The effects of resveratrol supplementation on cardiovascular risk factors in patients with non-alcoholic fatty liver disease: A randomised, double-blind, placebo-controlled study
Open accessAbstract
Non-alcoholic fatty liver disease (NAFLD) is usually associated with insulin resistance, central obesity, reduced glucose tolerance, type 2 diabetes mellitus and hypertriacylglycerolaemia. The beneficial effects of resveratrol on metabolic disorders have been shown previously. The aim of this study was to evaluate the effects of resveratrol supplementation on cardiovascular risk factors in patients with NAFLD. In this randomised double-blinded placebo-controlled clinical trial, fifty NAFLD patients were supplemented with either a 500-mg resveratrol capsule or a placebo capsule for 12 weeks. Both groups were advised to follow an energy-balanced diet and physical activity recommendations. resveratrol supplementation reduced alanine aminotransferase (ALT) and hepatic steatosis significantly more than placebo (P0·05). There were no significant changes in blood pressure, insulin resistance markers and TAG in either group (P>0·05). Our data have shown that 12-week supplementation of 500 mg resveratrol does not have any beneficial effect on anthropometric measurements, insulin resistance markers, lipid profile and blood pressure; however, it reduced ALT and hepatic steatosis in patients with NAFLD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The antiandrogenic effects of resveratrol in PCOS women are probably indirect and driven by the reduction of insulin resistance, in contrast to pharmacologic intervention with metformin.
“Given that chronic hyperinsulinemia can stimulate an excessive production of androgens in PCOS women, the antiandrogenic effects of resveratrol are probably indirect and driven by the reduction of IR in these patients [141,142,143,144], in contrast to pharmacologic intervention with metformin [145,146].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [143]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Compendium of physical activities: an update of activity codes and MET intensities
AINSWORTH, B. E., HASKELL, W. L., WHITT, M. C., IRWIN, M. L., SWARTZ, A. M., STRATH, S. J., O???BRIEN, W. L., BASSETT, D. R., SCHMITZ, K. H., EMPLAINCOURT, P. O., et al. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200009001-00009 · Cited by 8,497 · see citing works
Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.10.002 · Cited by 1,320 · see citing works
Brasnyó, P., Molnár, G. A., Mohás, M., Markó, L., Laczy, B., Cseh, J., Mikolás, E., Szijártó, I. A., Mérei, Á., Halmai, R., et al. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511000316 · Cited by 680 · see citing works
Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus
Bhatt, J. K., Thomas, S., & Nanjan, M. J. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.06.003 · Cited by 475 · see citing works
High-Dose Resveratrol Supplementation in Obese Men
Poulsen, M. M., Vestergaard, P. F., Clasen, B. F., Radko, Y., Christensen, L. P., Stødkilde-Jørgensen, H., Møller, N., Jessen, N., Pedersen, S. B., & Jørgensen, J. O. L. (2013) · Diabetes · doi:10.2337/db12-0975 · Cited by 455 · see citing works
Eslamparast, T., Poustchi, H., Zamani, F., Sharafkhah, M., Malekzadeh, R., & Hekmatdoost, A. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.068890 · Cited by 406 · see citing works
Rivera, L., Morón, R., Zarzuelo, A., & Galisteo, M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.027 · Cited by 391 · see citing works
Yoshino, J., Conte, C., Fontana, L., Mittendorfer, B., Imai, S., Schechtman, K. B., Gu, C. C., Kunz, I., Fanelli, F. R., Patterson, B. W., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.09.015 · Cited by 381 · see citing works
GI Epidemiology: nonalcoholic fatty liver disease
