The DOI matches its Crossref record.
Acute effect of brief low- and high-intensity exercise on circulating insulin-like growth factor (IGF) I, II, and IGF-binding protein-3 and its proteolysis in young healthy men
Open accessAbstract
We measured circulating levels of the GH insulin-like growth factor (IGF) system in response to brief exercise of different intensities. Ten males (mean age 28 +/- 5 yr) were studied on three separate occasions: once under resting conditions (control) and once each performing 10 min of low- or high-intensity exercise. Blood samples were assayed by RIA for GH, IGF-I and -II, IGF-binding protein-3 (IGFBP-3), and IGFBP-3 proteolytic activity. After 10 min of low-intensity exercise, IGF-I and IGFBP-3 had increased over preexercise baseline by 7.7 +/- 2.7% (P < 0.05) and 12.5 +/- 3.3% (P < 0.004), respectively. After 10 min of high-intensity exercise, all measured components of the IGF system were increased: IGF-I by 13.3 +/- 3.2% (P < 0.002), IGF-II by 15.7 +/- 3.1 (P < 0.01), and IGFBP-3 by 23 +/- 6% (P < 0.001). IGFBP-3 proteolytic activity also was increased (44 +/- 14% above baseline, P < 0.05). GH reached its peak 10 min after the cessation of high-intensity exercise, unlike the earlier peaks of IGF-I and II. In summary: 1) brief exercise leads to small but significant increases in circulating IGF-I, IGF-II, IGFBP-3, and IGFBP-3 proteolysis; and 2) these responses may be influenced by exercise intensity. The IGF responses seem to be unrelated to GH. Acute exercise-induced proteolysis of IGFBP-3 may contribute to anabolic effects of physical activity by increasing the bioavailability of IGF-I.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Exercise: a behavioral intervention to enhance brain health and plasticity
Cotman, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02143-4 · Cited by 2,739
Exercise builds brain health: key roles of growth factor cascades and inflammation
Cotman, C. W., Berchtold, N. C., & Christie, L.-A. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.011 · Cited by 2,268
Basso, J. C., & Suzuki, W. A. (2016) · Brain Plasticity · doi:10.3233/bpl-160040 · Cited by 911
Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging
Ahlskog, J. E., Geda, Y. E., Graff-Radford, N. R., & Petersen, R. C. (2011) · Mayo Clinic Proceedings · doi:10.4065/mcp.2011.0252 · Cited by 885
VEGF is necessary for exercise‐induced adult hippocampal neurogenesis
Fabel, K., Fabel, K., Tam, B., Kaufer, D., Baiker, A., Simmons, N., Kuo, C. J., & Palmer, T. D. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03041.x · Cited by 861
Circulating Insulin-Like Growth Factor I Mediates Effects of Exercise on the Brain
Carro, E., Nuñez, A., Busiguina, S., & Torres-Aleman, I. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-08-02926.2000 · Cited by 762
Physical activity and memory functions: An interventional study
Ruscheweyh, R., Willemer, C., Krüger, K., Duning, T., Warnecke, T., Sommer, J., Völker, K., Ho, H. V., Mooren, F., Knecht, S., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.001 · Cited by 499
Red blood cells in sports: Effects of exercise and training on oxygen supply by red blood cells
Mairbäurl, H. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00332 · Cited by 482
Chastin, S. F. M., De Craemer, M., De Cocker, K., Powell, L., Van Cauwenberg, J., Dall, P., Hamer, M., & Stamatakis, E. (2019) · British Journal of Sports Medicine · doi:10.1136/bjsports-2017-097563 · Cited by 465
Cardiovascular fitness is associated with cognition in young adulthood
Åberg, M. A. I., Pedersen, N. L., Torén, K., Svartengren, M., Bäckstrand, B., Johnsson, T., Cooper-Kuhn, C. M., Åberg, N. D., Nilsson, M., & Kuhn, H. G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905307106 · Cited by 382
A primer on investigating the after effects of acute bouts of physical activity on cognition
Pontifex, M. B., McGowan, A. L., Chandler, M. C., Gwizdala, K. L., Parks, A. C., Fenn, K., & Kamijo, K. (2019) · Psychology of Sport and Exercise · doi:10.1016/j.psychsport.2018.08.015 · Cited by 339
Acute exercise improves motor memory: exploring potential biomarkers.
Skriver, K., Roig, M., Lundbye-Jensen, J., Pingel, J., Helge, J. W., Kiens, B., & Nielsen, J. B. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.08.004 · Cited by 326
Aging Hallmarks: The Benefits of Physical Exercise
Rebelo-Marques, A., De Sousa Lages, A., Andrade, R., Ribeiro, C. F., Mota-Pinto, A., Carrilho, F., & Espregueira-Mendes, J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00258 · Cited by 246
Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?
Müller, P., Duderstadt, Y., Lessmann, V., & Müller, N. G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041136 · Cited by 241
Blood-to-brain communication in aging and rejuvenation
Bieri, G., Schroer, A. B., & Villeda, S. A. (2023) · Nature Neuroscience · doi:10.1038/s41593-022-01238-8 · Cited by 156
Sanders, L. M. J., Hortobágyi, T., Karssemeijer, E. G. A., Van der Zee, E. A., Scherder, E. J. A., & van Heuvelen, M. J. G. (2020) · Alzheimer's Research & Therapy · doi:10.1186/s13195-020-00597-3 · Cited by 154
Hormone Replacement Therapy and Physical Function in Healthy Older Men. Time to Talk Hormones?
Giannoulis, M. G., Martin, F. C., Nair, K. S., Umpleby, A. M., & Sonksen, P. (2012) · Endocrine Reviews · doi:10.1210/er.2012-1002 · Cited by 132
Johnson, R. A., Rhodes, J. S., Jeffrey, S. L., Garland, T., & Mitchell, G. S. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00422-6 · Cited by 113
Nicolini, C., Michalski, B., Toepp, S. L., Turco, C. V., D'Hoine, T., Harasym, D., Gibala, M. J., Fahnestock, M., & Nelson, A. J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.03.042 · Cited by 69
Interplay between hormones and exercise on hippocampal plasticity across the lifespan
Bettio, L. E. B., Thacker, J. S., Rodgers, S. P., Brocardo, P. S., Christie, B. R., & Gil-Mohapel, J. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165821 · Cited by 40
Rahimi, R., Mirzaei, B., Rahmani-Nia, F., & Salehi, Z. (2015) · Journal of Research in Medical Sciences · doi:10.4103/1735-1995.168320 · Cited by 11
Metadata
- Authors
- Schwarz, A. J.
- Venue
- Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1996-10-01
- Volume
- 81
- Issue
- 10
- Pages
- 3492-3497
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W2062159547
- Cited by
- 284
- References
- 0
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
