10.1530/ec-17-0129 · Cited by 115 · see citing works
Beroukhim, G., Esencan, E., & Seifer, D. B. (2022) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-022-00889-3 · Cited by 115 · see citing works
Sleep disturbances in a community-based sample of women with polycystic ovary syndrome
Moran, L. J., March, W. A., Whitrow, M. J., Giles, L. C., Davies, M. J., & Moore, V. M. (2015) · Human Reproduction · doi:10.1093/humrep/deu318 · Cited by 98 · see citing works
Sleep disturbances and insulin resistance
Van Cauter, E. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03459.x · Cited by 97 · see citing works
Kahal, H., Kyrou, I., Uthman, O. A., Brown, A., Johnson, S., Wall, P. D. H., Metcalfe, A., Parr, D. G., Tahrani, A. A., & Randeva, H. S. (2020) · Sleep and Breathing · doi:10.1007/s11325-019-01835-1 · Cited by 87 · see citing works
Circadian Rhythms Within the Female HPG Axis: From Physiology to Etiology
Shao, S., Zhao, H., Lu, Z., Lei, X., & Zhang, Y. (2021) · Endocrinology · doi:10.1210/endocr/bqab117 · Cited by 81 · see citing works
Quintessential Risk Factors: Their Role in Promoting Cognitive Dysfunction and Alzheimer’s Disease
Daulatzai, M. A. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0854-6 · Cited by 72 · see citing works
Kahal, H., Kyrou, I., Tahrani, A. A., & Randeva, H. S. (2017) · Clinical Endocrinology · doi:10.1111/cen.13392 · Cited by 70 · see citing works
Cardiometabolic Risk in PCOS: More than a Reproductive Disorder
Torchen, L. C. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0956-2 · Cited by 65 · see citing works
Mokhlesi, B., Scoccia, B., Mazzone, T., & Sam, S. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.12.024 · Cited by 61 · see citing works
Sleep-disordered breathing and daytime napping are associated with maternal hyperglycemia
Izci‐Balserak, B., JACKSON, N. J., Ratcliffe, S. J., Pack, A. I., & Pien, G. W. (2013) · Sleep And Breathing · doi:10.1007/s11325-013-0809-4 · Cited by 60 · see citing works
Lin, T.-Y., Lin, P.-Y., Su, T., Li, C., Lin, W.-C., Chang, W.-H., Chen, T., Bai, Y., & Chen, M. (2017) · Sleep Medicine · doi:10.1016/j.sleep.2016.12.029 · Cited by 56 · see citing works
de Sousa, G., Schlüter, B., Buschatz, D., Menke, T., Trowitzsch, E., Andler, W., & Reinehr, T. (2009) · Sleep And Breathing · doi:10.1007/s11325-009-0276-0 · Cited by 54 · see citing works
Obstructive Sleep Apnea and Cardiovascular Disease
Gopalakrishnan, P. P., & Tak, T. (2011) · Cardiology in Review · doi:10.1097/crd.0b013e318223bd08 · Cited by 54 · see citing works
Pathogenesis and Consequences of Disordered Sleep in PCOS
Sam, S., & Ehrmann, D. A. (2019) · Clinical Medicine Insights Reproductive Health · doi:10.1177/1179558119871269 · Cited by 54 · see citing works
Self-citationVascular Dysfunction in Obstructive Sleep Apnea and Type 2 Diabetes Mellitus
Yim‐Yeh, S., Rahangdale, S., Nguyen, A. T. D., Stevenson, K. E., Novack, V., Veves, A., & Malhotra, A. (2010) · Obesity · doi:10.1038/oby.2010.116 · Cited by 51 · see citing works
Kahal, H., Kyrou, I., Uthman, O., Brown, A., Johnson, S., Wall, P., Metcalfe, A., Tahrani, A. A., & Randeva, H. S. (2018) · Sleep · doi:10.1093/sleep/zsy085 · Cited by 49 · see citing works
Sleep, Circadian Rhythms, and Fertility
Goldstein, C. A., & Smith, Y. R. (2016) · Current Sleep Medicine Reports · doi:10.1007/s40675-016-0057-9 · Cited by 41 · see citing works
Apnea–hypopnea index in nonobese women with polycystic ovary syndrome
Yang, H., Kang, J., Su, H., Tzeng, C., Liu, W., & Huang, S. (2009) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2009.02.004 · Cited by 40 · see citing works