Angulo, P. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03246.x · Cited by 370 · see citing works
Qiao, Y., Sun, J., Xia, S., Tang, X., Shi, Y., & Le, G. (2014) · Food & Function · doi:10.1039/c3fo60630a · Cited by 367 · see citing works
Faghihzadeh, F., Adibi, P., Rafiei, R., & Hekmatdoost, A. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.09.005 · Cited by 345 · see citing works
Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease
Chachay, V., Macdonald, G. A., Martin, J. H., Whitehead, J. P., O'Moore‐Sullivan, T. M., Lee, P., Franklin, M. E., Klein, K., Taylor, P. J., Ferguson, M. L., et al. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.02.024 · Cited by 291 · see citing works
Non-alcoholic fatty liver disease pathogenesis: The present and the future
Petta, S., Muratore, C., & Craxı̀, A. (2009) · Digestive and Liver Disease · doi:10.1016/j.dld.2009.01.004 · Cited by 284 · see citing works
Pilot study of resveratrol in older adults with impaired glucose tolerance
Crandall, J. P., Oram, V., Trandafirescu, G., Reid, M., Kishore, P., Hawkins, M., Cohen, H. W., & Barzilai, N. (2012) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glr235 · Cited by 281 · see citing works
Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase
SHANG, J., CHEN, L.-L., XIAO, F.-X., SUN, H., DING, H.-C., & XIAO, H. (2008) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2008.00807.x · Cited by 274 · see citing works
Thirunavukkarasu, M., Penumathsa, S. V., Koneru, S., Juhász, B., Zhan, L., Otani, H., Bagchi, D., Das, D. K., & Maulik, N. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.004 · Cited by 271 · see citing works
Resveratrol inhibits nonalcoholic fatty liver disease in rats
Bujanda, L., Hijona, E., Larzábal, M., Beraza, M., Aldazábal, P., García‐Urkía, N., Sarasqueta, C., Cosme, Á., Irastorza, B., González, A., et al. (2008) · BMC Gastroenterology · doi:10.1186/1471-230x-8-40 · Cited by 224 · see citing works
Yilmaz, Y. N. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12046 · Cited by 217 · see citing works
Bo, S., Ciccone, G., Castiglione, A., Gambino, R., Michieli, F. D., Villois, P., Durazzo, M., Cavallo‐Perin, P., & Cassader, M. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320100009 · Cited by 209 · see citing works
Gómez‐Zorita, S., Fernández‐Quintela, A., Macarulla, M. T., Aguirre, L., Hijona, E., Bujanda, L., Milagro, F. I., Martínez, J. A., & Portillo, M. P. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511002753 · Cited by 164 · see citing works
Askari, F., Rashidkhani, B., & Hekmatdoost, A. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.11.005 · Cited by 164 · see citing works
Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation
Yang, S. J., & Lim, Y. (2014) · Metabolism · doi:10.1016/j.metabol.2014.02.003 · Cited by 141 · see citing works
Li, L., Jie, H., Li, Z., Zhang, Y., Peng, H., Li, K., & Weng, X. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.08.036 · Cited by 134 · see citing works
Cho, S.-J., Jung, U. J., & Choi, M. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512000347 · Cited by 130 · see citing works
Eslamparast, T., Zamani, F., Hekmatdoost, A., Sharafkhah, M., Eghtesad, S., Malekzadeh, R., & Poustchi, H. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514000919 · Cited by 128 · see citing works
Effect of 6-month nutritional intervention on non-alcoholic fatty liver disease
Elias, M. C., Parise, E. R., de Carvalho, L., Szejnfeld, D., & Netto, J. P. (2009) · Nutrition · doi:10.1016/j.nut.2009.09.001 · Cited by 98 · see citing works
Nonalcoholic Fatty Liver Disease
Law, K., & Brunt, E. M. (2010) · Clinics in Liver Disease · doi:10.1016/j.cld.2010.07.006 · Cited by 79 · see citing works
How Much Weight Loss is Effective on Nonalcoholic Fatty Liver Disease?
Ghaemi, A., Taleban, F. A., Hekmatdoost, A., Rafiei, A., Hosseini, V., Amiri, Z., Homayounfar, R., & Fakheri, H. T. (2013) · Hepatitis Monthly · doi:10.5812/hepatmon.15227 · Cited by 79 · see citing works
Xin, P., Han, H., Gao, D., Cui, W., Yang, X., Ying, C., Sun, X., & Hao, L. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.10.026 · Cited by 71 · see citing works
Labbé, A., Garand, C., Cogger, V. C., Paquet, É. R., Desbiens, M., Couteur, D. G. L., & Lebel, M. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq184 · Cited by 71 · see citing works
Burgess, T. A. (2011) · Archives of Surgery · doi:10.1001/archsurg.2011.100 · Cited by 63 · see citing works
Choi, Y., Suh, H.-R., Yoon, Y., Lee, K. J., Kim, D. G., Kim, S., & Lee, B. (2014) · Archives of Pharmacal Research · doi:10.1007/s12272-014-0347-z · Cited by 47 · see citing works
Fibroscan for assessing liver fibrosis: An acceptable alternative for liver biopsy
Malekzadeh, R., & Poustchi, H. (2011) · Hepatitis Monthly · Cited by 31 · see citing works
Malekzadeh, R., & Poustchi, H. (2011) · PubMed · Cited by 31 · see citing works
Furimsky, A. M., Green, C. E., Sharp, L. E. H., Catz, P., Adjei, A. A., Parman, T., Kapetanović, I. M., Weinshilboum, R. M., & Iyer, L. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.107.016725 · Cited by 29 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
ESPEN guideline on clinical nutrition in liver disease
Plauth, M., Bernal, W., Dasarathy, S., Merli, M., Plank, L. D., Schütz, T., & Bischoff, S. C. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.12.022 · Cited by 674 · see citing works
Antioxidant effects of resveratrol in the cardiovascular system
Xia, N., Daiber, A., Förstermann, U., & Li, H. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13492 · Cited by 576 · see citing works
Health benefits of resveratrol: Evidence from clinical studies
Singh, A. P., Singh, R., Verma, S. S., Rai, V., Kaschula, C. H., Maiti, P., & Gupta, S. C. (2019) · Medicinal Research Reviews · doi:10.1002/med.21565 · Cited by 523 · see citing works
Resveratrol and Cardiovascular Diseases
Bonnefont‐Rousselot, D. (2016) · Nutrients · doi:10.3390/nu8050250 · Cited by 447 · see citing works
ESPEN practical guideline: clinical nutrition in liver disease
Bischoff, S. C., Bernal, W., Dasarathy, S., Merli, M., Plank, L. D., Schütz, T., & Plauth, M. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.09.001 · Cited by 383 · see citing works
Emerging roles of SIRT1 in fatty liver diseases
Ding, R., Bao, J., & Deng, C. (2017) · International Journal of Biological Sciences · doi:10.7150/ijbs.19370 · Cited by 359 · see citing works
Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases
Mirabelli, M., Chiefari, E., Arcidiacono, B., Corigliano, D. M., Brunetti, F. S., Maggisano, V., Russo, D., Foti, D. P., & Brunetti, A. (2020) · Nutrients · doi:10.3390/nu12041066 · Cited by 272 · see citing works
Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases
Gupta, S. C., Kunnumakkara, A. B., Aggarwal, S., & Aggarwal, B. B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02160 · Cited by 246 · see citing works
Resveratrol, Metabolic Syndrome, and Gut Microbiota
Chaplin, A. M. L., Carpéné, C., & Mercader, J. (2018) · Nutrients · doi:10.3390/nu10111651 · Cited by 248 · see citing works
Bagherniya, M., Nobili, V., Blesso, C. N., & Sahebkar, A. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.020 · Cited by 225 · see citing works
Zhu, X., Wu, C., Qiu, S., Yuan, X., & Li, L. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0217-z · Cited by 196 · see citing works
Brown, K., Theofanous, D., Britton, R. G., Aburido, G., Pepper, C., Undru, S. S., & Howells, L. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020747 · Cited by 190 · see citing works
