Improved hepatic lipid composition following short-term exercise in nonalcoholic fatty liver disease
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CONTEXT: Hepatic steatosis, insulin resistance, inflammation, low levels of polyunsaturated lipids, and adiponectin are implicated in the development and progression of nonalcoholic fatty liver disease (NAFLD). OBJECTIVE: We examined the effects of short-term aerobic exercise on these metabolic risk factors. DESIGN AND PARTICIPANTS: Obese individuals (N = 17, 34.3 ± 1.0 kg/m²) with clinically confirmed NAFLD were enrolled in a short-term aerobic exercise program that consisted of 7 consecutive days of treadmill walking at ~85% of maximal heart rate for 60 minutes per day. Preintervention and postintervention measures included hepatic triglyceride content, and a lipid saturation index and polyunsaturated lipid index (PUI) of the liver, obtained by (1)H magnetic resonance spectroscopy (N = 14). Insulin sensitivity was estimated from an oral glucose tolerance test (OGTT), and mononuclear cells were isolated to assess reactive oxygen species production during the OGTT. Circulating glucose, insulin, and high molecular weight (HMW) adiponectin were determined from plasma. MAIN OUTCOME: Short-term aerobic exercise training improved hepatic lipid composition in patients with NAFLD. RESULTS: Exercise training resulted in an increase in liver PUI (P < .05), increased insulin sensitivity (Matsuda Index: P < .05), HMW adiponectin (P < .05), and maximal oxygen consumption (P < .05). Reactive oxygen species production during the OGTT was reduced following exercise training (P < .05). HMW adiponectin was increased after the exercise program and the increase was positively correlated with the increase in liver PUI (r = 0.52, P = .05). Body weight remained stable during the program (P > .05). CONCLUSION: Short-term exercise can target hepatic lipid composition, which may reduce the risk of NAFLD progression. The improvement in hepatic lipid composition may be driven by adiponectin.
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Aerobic exercise can decrease serum levels of resistin and increase levels of high molecular weight adiponectin.
“Studies have shown that aerobic exercise can decrease serum levels of resistin and increase levels of high molecular weight adiponectin, indicating potential benefits for individuals with conditions like hypertension and MASLD (73–75).”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [74]
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Self-citation
- Authors
- Haus, J. M., Solomon, T. P. J., Kelly, K. R., Fealy, C. E., Kullman, E. L., Scelsi, A. R., Lu, L., Pagadala, M. R., McCullough, A. J., Flask, C. A., & Kirwan, J. P.
- Affiliations
- Cleveland Clinic (US)
- Department of Pathobiology (J.M.H., T.P.J.S., K.R.K., C.E.F., E.L.K., A.R.S., J.P.K.), Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195;
- Department of Radiology (L.L., C.A.F.), Case Western Reserve University, Cleveland, Ohio 44195;
- Case Western Reserve University (US)
- Corresponding author
- Kirwan, John P.
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2013-07-01
- Volume
- 98
- Issue
- 7
- Pages
- E1181-E1188
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC3701282
- OpenAlex
- W2013629598
- Cited by
- 100
- References
- 42
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 13 · 2023: 8 · 2022: 9 · 2021: 12 · 2020: 8 · 2019: 3 · 2018: 8 · 2017: 5 · 2016: 6 · 2015: 9 · 2014: 11
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Case Western Reserve University
- Georgia Clinical and Translational Science Alliance (1UL1RR024989)
- National Institutes of Health (UL1TR000439, CTSA 1UL1RR024989, AG12834)
- National Institute on Aging (R01AG012834, R01AG12834)
- National Heart, Lung, and Blood Institute (T32HL007887)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK061917, DK061917)
- National Center for Research Resources (UL1RR024989, CTSA 1UL1RR024989)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- non-alcoholic fatty liver disease, aerobic exercise, hepatic lipid composition, polyunsaturated fatty acids, adiponectin, insulin sensitivity, hepatic steatosis, reactive oxygen species, obesity, treadmill walking, VO2max, hepatic triglycerides
- MeSH terms
- Fatty Liver, Female, Humans, Insulin Resistance, Leukocytes, Mononuclear, Liver, Male, Middle Aged, Molecular Weight, Motor Activity, Obesity, Ohio, Risk Factors, Triglycerides, Biomarkers, Exercise, Body Mass Index, Walking, Oxidative Stress, Intra-Abdominal Fat, Lipid Metabolism, Adiponectin, Non-alcoholic Fatty Liver Disease
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