Rani, R., Hajam, Y. A., Kumar, R., Bhat, R. A., Rai, S., & Rather, M. A. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100161 · Cited by 43 · see citing works
Dead adipocytes and metabolic dysfunction: recent progress
West, M. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3283292327 · Cited by 38 · see citing works
Endocrine Physiology in Relation to Sleep and Sleep Disturbances
Cauter, E. V., & Tasali, E. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-6645-3.00026-8 · Cited by 38 · see citing works
Self-citationTock, L., Carneiro, G., Togeiro, S. M., Hachul, H., Pereira, A. Z., Tufik, S., & Zanella, M. T. (2013) · Endocrine Practice · doi:10.4158/ep12366.or · Cited by 35 · see citing works
Disturbed Subjective Sleep in Chinese Females with Type 2 Diabetes on Insulin Therapy
Song, Y., Ye, X., Ye, L., Li, B., Wang, L., & Hua, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054951 · Cited by 34 · see citing works
Zhang, J., Ye, J., Tao, X., Lu, W., Chen, X., & Liu, C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.971604 · Cited by 33 · see citing works
Wagshul, M. E., Sin, S., Lipton, M. L., Shifteh, K., & Arens, R. (2013) · Magnetic Resonance in Medicine · doi:10.1002/mrm.24608 · Cited by 33 · see citing works
Nonalcoholic fatty liver disease and obstructive sleep apnea in women with polycystic ovary syndrome
Doycheva, I., & Ehrmann, D. A. (2022) · Fertility and Sterility · doi:10.1016/j.fertnstert.2022.03.020 · Cited by 33 · see citing works
Self-citationDE SOUSA, G., SCHLÜTER, B., MENKE, T., TROWITZSCH, E., ANDLER, W., & REINEHR, T. (2011) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2010.00902.x · Cited by 28 · see citing works
Lifestyle Modifications in PCOS
Aly, J. M., & DeCherney, A. H. (2020) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000594 · Cited by 27 · see citing works
Adiposity and metabolic dysfunction in polycystic ovary syndrome
Sam, S. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0008 · Cited by 26 · see citing works
Adeva‐Andany, M. M., Domínguez-Montero, A., Castro-Quintela, E., Funcasta-Calderón, R., & Fernández‐Fernández, C. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2506231 · Cited by 24 · see citing works
de Sousa, G., Schlüter, B., Menke, T., Trowitzsch, E., Andler, W., & Reinehr, T. (2011) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2010.0081 · Cited by 24 · see citing works
Polycystic Ovary Syndrome: Features, Diagnostic Criteria and Treatments
Gullo, G. (2014) · Endocrinology & Metabolic Syndrome · doi:10.4172/2161-1017.1000136 · Cited by 23 · see citing works
Role of obstructive sleep apnea in metabolic risk in PCOS
Sam, S., & Tasali, E. (2021) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2021.01.002 · Cited by 21 · see citing works
Self-citationde Sousa, G., Schlüter, B., Buschatz, D., Menke, T., Trowitzsch, E., Andler, W., & Reinehr, T. (2011) · Sleep And Breathing · doi:10.1007/s11325-010-0469-6 · Cited by 21 · see citing works
Bennett, C., Mansfield, D. R., Mo, L., Joham, A. E., Cain, S. W., Blumfield, M., Hodge, A. M., & Moran, L. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521002361 · Cited by 21 · see citing works
A meta-analysis of the relationship between polycystic ovary syndrome and sleep disturbances risk
Wang, C., Huang, T., Song, W., Zhu, J., Liu, Y., Chen, X., Sun, X., Wu, Q., Chen, H., Liao, H., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.957112 · Cited by 19 · see citing works
Hyperandrogenism, Hirsutism, and Polycystic Ovary Syndrome
Rosenfield, R. L., Barnes, R. B., & Ehrmann, D. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00133-5 · Cited by 17 · see citing works
