Cited by 188Sirtuins and Resveratrol in MedicineLiver Disease Diagnosis and TreatmentAlcohol Consumption and Health Effects

The effects of resveratrol supplementation on cardiovascular risk factors in patients with non-alcoholic fatty liver disease: A randomised, double-blind, placebo-controlled study

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Faghihzadeh, Forouzan, Adibi, Payman, Hekmatdoost, Azita·2015·British Journal Of Nutrition

Abstract

Non-alcoholic fatty liver disease (NAFLD) is usually associated with insulin resistance, central obesity, reduced glucose tolerance, type 2 diabetes mellitus and hypertriacylglycerolaemia. The beneficial effects of resveratrol on metabolic disorders have been shown previously. The aim of this study was to evaluate the effects of resveratrol supplementation on cardiovascular risk factors in patients with NAFLD. In this randomised double-blinded placebo-controlled clinical trial, fifty NAFLD patients were supplemented with either a 500-mg resveratrol capsule or a placebo capsule for 12 weeks. Both groups were advised to follow an energy-balanced diet and physical activity recommendations. resveratrol supplementation reduced alanine aminotransferase (ALT) and hepatic steatosis significantly more than placebo (P0·05). There were no significant changes in blood pressure, insulin resistance markers and TAG in either group (P>0·05). Our data have shown that 12-week supplementation of 500 mg resveratrol does not have any beneficial effect on anthropometric measurements, insulin resistance markers, lipid profile and blood pressure; however, it reduced ALT and hepatic steatosis in patients with NAFLD.

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  • The antiandrogenic effects of resveratrol in PCOS women are probably indirect and driven by the reduction of insulin resistance, in contrast to pharmacologic intervention with metformin.

    “Given that chronic hyperinsulinemia can stimulate an excessive production of androgens in PCOS women, the antiandrogenic effects of resveratrol are probably indirect and driven by the reduction of IR in these patients [141,142,143,144], in contrast to pharmacologic intervention with metformin [145,146].”

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Authors
Faghihzadeh, F., Adibi, P., & Hekmatdoost, A.
Affiliations
National Nutrition and Food Technology Research Institute (IR)
Corresponding author
Hekmatdoost, Azita
Venue
British Journal Of Nutrition
Published
2015-08-03
Volume
114
Issue
5
Pages
796-803
ISSN
  • 0007-1145 (ISSN-L)
  • 1475-2662
OpenAlex
W2246929884
Cited by
188
References
35
Citations by year
2026: 9 · 2025: 9 · 2024: 17 · 2023: 13 · 2022: 28 · 2021: 18 · 2020: 17 · 2019: 15 · 2018: 20 · 2017: 12 · 2016: 25 · 2015: 2 · 2012: 3
FWCI
9.94
Type
journal article
Language
en
Open access
Locations
  • British Journal Of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • Iran National Science Foundation
  • National Nutrition and Food Technology Research Institute
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
resveratrol, non-alcoholic fatty liver disease, cardiovascular risk factors, insulin resistance, alanine aminotransferase, hepatic steatosis, lipid profile, blood pressure, hypertriglyceridemia, dietary supplementation
MeSH terms
Resveratrol, Adult, Alanine Transaminase, Anti-Inflammatory Agents, Antioxidants, Blood Pressure, Cardiovascular Diseases, Double-Blind Method, Fatty Liver, Female, Humans, Insulin Resistance, Liver, Male, Phytotherapy, Middle Aged, Plant Extracts, Risk Factors, Stilbenes, Triglycerides, Biomarkers, Dietary Supplements, Lipid Metabolism, Non-alcoholic Fatty Liver Disease

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