Cited by 128Stress Responses and CortisolRegulation of Appetite and ObesityNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Excessive Sugar Consumption May Be a Difficult Habit to Break: A View From the Brain and Body

Open access

Tryon, Matthew S., Stanhope, Kimber L., Epel, Elissa S., Mason, Ashley E., Brown, Rashida, Medici, Valentina, Havel, Peter J., Laugero, Kevin D.·2015·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2014-4353PMC PMC4454811

Open this paper in CoChat — free account Open PDF

Abstract

CONTEXT: Sugar overconsumption and chronic stress are growing health concerns because they both may increase the risk for obesity and its related diseases. Rodent studies suggest that sugar consumption may activate a glucocorticoid-metabolic-brain-negative feedback pathway, which may turn off the stress response and thereby reinforce habitual sugar overconsumption. OBJECTIVE: The objective of the study was to test our hypothesized glucocorticoid-metabolic-brain model in women consuming beverages sweetened with either aspartame of sucrose. DESIGN: This was a parallel-arm, double-masked diet intervention study. SETTING: The study was conducted at the University of California, Davis, Clinical and Translational Science Center's Clinical Research Center and the University of California, Davis, Medical Center Imaging Research Center. PARTICIPANTS: Nineteen women (age range 18-40 y) with a body mass index (range 20-34 kg/m(2)) who were a subgroup from a National Institutes of Health-funded investigation of 188 participants assigned to eight experimental groups. INTERVENTION: The intervention consisted of sucrose- or aspartame-sweetened beverage consumption three times per day for 2 weeks. MAIN OUTCOME MEASURES: Salivary cortisol and regional brain responses to the Montreal Imaging Stress Task were measured. RESULTS: Compared with aspartame, sucrose consumption was associated with significantly higher activity in the left hippocampus (P = .001). Sucrose, but not aspartame, consumption associated with reduced (P = .024) stress-induced cortisol. The sucrose group also had a lower reactivity to naltrexone, significantly (P = .041) lower nausea, and a trend (P = .080) toward lower cortisol. CONCLUSION: These experimental findings support a metabolic-brain-negative feedback pathway that is affected by sugar and may make some people under stress more hooked on sugar and possibly more vulnerable to obesity and its related conditions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1210/jc.2014-4353

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets
Maldjian, J. A., Laurienti, P. J., Kraft, R., & Burdette, J. H. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00169-1 · Cited by 5,066
A new predictive equation for resting energy expenditure in healthy individuals
Mifflin, M., St Jeor, S., Hill, L., Scott, B., Daugherty, S., & Koh, Y. (1990) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/51.2.241 · Cited by 2,544 · cited 1×
“We used the Mifflin equation (16) with a 1.”
Method
Endocrinology of the stress response
Charmandari, E., Tsigos, C., & Chrousos, G. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040403.120816 · Cited by 1,799
Stress, eating and the reward system
Adam, T. C., & Epel, E. S. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.011 · Cited by 1,732
Self-citation
Chronic stress and obesity: a new view of “comfort food”
Dallman, M. F., Pecoraro, N., Akana, S. F., la Fleur, S. E., Gomez, F., Houshyar, H., Bell, M. E., Bhatnagar, S., Laugero, K. D., & Manalo, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1934666100 · Cited by 1,369
Self-citation
CRF and CRF receptors: role in stress responsivity and other behaviors
Bale, T. L., & Vale, W. W. (2004) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121410 · Cited by 1,270
A new view on hypocortisolism
Fries, E., Hesse, J., Hellhammer, J., & Hellhammer, D. H. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.04.006 · Cited by 1,204
Brain on stress: how the social environment gets under the skin
McEwen, B. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121254109 · Cited by 1,200
Emotional influences on food choice: Sensory, physiological and psychological pathways
Gibson, E. L. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.01.024 · Cited by 783
Corticotropin-releasing factor, norepinephrine, and stress
Koob, G. F. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00164-x · Cited by 629

Show all 37 references

Sorted by citations

More than a feeling: A unified view of stress measurement for population science
Epel, E. S., Crosswell, A. D., Mayer, S. E., Prather, A. A., Slavich, G. M., Puterman, E., & Mendes, W. B. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.03.001 · Cited by 1,077
“For example, consuming high sugar beverages (Tryon et al., 2015), smoking (Wardle et al.”