Self-citationPolycystic ovary syndrome in obstructive sleep apnea-hypopnea syndrome: an updated meta-analysis
He, J., Ruan, X., & Li, J. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1418933 · Cited by 16 · see citing works
Gender Differences in Sleep Disordered Breathing—a Review of Literature
Zaw, M., Hein, L., Chacón, A. R., Ascher, K. B., Abreu, A. R., & Chediak, A. D. (2021) · Current Pulmonology Reports · doi:10.1007/s13665-021-00278-y · Cited by 15 · see citing works
Sleep and obstructive sleep apnea in women with infertility
Ibrahim, S., Mehra, R., Tantibhedhyangkul, J., Bena, J., & Flyckt, R. L. (2023) · Sleep And Breathing · doi:10.1007/s11325-022-02770-4 · Cited by 16 · see citing works
Managing nocturia: The multidisciplinary approach
Robinson, D., & Suman, S. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.08.007 · Cited by 14 · see citing works
Obstructive sleep apnea syndrome in polycystic ovary syndrome: a systematic review and meta-analysis
Abdul Jafar, N. K., Al Balushi, A., Subramanian, A., Lee, S. I., Bennett, C. J., Moran, L. J., Mousa, A., Tay, C. T., Teede, H. J., & Mansfield, D. R. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1532519 · Cited by 15 · see citing works
Liu, A., Kim, S. H., Ariel, D., Abbasi, F., Lamendola, C. A., Cardell, J. A., Xu, S., Patel, S., Tomasso, V., Mojaddidi, H., et al. (2016) · Sleep Medicine · doi:10.1016/j.sleep.2016.06.005 · Cited by 13 · see citing works
Beyond counting sheep: Exploring the link between polycystic ovary syndrome and sleep health
Jafar, N. K. A., Bennett, C. J., Moran, L. J., & Mansfield, D. R. (2023) · Seminars in Reproductive Medicine · doi:10.1055/s-0043-1777724 · Cited by 12 · see citing works
The American Diabetes Association's 57th Annual Advanced Postgraduate Course
Bloomgarden, Z. T. (2010) · Diabetes Care · doi:10.2337/dc11-zb01 · Cited by 12 · see citing works
Jafar, N. K. A., Fan, M., Moran, L., Mansfield, D. R., & Bennett, C. (2025) · Clinical Endocrinology · doi:10.1111/cen.15219 · Cited by 14 · see citing works
Endocrine Physiology in Relation to Sleep and Sleep Disturbances
Cauter, E. V., & Tasali, E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00020-9 · Cited by 10 · see citing works
Self-citationde Sousa, G., Schlüter, B., Menke, T., Trowitzsch, E., Andler, W., & Reinehr, T. (2011) · Sleep And Breathing · doi:10.1007/s11325-011-0620-z · Cited by 11 · see citing works
Reda, D. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01903-5 · Cited by 10 · see citing works
Christ, J. P., Shinkai, K., Corley, J., Pasch, L. A., Cedars, M. I., & Huddleston, H. G. (2024) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.11012 · Cited by 10 · see citing works
Ong, Z. L., Chaturvedi, N., Tillin, T., Dale, C. E., & Garfield, V. (2021) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2020-215796 · Cited by 10 · see citing works
Circadian Rhythms in Neuroendocrine Systems
Arble, D. M., Copinschi, G., Vitaterna, M. H., Cauter, E. V., & Turek, F. W. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10012-5 · Cited by 10 · see citing works
Effects of Polycystic Ovary Syndrome and Menopause on Rat Soft Palate and Base of Tongue
Deveci, İ., Sürmeli, M., Deveci, H. S., Eriman, M., Habeşoğlu, M., Tek, A., Misirlioglu, K., & Güneş, P. (2013) · Otolaryngology · doi:10.1177/0194599812473241 · Cited by 9 · see citing works
The Relationship Between Mood and Sleep in Different Female Reproductive States
Polo‐Kantola, P., & Toffol, E. (2023) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2023.06.002 · Cited by 10 · see citing works
