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The Fall in Leptin Concentration Is a Major Determinant of the Metabolic Adaptation Induced by Caloric Restriction Independently of the Changes in Leptin Circadian Rhythms
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“leptin explained 6 % of the variance in AT only [49, 57].”
From Changes in energy expenditure with weight gain and weight loss in humans (2016) · cites this paper as [57]
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Changes in Energy Expenditure Resulting from Altered Body Weight
Leibel, R. L., Rosenbaum, M., & Hirsch, J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321001 · Cited by 2,012
Rosenbaum, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25977 · Cited by 575
Redman, L. M., Heilbronn, L. K., Martin, C. K., de Jonge, L., Williamson, D. A., Delany, J. P., Ravussin, E., & for the Pennington CALERIE team (2009) · PLoS ONE · doi:10.1371/journal.pone.0004377 · Cited by 355
Adaptive thermogenesis in humans
Rosenbaum, M., & Leibel, R. L. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.184 · Cited by 349
Effect of calorie restriction on resting metabolic rate and spontaneous physical activity.
Martin, C. K., Heilbronn, L. K., de Jonge, L., DeLany, J. P., Volaufova, J., Anton, S. D., Redman, L. M., Smith, S. R., & Ravussin, E. (2007) · Obesity · doi:10.1038/oby.2007.354 · Cited by 237
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Research works printed but not linked: 22
- [1]1. Doucet E, Imbeault P, St. Pierre S, Alméras N, Mauriège P, Després JP, Bouchard C, Tremblay A. 2003. Greater than predicted decrease in energy expenditure during exercise after body weight loss in obese men. Clin Sci (Lond) 105:89–95 [DOI] [PubMed] [Google Scholar]
- [3]3. Rosenbaum M, Murphy EM, Heymsfield SB, Matthews DE, Leibel RL. 2002. Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab 87:2391–2394 [DOI] [PubMed] [Google Scholar]
- [4]4. Rosenbaum M, Hirsch J, Gallagher DA, Leibel RL. 2008. Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight. Am J Clin Nutr 88:906–912 [DOI] [PubMed] [Google Scholar]
- [5]5. Rosenbaum M, Nicolson M, Hirsch J, Heymsfield SB, Gallagher D, Chu F, Leibel RL. 1996. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 81:3424–3427 [DOI] [PubMed] [Google Scholar]
- [6]6. Leibel RL. 2002. The role of leptin in the control of body weight. Nutr Rev 60:S15–S19; discussion S68–S84, S85–S87 [DOI] [PubMed] [Google Scholar]
- [8]8. Crujeiras AB, Goyenechea E, Abete I, Lage M, Carreira MC, Martínez JA, Casanueva FF. 2010. Weight regain after a diet-induced loss is predicted by higher baseline leptin and lower ghrelin plasma levels. J Clin Endocrinol Metab 95:5037–5044 [DOI] [PubMed] [Google Scholar]
- [9]9. Ravussin E, Pratley RE, Maffei M, Wang H, Friedman JM, Bennett PH, Bogardus C. 1997. Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med 3:238–240 [DOI] [PubMed] [Google Scholar]
- [10]10. Doucet E, St. Pierre S, Alméras N, Mauriège P, Richard D, Tremblay A. 2000. Changes in energy expenditure and substrate oxidation resulting from weight loss in obese men and women: is there an important contribution of leptin? J Clin Endocrinol Metab 85:1550–1556 [DOI] [PubMed] [Google Scholar]
- [11]11. Labayen I, Ortega FB, Ruiz JR, Lasa A, Simon E, Margareto J. 2011. Role of baseline leptin and ghrelin levels on body weight and fat mass changes after an energy-restricted diet intervention in obese women: effects on energy metabolism. J Clin Endocrinol Metab 96:E996–E1000 [DOI] [PubMed] [Google Scholar]
- [12]12. Wadden TA, Considine RV, Foster GD, Anderson DA, Sarwer DB, Caro JS. 1998. Short- and long-term changes in serum leptin dieting obese women: effects of caloric restriction and weight loss. J Clin Endocrinol Metab 83:214–218 [DOI] [PubMed] [Google Scholar]
- [13]13. Galgani JE, Greenway FL, Caglayan S, Wong ML, Licinio J, Ravussin E. 2010. Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin-deficient patients. J Clin Endocrinol Metab 95:851–855 [DOI] [PMC free article] [PubMed] [Google Scholar]
- [15]15. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. 1996. Role of leptin in the neuroendocrine response to fasting. Nature 382:250–252 [DOI] [PubMed] [Google Scholar]
- [16]16. Heilbronn LK, de Jonge L, Frisard MI, DeLany JP, Larson-Meyer DE, Rood J, Nguyen T, Martin CK, Volaufova J, Most MM, Greenway FL, Smith SR, Deutsch WA, Williamson DA, Ravussin E. 2006. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA 295:1539–1548 [DOI] [PMC free article] [PubMed] [Google Scholar]
- [19]19. Licinio J, Negrão AB, Mantzoros C, Kaklamani V, Wong ML, Bongiorno PB, Negro PP, Mulla A, Veldhuis JD, Cearnal L, Flier JS, Gold PW. 1998. Sex differences in circulating human leptin pulse amplitude: clinical implications. J Clin Endocrinol Metab 83:4140–4147 [DOI] [PubMed] [Google Scholar]
- [20]20. Saad MF, Riad-Gabriel MG, Khan A, Sharma A, Michael R, Jinagouda SD, Boyadjian R, Steil GM. 1998. Diurnal and ultradian rhythmicity of plasma leptin: effects of gender and adiposity. J Clin Endocrinol Metab 83:453–459 [DOI] [PubMed] [Google Scholar]
- [21]21. Havel PJ, Townsend R, Chaump L, Teff K. 1999. High-fat meals reduce 24-h circulating leptin concentrations in women. Diabetes 48:334–341 [DOI] [PubMed] [Google Scholar]
- [22]22. Kasa-Vubu JZ, Barkan A, Olton P, Meckmongkol T, Carlson NE, Foster CM. 2002. Incomplete modified fast in obese early pubertal girls leads to an increase in 24-hour growth hormone concentration and a lessening of the circadian pattern in leptin. J Clin Endocrinol Metab 87:1885–1893 [DOI] [PubMed] [Google Scholar]
- [23]23. Weigle DS, Cummings DE, Newby PD, Breen PA, Frayo RS, Matthys CC, Callahan HS, Purnell JQ. 2003. Roles of leptin and ghrelin in the loss of body weight caused by a low fat, high carbohydrate diet. J Clin Endocrinol Metab 88:1577–1586 [DOI] [PubMed] [Google Scholar]
- [24]24. Matkovic V, Ilich JZ, Badenhop NE, Skugor M, Clairmont A, Klisovic D, Landoll JD. 1997. Gain in body fat is inversely related to the nocturnal rise in serum leptin level in young females. J Clin Endocrinol Metab 82:1368–1372 [DOI] [PubMed] [Google Scholar]
- [25]25. R Development Core Team 2010. R: a language and environment for statistical computing. Version 2.11.1 ed. Vienna: R Foundation for Statistical Computing, http://www.R-project.org [Google Scholar]
- [26]26. Tremblay A, Pelletier C, Doucet E, Imbeault P. 2004. Thermogenesis and weight loss in obese individuals: a primary association with organochlorine pollution. Int J Obes Relat Metab Disord 28:936–939 [DOI] [PubMed] [Google Scholar]
- [27]27. Esterbauer H, Oberkofler H, Dallinger G, Breban D, Hell E, Krempler F, Patsch W. 1999. Uncoupling protein-3 gene expression: reduced skeletal muscle mRNA in obese humans during pronounced weight loss. Diabetologia 42:302–309 [DOI] [PubMed] [Google Scholar] Articles from The Journal of Clinical Endocrinology and Metabolism are provided here courtesy of The Endocrine Society
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Metadata
- Authors
- Lecoultre, V., Ravussin, E., & Redman, L. M.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2011-09
- Volume
- 96
- Issue
- 9
- Pages
- E1512-E1516
- ISSN
- 0021-972X
- 1945-7197
- Cited by
- 74
- References
- 5
- Language
- en
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