BackgroundSelf-citation
Sugar consumption, metabolic disease and obesity: The state of the controversy
Stanhope, K. L. (2016) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2015.1084990 · Cited by 739
Self-citation
Stress, depression, diet, and the gut microbiota: human–bacteria interactions at the core of psychoneuroimmunology and nutrition
Madison, A. A., & Kiecolt‐Glaser, J. K. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.01.011 · Cited by 383
Adolescent Obesity: Diet Quality, Psychosocial Health, and Cardiometabolic Risk Factors
Ruiz, L. D., Zuelch, M. L., Dimitratos, S. M., & Scherr, R. E. (2019) · Nutrients · doi:10.3390/nu12010043 · Cited by 336
The impact of sugar consumption on stress driven, emotional and addictive behaviors
Jacques, A., Chaaya, N., Beecher, K., Ali, S. A., Belmer, A., & Bartlett, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.021 · Cited by 271
Simultaneous measurement of salivary cortisol and alpha-amylase: Application and recommendations
Strahler, J., Skoluda, N., Kappert, M. B., & Nater, U. M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.015 · Cited by 272
Food Addiction, High-Glycemic-Index Carbohydrates, and Obesity
Lennerz, B. S., & Lennerz, J. K. (2017) · Clinical Chemistry · doi:10.1373/clinchem.2017.273532 · Cited by 172
A commentary on the “eating addiction” versus “food addiction” perspectives on addictive-like food consumption
LaFata, E. M., Potenza, M. N., & Gearhardt, A. N. (2016) · Appetite · doi:10.1016/j.appet.2016.10.033 · Cited by 176
Emotions and Food Consumption: Emotional Eating Behavior in a European Population
Ljubičić, M., Sarić, M. M., Klarin, I., Rumbak, I., Barić, I. C., Ranilović, J., Dželalija, B., Sarić, A., Nakić, D., Djekic, I. V., et al. (2023) · Foods · doi:10.3390/foods12040872 · Cited by 110
Role of oxytocin in the control of stress and food intake
Onaka, T., & Takayanagi, Y. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12700 · Cited by 102
Food cue reactivity in food addiction: A functional magnetic resonance imaging study
LaFata, E. M., Yokum, S., Jahn, A., & Gearhardt, A. N. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112574 · Cited by 87
Hair cortisol levels, perceived stress and body mass index in women and children living in socioeconomically disadvantaged neighborhoods: the READI study
Olstad, D. L., Ball, K., Wright, C. R., Abbott, G., Brown, E. L., & Turner, A. I. (2016) · Stress · doi:10.3109/10253890.2016.1160282 · Cited by 73
The Cambridge Handbook of Substance and Behavioral Addictions
Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591 · Cited by 64
Transforming Life: A Broad View of the Developmental Origins of Health and Disease Concept from an Ecological Justice Perspective
Prescott, S. L., & Logan, A. C. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13111075 · Cited by 70
Relationship between adherence to Dietary Approaches to Stop Hypertension (DASH) diet indices and incidence of depression during up to 8 years of follow-up
Perez‐Cornago, A., Sánchez‐Villegas, A., Bes‐Rastrollo, M., Gea, A., Molero, P., Lahortiga‐Ramos, F., & Martínez‐González, M. Á. (2016) · Public Health Nutrition · doi:10.1017/s1368980016001531 · Cited by 70
Stress, self-regulation, and context: Evidence from the health and retirement survey
Mezuk, B. R., Ratliff, S. M., Concha, J. B., Abdou, C. M., Rafferty, J. A., Lee, H. E., & Jackson, J. S. (2017) · SSM - Population Health · doi:10.1016/j.ssmph.2017.05.004 · Cited by 66
Diet and Bipolar Disorder: A Review of Its Relationship and Potential Therapeutic Mechanisms of Action
Lopresti, A. L., & Jacka, F. N. (2015) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2015.0125 · Cited by 62
Energetic stress: The reciprocal relationship between energy availability and the stress response
Harrell, C. S., Gillespie, C. F., & Neigh, G. N. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.10.009 · Cited by 51
Behavioral Economic Considerations of Novel Addictions and Nonaddictive Behavior: Research and Analytic Methods
Reed, D. D., Naudé, G. P., Gelino, B. W., & Amlung, M. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.011 · Cited by 48
Cookie or clementine? Psychophysiological stress reactivity and recovery after eating healthy and unhealthy comfort foods
Finch, L. E., Cummings, J. R., & Tomiyama, A. J. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.04.022 · Cited by 52
The Prevention and Treatment of Gambling Disorders: Some Art, Some Science
Derevensky, J. L. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.024 · Cited by 45
Considering the Overlap and Nonoverlap of Compulsivity, Impulsivity, and Addiction
Blum, A. W., & Grant, J. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.038 · Cited by 44
Neurobiological Foundations of Behavioral Addictions
Vaccaro, A. G., & Potenza, M. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.016 · Cited by 45
Neurobiology of Substance Addictions
Christie, N. C., & Bechara, A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.015 · Cited by 44
Sensitization of Incentive Salience and the Transition to Addiction
Warlow, S. M., Baumgartner, H. M., Freeland, C. M., Naffziger, E. E., Olney, J. J., Berridge, K. C., & Robinson, M. J. F. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.006 · Cited by 46
Self-medication with sucrose
Ulrich‐Lai, Y. M. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.02.015 · Cited by 54
Mindfulness-Based Interventions Applied to Addiction Treatments
Kechter, A., & Black, D. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.040 · Cited by 43
Multiple Memory Systems, Addiction, and Health Habits: New Routes for Translational Science
Stacy, A. W., Pike, J. R., & Lee, A. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.017 · Cited by 43
Tanning as an Addiction: The State of the Research and Implications for Intervention
Miller, K. A., & Mays, D. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.037 · Cited by 43
Food versus Eating Addictions
Schulte, E. M., Schiestl, E. T., & Gearhardt, A. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.035 · Cited by 43
Behavioral Economics and Addictive Disorders
Jarmolowicz, D. P., & Schneider, T. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.005 · Cited by 42
Prevention and Treatment of Compulsive Buying Disorder
Galimov, A., & Black, D. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.027 · Cited by 42
Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis
Blum, K., Roy, A. K., Podesta, A., Modestino, E. J., Steinberg, B., Gondré-Lewis, M. C., Baron, D. A., Thanos, P. K., Lott, L., Badgaiyan, S., et al. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.031 · Cited by 42
Prevention and Treatment of “Food Addiction”
Davis, C., & Mason, A. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.023 · Cited by 42
Self-citation
Human Neurobiological Approaches to Hedonically Motivated Behaviors
Burger, K. S., Shearrer, G. E., & Sadler, J. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.009 · Cited by 42
Feedback Models for Gambling Control: The Use and Efficacy of Online Responsible Gambling Tools
Griffiths, M. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.034 · Cited by 42
Effects of Consuming Sugar-Sweetened Beverages for 2 Weeks on 24-h Circulating Leptin Profiles, Ad Libitum Food Intake and Body Weight in Young Adults
Sigala, D. M., Widaman, A. M., Hieronimus, B., Nuñez, M. V., Lee, V., Benyam, Y., Bremer, A. A., Medici, V., Havel, P. J., Stanhope, K. L., et al. (2020) · Nutrients · doi:10.3390/nu12123893 · Cited by 40
Self-citation
Differential effects of eating and drinking on wellbeing—An ecological ambulatory assessment study
Strahler, J., & Nater, U. M. (2017) · Biological Psychology · doi:10.1016/j.biopsycho.2017.01.008 · Cited by 39
The Energy Costs of Prematurity and the Neonatal Intensive Care Unit (NICU) Experience
Tan, J. B. C., Boskovic, D. S., & Angeles, D. M. (2018) · Antioxidants · doi:10.3390/antiox7030037 · Cited by 34
Obesity in pregnancy—Long‐term effects on offspring hypothalamic‐pituitary‐adrenal axis and associations with placental cortisol metabolism: A systematic review
Volqvartz, T., Andersen, H. H., Pedersen, L. H., & Larsen, A. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16184 · Cited by 31
DRD2/ANKK1 TaqI A1 polymorphism associates with overconsumption of unhealthy foods and biochemical abnormalities in a Mexican population
Rivera‐Íñiguez, I., Panduro, A., Ramos-López, O., Villaseñor-Bayardo, S. J., & Román, S. (2018) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-018-0596-9 · Cited by 32