Insulin sensitivity and obstructive sleep apnea in adolescents with polycystic ovary syndrome
Underland, L., Kenigsberg, L., AGARWAL, C., Sin, S., Punjabi, N. P., Heptulla, R. A., & Arens, R. (2022) · Minerva Endocrinology · doi:10.23736/s2724-6507.22.03619-3 · Cited by 7 · see citing works
d’Annunzio, G., Russo, C., & Lorini, R. (2010) · Diabetes Care · doi:10.2337/dc10-0827 · Cited by 7 · see citing works
Liu, P., Zhang, Q., Ding, H., & Zou, H. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1429783 · Cited by 7 · see citing works
Sleep Disturbances in General Medical Disorders
Chokroverty, S. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6578-6_47 · Cited by 5 · see citing works
Kahal, H., Kyrou, I., Uthman, O. A., Brown, A., Johnson, S. A., Wall, P. D. H., Metcalfe, A., Tahrani, A. A., & Randeva, H. S. (2017) · Endocrine Abstracts · doi:10.1530/endoabs.50.p339 · Cited by 5 · see citing works
Polycystic ovary syndrome in North America
Shahid, M., & Wajid, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-87932-3.00039-6 · Cited by 4 · see citing works
Sacerdote, A. S., & Bahtiyar, G. (2015) · InTech eBooks · doi:10.5772/58953 · Cited by 4 · see citing works
The polycystic ovary syndrome: a position statement from the European Society of
Conway, G. S., Dewailly, D., Diamanti‐Kandarakis, E., Franks, S., Gambineri, A., Keleştimur, F., Μacut, D., Micić, D., Pasquali, R., Pfeifer, M., et al. (2014) · Cited by 3 · see citing works
Urological Manifestations of Obstructive Sleep Apnea Syndrome: A Review of Current Literature
Dagur, G., & Warren, K. (2015) · Translational Biomedicine · doi:10.21767/2172-0479.100022 · Cited by 3 · see citing works
Ioachimescu, A. G., & Ioachimescu, O. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00132-x · Cited by 3 · see citing works
Correlations between Obesity, Polycystic Ovary Syndrome, and Sleep Apnea: A Meta-Analysis
Jayanti, S. E. R., Widyaningsih, V., & Budihastuti, U. R. (2022) · Journal of Maternal and Child Health · doi:10.26911/thejmch.2022.07.04.07 · Cited by 2 · see citing works
Zignoli, A., Martinez‐Gonzalez, B., Skroče, K., Lipman, D. J., Zisser, H., & Giorgi, A. (2024) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2024-0119 · Cited by 2 · see citing works
de Sousa, G., Schlüter, B., Menke, T., Trowitzsch, E., Andler, W., & Reinehr, T. (2010) · International Journal of Clinical Medicine · doi:10.4236/ijcm.2010.12009 · Cited by 2 · see citing works
Obstructive sleep apnea and polycystic ovary syndrome: cause or association?
Mokhlesi, B., Sam, S., & Ehrmann, D. A. (2017) · Sleep Medicine · doi:10.1016/j.sleep.2017.01.001 · Cited by 2 · see citing works
Self-citationChristou, M., Mintziori, G., Goulis, D. G., & Tarlatzis, B. C. (2023) · ISGE series · doi:10.1007/978-3-031-22378-5_8 · Cited by 2 · see citing works
Malhotra, A., Nischal, N., Pandey, R., Sinha, S., Saha, S., & Singh, S. (2022) · The Indian Journal of Chest Diseases and Allied Sciences · doi:10.5005/jp-journals-11007-0021 · Cited by 1 · see citing works
Polycystic Ovary Syndrome and Obstructive Sleep Apnea
Aubuchon, M. (2020) · Current clinical neurology · doi:10.1007/978-3-030-40842-8_13 · Cited by 1 · see citing works
Stracquadanio, M., & Ciotta, L. (2015) · Springer eBooks · doi:10.1007/978-3-319-16760-2_3 · Cited by 1 · see citing works
Polycystic Ovary Syndrome and Metabolic Syndrome
Pesant, M.-H., & Baillargeon, J. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-192-5_14 · Cited by 1 · see citing works
Синдром поликистозных яичников. Официальное заявление Европейского общества эндокринологии
Conway, G. S., Dewailly, D., & Diamanti‐Kandarakis, E. (2015) · The Scientific Issues of Ternopil Volodymyr Hnatiuk National Pedagogical University Series pedagogy · doi:10.18370/2309-4117.2015.25.32-52 · Cited by 1 · see citing works
Polycystic Ovary Syndrome and Obstructive Sleep Apnea
Aubuchon, M. (2013) · Humana Press eBooks · doi:10.1007/978-1-62703-324-4_11 · Cited by 1 · see citing works
Alteraciones del sueño en las enfermedades médicas generales
Chokroverty, S. (2011) · Elsevier eBooks · doi:10.1016/b978-84-8086-733-7.00033-4 · Cited by 1 · see citing works
Visceral fat and cardiovascular risk in patients with polycystic ovary syndrome
Cascella, T., Palomba, S., Giallauria, F., de Sio, I., Colao, A., Lombardi, G., Orio, M., & Orio, F. (2009) · Clinical Lipidology · doi:10.2217/clp.09.55 · Cited by 1 · see citing works
World Congress on the Insulin Resistance Syndrome, 2009
Bloomgarden, Z. T. (2010) · Diabetes Care · doi:10.2337/dc10-zb10
Lansdown, A. (2016) · ORCA Online Research @Cardiff (Cardiff University)
Anxiety and Other Psychological Issues in PCOS
Barry, J. A. (2019) · Springer eBooks · doi:10.1007/978-3-030-30290-0_3
Dixit, R., Verma, S., Jalutharia, J., & Sharma, A. (2018) · RUHS Journal of Health Science · doi:10.37821/ruhsjhs.3.1.2018.43-53
Sleep-Related Breathing Disorders
Kryger, M. H., Rosenberg, R. P., Pegram, G. V., & Martin, L. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-2651-0.00010-8
Chouhan, S., Haldar, A., Singh, R., & Shrivastava, R. (2021) · Journal of Applied Sciences and Clinical Practice · doi:10.4103/jascp.jascp_7_20
Sleep Disturbances in General Medical Disorders
Chokroverty, S. (2009) · Elsevier eBooks · doi:10.1016/b978-0-7506-7584-0.00033-1
Ehrmann, D. A., & Sam, S. (2022) · doi:10.1093/med/9780198870197.003.0160
Self-citationPolycystic Ovary Syndrome and Metabolic Syndrome
Carreau, A., Pesant, M.-H., & Baillargeon, J. (2019) · Contemporary Endocrinology · doi:10.1007/978-3-030-25057-7_16
Kyrou, I., Kahal, H., Weickert, M. O., Barber, T. M., & Randeva, H. S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823045-9.00029-8
- Authors
- Tasali, E., Van Cauter, E., Hoffman, L., & Ehrmann, D. A.
- Affiliations
- University of Chicago (US)
- Endocrinology, Diabetes, and Metabolism (E.V.C., L.H., D.A.E.), The University of Chicago, Chicago, Illinois 60637
- Corresponding author
- Ehrmann, David A.
- ORCID
- Tasali, Esra
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2008-10-01
- Volume
- 93
- Issue
- 10
- Pages
- 3878-3884
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC2579653
- OpenAlex
- W2065404502
- Cited by
- 111
- References
- 49
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 5 · 2023: 9 · 2022: 10 · 2021: 8 · 2020: 2 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 6 · 2012: 6
- FWCI
- 8.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Chicago
- National Institutes of Health
- National Institute on Aging (P01AG011412)
- National Heart, Lung, and Blood Institute (R01HL075079)
- National Institute of Diabetes and Digestive and Kidney Diseases (P60DK020595)
- National Center for Research Resources (P41RR013642, M01RR000055)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD057796)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- obstructive sleep apnea, polycystic ovary syndrome, insulin resistance, impaired glucose tolerance, type 2 diabetes, women, HOMA index, fasting insulin, OSA severity, metabolic dysfunction
- MeSH terms
- Adult, Arousal, Female, Glucose Tolerance Test, Humans, Insulin Resistance, Polycystic Ovary Syndrome, Prospective Studies, Case-Control Studies, Polysomnography, Glucose Intolerance, Sleep Apnea, Obstructive
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
