Cited by 178Circadian rhythm and melatoninHypothalamic control of reproductive hormonesOvarian function and disorders

The DOI matches its Crossref record.

The Circadian Rhythm of Plasma Melatonin During the Normal Menstrual Cycle and in Amenorrheic Women*

BRZEZINSKI, AMNON, LYNCH, H. J., SEIBEL, M. M., DENG, M. H., NADER, T. M., WURTMAN, R. J.·1988·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-66-5-891

Open this paper in CoChat — free account

Abstract

Plasma melatonin, PRL, and LH levels were measured in samples collected every 2 h for 24 h from 14 normally cycling women during the early follicular, periovulatory, and luteal phases of their menstrual cycles. Plasma melatonin levels also were measured in samples collected at the same interval from 7 patients with hypothalamic amenorrhea. A distinct daily rhythm in plasma melatonin was evident in all subjects, with peaks occurring around 0300 h. Each woman's rhythm was remarkably consistent throughout the menstrual cycle (in terms of the phase, amplitude, and total melatonin secreted). Plasma PRL levels also exhibited daily rhythms which did not change during the menstrual cycle; the nocturnal peak plasma PRL level tended to occur 1-2 h after that for melatonin. Among the amenorrheic women, both daytime and nighttime melatonin levels were significantly higher (P less than 0.005) than in the normal women. Their plasma PRL levels were similar to those in the normal women. We conclude that, as for PRL, the circadian rhythm of melatonin secretion does not change significantly during the normal menstrual cycle. The elevated plasma melatonin levels in women with hypothalamic amenorrhea suggest that the hormone may be involved in the neuroendocrine pathology underlying this disorder.

Integrity signals

Registry

Crossref · 10.1210/jcem-66-5-891

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*
REITER, R. J. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-151 · Cited by 2,192
Melatonin in Humans
Brzezinski, A. (1997) · New England Journal of Medicine · doi:10.1056/nejm199701163360306 · Cited by 1,549
Self-citation
Human pineal physiology and functional significance of melatonin
Macchi, M. M., & Bruce, J. N. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.08.001 · Cited by 545
“, sleep disturbances, fatigue, and muscle pain), while levels in anorexia nervosa patients have been reported as elevated or normal, possibly depending on diVerences in relative weight loss and acute nutritional deWciencies [28,30].”
Background
Circadian rhythms, sleep, and the menstrual cycle
Baker, F. C., & Driver, H. S. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.09.011 · Cited by 529
“FP: no change in onset or offset [21,25,34,36,38,39] conflicting results about amplitude or 24-h area under curve [21,25,36,38,39]”
Background
Neuroendocrine Aberrations in Women With Functional Hypothalamic Amenorrhea*
BERGA, S. L., MORTOLA, J. F., GIRTON, L., SUH, B., LAUGHLIN, G., PHAM, P., & YEN, S. S. C. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-68-2-301 · Cited by 337
Physiology and pharmacology of melatonin in relation to biological rhythms
Zawilska, J. B., Skene, D. J., & Arendt, J. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70081-7 · Cited by 348
“The ovulatory rise in temperature during the menstrual cycle is associated with a reported decline in the amplitude of melatonin [338], and luteal phase melatonin was reported to be higher than follicular phase melatonin [335], but these observations are not consistent [44, 45, 88, 240].”
Result
Sex Differences in Phase Angle of Entrainment and Melatonin Amplitude in Humans
Cain, S. W., Dennison, C. F., Zeitzer, J. M., Guzik, A. M., Khalsa, S. B. S., Santhi, N., Schoen, M. W., Czeisler, C. A., & Duffy, J. F. (2010) · Journal of Biological Rhythms · doi:10.1177/0748730410374943 · Cited by 343
“, 2000), or unchanged (Berga and Yen, 1990; Brzezinski et al., 1988; Delfs et al., 1994; Ito et al., 1993; Parry et al., 1997; Wright Jr. and Badia, 1999) when compared to the follicular phase.”
Background
Individual Differences in the Amount and Timing of Salivary Melatonin Secretion
Burgess, H. J., & Fogg, L. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003055 · Cited by 270
“Furthermore, menstrual phase in women not using hormonal birth control was not associated with alterations in any of the melatonin parameters, in agreement with previous studies [39,43,44,45].”