A Landscape of Subjective and Objective Stress in African-American Dementia Family Caregivers
Cothran, F. A., Chang, E., Beckett, L., Bidwell, J. T., Price, C. A., & Gallagher-Thompson, D. (2022) · Western Journal of Nursing Research · doi:10.1177/01939459211062956 · Cited by 30
Diet Quality for Sodium and Vegetables Mediate Effects of Whole Food Diets on 8-Week Changes in Stress Load
Soltani, H., Keim, N. L., & Laugero, K. D. (2018) · Nutrients · doi:10.3390/nu10111606 · Cited by 32
Self-citation
Investigating the perceived psychological stress in relevance to urban spaces’ different perceived personalities
Elrafie, N. S. S., Hassan, G. F., Fayoumi, M. A. E., & Ismail, A. (2023) · Ain Shams Engineering Journal · doi:10.1016/j.asej.2023.102116 · Cited by 27
Association between physiological stress load and diet quality patterns differs between male and female adults
Dimitratos, S. M., Hercules, M., Stephensen, C. B., Cervantes, E., & Laugero, K. D. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113538 · Cited by 24
Self-citation
Highly processed food intake and immediate and future emotions in everyday life
Cummings, J. R., Schiestl, E. T., Tomiyama, A. J., Mamtora, T., & Gearhardt, A. N. (2021) · Appetite · doi:10.1016/j.appet.2021.105868 · Cited by 27
Impact of the COVID-19 Pandemic on Changes in Consumer Purchasing Behavior in the Food Market with a Focus on Meat and Meat Products—A Comprehensive Literature Review
Żurek, J., & Rudy, M. (2024) · Foods · doi:10.3390/foods13060933 · Cited by 37
History of child maltreatment and excessive dietary and screen time behaviors in young adults: Results from a nationally representative study
Cammack, A. L., Gazmararian, J. A., & Suglia, S. F. (2020) · Preventive Medicine · doi:10.1016/j.ypmed.2020.106176 · Cited by 21
Soft drink consumption and mental health problems: Longitudinal relations in children and adolescents
Kadel, P., Schneider, S. O., & Mata, J. (2020) · Social Science & Medicine · doi:10.1016/j.socscimed.2020.113123 · Cited by 21
How Does Our Brain Process Sugars and Non-Nutritive Sweeteners Differently: A Systematic Review on Functional Magnetic Resonance Imaging Studies
Yeung, A. W. K., & Wong, N. S. M. (2020) · Nutrients · doi:10.3390/nu12103010 · Cited by 21
Real-World Intake of Dietary Sugars Is Associated with Reduced Cortisol Reactivity Following an Acute Physiological Stressor
Polito, N. D., Stylianakis, A. A., Richardson, R., & Baker, K. (2023) · Nutrients · doi:10.3390/nu15010209 · Cited by 23
Stress differentially regulates brain expression of corticotropin-releasing factor in binge-like eating prone and resistant female rats
Calvez, J., de Ávila, C., Guèvremont, G., & Timofeeva, E. (2016) · Appetite · doi:10.1016/j.appet.2016.09.010 · Cited by 21
Associations of maternal fructose and sugar-sweetened beverage and juice intake during lactation with infant neurodevelopmental outcomes at 24 months
Berger, P. K., Plows, J. F., Jones, R. B., Alderete, T. L., Rios, C., Pickering, T. A., Fields, D. A., Bode, L., Peterson, B. S., & Goran, M. I. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa255 · Cited by 20
Stress Management as an Effective Complementary Therapeutic Strategy for Weight Loss in Children and Adolescents with Obesity: A Systematic Review of Randomized Controlled Trials
Paltoglou, G., Chrousos, G. P., & Bacopoulou, F. (2021) · Children · doi:10.3390/children8080670 · Cited by 17
Healthy versus unhealthy comfort eating for psychophysiological stress recovery in low-income Black and Latinx adults
Standen, E. C., Finch, L. E., Tiongco-Hofschneider, L., Schopp, E. M., Lee, K. M., Parker, J. E., Bamishigbin, O. N., & Tomiyama, A. J. (2022) · Appetite · doi:10.1016/j.appet.2022.106140 · Cited by 20
Validity of mental and physical stress models
Hendry, E., McCallister, B., Elman, D. J., Freeman, R. L., Borsook, D., & Elman, I. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105566 · Cited by 18
Association of perceived ethnic discrimination with general and abdominal obesity in ethnic minority groups: the HELIUS study
Schmengler, H., Ikram, U. Z., Snijder, M. B., Kunst, A. E., & Agyemang, C. O. (2016) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2016-207875 · Cited by 16