Banaszewska, B., Wrotyńska-Barczyńska, J., Spaczynski, R. Z., Pawelczyk, L., & Duleba, A. J. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1858 · Cited by 173 · see citing works
Nonalcoholic Fatty Liver Disease, the Gut Microbiome, and Diet
Mokhtari, Z., Gibson, D. L., & Hekmatdoost, A. (2017) · Advances in Nutrition · doi:10.3945/an.116.013151 · Cited by 168 · see citing works
Samsamikor, M., Daryani, N. E., Rezanejad-Asl, P., & Hekmatdoost, A. (2016) · Archives of Medical Research · doi:10.1016/j.arcmed.2016.07.003 · Cited by 146 · see citing works
Fogacci, F., Tocci, G., Presta, V., Fratter, A., Borghi, C., & Cicero, A. F. G. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1422480 · Cited by 143 · see citing works
Dietary Polyphenols and Non-Alcoholic Fatty Liver Disease
Abenavoli, L., Larussa, T., Corea, A., Procopio, A. C., Boccuto, L., Dallio, M., Federico, A., & Luzza, F. (2021) · Nutrients · doi:10.3390/nu13020494 · Cited by 133 · see citing works
Liu, K., Luo, M., & Wei, S. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/6713194 · Cited by 125 · see citing works
Yari, Z., Rahimlou, M., Eslamparast, T., Ebrahimi-Daryani, N., Poustchi, H., & Hekmatdoost, A. (2016) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2016.1161011 · Cited by 118 · see citing works
Self-citationThe Protective Effect of Antioxidants Consumption on Diabetes and Vascular Complications
Dal-Ros, S., & Sigrist, S. (2016) · Diseases · doi:10.3390/diseases4030024 · Cited by 112 · see citing works
Saadati, S., Hatami, B., Yari, Z., Shahrbaf, M. A., Eghtesad, S., Mansour, A., Poustchi, H., Hedayati, M., Aghajanpoor-pasha, M., Sadeghi, A., et al. (2019) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0382-9 · Cited by 110 · see citing works
Self-citationJavid, A. Z., Hormoznejad, R., Yousefimanesh, H. A., Zakerkish, M., Haghighizadeh, M. H., Dehghan, P., & Ravanbakhsh, M. (2016) · Phytotherapy Research · doi:10.1002/ptr.5737 · Cited by 110 · see citing works
Natural Polyphenols in Metabolic Syndrome: Protective Mechanisms and Clinical Applications
Zhang, S., Xu, M., Zhang, W., Liu, C., & Chen, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116110 · Cited by 102 · see citing works
Hekmatdoost, A., Shamsipour, A., Meibodi, M., Gheibizadeh, N., Eslamparast, T., & Poustchi, H. (2016) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2016.1210101 · Cited by 98 · see citing works
Asghari, S., Jafarabadi, M. A., Somi, M. H., Ghavami, S.-M., & Rafraf, M. (2018) · Journal of the American College of Nutrition · doi:10.1080/07315724.2017.1392264 · Cited by 92 · see citing works
The role of nutraceuticals for the treatment of non‐alcoholic fatty liver disease
Ben, M. D., Polimeni, L., Baratta, F., Pastori, D., & Angelico, F. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12899 · Cited by 88 · see citing works
Haghighatdoost, F., & Hariri, M. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.033 · Cited by 88 · see citing works
Charytoniuk, T., Drygalski, K., Konstantynowicz-Nowicka, K., Berk, K., & Chabowski, A. (2016) · Nutrition · doi:10.1016/j.nut.2016.09.001 · Cited by 89 · see citing works
Curcumin and Weight Loss: Does It Work?
Kasprzak‐Drozd, K., Oniszczuk, T., Gancarz, M., Kondracka, A., Rusinek, R., & Oniszczuk, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020639 · Cited by 87 · see citing works
Yang, K., Chen, J., Zhang, T., Yuan, X., Ge, A., Wang, S., Xu, H., Zeng, L., & Ge, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.949746 · Cited by 85 · see citing works
Targeting Oxidative Stress with Polyphenols to Fight Liver Diseases
Machado, I. F., Miranda, R. G., Dorta, D. J., Rolo, A. P., & Palmeira, C. M. (2023) · Antioxidants · doi:10.3390/antiox12061212 · Cited by 85 · see citing works
Adipose tissue NAD + biology in obesity and insulin resistance: From mechanism to therapy
Yamaguchi, S., & Yoshino, J. (2017) · BioEssays · doi:10.1002/bies.201600227 · Cited by 83 · see citing works
Park, J.-S., Rustamov, N., & Roh, Y. (2023) · Antioxidants · doi:10.3390/antiox12111928 · Cited by 76 · see citing works
Bioavailability of resveratrol: Possibilities for enhancement
de Vries, K., Strydom, M. A., & Steenkamp, V. (2017) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2017.09.002 · Cited by 74 · see citing works
SIRT1: Harnessing multiple pathways to hinder NAFLD
Tian, C., Huang, R., & Xiang, M. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107155 · Cited by 77 · see citing works
At the interface of antioxidant signalling and cellular function: Key polyphenol effects
Kerimi, A., & Williamson, G. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500940 · Cited by 71 · see citing works
Alves, J. L. D. B., de Sousa, V. P., Neto, M. P. C., Magnani, M., Braga, V. A., Costa‐Silva, J. H., Leandro, C. G., Vidal, H., & Pirola, L. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00448 · Cited by 71 · see citing works
Marques, B. C., Trindade, M., Aquino, J. C. F., Cunha, A. R., Gismondi, R. A., Neves, M. F., & Oigman, W. (2018) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2017.1288741 · Cited by 67 · see citing works
Mousavi, S. M., Milajerdi, A., Sheikhi, A., Kord‐Varkaneh, H., Feinle‐Bisset, C., Larijani, B. A., & Esmaillzadeh, A. (2018) · Obesity Reviews · doi:10.1111/obr.12775 · Cited by 67 · see citing works
Huang, H., Chen, G., Liao, D., Zhu, Y., Pu, R., & Xue, X. (2016) · Obesity Reviews · doi:10.1111/obr.12458 · Cited by 66 · see citing works
Tiao, M., Lin, Y., Yu, H., Sheen, J., Lin, I.-C., Lai, Y., Tain, Y., Huang, L., & Tsai, C. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0824-3 · Cited by 65 · see citing works
Hepatoprotective effects of natural drugs: Current trends, scope, relevance and future perspectives
Datta, S., Aggarwal, D., Sehrawat, N., Yadav, M. K., Sharma, V., Sharma, A. K., Zghair, A. N., Dhama, K., Sharma, A., Kumar, V., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155100 · Cited by 69 · see citing works
Navarro, G., Martínez‐Pinilla, E., Ortiz, R., Noé, V., Ciudad, C. J., & Franco, R. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12359 · Cited by 63 · see citing works
Cano, R., Bermúdez, V., Galbán, N., Garrido, B., Santeliz, R., Gotera, M. P., Durán, P., Boscan, A., Carbonell, A., Durán‐Agüero, S., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169118 · Cited by 60 · see citing works
Du, F., Huang, R., Lin, D., Wang, Y., Yang, X., Huang, X., Zheng, B., Chen, Z., Huang, Y., Wang, X., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.611323 · Cited by 58 · see citing works
A Molecular Insight into the Role of Antioxidants in Nonalcoholic Fatty Liver Diseases
Ezhilarasan, D., & Thangavelu, L. P. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9233650 · Cited by 63 · see citing works
Role of the AMPK/SIRT1 pathway in non‑alcoholic fatty liver disease (Review)
Anggreini, P., Kuncoro, H., Sumiwi, S. A., & Levita, J. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12922 · Cited by 58 · see citing works
Noori, M., Jafari, B., & Hekmatdoost, A. (2016) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8042 · Cited by 57 · see citing works
Akbari, M., Tamtaji, O. R., Lankarani, K. B., Tabrizi, R., Dadgostar, E., Haghighat, N., Kolahdooz, F., Ghaderi, A., Mansournia, M. A., & Asemi, Z. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-1198-x · Cited by 57 · see citing works
Challenges in Analyzing the Biological Effects of Resveratrol
Erdogan, C. S., & Vang, O. (2016) · Nutrients · doi:10.3390/nu8060353 · Cited by 54 · see citing works
Nut consumption and total and cause-specific mortality: results from the Golestan Cohort Study
Eslamparast, T., Sharafkhah, M., Poustchi, H., Hashemian, M., Dawsey, S. M., Freedman, N. D., Boffetta, P., Abnet, C. C., Etemadi, A., Pourshams, A., et al. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyv365 · Cited by 53 · see citing works
Weaver, S. R., Rendeiro, C., McGettrick, H. M., Philp, A., & Lucas, S. J. E. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02247-8 · Cited by 56 · see citing works
Godos, J., Romano, G. L., Gozzo, L., Laudani, S., Paladino, N., Azpíroz, I. D., López, N. M. M., Giampieri, F., Quiles, J. L., Battino, M. A., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1368949 · Cited by 51 · see citing works
Jakubczyk, K., Skonieczna‐Żydecka, K., Kałduńska, J., Stachowska, E., Gutowska, I., & Janda, K. (2020) · Nutrients · doi:10.3390/nu12082435 · Cited by 49 · see citing works
Figueiredo, P. S., Inada, A. C., Fernandes, M. R., Arakaki, D. G., Freitas, K. D. C., Guimarães, R. D. C. A., do Nascimento, V. A., & Hiane, P. A. (2018) · Molecules · doi:10.3390/molecules23040877 · Cited by 48 · see citing works
Potential Therapeutic Benefits of Herbs and Supplements in Patients with NAFLD
Perumpail, B. J., Li, A. A., Iqbal, U., Sallam, S., Shah, N. D., Kwong, W., Cholankeril, G. T., Kim, D., & Ahmed, A. (2018) · Diseases · doi:10.3390/diseases6030080 · Cited by 48 · see citing works
Zhang, C., Yuan, W., Fang, J., Wang, W., He, P., Lei, J., & Wang, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161792 · Cited by 47 · see citing works
Dietary supplementation in patients with alcoholic liver disease: a review on current evidence
Ghorbani, Z., Hajizadeh, M., & Hekmatdoost, A. (2016) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(16)60096-6 · Cited by 46 · see citing works
Darand, M., Darabi, Z., Yari, Z., Saadati, S., Hedayati, M., Khoncheh, A., Ahangar, B. H., Alavian, S. M., & Hekmatdoost, A. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.04.014 · Cited by 45 · see citing works
Farzin, L., Asghari, S., Rafraf, M., Jafarabadi, M. A., & Shirmohammadi, M. (2019) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000528 · Cited by 45 · see citing works
Silva, P., Sureda, A., Tur, J. A., Andreoletti, P., Cherkaoui‐Malki, M., & Latruffe, N. (2019) · Free Radical Research · doi:10.1080/10715762.2019.1614176 · Cited by 44 · see citing works
Akbari, M., Tamtaji, O. R., Lankarani, K. B., Tabrizi, R., Dadgostar, E., Kolahdooz, F., Jamilian, M., Mirzaei, H., & Asemi, Z. (2019) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-019-00324-6 · Cited by 43 · see citing works
Targeting Abdominal Obesity and Its Complications with Dietary Phytoestrogens
Kuryłowicz, A., Cakala, M., & Puzianowska‐Kuźnicka, M. (2020) · Nutrients · doi:10.3390/nu12020582 · Cited by 43 · see citing works
In Search of New Therapeutic Targets in Obesity Treatment: Sirtuins
Kuryłowicz, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040572 · Cited by 43 · see citing works
Egg consumption and risk of non-alcoholic fatty liver disease
Mokhtari, Z., Poustchi, H., Eslamparast, T., & Hekmatdoost, A. (2017) · World Journal of Hepatology · doi:10.4254/wjh.v9.i10.503 · Cited by 42 · see citing works
Poulsen, M. K., Nellemann, B., Bibby, B. M., Stødkilde‐Jørgensen, H., Pedersen, S. B., Grønbæk, H., & Nielsen, S. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13409 · Cited by 41 · see citing works
Dietary Composition and Cardiovascular Risk: A Mediator or a Bystander?
Korakas, E., Dimitriadis, G., Raptis, A. E., & Lambadiari, V. (2018) · Nutrients · doi:10.3390/nu10121912 · Cited by 42 · see citing works
Frendo‐Cumbo, S., MacPherson, R. E. K., & Wright, D. C. (2016) · Physiological Reports · doi:10.14814/phy2.12877 · Cited by 39 · see citing works
Hypoglycemic Effect of Resveratrol: A Systematic Review and Meta-Analysis
García-Martínez, B. I., Ruíz-Ramos, M., Pedraza‐Chaverrí, J., Santiago‐Osorio, E., & Mendoza-Núñez, V. M. (2021) · Antioxidants · doi:10.3390/antiox10010069 · Cited by 39 · see citing works
Liudvytska, O., & Kołodziejczyk-Czepas, J. (2022) · Nutrients · doi:10.3390/nu14102053 · Cited by 38 · see citing works
Therapeutic Potential of Resveratrol in Diabetic Nephropathy According to Molecular Signaling
Salami, M., Salami, R., Mafi, A., Aarabi, M. H., Vakili, O., & Asemi, Z. (2021) · Current Molecular Pharmacology · doi:10.2174/1874467215666211217122523 · Cited by 37 · see citing works
Zhou, Q., Wang, Y., Han, X., Fu, S., Zhu, C., & Chen, Q. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.795980 · Cited by 37 · see citing works
The Effects of Onion Consumption on Prevention of Nonalcoholic Fatty Liver Disease
Emamat, H., Foroughi, F., Eini‐Zinab, H., & Hekmatdoost, A. (2017) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-017-0636-7 · Cited by 35 · see citing works
Guo, X., Li, J., Tang, J., & Li, D. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1349076 · Cited by 35 · see citing works
Emamat, H., Foroughi, F., Eini‐Zinab, H., Taghizadeh, M., Rismanchi, M., & Hekmatdoost, A. (2015) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/s40200-016-0248-4 · Cited by 34 · see citing works
Amin‐Esmaeili, M., Rahimi‐Movaghar, A., Razaghi, E. M., Baghestani, A. R., & Jafari, S. (2012) · Hepatitis Monthly · doi:10.5812/kowsar.1735143x.806 · Cited by 33 · see citing works
Sangouni, A. A., Abdollahi, S., & Mozaffari–Khosravi, H. (2022) · BMC Cardiovascular Disorders · doi:10.1186/s12872-022-02637-2 · Cited by 32 · see citing works
Stadler, J. T., & Marsche, G. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.761170 · Cited by 31 · see citing works
Gartziandia, O., Lasa, A., Pedraz, J. L., Miranda, J., Portillo, M. P., Igartúa, M., & Hernández, R. M. (2018) · Molecules · doi:10.3390/molecules23081886 · Cited by 28 · see citing works
Alanazi, A. Z., Alqinyah, M., Alhamed, A. S., Mohammed, H., Raish, M., Aljerian, K., Alsabhan, J. F., & Alhazzani, K. (2024) · Redox Report · doi:10.1080/13510002.2024.2416835 · Cited by 26 · see citing works
Beneficial Effects of Plant-Derived Natural Products on Non-alcoholic Fatty Liver Disease
Simental‐Mendía, L. E., Gamboa‐Gómez, C. I., Guerrero‐Romero, F., Simental-Mendía, M. A., Sánchez‐García, A., & Rodríguez-Ramírez, M. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-64872-5_18 · Cited by 26 · see citing works
Resveratrol Metabolites Are Able to Reduce Steatosis in Cultured Hepatocytes
Trepiana, J., Krisa, S., Renouf, E., & Portillo, M. P. (2020) · Pharmaceuticals · doi:10.3390/ph13100285 · Cited by 25 · see citing works
Ferro, Y., Pujia, R., Mazza, E., Lascala, L., Lodari, O., Maurotti, S., Pujia, A., & Montalcini, T. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03579-1 · Cited by 25 · see citing works
xu, X., Liu, Q., Li, J., Xiao, M., Gao, T., Zhang, X., Lu, G., Wang, J., Guo, Y., Wen, P., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.940406 · Cited by 25 · see citing works
Arbizu, S., Mertens‐Talcott, S. U., Talcott, S. T., & Noratto, G. D. (2023) · Nutrients · doi:10.3390/nu15030681 · Cited by 25 · see citing works
Current strategies for nonalcoholic fatty liver disease treatment (Review)
Sun, J., Jin, X., & Li, Y. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5412 · Cited by 24 · see citing works
Askari, G., Aghajani, M., Salehi, M., Najafgholizadeh, A., Keshavarzpour, Z., Fadel, A., Venkatakrishnan, K., Salehi‐Sahlabadi, A., Hadi, A., & Pourmasoumi, M. (2020) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2020.100364 · Cited by 26 · see citing works
Murugan, D. D., Balan, D., & Wong, P. (2021) · Phytotherapy Research · doi:10.1002/ptr.7205 · Cited by 24 · see citing works
Sergi, C. M., Chiu, B., Feulefack, J., Shen, F., & Chiu, B. (2020) · Archives of Medical Science - Atherosclerotic Diseases · doi:10.5114/amsad.2020.95884 · Cited by 23 · see citing works
Effect of resveratrol supplementation on biomarkers associated with atherosclerosis in humans
Santana, T. M., Ogawa, L. Y., Rogero, M. M., Barroso, L. P., & de Castro, I. A. (2021) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2021.101491 · Cited by 20 · see citing works
Hesarooeyeh, Z. G., Basham, A., Sheybani‐Arani, M., Abbaszadeh, M., Asl, A. S., Moghbeli, M., & Saburi, E. (2023) · Phytotherapy Research · doi:10.1002/ptr.8023 · Cited by 20 · see citing works
Current understanding and controversies on the clinical implications of fibroblast growth factor 21
Badakhshi, Y., & Jin, T. (2020) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2020.1864278 · Cited by 20 · see citing works
Yang, M., Shen, Y., Zhao, S., Zhang, R., Dong, W., & Lei, X. (2023) · BMC Neuroscience · doi:10.1186/s12868-023-00797-1 · Cited by 19 · see citing works
Plant-Derived Nutraceuticals Involved in Body Weight Control by Modulating Gene Expression
Vrânceanu, M., Hegheş, S. C., Cozma-Petruț, A. P., Banc, R., Stroia, C. M., Raischi, V., Miere, D., Popa, D., & Filip, L. A. (2023) · Plants · doi:10.3390/plants12122273 · Cited by 19 · see citing works
Non-alcoholic fatty liver disease: Dietary and nutraceutical approaches
Cogorno, L., Formisano, E., Vignati, A., Prigione, A., Tramacere, A., Borgarelli, C., Sukkar, S. G., & Pisciotta, L. (2023) · Liver Research · doi:10.1016/j.livres.2023.08.005 · Cited by 19 · see citing works
Venkatesan, T., Jeong, M.-J., Choi, Y.-W., Park, E. J., El‐Desouky, S. K., & Kim, Y. (2016) · Integrative Cancer Therapies · doi:10.1177/1534735416636958 · Cited by 19 · see citing works
Jin, T. (2018) · Obesity Medicine · doi:10.1016/j.obmed.2018.11.002 · Cited by 19 · see citing works
Zhou, T., Jin, Z., Jiang, R., & Li, W. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1600439 · Cited by 19 · see citing works
Charytoniuk, T., Harasim‐Symbor, E., Polak, A., Drygalski, K., Berk, K., Chabowski, A., & Konstantynowicz-Nowicka, K. (2018) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520619666181224161255 · Cited by 17 · see citing works
The Clock‐NAD+‐Sirtuin connection in nonalcoholic fatty liver disease
Aggarwal, S., Trehanpati, N., Nagarajan, P., & Ramakrishna, G. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30772 · Cited by 17 · see citing works
- Authors
- Faghihzadeh, F., Adibi, P., & Hekmatdoost, A.
- Affiliations
- National Nutrition and Food Technology Research Institute (IR)
- Corresponding author
- Hekmatdoost, Azita
- ORCID
- Hekmatdoost, Azita
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2015-08-03
- Volume
- 114
- Issue
- 5
- Pages
- 796-803
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2246929884
- Cited by
- 188
- References
- 35
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 17 · 2023: 13 · 2022: 28 · 2021: 18 · 2020: 17 · 2019: 15 · 2018: 20 · 2017: 12 · 2016: 25 · 2015: 2 · 2012: 3
- FWCI
- 9.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Iran National Science Foundation
- National Nutrition and Food Technology Research Institute
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- resveratrol, non-alcoholic fatty liver disease, cardiovascular risk factors, insulin resistance, alanine aminotransferase, hepatic steatosis, lipid profile, blood pressure, hypertriglyceridemia, dietary supplementation
- MeSH terms
- Resveratrol, Adult, Alanine Transaminase, Anti-Inflammatory Agents, Antioxidants, Blood Pressure, Cardiovascular Diseases, Double-Blind Method, Fatty Liver, Female, Humans, Insulin Resistance, Liver, Male, Phytotherapy, Middle Aged, Plant Extracts, Risk Factors, Stilbenes, Triglycerides, Biomarkers, Dietary Supplements, Lipid Metabolism, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review