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Cited by 237Regulation of Appetite and ObesityDietary Effects on HealthObesity, Physical Activity, Diet

Effect of calorie restriction on resting metabolic rate and spontaneous physical activity.

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Martin, Corby K., Heilbronn, Leonie K., de Jonge, Lilian, DeLany, James P., Volaufova, Julia, Anton, Stephen D., Redman, Leanne M., Smith, Steven R. +1 more·2007·Obesity
DOI 10.1038/oby.2007.354
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Abstract

Objective: It is unclear if resting metabolic rate (RMR) and spontaneous physical activity (SPA) decrease in weight‐reduced non‐obese participants. Additionally, it is unknown if changes in SPA, measured in a respiratory chamber, reflect changes in free‐living physical activity level (PAL). Research Methods and Procedures: Participants (N = 48) were randomized into 4 groups for 6 months: calorie restriction (CR, 25% restriction), CR plus structured exercise (CR+EX, 12.5% restriction plus 12.5% increased energy expenditure via exercise), low‐calorie diet (LCD, 890 kcal/d supplement diet until 15% weight loss, then weight maintenance), and control (weight maintenance). Measurements were collected at baseline, Month 3, and Month 6. Body composition and RMR were measured by DXA and indirect calorimetry, respectively. Two measures of SPA were collected in a respiratory chamber (percent of time active and kcal/d). Free‐living PAL (PAL = total daily energy expenditure by doubly labeled water/RMR) was also measured. Regression equations at baseline were used to adjust RMR for fat‐free mass and SPA (kcal/d) for body weight. Results: Adjusted RMR decreased at Month 3 in the CR group and at Month 6 in the CR+EX and LCD groups. Neither measure of SPA decreased significantly in any group. PAL decreased at Month 3 in the CR and LCD groups, but not in the CR+EX group, who engaged in structured exercise. Changes in SPA in the chamber and free‐living PAL were not related. Discussion: Body weight is defended in non‐obese participants during modest caloric restriction, evidenced by metabolic adaptation of RMR and reduced energy expenditure through physical activity.

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  • Higher resting vagal tone in bulimia nervosa may be due to decreased resting metabolic rate originating from limited calorie intake.

    “There are some exceptions to this general rule (e.g., Stein et al., 2005; Peschel et al., 2016), for example when a higher resting vagal tone level is observed in the case of eating disorders such as bulimia nervosa (Peschel et al., 2016), which may be due to decreased resting metabolic rate originating from limited calorie intake (Martin et al., 2007).”

    From Heart Rate Variability and Cardiac Vagal Tone in Psychophysiological Research – Recommendations for Experiment Planning, Data Analysis, and Data Reporting (2017) · cites this paper as Martin et al., 2007

    The Metabolic Adaptation results (page unavailable) report that resting metabolic rate decreased in the calorie-restricted groups. The paper does not establish that this decrease explains higher resting vagal tone in bulimia nervosa; that proposed link extends beyond its findings. (LLM, conf=0.86)

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  • The 2-4% reduction in energy expenditure after resveratrol is consistent with the 6% reduction observed after calorie restriction.

    “The 2-4% reduction in energy expenditure upon resveratrol treatment is consistent with the effects observed after calorie restriction (6% reduction) (Heilbronn et al., 2006; Martin et al., 2007).”

    From Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans (2011) · cites this paper as Martin et al., 2007

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Authors
Martin, C. K., Heilbronn, L. K., de Jonge, L., DeLany, J. P., Volaufova, J., Anton, S. D., Redman, L. M., Smith, S. R., & Ravussin, E.
Affiliations
  • Pennington Biomedical Research Center (US)
  • Garvan Institute of Medical Research (AU)
  • University of Pittsburgh (US)
Corresponding author
Martin, Corby K.
ORCID
Venue
Obesity
Publisher
Wiley
Published
2007-12
Volume
15
Issue
12
Pages
2964-2973
ISSN
  • 1930-7381 (ISSN-L)
  • 1930-739X
DOI
10.1038/oby.2007.354
OpenAlex
W2128090166
Cited by
237
References
33
Citations by year
2026: 6 · 2025: 3 · 2024: 9 · 2023: 7 · 2022: 10 · 2021: 15 · 2020: 11 · 2019: 7 · 2018: 16 · 2017: 11 · 2016: 22 · 2015: 13 · 2014: 22 · 2013: 12 · 2012: 19
FWCI
5.03
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1741 d)
Locations
  • Obesity (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders
  • National Institutes of Health (5k23dk068052-04)
  • National Institute on Aging (U01AG020478, U01-AG20478)
  • National Institute of Diabetes and Digestive and Kidney Diseases (1K23 DK 068052-01A2, P30DK072476)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
caloric restriction, resting metabolic rate, spontaneous physical activity, weight loss, non-obese adults, metabolic adaptation, structured exercise, hypocaloric diet, energy expenditure, body composition
MeSH terms
Adult, Basal Metabolism, Body Weight, Energy Metabolism, Female, Humans, Male, Middle Aged, Motor Activity, Weight Loss, Body Mass Index, Caloric Restriction, Overweight

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