Increasing Dietary Carbohydrate as Part of a Healthy Whole Food Diet Intervention Dampens Eight Week Changes in Salivary Cortisol and Cortisol Responsiveness
Soltani, H., Keim, N. L., & Laugero, K. D. (2019) · Nutrients · doi:10.3390/nu11112563 · Cited by 16
Self-citation
The relationship between perceived stress and emotional eating among university students in Saudi Arabia
ElZayat, A., Sultan, S., Alharthi, S., Jamal, D., Abdullah, A., & Albusati, N. (2025) · Discover Mental Health · doi:10.1007/s44192-025-00215-4 · Cited by 23
Microbes, oxytocin and stress: Converging players regulating eating behavior
Cuesta‐Marti, C., Uhlig, F., Muguerza, B., Hyland, N. P., Clarke, G. A., & Schellekens, H. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13243 · Cited by 17
Effects of Consuming Beverages Sweetened with Fructose, Glucose, High-Fructose Corn Syrup, Sucrose, or Aspartame on OGTT-Derived Indices of Insulin Sensitivity in Young Adults
Hieronimus, B., Medici, V., Lee, V., Nuñez, M. V., Sigala, D. M., Bremer, A. A., Cox, C. L., Keim, N. L., Schwarz, J., Pacini, G., et al. (2024) · Nutrients · doi:10.3390/nu16010151 · Cited by 16
Self-citation
Tea-induced calmness: Sugar-sweetened tea calms consumers exposed to acute stressor
Samant, S. S., Wilkes, K., Odek, Z., & Seo, H. (2016) · Scientific Reports · doi:10.1038/srep36537 · Cited by 15
A Brief Motivational Intervention Differentially Reduces Sugar-sweetened Beverage (SSB) Consumption
Mason, A. E., Schmidt, L. A., Ishkanian, L., Jacobs, L. M., Leung, C. W., Jensen, L., Cohn, M., Schleicher, S., Hartman, A. R., Wojcicki, J. M., et al. (2021) · Annals of Behavioral Medicine · doi:10.1093/abm/kaaa123 · Cited by 13
Self-citation
Appetitive Needs and Addiction
Sussman, S. Y., & Pakdaman, S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.004 · Cited by 12
Limited cheese intake reduces HPA axis and behavioral stress responses in male rats
Fourman, S. M., Buesing, D. R., Girvin, S., Nashawi, H., & Ulrich‐Lai, Y. M. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113614 · Cited by 11
Understanding food insecurity in Los Angeles County during the COVID-19 pandemic and its aftermath: A qualitative interview study
Scott, J. J., de Bruin, W. B., Rabinovich, L., Frazzini, A., & de la Haye, K. (2024) · Appetite · doi:10.1016/j.appet.2024.107323 · Cited by 11
Lower ΔFosB expression in the dopaminergic system after stevia consumption in rats housed under environmental enrichment conditions
Salinas-Velarde, I. D., Bernal‐Morales, B., Pacheco, P., Sánchez-Aparicio, P., Pascual-Mathey, L. I., & Venebra-Muñoz, A. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.10.001 · Cited by 10
Commentary: Reconsidering the Role of Context in Diabetes Prevention
Mezuk, B. R., Concha, J. B., Perrin, P. B., & Green, T. (2017) · Ethnicity & Disease · doi:10.18865/ed.27.1.63 · Cited by 10
What’s eating you? Risk factors for poor health behaviors among family caregivers
Koumoutzis, A., & Cichy, K. E. (2020) · Aging & Mental Health · doi:10.1080/13607863.2020.1805722 · Cited by 9
Effect of nutritive and non-nutritive sweeteners on hemodynamic responses to acute stress: a randomized crossover trial in healthy women
Cros, J., Bidlingmeyer, L., Rosset, R., Seyssel, K., Crézé, C., Stefanoni, N., Schneiter, P., & Tappy, L. (2020) · Nutrition and Diabetes · doi:10.1038/s41387-019-0104-y · Cited by 9
Qualitative Approaches to the Study of Substance and Behavioral Addictions
Simpson, K. A., & Bluthenthal, R. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.013 · Cited by 10
Internalizing symptoms modulate real-world affective response to sweet food and drinks in children
Mason, T. B., Naya, C. H., Schembre, S. M., Smith, K. E., & Dunton, G. F. (2020) · Behaviour Research and Therapy · doi:10.1016/j.brat.2020.103753 · Cited by 7
Joint associations of regular exercise and healthy diet with psychobiological stress reactivity in a healthy male sample
Strahler, J., Wurst, R., Fuchs, R., & Wunsch, K. (2021) · Stress · doi:10.1080/10253890.2021.1878496 · Cited by 7
Multimodal Neuroimaging of Obesity: From Structural-Functional Mechanisms to Precision Interventions
Liu, W., Li, N., Tang, D., Qin, L., & Zhu, Z. (2025) · Brain Sciences · doi:10.3390/brainsci15050446 · Cited by 6
Is there a link between depression, neurochemical asymmetry and cardiovascular function?
Segarra, A. B., Prieto, I., Martínez‐Cañamero, M., & Ramírez‐Sánchez, M. (2020) · AIMS neuroscience · doi:10.3934/neuroscience.2020022 · Cited by 6
Substance and Behavioral Addictions Assessment Instruments
Grigsby, T. J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.012 · Cited by 6
What nutritional physiology tells us about diet, sugar and obesity
Tappy, L. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.11 · Cited by 5
Prenatal Sugar Consumption and Late-Life Human Capital and Health: Analyses Based on Postwar Rationing and Polygenic ScoresPreprint
von Hinke, S., van den Berg, G. J., & Wang, R. A. H. (2022) · SSRN Electronic Journal · doi:10.1920/wp.ifs.2022.3822 · Cited by 5
High-Fructose Diet and Chronic Unpredictable Stress Modify Each Other’s Neurobehavioral Effects in Female Rats
Kovačević, S., Pavković, Ž., Brkljačić, J. M., Elaković, I., Milutinović, D. V., Djordjevic, A. D., & Pešić, V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111721 · Cited by 5
Prevention and Treatment of Sex Addiction
Reid, R. C., Grubbs, J. B., & Kraus, S. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.025 · Cited by 4
Self-Regulatory Coping Behaviors and Stress Reactivity: Exploring the Environmental Affordance Model of Health Disparities
Mezuk, B. R., Kalesnikava, V. A., Spears, E. C., Kirk, K. F., Rafferty, J. A., & Toro, J. D. (2022) · Journal of Aging and Health · doi:10.1177/08982643221085403 · Cited by 3
Gaming Disorder and Its Treatment
Griffiths, M. D., Kuss, D. J., & Pontes, H. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.029 · Cited by 6
Treatment of Alcohol, Tobacco, and Other Drug (ATOD) Misuse
Sussman, S. Y., & Bolshakova, M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.022 · Cited by 3
The Role of Culture in Addiction
Hoffman, B. R., & Unger, J. B. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.018 · Cited by 3
Prenatal sugar exposure shapes late-life human capital and health
van den Berg, G. J., von Hinke, S., & Wang, R. A. H. (2025) · PNAS Nexus · doi:10.1093/pnasnexus/pgaf301 · Cited by 6
Depression symptoms and sweet foods consumption in Mexican college men: the role of emotional eating
Irigoyen‐Camacho, M. E., Lazarevich, I., Zepeda‐Zepeda, M. A., Velázquez-Alva, M. C., & Sánchez‐Pérez, L. (2023) · Nutrición Hospitalaria · doi:10.20960/nh.04493 · Cited by 2
Slow starch digestibility promotes the development of favorable feeding behaviors and metabolic health in mice
Jian, Y., Cheng, L., Hong, Y., Li, Z., Li, C., Ban, X., Zhu, L., & Gu, Z. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117062 · Cited by 2
Nutritional Impact of Child-Directed TV Food Advertising Regulation: Are We Rearranging the Deck Chairs on the Titanic?
Silva, A., Higgins, L. M., & Kulesz, M. M. (2016) · Journal of the Association for Consumer Research · doi:10.1086/686902 · Cited by 2
Soft Drink Consumption and Suicide Attempts in Adolescents: The Korean Youth Risk Behavior Web-Based Survey
Park, D., Kim, J. L., & Cho, J. (2016) · Journal of Preventive Medicine · doi:10.21767/2572-5483.100009 · Cited by 2
Passionate Love Addiction: An Evolutionary Survival Mechanism That Can Go Terribly Wrong
Bolshakova, M., Fisher, H. E., Aubin, H., & Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.026 · Cited by 2
Philosophical Issues in the Addictions
Glackin, S. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.007 · Cited by 2
Hidden Sugar and its Bitter Obstacles for the Wellbeing of Consumers
Ngo, A. N. (2020) · Markets Globalization & Development Review · doi:10.23860/mgdr-2020-05-02-02 · Cited by 2
Prevention and Treatment
(2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.020 · Cited by 2
Neuroimaging of compulsive disorders
Yokum, S., & Stice, E. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816207-1.00011-1 · Cited by 2
Letter to the Editor: RE: Excessive Sugar Consumption May Be a Difficult Habit to Break: A View From the Brain and Body.
Grace, F., Hayes, L. D., & Sculthorpe, N. F. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2223 · Cited by 2
The Influence of Unlimited Sucrose Intake on Body Weight and Behavior—Findings from a Mouse Model
Dubljević, O., Ković, V., Pavković, Ž., Mitić, M., & Pešić, V. (2022) · Brain Sciences · doi:10.3390/brainsci12101332 · Cited by 1
The challenge of dietary management in soft drink consumption and its oral and systemic repercussions
Mengoa, M. G. R., Rangel, B. T., Garcia, A. A. M. N., Sugio, C. Y. C., Gomes, A. C. G., Sugio, C. T. C., Orikasa, G. T., & Neppelenbroek, K. H. (2022) · Nutrition and Health · doi:10.1177/02601060221136356 · Cited by 1
Sugar-sweetened Beverages and Caffeine
Sigala, D. M., & Falbe, J. (2024) · doi:10.1093/oso/9780190671051.003.0038 · Cited by 1
Dietary Modification of Physiological Responses to Chronic Psychosocial Stress: Implications for the Obesity Epidemic
Shively, C. A., Fimmel, A., Jones, S. R., & Nader, M. A. (2016) · Developments in primatology · doi:10.1007/978-3-319-30872-2_8 · Cited by 1
Prevention and Treatment of Work Addiction
Quiñones, C., & Griffiths, M. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.028 · Cited by 2

Authors: Tryon, M. S., Stanhope, K. L., Epel, E. S., Mason, A. E., Brown, R., Medici, V., Havel, P. J., & Laugero, K. D.
Affiliations: Departments of Nutrition (M.S.T., K.L.S., K.D.L., P.J.H.), California 95616
University of California, San Francisco (US)
University of California, Davis (US)
Agricultural Research Service (US)
Corresponding author: Laugero, Kevin D.
ORCID: Tryon, Matthew S.
Stanhope, Kimber L.
Epel, Elissa S.
Mason, Ashley E.
Medici, Valentina
Havel, Peter J.
Laugero, Kevin D.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2015-06-01
Volume: 100
Issue: 6
Pages: 2239-2247
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2014-4353
PMC: PMC4454811
OpenAlex: W2125159096
Cited by: 128
References: 37
Citations by year: 2026: 3 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 6 · 2021: 11 · 2020: 54 · 2019: 9 · 2018: 4 · 2017: 5 · 2016: 13 · 2015: 4
FWCI: 4.47
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: Office of Dietary Supplements
U.S. Department of Agriculture (CA 95616, UL1 RR024146)
National Institutes of Health (5r01hl091333-02, CA 95616, RR024146)
University of California, Davis (95616, K12 HD051958, CA 95616, RR024146, UL1 RR024146)
Agricultural Research Service
National Heart, Lung, and Blood Institute (F32HL009133, 1R01HL09133, R01 HL-091333, R01HL121324, HL107256, RR024146, R01HL107256, HL09133)
National Institute of Child Health and Human Development
National Center for Research Resources (RR-024146, UL1RR024146)
Office of Research on Women's Health (K12 HD051958)
National Center for Complementary and Integrative Health (T32AT003997)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD051958)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: sucrose, aspartame, artificial sweeteners, stress response, salivary cortisol, hippocampus, Montreal Imaging Stress Task, naltrexone, nausea, obesity, women
MeSH terms: Adolescent, Adult, Beverages, Brain, Energy Intake, Dietary Carbohydrates, Feeding Behavior, Female, Humans, Hydrocortisone, Magnetic Resonance Imaging, Obesity, Stress, Psychological, Sweetening Agents, Weight Gain, Substance-Related Disorders, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Excessive Sugar Consumption May Be a Difficult Habit to Break: A View From the Brain and Body

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks