A MID-DAY SURGE IN CORTISOL LEVELS
Abstract
A dramatic mid-day surge of cortisol with its onset concomitant with food intake was observed. Cortisol levels were unaffected by the evening meal. The magnitude and time course of the initiation of this mid-day peak of cortisol are markedly attenuated by food deprivation. These observations establish that within the circadian periodicity there exists a mid-day rhythm of cortisol secretion which appears to be synchronized by food intake.
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Ingestion of glucose, amino acids, protein, or mixed meals tends to increase serum and salivary cortisol concentrations in healthy adults.
“Ingestion of glucose, amino acids, protein, or mixed meals tends to increase serum and salivary cortisol concentrations in healthy adults (1–8).”
From Glucose ingestion selectively amplifies ACTH and cortisol secretory-burst mass and enhances their joint synchrony in healthy men. (2011) · cites this paper as [2]
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The hypothalamic-pituitary-adrenal (HPA) axis: A major mediator of the adaptive responses to stress
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Endocrine Ultradian Rhythms During Sleep and Wakefulness
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Relevance of cortisol and copeptin blood concentration changes in an experimental pain model
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Plasma cortisol and appetitively motivated arousal in monkeys.
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- Authors
- QUIGLEY, M. E., & YEN, S. S. C.
- Affiliations
- National Institutes of Health (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1979-12
- Volume
- 49
- Issue
- 6
- Pages
- 945-947
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2049002632
- Cited by
- 135
- References
- 8
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- cortisol, circadian rhythm, dietary intake, food deprivation, cortisol secretion, meal timing, circadian synchronization
- MeSH terms
- Adult, Circadian Rhythm, Eating, Fasting, Female, Humans, Hydrocortisone
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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