Effect of aerobic and resistance exercise training on liver enzymes and hepatic fat in Iranian men with nonalcoholic fatty liver disease

Shamsoddini, Alireza; Sobhani, Vahid; Ghamar Chehreh, Mohammad Ebrahim; Alavian, Seyed Moayed; Zaree, Ali

doi:10.5812/hepatmon.31434

Cited by 126Liver Disease Diagnosis and TreatmentPhysical Activity and HealthExercise and Physiological Responses

Effect of aerobic and resistance exercise training on liver enzymes and hepatic fat in Iranian men with nonalcoholic fatty liver disease

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Shamsoddini, Alireza, Sobhani, Vahid, Ghamar Chehreh, Mohammad Ebrahim, Alavian, Seyed Moayed, Zaree, Ali·2015·Hepatitis Monthly

DOI 10.5812/hepatmon.31434PMC PMC4644631

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Abstract

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) has different prevalence rates in various parts of the world and is a risk factor for diabetes and cardiovascular disease that could progress to nonalcoholic steatohepatitis, cirrhosis, and liver failure. OBJECTIVES: The current study aimed to investigate the effect of Aerobic Training (AT) and resistance training (RT) on hepatic fat content and liver enzyme levels in Iranian men. PATIENTS AND METHODS: In a randomized clinical trial study, 30 men with clinically defined NAFLD were allocated into three groups (aerobic, resistance and control). An aerobic group program consisted of 45 minutes of aerobic exercise at 60% - 75% maximum heart rate intensity, a resistance group performed seven resistance exercises at intensity of 50% - 70% of 1 repetition maximum (1RM ) and the control group had no exercise training program during the study. Before and after training, anthropometry, insulin sensitivity, liver enzymes and hepatic fat were elevated. RESULTS: After training, hepatic fat content was markedly reduced, to a similar extent, in both the aerobic and resistance exercise training groups (P ≤ 0.05). In the two exercise training groups, alanine amino transferase and aspartate amino transferase serum levels were significantly decreased compared to the control group (P = 0.002) and (P = 0.02), respectively. Moreover, body fat (%), fat mass (kg), homeostasis model assessment insulin resistance (HOMI-IR) were all improved in the AT and RT. These changes in the AT group were independent of weight loss. CONCLUSIONS: This study demonstrated that RT and AT are equally effective in reducing hepatic fat content and liver enzyme levels among patients with NAFLD. However, aerobic exercise specifically improves NAFLD independent of any change in body weight.

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Two RCTs found both aerobic and resistance training significantly reduced liver steatosis.
“Two RCTs found both aerobic and resistance training significantly reduced liver steatosis [66, 90].”
From Effects of Mediterranean diet, exercise, and their combination on body composition and liver outcomes in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of randomized controlled trials (2025) · cites this paper as [90]
Based on seven protocols from seven studies, a reduction in hepatic steatosis was observed in 85.7% of resistance exercise protocols, including five randomized controlled trials.
“Based on seven protocols from seven studies, a reduction in hepatic steatosis was observed in 85.7% of the protocols, including five randomized controlled trials (76–82).”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [81]

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Comments on “The Effects of Aerobic and Resistance Exercise Training on Liver Enzymes and Hepatic Fat in Iranian Men With Nonalcoholic Fatty Liver Disease”
Cheraghpour, M., Hekmatdoost, A., & Ghaemi, A. (2016) · Hepatitis Monthly · doi:10.5812/hepatmon.35162
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Comments on “The Effects of Aerobic and Resistance Exercise Training on Liver Enzymes and Hepatic Fat in Iranian Men With Nonalcoholic Fatty Liver Disease”
Cheraghpour, M., Hekmatdoost, A., & Ghaemi, A. (2016) · Hepatitis Monthly · doi:10.5812/hepatmon.35162
The Effect of Combined Aerobic and Resistance Training on Hepatic Enzymes in Males With Nonalcoholic Fatty Liver
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Jayaraman, K. (2021) · Gastroenterology Hepatology and Endoscopy Practice · doi:10.4103/ghep.ghep_39_21
Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 randomized trial)
Bacchi, E., Negri, C., Targher, G., Faccioli, N., Lanza, M., Zoppini, G., Zanolin, E., Schena, F., Bonora, E., & Moghetti, P. (2013) · Hepatology · doi:10.1002/hep.26393 · Cited by 350 · see citing works

Authors: Shamsoddini, A., Sobhani, V., Ghamar Chehreh, M. E., Alavian, S. M., & Zaree, A.
Affiliations: Baqiyatallah University of Medical Sciences (IR)
Corresponding author: Alavian, Seyed Moayed
ORCID: Shamsoddini, Alireza
Sobhani, Vahid
Alavian, Seyed Moayed
Venue: Hepatitis Monthly
Publisher: Brieflands
Published: 2015-10-10
Volume: 15
Issue: 10
Pages: e31434-e31434
ISSN: 1735-143X (ISSN-L)
1735-3408
DOI: 10.5812/hepatmon.31434
PMC: PMC4644631
OpenAlex: W2212486231
Cited by: 126
References: 56
Citations by year: 2026: 8 · 2025: 9 · 2024: 14 · 2023: 15 · 2022: 16 · 2021: 18 · 2020: 14 · 2019: 10 · 2018: 11 · 2017: 5 · 2016: 6
FWCI: 5.75
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Hepatitis Monthly (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Funders: Baqiyatallah University of Medical Sciences
Topics: Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Physiology › Physical Activity and Health
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords: non-alcoholic fatty liver disease, aerobic exercise training, resistance training, hepatic fat content, liver enzymes, alanine aminotransferase, aspartate aminotransferase, insulin resistance, fat mass, men

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Effect of aerobic and resistance exercise training on liver enzymes and hepatic fat in Iranian men with nonalcoholic fatty liver disease

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