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Relationships Between Fasting Plasma Glucose Levels and Insulin Secretion During Intravenous Glucose Tolerance Tests
Abstract
Insulin secretion and glucose disappearance rate were measured in 66 subjects with a wide range of fasting plasma glucose levels. The acute insulin response was present in subjects with fasting glucose levels below 115 mg/dl but was absent above this level. The glucose disappearance rate related to the relative acute insulin response in subjects with fasting glucose below 115 mg/dl and to total insulin response when fasting glucose levels were above 115 mg/dl. A calculated glucose disappearance rate of 1.06 per cent per minute was found when the acute isulin response was zero. All subjects with fasting glucose levels greater than 115 mg/dl had glucose disappearance rates greater than 1.06. These studies support 1) epidemiological data indicating 115 mg/dl as an upper limit of normal for fasting plasma glucose levels and 1.0 per cent per minute as a lower limit of normal for the glucose disappearance rate, and 2) evidence for an important role for the acute insulin response in the determination of glucose disappearance rates during intravenous glucose tolerance tests.
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Citations
Cites
Studies of pancreatic alpha cell function in normal and diabetic subjects
Unger, R. H., Aguilar-Parada, E., Müller, W. A., & Eisentraut, A. M. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106297 · Cited by 837
Seltzer, H. S., Allen, E. W., Herron, A. L., & Brennan, M. T. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105534 · Cited by 819
Bagdade, J. D., Bierman, E. L., & Porte, D. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105646 · Cited by 672
Self-citationDynamics of Insulin Secretion by the Perfused Rat Pancreas
CURRY, D. L., BENNETT, L. L., & GRODSKY, G. M. (1968) · Endocrinology · doi:10.1210/endo-83-3-572 · Cited by 601
THE PLASMA INSULIN RESPONSE TO GLUCOSE INFUSION IN HEALTHY SUBJECTS AND IN DIABETES MELLITUS
Cerasi, E., & Luft, R. (1967) · Acta Endocrinologica · doi:10.1530/acta.0.0550278 · Cited by 371
Perley, M., & Kipnis, D. M. (1966) · Diabetes · doi:10.2337/diab.15.12.867 · Cited by 330
Insulin responses to glucose: evidence for a two pool system in man
Porte, D., & Pupo, A. A. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106197 · Cited by 219
Self-citation
Cited by
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2003) · Diabetes Care · doi:10.2337/diacare.26.2007.s5 · Cited by 2,689
Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-002-1009-0 · Cited by 2,166
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166
Weyer, C., Bogardus, C., Mott, D. M., & Pratley, R. E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7231 · Cited by 1,940
Buchanan, T. A., Xiang, A. H., Peters, R. K., Kjos, S. L., Marroquin, A., Goico, J., Ochoa, C., Tan, S., Berkowitz, K., Hodis, H. N., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2796 · Cited by 1,339
Pathogenesis of type 2 diabetes mellitus
DeFronzo, R. A. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.04.013 · Cited by 1,342
Five stages of evolving beta-cell dysfunction during progression to diabetes
Weir, G. C., & Bonner-Weir, S. (2004) · Diabetes · doi:10.2337/diabetes.53.suppl_3.s16 · Cited by 1,126
Ferrannini, E., Gastaldelli, A., Miyazaki, Y., Matsuda, M., Mari, A., & DeFronzo, R. A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1133 · Cited by 540
Palmer, J. P., Fleming, G. A., Greenbaum, C. J., Herold, K. C., Jansa, L. D., Kolb, H., Lachin, J. M., Polonsky, K. S., Pozzilli, P., Skyler, J. S., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.1.250 · Cited by 491
Pathogenesis of Type 2 Diabetes Mellitus
Leahy, J. L. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.01.003 · Cited by 469
Beta-cell adaptation and decompensation during the progression of diabetes
Weir, G. C., Laybutt, D. R., Kaneto, H., Bonner-Weir, S., & Sharma, A. (2001) · Diabetes · doi:10.2337/diabetes.50.2007.s154 · Cited by 462
Insulin resistance as the core defect in type 2 diabetes mellitus
Goldstein, B. J. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02553-5 · Cited by 432
Increased Prevalence of Impaired Glucose Tolerance in Patients With Painful Sensory Neuropathy
Singleton, J. R., Smith, A. G., & Bromberg, M. B. (2001) · Diabetes Care · doi:10.2337/diacare.24.8.1448 · Cited by 364
Dynamics of insulin secretion and the clinical implications for obesity and diabetes
Seino, S., Shibasaki, T., & Minami, K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45680 · Cited by 364
β-cell loss and β-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition
Jurgens, C. A., Toukatly, M. N., Fligner, C. L., Udayasankar, J., Subramanian, S. L., Zraika, S., Aston-Mourney, K., Carr, D. B., Westermark, P., Westermark, G. T., et al. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.02.036 · Cited by 329
Marselli, L., Thorne, J., Dahiya, S., Sgroi, D. C., Sharma, A., Bonner-Weir, S., Marchetti, P., & Weir, G. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011499 · Cited by 313
Fehse, F., Trautmann, M., Holst, J. J., Halseth, A. E., Nanayakkara, N., Nielsen, L. L., Fineman, M. S., Kim, D. D., & Nauck, M. A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1093 · Cited by 297
Islet β cell mass in diabetes and how it relates to function, birth, and death
Weir, G. C., & Bonner‐Weir, S. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12031 · Cited by 296
Gerich, J. E. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s117 · Cited by 264
Meier, J. J., & Nauck, M. A. (2010) · Diabetes · doi:10.2337/db09-1899 · Cited by 215
Pathophysiology of prediabetes
Ferrannini, E., Gastaldelli, A., & Iozzo, P. (2011) · Medical Clinics of North America · doi:10.1016/j.mcna.2010.11.005 · Cited by 177
Human IAPP–induced pancreatic β cell toxicity and its regulation by autophagy
Shigihara, N., Fukunaka, A., Hara, A., Komiya, K., Honda, A., Uchida, T., Abe, H., Toyofuku, Y., Tamaki, M., Ogihara, T., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci69866 · Cited by 177
Longitudinal studies on the development of diabetes in individual Macaca nigra
Howard, C. F. (1986) · Diabetologia · doi:10.1007/bf00452067 · Cited by 141
Loss of beta cell function as fasting glucose increases in the non-diabetic range
Godsland, I. F., Jeffs, J. A. R., & Johnston, D. G. (2004) · Diabetologia · doi:10.1007/s00125-004-1454-z · Cited by 131
User’s guide to mechanism of action and clinical use of GLP-1 receptor agonists
Shaefer, C. F., Kushner, P., & Aguilar, R. (2015) · Postgraduate Medicine · doi:10.1080/00325481.2015.1090295 · Cited by 128
Hosker, J. P., Rudenski, A. S., Burnett, M. A., Matthews, D. R., & Turner, R. C. (1989) · Metabolism · doi:10.1016/0026-0495(89)90064-4 · Cited by 125
Brunzell, J. D., Porte, D., & Bierman, E. L. (1979) · Metabolism · doi:10.1016/0026-0495(79)90089-1 · Cited by 86
Self-citationActivation of melatonin signaling promotes β-cell survival and function
Costes, S., Boss, M., Thomas, A. P., & Matveyenko, A. V. (2015) · Molecular Endocrinology · doi:10.1210/me.2014-1293 · Cited by 84
Kaihara, K. A., Dickson, L. M., Jacobson, D. A., Tamarina, N., Roe, M. W., Philipson, L. H., & Wicksteed, B. (2013) · Diabetes · doi:10.2337/db12-1013 · Cited by 80
β-Cell failure in type 2 diabetes
Leibowitz, G., Kaiser, N., & Cerasi, E. (2011) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2010.00094.x · Cited by 78
Severe hypertriglyceridemia: role of familial and acquired disorders.
Chait, A., & Brunzell, J. D. (1983) · Metabolism · doi:10.1016/0026-0495(83)90184-1 · Cited by 69
Self-citationAN INTEGRATED VIEW OF β-CELL DYSFUNCTION IN TYPE-II DIABETES
Poitout, D., & Robertson, M. D. (1996) · Annual Review of Medicine · doi:10.1146/annurev.med.47.1.69 · Cited by 62
Dalle, S., Burcelin, R., & Gourdy, P. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2012.11.009 · Cited by 60
Göke, B. (2008) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01686.x · Cited by 58
Groop, L. C., Ratheiser, K., Luzi, L., Melander, A., Simonson, D. C., Petrides, A., Bonadonna, R. C., Wid�n, E., & DeFronzo, R. A. (1991) · Acta Diabetologica · doi:10.1007/bf00579720 · Cited by 39
Babu, A., Mehta, A., Guerrero, P., Chen, Z., Meyer, P. M., Koh, C. K., Roberts, R., Schaider, J., & Fogelfeld, L. (2009) · Endocrine Practice · doi:10.4158/ep09117.orr · Cited by 34
Acute hyperglycemia alters the ability of the normal β-cell to sense and respond to glucose
Meyer, J., Sturis, J., Katschinski, M., Arnold, R., Göke, B., & Byrne, M. M. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00427.2001 · Cited by 25
PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control
Kaihara, K. A., Dickson, L. M., Ellenbroek, J. H., Orr, C. M. D., Layden, B. T., & Wicksteed, B. (2015) · Diabetes · doi:10.2337/db14-1051 · Cited by 22
Amblee, A., Lious, D., & Fogelfeld, L. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-4097 · Cited by 16
HIF-2α Preserves Mitochondrial Activity and Glucose Sensing in Compensating β-Cells in Obesity
Moon, J.-S., Riopel, M., Seo, J. B., Herrero-Aguayo, V., Isaac, R., & Lee, Y. S. (2022) · Diabetes · doi:10.2337/db21-0736 · Cited by 13
Metadata
- Authors
- BRUNZELL, J. D., ROBERTSON, R. P., LERNER, R. L., HAZZARD, W. R., ENSINCK, J. W., BIERMAN, E. L., & PORTE, D.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1976-02
- Volume
- 42
- Issue
- 2
- Pages
- 222-229
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2160812382
- Cited by
- 505
- References
- 7
- FWCI
- 12.18
- Type
- journal article
- Language
- en
- Open access
- closed
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