Result
Women's sleep in health and disease
Dzaja, A., Arber, S., Hislop, J., Kerkhofs, M., Kopp, C., Pollmächer, T., Polo‐Kantola, P., Skene, D. J., Stenuit, P., Tobler, I., et al. (2004) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2004.05.008 · Cited by 227
Sleep, hormones, and circadian rhythms throughout the menstrual cycle in healthy women and women with premenstrual dysphoric disorder
Shechter, A., & Boivin, D. B. (2010) · International Journal of Endocrinology · doi:10.1155/2010/259345 · Cited by 194
“[60] 1988 n = 14 healthy 1x/2-hour for 24-hours Plasma melatonin plasma PRL early-FP”
Background
Circadian and Seasonal Variation in Human Preovulatory Follicular Fluid Melatonin Concentration*
Rönnberg, L., Kauppila, A., Leppäluoto, J., Martikainen, H. K., & Vakkuri, O. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-2-493 · Cited by 170
Rotating Shift Work and Menstrual Cycle Characteristics
Lawson, C. C., Whelan, E. A., Hibert, E. N. L., Spiegelman, D. L., Schernhammer, E. S., & Rich-Edwards, J. W. (2011) · Epidemiology · doi:10.1097/ede.0b013e3182130016 · Cited by 180
“In one study, plasma melatonin levels remained consistent throughout the menstrual cycle, though melatonin levels were nearly twice as high in amenorrheic women as controls.(26) However, smaller studies have suggested an inverse association between exogenously administered melatonin and estrogen levels.”
Melatonin in relation to physiology in adult humans
Cagnacci, A. (1996) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1996.tb00287.x · Cited by 164
Adverse Events Associated with Melatonin for the Treatment of Primary or Secondary Sleep Disorders: A Systematic Review
Besag, F., Vasey, M. J., Lao, K. S. J., & Wong, I. C. K. (2019) · CNS Drugs · doi:10.1007/s40263-019-00680-w · Cited by 170
Effects of menstrual cycle phase and oral contraceptives on alertness, cognitive performance, and circadian rhythms during sleep deprivation
Wright, K. P., & Badia, P. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00042-x · Cited by 134
Plasma Melatonin Circadian Rhythms during the Menstrual Cycle and after Light Therapy in Premenstrual Dysphoric Disorder and Normal Control Subjects
Parry, B. L., Berga, S. L., Mostofi, N., Klauber, M. R., & Resnick, A. (1997) · Journal of Biological Rhythms · doi:10.1177/074873049701200107 · Cited by 129
Altered Waveform of Plasma Nocturnal Melatonin Secretion in Premenstrual Depression
Parry, B. L. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810240059010 · Cited by 128
Stress and human reproduction
Schenker, J. G., Meirow, D., & Schenker, E. (1992) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(92)90186-3 · Cited by 125
Role of melatonin in health and disease
Webb, S. M., & Puig‐Domingo, M. (1995) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1995.tb01869.x · Cited by 122
Effects of the Menstrual Cycle on Dependent Variables in Mood Disorder Research
Leibenluft, E. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950100009002 · Cited by 121
Neuroendocrine Aspects of Primary Endogenous Depression
Rubín, R. T. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820070052008 · Cited by 121
Light, melatonin and the sleep-wake cycle.
Brown, G. M. (1994) · PubMed Central · Cited by 116
Melatonin and human reproduction: Shedding light on the darkness hormone
Srinivasan, V., Spence, W., Pandi-Perumal, S. R., Zakharia, R., Bhatnagar, K. P., & Brzezinski, A. (2009) · Gynecological Endocrinology · doi:10.3109/09513590903159649 · Cited by 114
“with decreased GnRH /LH pulsatile secretion [42,43].”
Self-citation
The pineal gland and reproduction
Aleandri, V. (1996) · Human Reproduction Update · doi:10.1093/humupd/2.3.225 · Cited by 112
“nin concentrations does not mean that melatonin has no role in modulation of the menstrual cycle (Brzezinski et al., 1988).”
BackgroundResultInfluential
Geomagnetic Storms: Association with Incidence of Depression as Measured by Hospital Admission
Kay, R. W. (1994) · British Journal of Psychiatry · doi:10.1192/bjp.164.3.403 · Cited by 108
Endogenous Melatonin Levels and the Fate of Exogenous Melatonin: Age Effects
Zhdanova, I. V., Wurtman, R. J., Balcioglu, A., Kartashov, A. I., & Lynch, H. J. (1998) · The Journals of Gerontology Series A · doi:10.1093/gerona/53a.4.b293 · Cited by 107
“Increases in circulating melatonin levels have been associated with hypothalamic amenorrhea (25,26), and with certain types of hypogonadism (27,28).”
BackgroundSelf-citation
Saliva and serum samples were collected from eight healthy volunteers every two hours during a 26‐hour period. Melatonin concentrations were measured by radioimmunoassay after chloroform extraction using radioiodinated melatonin as a tracer. Five of the subjects had high serum melatonin levels at night (peak levels higher than 75 pg/ml); in three subjects the highest serum melatonin concentration was 20‐40 pg/ml. All subjects had low levels (<10 pg/ml) during the day. The correlations between salivary and serum levels were calculated. The regression line y =0.33×+ 3.7 pg/ml, r= 0.95, P <0.001, was obtained for all detectable value pairs (n= 73). The regression and correlation coefficients were almost equal for the peak values of melatonin and during the rising and descending phases of the secretion patterns. However, no significant correlation was found between low daytime salivary and serum concentrations when calculated separately. In the five high‐secretors the melatonin levels in saliva reflected reliably the changes in serum, but in the three low‐secretors the correlation between salivary and serum melatonin was not significant. The proportion of melatonin found in saliva decreased with increasing serum melatonin levels. Circadian rhythm parameters were estimated by single cosinor analysis. The acrophases did not differ significantly within a subject in the concomitant measurements of serum and salivary melatonin. The measurements of salivary melatonin levels seem valid for studies on melatonin rhythms, but the melatonin concentrations measured in saliva do not always consistently reflect the absolute concentrations in blood.
Laakso, M., Porkka‐Heiskanen, T., Alila, A., et al. (1990) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1990.tb00692.x · Cited by 106
Melatonin Administration Alters Semen Quality in Healthy Men
Luboshitzky, R., Shen‐Orr, Z., Nave, R., Lavi, S., & Lavie, P. (2002) · Journal of Andrology · doi:10.1002/j.1939-4640.2002.tb02281.x · Cited by 104
Gender differences in the temporal organization of proclactin (PRL) secretion: evidence for a sleep-independent circadian rhythm of circulating PRL levels- a clinical research center study.
Waldstreicher, J., Duffy, J. F., Brown, E. N., Rogacz, S., Allan, J. S., & Czeisler, C. A. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636355 · Cited by 100
Plasma Melatonin Circadian Rhythm Disturbances During Pregnancy and Postpartum in Depressed Women and Women With Personal or Family Histories of Depression
Parry, B. L., Meliska, C. J., Sorenson, D. L., López, A. M. V., Martínez, L. F., Nowakowski, S., Elliott, J. A., Hauger, R. L., & Kripke, D. F. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08050709 · Cited by 95
“Initial assays for melatonin, estradiol, and progesterone have been described elsewhere (24, 25).”
Method
Sleep, rhythms and women's mood. Part I. Menstrual cycle, pregnancy and postpartum
Parry, B. L., Martínez, L. F., Maurer, E. L., López, A. M. V., Sorenson, D. L., & Meliska, C. J. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.09.003 · Cited by 95
“In more extensive normal control studies, Brzezinski et al.(13) (sampling every 2 h) and Berga and Yen(14) (sampling every 30 min) found that melatonin circadian rhythms were relatively stable and resistant to hormonal influences during the menstrual cycle.”
Background
Systematic review of melatonin treatment in children with neurodevelopmental disabilities and sleep impairment
Phillips, L., & Appleton, R. E. (2004) · Developmental Medicine & Child Neurology · doi:10.1017/s001216220400132x · Cited by 91
Melatonin in perimenopausal and postmenopausal women
Toffol, E., Kalleinen, N., Haukka, J. K., Vakkuri, O., Partonen, T., & Polo‐Kantola, P. (2013) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3182a6c8f3 · Cited by 92
New sensitive serum melatonin radioimmunoassay employing the Kennaway G280 antibody: Syrian hamster morning adrenergic response
Vaughan, G. (1993) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1993.tb00514.x · Cited by 82
Systematic review of melatonin treatment in children with neurodevelopmental disabilities and sleep impairment
Phillips, L., & Appleton, R. E. (2004) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2004.tb00998.x · Cited by 81
“…reports of precocious puberty in children with low levels of melatonin secretion for their age (Waldhauser et al. 1991) and also increased melatonin concentrations in women with hypothalamic amenorrhoea (Brzezinski et al 1988) and men with hypogonadotropic hypogonadism (Puig-Domingo et al. 1992).”
Background
Marked Augmentation of Nocturnal Melatonin Secretion in Amenorrheic Athletes, but not in Cycling Athletes: Unaltered by Opioidergic or Dopaminergic Blockade*
Laughlin, G. A., Loucks, A. B., & YEN, S. S. C. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-6-1321 · Cited by 75
Melatonin-Related Hypogonadotropic Hypogonadism
Puig‐Domingo, M., Webb, S. M., Serrano, J., Peinado, M. A., Corcoy, R., Ruscalleda, J., Reiter, R. J., & de Leiva, A. (1992) · New England Journal of Medicine · doi:10.1056/nejm199211053271905 · Cited by 72
Shift work and subfecundity: a causal link or an artefact?
Zhu, J. L., Hjøllund, N. H., Bøggild, H., et al. (2003) · Occupational and Environmental Medicine · doi:10.1136/oem.60.9.e12 · Cited by 71
Melatonin and human puberty: Current perspectives
Cavallo, A. (1993) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1993.tb00517.x · Cited by 71
Effects of Electric and Magnetic Fields from High-power Lines on Female Urinary Excretion of 6-Sulfatoxymelatonin
Levallois, P. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.7.601 · Cited by 69
Characteristics of Menstrual Cycle in Shift Workers
Attarchi, M., Darkhi, H., Khodarahmian, M., Dolati, M., Kashanian, M., Ghaffari, M., Mirzamohammadi, E., & Mohammadi, S. (2013) · Global Journal of Health Science · doi:10.5539/gjhs.v5n3p163 · Cited by 62
“For example, previous studies have indicated a relationship between the urine levels of melatonin metabolites and work schedule and amenorrhea (Brzezinski et al., 1988; Hansen et al., 2006; Schernhammer et al., 2004; Schernhammer et al., 2006).”
Result
Influence of melatonin and photoperiod on animal and human reproduction
Cagnacci, A., & Volpe, A. (1996) · Journal of Endocrinological Investigation · doi:10.1007/bf03344974 · Cited by 61
Gonadal steroid modulation of neuroendocrine transduction: A transynaptic view
Solís, R. A., Abreu, P. M., G.‐Coviella, I. L., Hernández, G., Fajardo, N., Hernández-Díaz, F., Díaz-Cruz, A., & Hernandez, A. A. T. (1996) · Cellular and Molecular Neurobiology · doi:10.1007/bf02088101 · Cited by 62
Melatonin and Sex Hormone Interrelationships - A Review
Luboshitzky, R., & Lavie, P. (1999) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.1999.12.3.355 · Cited by 62
Neuroendocrine aspects of primary endogenous depression XV: mathematical modeling of nocturnal melatonin secretion in major depressives and normal controls
Sekula, L. K., Lucke, J. F., Heist, E. K., Czambel, R. K., & Rubín, R. T. (1997) · Psychiatry Research · doi:10.1016/s0165-1781(96)02937-x · Cited by 59
“While the premenopausal depressives were not matched with their controls on phase of the menstrual cycle, studies using frequent sampling suggest that circulating MEL concentrations do not vary consistently across the cycle (Brzezinski et al., 1988; Berga and Yen, 1990).”
Increased nocturnal melatonin secretion in male patients with hypogonadotropic hypogonadism and delayed puberty
Luboshitzky, R., Lavi, S., Thuma, I., & Lavie, P. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.7.7608268 · Cited by 59
Neurohypophysial hormone and melatonin secretion over the natural and suppressed menstrual cycle in premenopausal women
Kostoglou‐Athanassiou, I., Athanassiou, P., Treacher, D., Wheeler, M. J., & Forsling, M. L. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00504.x · Cited by 56
Effects of melatonin on progesterone production by human granulosa lutein cells in culture
Brzezinski, A., Fibich, T., Cohen, M. M., et al. (1992) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55257-1 · Cited by 56
Self-citation
Age at menarche, menstrual problems, and daytime sleepiness in Chinese adolescent girls
Wang, Z.-Y., Liu, Z., Jia, C.-X., & Liu, X. (2019) · SLEEP · doi:10.1093/sleep/zsz061 · Cited by 54
Effects of Leuprolide-Induced Hypogonadism and Testosterone Replacement on Sleep, Melatonin, and Prolactin Secretion in Men
Leibenluft, E., Schmidt, P. J., Turner, E. H., Danaceau, M. A., Ashman, S. B., Wehr, T. A., & Rubinow, D. R. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4270 · Cited by 56
Increased 6-sulfatoxymelatonin excretion in women with polycystic ovary syndrome
Luboshitzky, R., Qupti, G., Ishay, A., Shen‐Orr, Z., Futerman, B., & Linn, S. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)01930-6 · Cited by 51
Increase in Plasma Melatonin, β-Endorphin, and Cortisol after a 28.5-Mile Mountain Race: Relationship to Performance and Lack of Effect of Naltrexone*
Strassman, R. J., Appenzeller, O., Lewy, A. J., Qualls, C., & Peake, G. T. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-3-540 · Cited by 51
Long-term melatonin administration does not alter pituitary-gonadal hormone secretion in normal men
Luboshitzky, R., Levi, M., Shen‐Orr, Z., et al. (2000) · Human Reproduction · doi:10.1093/humrep/15.1.60 · Cited by 50
SEMINAL PLASMA MELATONIN AND GONADAL STEROIDS CONCENTRATIONS IN NORMAL MEN
Luboshitzky, R., Shen‐Orr, Z., & Herer, P. (2002) · Archives of Andrology · doi:10.1080/01485010252869324 · Cited by 49
Melatonin: a contraceptive for the nineties
Silman, R. E. (1993) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(93)90099-x · Cited by 49
Chapter II Neurobiology and neuropathology of the human hypothalamus
Swaab, D. F. (1997) · Handbook of chemical neuroanatomy · doi:10.1016/s0924-8196(97)80004-8 · Cited by 102
Melatonin concentrations in the sudden infant death syndrome
Sturner, W. Q., Lynch, H. J., Deng, M., Gleason, R. E., & Wurtman, R. J. (1990) · Forensic Science International · doi:10.1016/0379-0738(90)90234-p · Cited by 49
Self-citation
The pineal gland in human beings: Relevance to pediatrics†
Cavallo, A. (1993) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)80377-4 · Cited by 49
Light Exposure, Melatonin Secretion, and Menstrual Cycle Parameters: An Integrative Review
Barron, M. L. (2007) · Biological Research For Nursing · doi:10.1177/1099800407303337 · Cited by 48
“…including polycystic ovarian syndrome (PCOS), suggesting that melatonin has a role in promoting ovulation (Bellipani, Bianchi, Pierpaoli, Bulian, & Ilyia, 2001; Berga, Mortola, & Yen, 1988; Brzezinski et al., 1988; Luboshitzsky et al., 2001; Tang, Chan, Tang, & Pang, 1998; Turi & Garzetti, 1993).”
Background
AMPLIFICATION OF PULSATILE LH SECRETION BY EXOGENOUS MELATONIN IN WOMEN
Cagnacci, A., Elliott, J. A., & YEN, S. S. C. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-1-210 · Cited by 48
Maternal pineal melatonin in gestation and lactation physiology, and in fetal development and programming
Gomes, P. R. L., Motta‐Teixeira, L. C., Gallo, C. C., Buonfiglio, D. D. C., de Camargo, L. S., Quintela, T., Reiter, R. J., do Amaral, F. G., & Cipolla‐Neto, J. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113633 · Cited by 51
Amplification of nocturnal melatonin secretion in women with functional secondary amenorrhoea: relation to endogenous oestrogen concentration
Okatani, Y., & Sagara, Y. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02791.x · Cited by 45
The effect of melatonin on cleavage rate of C57BL/6 and CB A/Ca preimplantation embryos cultured in vitro
McElhinny, A., Davis, F. C., & Warner, C. M. (1996) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1996.tb00269.x · Cited by 43
Effect of Menopause on Melatonin and Alertness Rhythms Investigated in Constant Routine Conditions
Walters, J. F., Hampton, S., Ferns, G. A., & Skene, D. J. (2005) · Chronobiology International · doi:10.1080/07420520500263193 · Cited by 43
“Nocturnal melatonin production has been shown to increase in women with amenorrhoea in association with changes in hypothalamic-pituitary-gonadal dysfunction (Berga et al., 1988; Brzezinski et al., 1988; Walker et al., 1996).”
Background
Testosterone treatment alters melatonin concentrations in male patients with gonadotropin-releasing hormone deficiency.
Luboshitzky, R., Lavi, S., Thuma, I., et al. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.2.8636302 · Cited by 40
Influence of Melatonin on the Sleep‐Independent Component of Prolactin Secretion
Bispink, G., Zimmermann, R. C., Weise, H. C., & Leidenberger, F. (1990) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1990.tb00669.x · Cited by 38
Intra- and inter-individual variability of longitudinal daytime melatonin secretion patterns in depressed and non-depressed individuals
Bouwmans, M. E. J., Bos, E. H., Booij, S. H., van Faassen, M. H. J. R., Oldehinkel, A. J., & de Jonge, P. (2014) · Chronobiology International · doi:10.3109/07420528.2014.973114 · Cited by 38
“Multiple-day assessments of 24-h melatonin levels have been performed before, for example, to study the consistency of plasma melatonin levels between days of different menstruation phases (Brzezinski et al., 1988).”
Clearance of melatonin and 6‐sulfatoxymelatonin by hemodialysis in patients with end‐stage renal disease
Lüdemann, P., Zwernemann, S., & Lerchl, A. (2001) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2001.310305.x · Cited by 35
A potential role of endogenous progesterone in modulation of GH, prolactin and thyrotrophin secretion during normal menstrual cycle
Caufriez, A., Leproult, R., L’Hermite‐Balériaux, M., Moreno‐Reyes, R., & Copinschi, G. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03539.x · Cited by 34
Plasma Melatonin Levels in Anorexia Nervosa
Arendt, J., Bhanji, S., Franey, C. S., et al. (1992) · The British Journal of Psychiatry · doi:10.1192/bjp.161.3.361 · Cited by 34
Endocrine and chronobiological effects of fasting in women
Berga, S. L., Loucks, T. L., & Cameron, J. L. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)01686-7 · Cited by 35
Weight loss and menstrual cycle: clinical and endocrinological evaluation
Falsetti, L., Pasinetti, E., Mazzani, M. D., & Gastaldi, A. (1992) · Gynecological Endocrinology · doi:10.3109/09513599209081006 · Cited by 33
Evening administration of melatonin enhances the pulsatile secretion of prolactin but not of LH and TSH in normally cycling women
Terzolo, M., Revelli, A., Guidetti, D., Piovesan, A., Cassoni, P., Paccotti, P., Angeli, A., & Massobrio, M. (1993) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1993.tb01772.x · Cited by 31
“Furthermore, a widened and lengthened nocturnal MT peak was documented in patients with functional hypothalamic amenorrhoea (Berga et al., 1988; Brzezinski et al., 1988).”
Background
Melatonin Pharmacokinetics in Premenopausal and Postmenopausal Healthy Female Volunteers
Markantonis, S. L., Tsakalozou, E., Paraskeva, A., Staikou, ‪., & Fassoulaki, A. (2007) · The Journal of Clinical Pharmacology · doi:10.1177/0091270007311112 · Cited by 31
Changes in nocturnal pineal melatonin synthesis during the perimenopausal period: Relation to estrogen levels in female rats
Okatani, Y., Morioka, N., & Hayashi, K. (1999) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1999.tb00598.x · Cited by 30
Abnormal melatonin secretion in male patients with hypogonadism
Luboshitzky, R., Wagner, O., Lavi, S., et al. (1996) · Journal of Molecular Neuroscience · doi:10.1007/bf02736789 · Cited by 30
“Increased melatonin levels were demonstrated in women with hypothalamic ammenorrhea (Berga et al., 1988; Brzezinski et al., 1988; Laughlin et al., 1991), anorexia nervosa (Tortosa et al.”
Background
Seasonal Variation of Gonadotropins and Gonadal Steroids Receptors in the Human Pineal Gland
Luboshitzky, R., Dharan, M., Goldman, D., Herer, P., Hiss, Y., & Lavie, P. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00106-8 · Cited by 30
Elevated Nocturnal Melatonin Is a Consequence of Gonadotropin-Releasing Hormone Deficiency in Women with Hypothalamic Amenorrhea
Kadva, A., Djahanbakhch, O., Monson, J. P., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.10.5155 · Cited by 29
“with varying levels of the normal range of E2) of the normal menstrual cycle, there was no significant difference in nocturnal melatonin secretion ( 2 , 15).”
Background
Multiple Sclerosis: The Role of Puberty and the Pineal Gland in its Pathogenesis
Sandyk, R. (1993) · International Journal of Neuroscience · doi:10.3109/00207459308994277 · Cited by 28
Development of pre-implantation, mouse embryos under the influence of pineal indoles
Chan, W. Y., & Ng, T. B. (1994) · Journal of Neural Transmission · doi:10.1007/bf01277925 · Cited by 28
“Patients with hypothalamic hypogonadism have unusually high plasma melatonin concentrations (Berga etal., 1988; Brzezinski etal., 1988; Tortosa etal., 1989), suggesting that an increased pineal activity may be involved in the pathogenesis of this condition.”
Background
Nocturnal melatonin levels are unaltered by ovarian suppression in girls with central precocious puberty
Berga, S. L., Jones, K. L., Kaufmann, S., et al. (1989) · Fertility and Sterility · doi:10.1016/s0015-0282(16)53155-0 · Cited by 28
Effects of exogenous melatonin on pituitary hormones in humans
Ninomiya, T., Iwatani, N., Tomoda, A., & Miike, T. (2001) · Clinical Physiology · doi:10.1046/j.1365-2281.2001.00330.x · Cited by 27
Antepartum Depression Severity is Increased During Seasonally Longer Nights: Relationship to Melatonin and Cortisol Timing and Quantity
Meliska, C. J., Martínez, L. F., López, A. M. V., Sorenson, D. L., Nowakowski, S., Kripke, D. F., Elliott, J. A., & Parry, B. L. (2013) · Chronobiology International · doi:10.3109/07420528.2013.808652 · Cited by 28
“Initial assays for melatonin were described in previously published papers (Anderson et al., 1976; Brzezinski et al., 1988).”
Method
Spontaneous episodic release of adenohypophyseal hormones in hypothalamic amenorrhea
Genazzani, A. D., Gastaldi, M., Volpe, A., Petraglia, F., & Genazzani, A. R. (1995) · Gynecological Endocrinology · doi:10.3109/09513599509160467 · Cited by 25
Menstrual changes in sleep, rectal temperature and melatonin rhythms in a subject with premenstrual syndrome
Shinohara, K., Uchiyama, M., Okawa, M., Saito, K., Kawaguchi, M., Funabashi, T., & Kimura, F. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00826-0 · Cited by 26
A Short-Day Photoperiod Delays the Timing of Puberty in Female Mice via Changes in the Kisspeptin System
Bohlen, T. M., Silveira, M. A., Buonfiglio, D. D. C., Ferreira‐Neto, H. C., Cipolla‐Neto, J., Donato, J., & Frazão, R. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00044 · Cited by 25
Immunohistochemical Localization of Gonadotropin and Gonadal Steroid Receptors in Human Pineal Glands1
Luboshitzky, R., Dharan, M., Goldman, D., et al. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.3.3829 · Cited by 25
Menstrual cycle, exercise and health
Dawson, E. A., & Reilly, T. (2008) · Biological Rhythm Research · doi:10.1080/09291010802067213 · Cited by 25
“Brzezinski et al. (1988) reported that women with hypothalamic amenorrhea had elevated levels of melatonin, suggesting that disturbances in the hormone may be involved in the neuroendocrine pathology underlying this disorder.”
BackgroundInfluential
Late, but not early, wake therapy reduces morning plasma melatonin: Relationship to mood in Premenstrual Dysphoric Disorder
Parry, B. L., Meliska, C. J., Martínez, L. F., López, A. M. V., Sorenson, D. L., Hauger, R. L., & Elliott, J. A. (2008) · Psychiatry Research · doi:10.1016/j.psychres.2007.11.017 · Cited by 24
“In contrast, melatonin rhythms did not change with the menstrual cycle in 11 NC subjects, as also reported by Brzezinski et al. (1988) and Berga and Yen (1990).”
Background
Pineal and adrenal function before and after refeeding in anorexia nervosa
Kennedy, S. H., Brown, G. M., McVey, G. L., & Garfinkel, P. E. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90106-v · Cited by 23
Circadian and seasonal rhythms of melatonin production in mules (Equus asinus × Equus caballus)
Cozzi, B., Morei, G., Ravault, J. P., Chesneau, D., & Reiter, R. J. (1991) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1991.tb00829.x · Cited by 23
Melatonin and the ovulatory luteinizing hormone surge
Zimmermann, R. C., Schröder, S., Baars, S., et al. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)53817-5 · Cited by 23
The effect of geomagnetic storms on suicide
Gordon, C., & Berk, M. (2003) · Deakin Research Online (Deakin University) · Cited by 21
Abnormal twenty‐four hour pattern of pulsatile luteinizing hormone secretion and the response to naloxone in women with hyperprolactinaemic amenorrhoea
Tay, C. C. K., Glasier, A. F., Illingworth, P. J., et al. (1993) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1993.tb02415.x · Cited by 21
INCREASED SENSITIVITY TO LIGHT-INDUCED MELATONIN SUPPRESSION IN PREMENSTRUAL DYSPHORIC DISORDER
Parry, B. L., Meliska, C. J., Sorenson, D. L., López, A. M. V., Martínez, L. F., Hauger, R. L., & Elliott, J. A. (2010) · Chronobiology International · doi:10.3109/07420528.2010.503331 · Cited by 20
“Initial assays for plasma melatonin are described previously (Anderson et al., 1976; Brzezinski et al., 1988).”
Method
Melatonin Administered in the Afternoon Decreases Next-Day Luteinizing Hormone Levels in Men: Lack of Antagonism by Flumazenil
Luboshitzky, R., Shen‐Orr, Z., Shochat, T., et al. (1999) · Journal of Molecular Neuroscience · doi:10.1385/jmn:12:1:75 · Cited by 19
“Current information suggests that in humans, melatonin and the reproductive hormones maybe interrelated (Brzezinski et al., 1988; Okatani and Sagara, 1994; Luboshitzky et al., 1996a,b,c).”
Background
Reduced Phase-Advance of Plasma Melatonin After Bright Morning Light in The Luteal, But Not Follicular, Menstrual Cycle Phase in Premenstrual Dysphoric Disorder: An Extended Study
Parry, B. L., Meliska, C. J., Sorenson, D. L., Martínez, L. F., López, A. M. V., Elliott, J. A., & Hauger, R. L. (2011) · Chronobiology International · doi:10.3109/07420528.2011.567365 · Cited by 18
“Initial assays are described previously (Anderson et al., 1976; Brzezinski et al., 1988).”
EFFECTS OF LIFESTYLE AND BODY COMPOSITION ON THE OVARY
Yen, S. S. C. (1998) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70047-5 · Cited by 18
RAPID DECREASE IN MELATONIN PRODUCTION DURING SUCCESSFUL TREATMENT OF DELAYED PUBERTY
Arendt, J., Labib, M. H., Bojkowski, C., et al. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92716-5 · Cited by 18
Sleep Modulation of Neuroendocrine Function: Developmental Changes in Gonadotropin-Releasing Hormone Secretion during Sexual Maturation
Landy, H., Boepple, P. A., Mansfield, M. J., Charpie, P. M., Schoenfeld, D., Link, K., Romero, G., Crawford, J. D., Crigler, J. F., Blizzard, R. M., et al. (1990) · Pediatric Research · doi:10.1203/00006450-199009000-00011 · Cited by 17

Authors: BRZEZINSKI, A., LYNCH, H. J., SEIBEL, M. M., DENG, M. H., NADER, T. M., & WURTMAN, R. J.
Affiliations: Harvard University (US)
ORCID: BRZEZINSKI, AMNON
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1988-05
Volume: 66
Issue: 5
Pages: 891-895
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-66-5-891
OpenAlex: W2009634330
Cited by: 177
References: 0
Citations by year: 2025: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 2 · 2013: 7 · 2012: 1
FWCI: 8.14
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Center for Research Resources (5MO1 RR00088)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords: plasma melatonin, circadian rhythm, menstrual cycle, hypothalamic amenorrhea, prolactin, luteinizing hormone, nocturnal melatonin secretion
MeSH terms: Adult, Amenorrhea, Circadian Rhythm, Female, Follicular Phase, Follicle Stimulating Hormone, Humans, Hypothalamic Diseases, Luteinizing Hormone, Luteal Phase, Melatonin, Menstrual Cycle, Prolactin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Circadian Rhythm of Plasma Melatonin During the Normal Menstrual Cycle and in Amenorrheic Women*

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks